Sessions

Molecular mechanism of Akt signaling evoked by 1, 2-naphthoquinone

[Speaker] Kengo Nakahara:1
[Co-author] Hideki Hiraoka:1, Kyohei Hamada:1, Yoshito Kumagai:2, Takashi Uehara:1
1:Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Japan, 2:Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan

On Chemo-and Pharmaco-Toxicology: Pathophysiological Reactions on Toxicants

[Speaker] Eva Neu:1
[Co-author] Michael Michailov:1, Ursula Welscher:1, Uli Haerlin:1, Hartwig W. Bauer:1,2, Viktor Foltin:1,3, Janka Foltinova:1,4, Dieter G. Weiss:1,5
1:Inst. Umweltmedizin c/o ICSD/IAS e. V. POB 340316, 80100 Muenchen (Int. Council Sci. Develop./Int. Acad. Sci. Berlin-Innsbruck-Muenchen-NewDelhi-Paris-Sofia-Vienna), Germany, 2:Fac. Med., Univ. Berlin & Univ. Muenchen, Germany, 3:St. Elizabeth Univ., Bratislava, Slovakia, 4:Med. Fac., Univ. Bratislava, Slovakia, 5:Inst. Cell Physiol., Univ. Rostock, Germany

The Role of AhR-regulated Nrf2 induced by Benzo[a]pyrene in Retinal Pigment Epithelium Cells

[Speaker] Yen-Ling Kuo:1
[Co-author] Chi-Hao Tsai:1, Yu-Wen Cheng:2, Jaw-Jou Kang:1
1:National Taiwan University College of Medicine Graduate Institute of Toxicology, Taiwan, 2:Taipei Medical University College of Medicine, Department of Pharmacpology, Taiwan

Characterization and Cytotoxicity Evaluation of Biologically Synthesized Silver Nanoparticles from Albuca setosa aqueous bulb extract

[Speaker] Samuel W Odeyemi:1
[Co-author] Anthony J Afolayan:1
1:University of Fort Hare, South Africa

Transcellular transport of Three kinds of diester Aconitineacross human intestinal Caco-2 cells

[Speaker] Fei Xiao Zhang:1
[Co-author] Dan Dan Liu:1, Xing Zi Ma:1, Xin Miao:1, Gang Li:1
1:Inner Mongolia Medical University, Inner Mongolia Hohhot City China, China

Dimethyl fumarate ameliorates chemotherapy agent-induced peripheral neuropathy

[Speaker] Takehiro Kawashiri:1
[Co-author] Anna Miyagi:1, Shiori Shimizu:1, Nao Shigematsu:1, Daisuke Kobayashi:1, Takao Shimazoe:1
1:Department of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan

Toxic effect of aberrant light/dark cycle on depression and other symptoms induced by chronic corticosterone treatment in mice

[Speaker] Hiroshi Kawai:1
[Co-author] Jin Inabe:2, Takuya Ishibashi:2, Atsushi Mitsumoto:2
1:Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Japan, 2:Faculty of Pharmaceutical Sciences, Josai International University, Japan

Expression of CYP1A1 by Benzo (a) pyrene in a daytime food synchronization in rats

[Speaker] Oscar Samuel Avila Rosales:1
[Co-author] Regina Dorinda Montero Montoya:1, Diaz Muñoz Mauricio:2, Jesus Javier Espinosa Aguirre:1
1:Medicina Genomica y Toxicologia Ambiental, Instituto de Investigaciones biomedicas, Universidad Nacional Autonoma de Mexico, Mexico, 2:Biologia Molecular, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Mexico

Antimutagenic effect of grapefruit juice compounds against 2-aminoanthracene activation by human and rat cytochrome P4501A1

[Speaker] Rebeca Santes-Palacios:1
[Co-author] Rafael Camacho-Carranza:1, Jesus Javier Espinosa-Aguirre:1
1:Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico

Evaluation of risk for injury by extravasation of vasopressor and hyperosmolar agents in a rat model

[Speaker] Yuuka Shibata:1
[Co-author] Yumeka Sagara:2, Takanori Taogoshi:1, Tomoharu Yokooji:2, Hiroaki Matsuo:1
1:Department of Pharmaceutical Services, Hiroshima University Hospital, Japan, 2:Faculty of Pharmaceutical Sciences, Hiroshima University, Japan

Increased Hepatic Triglyceride Level Induced by a Glucokinase Activator in Mice

[Speaker] Junichi Namekawa:1,2
[Co-author] Mari Yasui:1, Atsuko Katayanagi:1, Mitsuyuki Shirai:2, Fumitoshi Asai:2
1:Toxicology Research Department, TEIJIN PHARMA LIMITED, Japan, 2:Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Japan

Data mining techniques to identify potential clinical presentation modulators in drug-induced liver injury

[Speaker] MI Lucena:1
[Co-author] A Gonzalez-Jimenez:1, K Mceuen:2, M Robles-Diaz:1, I Medina-Caliz:1, A Cueto-Sanchez:1, M Chen:2, A Suzuki:3, C Stephens:1, R J Andrade:1
1:UGC Aparato Digestivo y Servicio de Farmacologia Clinica, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Malaga, CIBERehd, Malaga, Spain, 2:Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA, 3:Gastroenterology, Durham VA Medical Center, Duke University, Durham, NC, USA

AhR plays a key role on epigenetic regulation within HDAC inhibitor treatment

[Speaker] Chi-Hao Tsai:1
[Co-author] Yu-Wen Cheng:2, Ching-Hao Li:3, Chen-Chen Lee:4, Po-Lin Liao:2, Jaw-Jou Kang:1
1:Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan, 2:School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, 3:Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 4:Department of Microbiology and Immunology, School of Medicine, China Medicine University, Taichung, Taiwan

The LD50 Study of Chemical Derived from The Ash Of The De-Seeded Fruit Head Of Oil Palm In Mice

[Speaker] Uzoamaka A Okoli:1,2
[Co-author] Michael T Okafor:1, Nkoyo I Nubila:1, Aaron C Okpe:1, Iroka J Udeniya:1
1:Department of Pharmacology and Therapeutics, College of Medicine, University Of Nigeria Enugu Campus, Nigeria, 2:Department of Medical Biochemistry, College of Medicine, University of Nigeria EnuguCampus, Nigeria

Prediction of drug-induced hepatotoxicity using long-term stable primary hepatic 3D spheroid cultures

[Speaker] Sabine U Vorrink:1
[Co-author] Yitian Zhou:1, Magnus Ingelman-Sundberg:1, Volker M Lauschke:1
1:Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Sweden

The protective mechanism of magnesium isoglycyrrhizinate on FOLFOX induced hepatotoxicity in xenografted tumor-bearing mice

[Speaker] Yuzhu Cao:1
[Co-author] Yawen Xia:1, Hang Shi:1, Aiyun Wang:1,2,3, Yin Lu:1,2,3
1:School of Pharmacy, Nanjing University of Chinese Medicine, China, 2:Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, China, 3:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, China

Evaluation of the effect of ethanolic stem bark extract of Mangifera indica on Hormonal profile and Semen quality of male albino rats

[Speaker] Adeyinka A. Aderinola:1
[Co-author] Jane I. Ejiofor:2
1:Department of Pharmacology, Olabisi Onabanjo university, Ago-iwoye, Nigeria., Nigeria, 2:Department of Pharmacology and Therapeutic, Ahmadu Bello University, Zaria., Nigeria

On the benefit of melatonin in protection against ouabain-induced arrhythmia through modulation of oxidative stress factors in isolated rat atria

[Speaker] Vahid Nikoui:1
[Co-author] Fatemeh Tokazabani Belasi:2, Azam Bakhtiarian:3, Saeed Mehrzadi:1, Mohammad Yahya Karimi:1, Muhammad Imran Khan:4, Mehrdad Foroohandeh:5, Amir Rashidian:3, Roya Fallah:6, Shayan Amiri:7
1:Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran, 2:Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran, 3:Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 4:Department of Pharmacy, Kohat University of Science and Technology, 26000 Kohat, KPK, Pakistan, 5:Department of Oral Pathology, Dental School, Isfahan University of Medical Science, Isfahan, Iran, 6:Department of Cardiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 7:Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

Disruption of mitochondrial dynamics by azidothymidine-triphosphate causes lethal cardiomyopathy

[Speaker] Takeya Sato:1
[Co-author] Ryosuke Nomura:1,2, Shigeki Kushimoto:2, Teruyuki Yanagisawa:1
1:Molecular Pharmacology, Tohoku University Graduate School of Medicine, Japan, 2:Emergency and Critical Care, Tohoku University Graduate School of Medicine, Japan

Study of healing effects of irsogladine maleate-containing formulations for acetic acid-induced oral stomatitis in Syrian golden hamsters

[Speaker] Mitsutoshi Satoh:1
[Co-author] Atsune Kamada:1, Ayano Imamura:2, Yayoi Kawano:2, Takehisa Hanawa:2
1:Department of Toxicology and Pharmacology, Division of Pharmacy Practice, Meiji Pharmaceutical University, Japan, 2:Department of Clinical Pharmaceutical Preformulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan

Pre-treatment for exposure to organophosphate cholinesterase inhibitors

[Speaker] Georg Petroianu:1
[Co-author] Syed M Nurulain:2,3, Mohamed Y Hassan:2, Kamil Kuca:4, Dietrich E Lorke:1
1:Florida International University, USA, 2:College of Medicine & Health Sciences, UAE University, UAE, 3:Institute of Information Technology, Islamabad, Pakistan, 4:University of Hradec Kralove, Czech Republic

Effects of diazinon on mast cell activation

[Speaker] Kyohka Tanaka:1
[Co-author] Miyoko Matsushima:1, Kazuko Atsumi:1, Kanako Sasou:1, Tomoshi Sugiyama:2, Tomoko Ohdachi:3, Jun Ueyama:1, Naozumi Hashimoto:3, Tsutomu Kawabe:1
1:Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Japan, 2:Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Japan, 3:Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Japan

Antioxidant, biochemical and histologic responses to exposure to selected water bodies within Lagos Mainland, Nigeria

[Speaker] Olufunmilayo O Adeyemi:1
[Co-author] Joy A Oladimeji Salami:1,3, Oreoluwa Okebukunola:1, David Adeyemi:2, Abidemi J Akindele:1
1:Department of Pharmacology, Therapeutics and Toxicology, College of Medicine University of Lagos, Nigeria, 2:Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria, 3:National Biotechnology Development Agency, Ogbomosho, Oyo State, Nigeria

THE BURDEN OF CRUDE OIL TOXICITY IN THE NIGER DELTA REGION OF NIGERIA

[Speaker] Udeme O Georgewill:1
[Co-author] Owunari O Georgewill:1
1:PHARMACOLOGY, University Of Port Harcourt, Nigeria

Cell culture-induced variation of the HepG2 cell line proteome

[Speaker] Andrea A Ellero:1
[Co-author] Andrew D Cromarty:1, Tracey Hurrell:2
1:Pharmacology, University of Pretoria, South Africa, 2:Department of Physiology and Pharmacology, Karolinska Institutet, Sweden

Acute recreational drug toxicity - poor identification of Emergency Department presentations in Europe using routine hospital coding systems

[Speaker] Ali A Hosin:1
[Co-author] Luke De La Rue:1, Evangelia Liakoni:2, Matthias Liechti:3, Jürgens Gesche:4, Euro-Den Research Group, David M Wood:1, Paul I Dargan:1,5
1:Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust, London, UK, 2:Inselspital, University Hospital Bern, Bern, Switzerland, 3:University Hospital Basel, Basel, Switzerland, 4:Roskilde Hospital, Roskilde, Denmark, 5:Faculty of Life Sciences and Medicine, Kings College London, London, UK

Structural domains critical for the selectivity of diamide activators to lepidopterous ryanodine receptors

[Speaker] Makoto Uchiyama:1
[Co-author] Tatsuki Kurokawa:1, Tasuku Kimura:1, Emiko Mori:1, Shigeki Kiyonaka:1, Yasuo Mori:1
1:Laboratory of Molecular Biology Department of Synthetic Chemistry and Biological Chemistry Graduate School of Engineering Kyoto University, Japan

The new sight of AhR-regulated Socs3 in ocular inflammation

[Speaker] Yi Lee:1
[Co-author] Chi-Hao Tsai:1, Yu-Wen Cheng:2, Jaw-Jou Kang:1
1:National Taiwan University College of Medicine Graduate Institute of Toxicology, Taiwan, 2:Department of Pharmacology College of Medicine, Taipei Medical University, Taiwan

Effects of sunitinib on the expression of keratin 9 in human keratinocyte cell lines and a 3D skin model

[Speaker] Ayaka Yoshida:1,2
[Co-author] Kazuhiro Yamamoto:1, Akane Murakawa:1, Takahiro Ishida:3, Tsutomu Nakagawa:1, Tomoo Itoh:2, Ikuko Yano:1
1:Department of Pharmacy, Kobe University Hospita, Japan, 2:Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Japan, 3:R&D Department, Momotani Juntenkan Ltd., Japan

Method for Synthesis of Oxidized Derivatives and Metabolites for Comparative Toxicity Testing

[Speaker] Sergei V. Redkozubov:1
[Co-author] Dmitrii I. Nezhinskii:1, Anastasiia A. Boitsova:1, Ekaterina A. Karpova:1, Iuliia A. Zhukovskaia:1
1:Biology, Volgograd State Medical University, Russia

Stem cells are the most sensitive screening tool to identify toxicity of GATA4- targeted small-molecule compounds

[Speaker] Tuuli Karhu:1
[Co-author] Mika Valimaki:1, Mikael Jumppanen:2, Lotta Pohjolainen:1, Robert Leigh:1, Gabor Foldes:3,4, Gustav Boije Af Gennas:2, Jari Yli-Kauhaluoma:2, Heikki Ruskoaho:1, Virpi Talman:1
1:Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland, 2:Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland, 3:National Heart and Lung Institute, Imperial College London, UK, 4:Heart and Vascular Center, Semmelweis University, Budapest, Hungary

Comprehensive analysis of PPARα-induced gene expression in rat liver

[Speaker] Tetsuro Urushidani:1
[Co-author] Karin Ozaki:1, Yumiko Mizukawa:1, Yoko Amagase:1
1:Pharmaceutical Sciences, Laboratory of Pathophysiology, Doshisha Women's College of Liberal Arts, Japan

Preventive effect of Thioredoxin-Albumin Fusion Protein against Copper enhanced Zinc-induced Neurotoxicity

[Speaker] Ken-ichiro Tanaka:1
[Co-author] Mikako Shimoda:1, Ayane Shimizu:1, Ayaka Takafuji:1, Tatsuhiro Ishida:2, Yu Ishima:2, Masahiro Kawahara:1
1:Musashino University, Japan, 2:Tokushima University, Japan

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