Sessions

Effect of Afatinib plasma levels and pharmacokinetics-related genetic polymorphisms on the degree of side effects in patients with non-small cell lung cancer

[Speaker] Yoshihisa Fukuda:1
[Co-author] Hideki Hayashi:1,2,3, Hirotoshi Iihara:2,3, Naoki Mizusaki:2, Chiemi Hirose:3, Komei Yanase:4, Yasushi Ohno:4, Yoshinori Itoh:3, Tadashi Sugiyama:1,2, Michiko Obara:1
1:Community Healthcare Pharmacy, Gifu Pharmaceutical University, Japan, 2:Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Japan, 3:Department of Pharmacy, Gifu University Hospital, Japan, 4:2nd Department of Internal Medicine, Gifu University School of Medicine, Japan

Gene landscape and correlation between B cell infiltration and PD-L1 expression by analyses of TCGA lung adenocarcinoma patients

[Speaker] Kuo-Hao Ho:1,2
[Co-author] Peng-Hsu Chen:1,2, Chwen-Ming Shih:1,2, Ku-Chung Chen:1,2
1:Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taiwan, 2:Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taiwan

Overcoming cisplatin resistance by targeting Sonic Hedgehog with dihydroartemisinin in esophegeal cancer

[Speaker] Wei Cui:1
1:Department of Pharmacology, Shenyang Pharmaceutical University, China

Reprogrammed glucose metabolism promotes aggressiveness and metastasis in colon cancer

[Speaker] Cheng-Wei Lin:1
[Co-author] Chih-Chia Kuo:1, Hsiang-Hsi Ling:1
1:Taipei Medical University, Taiwan

Identification of the phospho-dependent substrates of Cullin-RING ubiquitin ligases using MS-based proteomics and phosphoproteomics approach

[Speaker] Ping Liu:1
[Co-author] Xiaoji Cong:1, Shengjie Liao:2, Minjia Tan:1
1:Chemistry Proteomics Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China, 2:Hubei Polythenic University, China

Role of 2677G>T>A Genetic Polymorphism in the ABCB1 Drug Transporter in the Interaction between Voriconazole and Cyclosporine and Cyclosporine Related Nephrotoxicity After Allogeneic Stem Cell Transplantation

[Speaker] Nathalie K Zgheib:1
[Co-author] Raafat Alameddine:2, Radwan Massoud:2, Rihab Nasr:3, Jean El Cheikh:2, Rami Mahfouz:4, Ali Bazarbachi:2
1:Pharmacology and Toxicology, American University of Beirut, Lebanon, 2:Hematology and Oncology, American University of Beirut, Lebanon, 3:Anatomy, Cell Biology and Physiology, American University of Beirut, Lebanon, 4:Pathology and Laboratory Medicine, American University of Beirut, Lebanon

Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway

[Speaker] Lihui Wang:1
1:Pharmacology, Shenyang Pharmaceutical University, China

High Expression of FOXC1 in EGFR-TKI Resistant Non-Small Cell Lung Cancer

[Speaker] Yu-Hsuan Yeh:1
[Co-author] Pin-Jyun Chen:1, Jin-Yuan Shih:2, Ching-Chow Chen:1
1:Department of Pharmacology, College of Medicine, National Taiwan University, Taiwan, 2:Department of Internal Medicine, National Taiwan University Hospital, Taiwan

GD3s, a novel drug target of cancer

[Speaker] Jinhua Wang:1,2
[Co-author] Wan Li:1,2, Jinyi Liu:1,2, Weiqi Fu:1,2, Tengfei Ji:1,2, Guanhua Du:1,2
1:The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, China, 2:Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, China

APOBECs Mediate the Metabolic Clearance and Chemoresistance of Gemcitabine

[Speaker] Li Tao:1,2
[Co-author] Yanqing Liu:1,2
1:Department of Pharmacy, College of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, China, 2:The Institute of Cancer Research, Yangzhou University, Yangzhou, Jiangsu, 225001, China

Role of HDAC6 in EGFR-TKI Resistance of Non-Small Cell Lung Cancer

[Speaker] Yu-Tsen Lai:1
[Co-author] Ching-Chow Chen:1
1:Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan

Regulation EGFR-TKI resistance by Long Noncoding RNA Clusterin in Non-Small Cell Lung Cancer

[Speaker] Hsiao-Hui Lin:1
[Co-author] Wen-Shu Chen:1, Jin-Yuan Shih:2, Kai-Chien Yang:1, Ching-Chow Chen:1
1:Pharmacology, National Taiwan University, Taiwan, 2:Internal Medicine, National Taiwan University Hospital, Taiwan

Role of AKT3 in EGFR-TKI resistance of non-small cell lung cancer

[Speaker] Shih-Hsiang Huang:1
[Co-author] Ching-Chow Chen:1, Jin-Yuan Shih:2
1:Pharmacology, National Taiwan University, College of Medicine, Taiwan, 2:Internal Medicine, National Taiwan University Hospital, Taiwan

Sensitivity for hydrogen peroxide in ρ0 cells and involvement of membrane status

[Speaker] Yuko Takashi:1,2
[Co-author] Kazuo Tomita:1, Yoshikazu Kuwahara:1,3, Sayuri Yamanishi:1,4, Hideki Nabika:5, Koh-Ich Tanaka:6, Junichi Kitanaka:7, Nobue Kitanaka:7, Motohiko Takemura:7, Nobuyoshi Nishiyama:6, Shouichi Miyawaki:4, Yoshihiro Nishitani:2, Tomoaki Sato:1
1:Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan, 2:Restorative Dentistry and Endodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan, 3:Radiation Biology and Medicine, Faculty of Medicine, Tohoku Medical and Phamaceutical University, Japan, 4:Orthodontics and Dentofacial Orthpedics, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan, 5:Material and Biological Chemistry, Faculty of Science, Yamagata University, Japan, 6:Division of Pharmacology, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Japan, 7:Department of Pharmacology, Hyogo College of Medicine, Japan

Effective Targeting of NAC1 Dimerization by a Small-Molecule Inhibitor and Application to Cancer Combination Therapy

[Speaker] Yi Zhang:1
[Co-author] Xiao-Hui Wang:1, Hong-Han Zhang:1, Cheng Ji:1, Ling-Chuan Guo:1, Jin-Ming Yang:2
1:Soochow University, China, 2:Penn State College of Medicine, Department of Pharmacology and The Penn State Cancer Institute, USA

Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase

[Speaker] Ying Shen:1
[Co-author] Jiang-Kai Dong:1, Hui-Min Lei:1, Qian Liang:1, Hong-Zhuan Chen:1, Liang Zhu:1
1:Shanghai Jiao Tong University School of Medicine, China

Effect of Ganoderma Polysaccharide Peptide on Tumor Growth and Metastasis of Tumor-bearing Mice with Sleep Fragmentation

[Speaker] Yan Pan:1
1:Pharmacology, Peking University, China

Anti-tumor growth effect of STIM1 suppression

[Speaker] Chong Han:1
[Co-author] Tohru Yoneyama:2, Yuichi Toyama:3, Manabu Yonekura:3, Chikara Ohyama:2, Manabu Murakami:1
1:Department of Pharmacology, Hirosaki University, Japan, 2:Department of Urology, Hirosaki University, Japan, 3:Department of Cardiology and Nephrology, Hirosaki University, Japan

Cancer-type organic anion transporting polypeptide 1B3 is a promising target for spliceosome-mediated RNA trans-splicing based suicide gene therapy

[Speaker] Hanae Morio:1
[Co-author] Yuchen Sun:2, Manami Harada:2, Ulrich Koller:3, Anna Stierschneider:3, Josefina Hofbauer:3, Christina Gruber:3, Hidetaka Akita:2, Naohiko Anzai:1, Tomomi Furihata:1,2
1:Department of Pharmacology, Graduate School of Medicine, Chiba University, Japan, 2:Labolatory of Pharmacology and Toxicology, Graduate school of Pharmaceutical Sciences, Chiba University, Japan, 3:EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, Paracelsus Medical University Salzburg, Austria

Loss of CYLD expression correlates with deep tumor invasion and poor prognosis in patients with invasive oral squamous cell carcinoma

[Speaker] Hirofumi Jono:1,2
[Co-author] Satoru Shinriki:3, Naoki Suenaga:2, Ayumi Kanemaru:2, Shunsuke Miyake:2, Kanako Takano:2, Shintaro Yoshida:2, Hideyuki Saito:1,2
1:Department of Pharmacy, Kumamoto University Hospital, Japan, 2:Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 3:Department of Molecular Laboratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan

Tumor suppressor Pdcd4 attenuates delta Np73 translation in human breast cancer cells

[Speaker] Noriko Yoshikawa:1
[Co-author] Eriko Kinoshita:1, Mayuko Hatai:1, Satomi Kagota:2, Kazumasa Shinozuka:2, Kazuki Nakamura:1
1:Department of Pharmacology I, School of Pharmaceutical Sciences, Mukogawa Women's University, Japan, 2:Department of Pharmacology II, School of Pharmaceutical Sciences, Mukogawa Women's University, Japan

Resistance mechanisms to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in lung adenocarcinoma cells harboring the EGFR-T790M mutation

[Speaker] Kaori Nakatani:1
[Co-author] Toshimitsu Yamaoka:2, Tohru Ohmori:2, Motoi Ohba:2, Ken-Ichi Fujita:2, Iori Taki:1, Daisuke Kamei:1, Shinichi Iawai:1, Yasutsuna Sasaki:2
1:Department of Health Care and Regulatory Sciences, Showa University School of Pharmacy, Japan, 2:Institute of Molecular Oncology, Showa University, Japan

Concentration of 6-Thioguanine nucleotide (6-TGN) and 6-methyl mercaptopurine (6-meMP) in Children with Acute Lymphoblastic Leukemia (ALL) during Maintenance Phase Therapy at Cipto Mangunkusumo Hospital: A Preliminary Study

[Speaker] Dewi S Rosdiana:1
[Co-author] Melva Louisa:1, Djajadiman Gatot:2, Rianto Setiabudy:1
1:Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Indonesia, 2:Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Indonesia

SIS3, a specific inhibitor of Smad3, reverses multidrug resistance mediated by ABCB1 and ABCG2 in cancer cell lines

[Speaker] Chung-Pu Wu:1,2,3,4
[Co-author] Sung-Han Hsiao:2, Te-Chun Liu:2, Ni Yeh:5, Yu-Shan Wu:5
1:Department of Physiology and Pharmacology, Chang Gung University, Taiwan, 2:Graduate Institute of Biomedical Sciences, Chang Gung University, Taiwan, 3:Molecular Medicine Research Center, Chang Gung University, Taiwan, 4:Department of Neurosurgery, Chang Gung Memorial Hospital, Taiwan, 5:Department of Chemistry, Tunghai University, Taiwan

Herbal medicines as P-glycoprotein inhibitors for multidrug resistance reversal in colorectal cancer: A review

[Speaker] Gayoung Lee:1
[Co-author] Cahnggue Son:2, Junghyo Cho:2, Namhun Lee:1,2
1:Cheonan Korean Medicine Hospital of Daejeon University, Korea, 2:Liver-Immune Research Center, Daejeon Korean Medicine Hospital of Daejeon University, Korea

Pharmacokinetics and hematotoxicity of UFT after repeated administration in colorectal cancer model rats

[Speaker] Maki Okamura:1
[Co-author] Takanori Nakamura:1, Motoi Tsuda:1, Shinji Kobuchi:1, Yukako Ito:1, Toshiyuki Sakaeda:1
1:Pharmacokinetics, Kyoto Pharmaceutical University, Japan

Umbelliprenin efficiently induces complete pathologic response in 4T1 Tumor-bearing Balb/c Mice

[Speaker] Mohsen Rashidi:1
[Co-author] Ali Bazi:2, Davar Amani:3, Hamidreza Jamshidi:3, Seyed Ali Ziai:3
1:Mazandaran University of Medical Scinces, Iran, 2:Clinical Research Development Unit, Zabol University of Medical Sciences, Zabol, Iran, 3:Department of Pharmacology, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

Antiproliferative effects of polyclonal antibody against (pro) renin receptor in pancreatic ductal adenocarcinoma cells

[Speaker] Asadur Rahman:1,2
[Co-author] Yuki Shibayama:2, Arif Ul Hasan:1,2, Hirofumi Hitomi:2, Daisuke Nakano:2, Hiroyuki Kobori:1, Akira Nishiyama:2
1:Department of Pharmacology, International University of Health and Welfare, Japan, 2:Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan

L-type amino acid transporter 1 (LAT1) in endothelial cells of tumor vessels contributes to tumor angiogenesis

[Speaker] Lili Quan:1
[Co-author] Ryuichi Ohgaki:1, Suguru Okuda:1, Shushi Nagamori:1, Yoshikatsu Kanai:1
1:Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Japan

Cross-species Discovery of Flubendazole against Melanoma Progression via MITF Downregulation and EMT Inhibition

[Speaker] Genta Kinoshita:1
[Co-author] Eiji Yamada:1,2, Hiroko Nakayama:3, Richard M White:4, Ewa B Snaar-Jagalska:5, Herman P Spaink:5, Yasuhito Shimada:1,2,6
1:Integrative Pharmacology, Mie University Graduate School of Medicine, Japan, 2:Mie University Zebrafish Anticancer Drug Screening Center, Japan, 3:Graduate School of Regional Innovation Studies, Mie University, Japan, 4:Memorial Sloan Kettering Cancer Center, USA, 5:Department of Molecular Biology, Institute of Biology, Leiden University, the Netherlands, 6:Department of Bioinformatics, Mie University Advanced Science Research Promotion Center, Japan

BPA-dipeptides, novel boron delivery agents for boron neutron capture therapy, are transported by oligopeptide transporter

[Speaker] Junji Miyabe:1,2
[Co-author] Ryuichi Ohgaki:1, Keijiro Saito:3, Ling Wei:1, Suguru Okuda:1, Shushi Nagamori:1, Hiroshi Ohki:3, Kazuo Yoshino:3, Hidenori Inohara:2, Yoshikatsu Kanai:1
1:Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Japan, 2:Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, Osaka University, Japan, 3:Department of Chemistry, Faculty of Science, Shinshu University, Japan

Preparation of Targeted PEG-PLGA Nanoparticles for the Treatment of Cancer Metastasis

[Speaker] Zamri Chik:1
[Co-author] Mohammed Abdullah Mahdi Alshawsh:1, Hasan Almoustafa:1
1:Department of Pharmacology, University of Malaya, Malaysia

TMU-0324, A Novel Class I Histone Deacetylase Inhibitor, Inhibits Human Colorectal Cancer Growth in vitro and in vivo

[Speaker] Shiow-Lin Pan:1,2,3
[Co-author] Ruei-Shian Wang:2, Han-Li Huang:1, Gorge Hsiao:2
1:The Ph. D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taiwan, 2:Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3:Ph. D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei, Taiwan

Loss of core fucosylation influenced c-Met-mediated cell proliferation in HepG2 cells

[Speaker] Yuqin Wang:1
[Co-author] Yuan Xue:1, Wei Zhang:1
1:Department of Pharmacology, Pharmacy College, Nantong University, China

The differential effects of ER stress inducers on LPA-induced A431 cell dispersion

[Speaker] Ryo Saito:1
[Co-author] Kayo Nishida:1, Yui Mizumoto:1, Norihisa Fujita:1
1:College of Pharmaceutical Sciences, Ritsumeikan University, Japan

Combined inhibition of PI3K delta and FLT3 signaling exerts synergistic antitumor activity and overcomes acquired drug resistance in FLT3-activated acute myeloid leukemia

[Speaker] Liguang Lou:1
[Co-author] Ye He:1, Liping Sun:1, Chengying Xie:1, Yongping Xu:1
1:Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

Anti-metastatic evalulation of a novel HDAC6 inhibitor YH308 in human breast cancer cells in vitro and in vivo

[Speaker] Chia-Ron Yang:1
[Co-author] Yi-Ling Hsieh:1, Huang-Ju Tu:1
1:School of Pharmacy, National Taiwan University, Taiwan

Hypoxia-inducible factor-1α regulates energy fuel metabolism and mediates metabolic plasticity during ammonia stress response in ovarian cancer stem-like cells

[Speaker] Shojiro Kitajima:1,5
[Co-author] Kian Leong Lee:2, Hiroki Hikasa:3, Shinji Matsunaga:1, Takehiro Yamaguchi:1, Shuhei Tomita:1, Marito Araki:4, Hiroyuki Kato:5, Lorenz Poellinger:5
1:Pharmacology, Osaka City University Graduate School of Medicine, Japan, 2:Cancer & Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 3:Department of Biochemistry, School of Medicine, The University of Occupational and Environmental Health, Japan, 4:Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University Graduate School of Medicine, Japan, 5:Cancer Science Institute of Singapore, National University of Singapore, Singapore

IFIT1 and IFIT3 modulate the drug response via enhancing EGFR signaling and in human oral squamous cell carcinoma cells

[Speaker] Te-Chang Lee:1
[Co-author] Vijaya Kumar Pidugu:1, Mei-Maan Wu:2, Chung-Ji Liu:3
1:Institute of Biomedical Sciences, Academia Sinica, Taiwan, 2:Department of Public Health, School of Medicine, Taipei Medical University, Taipei, Taiwan, 3:Department of Oral and Maxillofacial Surgery, Mackay Memorial Hospital, Taipei, Taiwan

Discovery of selective inhibitors for oncoprotein kinases

[Speaker] Kai Cheng Hsu:1
[Co-author] Shiow Lin Pan:1
1:Taipei Medical University, Taiwan

IL-6 induces epithelial-to-mesenchymal transition in MCF-7 cells via SRc-FAK signaling

[Speaker] Ya-Fen Hsu:1
[Co-author] Ming-Jen Hsu:2
1:Landseed Hospital, Department of Surgery, Taoyuan, Taiwan, 2:Department of Pharmacology, Taipei Medical University, Taipei, Taiwan

Determination of the Binding Mode of An Andrographolide Derivative to K-Ras Oncoprotein via Molecular Modelling and STD-NMR

[Speaker] Shun Ying Quah:1
[Co-author] Siying Tan:1, Kok Lian Ho:2, Nizar Abdul Manan:3, Sreenivasa R Sagineedu:4, Pran K Deb:5, Johnson Stanslas:1
1:Department of Medicine, Universiti Putra Malaysia, Malaysia, 2:Department of Pathology, Universiti Putra Malaysia, Malaysia, 3:Department of Human Anatomy, Universiti Putra Malaysia, Malaysia, 4:Department of Pharmaceutical Chemistry, International Medical University, Malaysia, 5:Faculty of Pharmacy, Philadelphia University, Jordan

Differentiation-inducing factor-1 suppresses migration and invasion of malignant melanoma cells by inhibiting Stat3 phosphorylation

[Speaker] Momoko Kubo:1
[Co-author] Masaki Arioka:1, Fumi Takahashi-Yanaga:2, Toshiyuki Sasaguri:1
1:Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Japan, 2:Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan

Hyaluronan synthase HAS2 promotes chemoresistance by upregulating NRF2 expression

[Speaker] Bo-hyun Choi:1
[Co-author] In-Geun Ryoo:1, Mi-Kyoung Kwak:1
1:College of Pharmacy, The Catholic University of Korea, Korea

Phosphoproteome analysis reveals novel cellular responses affect by inhibition of LAT1, a cancer type amino acid transporter

[Speaker] Pornparn Kongpracha:1
[Co-author] Shushi Nagamori:1, Pattama Wiriyasermkul:1, Suguru Okuda:2, Ryuichi Ohgaki:2, Yoshikatsu Kanai:2
1:Laboratory of Bio-molecular Dynamics, Department of Collaborative Research, Nara Medical University, Japan, 2:Bio-system Pharmacology, Graduate School of Medicine, Osaka University, Japan

Effects of the retinoic receptor agonists on proliferation of myelocytic leukemia cells

[Speaker] Takeaki Nitto:1
[Co-author] Yasuko Ohnuki:1, Tomoko Matsuda:1, Mizuki Saegusa:1, Rina Matsuda:1, Asako Tanaka:1, Kohei Sawaki:1
1:Laboratory of Pharmacotherapy, Yokohama University of Pharmacy, Japan

Differentiation-inducing factor-1 suppresses proliferation, migration and metastasis of breast cancer

[Speaker] Fumi Tetsuo:1,3
[Co-author] Masaki Arioka:1, Fumi Takahashi-Yanaga:2, Fusanori Nishimura:3, Toshiyuki Sasaguri:1
1:Department of Clinical Pharmacology, Faculty of Medical Science, Kyushu University, Fukuoka, Japan, 2:Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan, 3:Department of Periodontology Division of Oral Rehabilitation Faculty of Dental Science, Kyushu University, Fukuoka, Japan

Antitumoral synergistic effect of the combination of uncoupler of oxidative phosphorylation and mitochondrial ribosome inhibitor in human breast cancer: in vitro and in vivo evaluation

[Speaker] Sebastian A. Fuentes-Retamal:1
[Co-author] Liliana A. Peredo-Silva:1, Cristian A. Sandoval-Acuna:2, Ana I. Liempi:3, Daniela I. Guzman-Rivera:1, Mario A. Pavani:1, Vicente E. Castro-Castillo:4, Mabel E. Catalan:1, Ulrike Kemmerling:3, Jorge F. Ferreira:1
1:Clinical and Molecular Pharmacology Program, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Chile, 2:Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic, 3:Program of Anatomy and Developmental Biology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Chile, 4:Department of Organic and Physical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Chile

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