Sessions

Modification with SUMO to regulate HDAC2 deacetylation activity by carbocisteine in human tracheobronchial epithelial cells

[Speaker] Yongyao Cui:1
[Co-author] Yun Song:1, Ping Yu:1, Juan Li:1, Hong-Zhuan Chen:1
1:Department of Pharmacology, Shanghai Jiao Tong University School of Medicine, China

Deamidation of asparagine residues in Prohibitin1 is involved in lipid droplet formation and cell proliferation in alveolar epithelial cell line

[Speaker] Masahito Ogasawara:1
[Co-author] Masachika Shudo:2, Haruki Tamura:1, Kohei Yamauchi:3
1:Department of Pharmacology, Division of bioregulatory pharmacology, Iwate Medical University, Japan, 2:Advanced Research Support Center, Ehime University School of Medicine, Japan, 3:Department of Respiratory Medicine, Iwate Medical University, Japan

DECIPHER ROLE OF CLASS-1 HDACS ON P-GP EXPRESSION IN BRONCHIAL ASTHMA

[Speaker] Ravi Mishra:1
[Co-author] Harshit Singh:2, Saurabh Chaturvedi:2, Vikas Agarwal:2, Zia Hashim:1, Rachna Chaturvedi:3
1:Department of Pulmonary Medicine, Sanjay Gandhi Post Gratuate Istitute Of Medical Science, Lucknow, UP India, India, 2:Department of Clinical Immunology, Sanjay Gandhi Post Gratuate Istitute Of Medical Science, Lucknow, UP India, India, 3:Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow UP India

The antiasthmatic potential of morin in the setting of experimentally induced allergic asthma

[Speaker] Sona Franova:1
[Co-author] Ivana Kazimierova:1, Miroslava Molitorisova:1, Martina Sutovska:1
1:Department of Pharmacology, BioMed, Comenius University Bratislava, Jessenius Faculty of Medicine, Martin, Slovakia

Differential modulation of Pre-Administration of Bicuculline and/or Picrotoxin for antagonistic effects of Flumazenil on Diazepam-Induced Hypoglossal Nerve Inhibition

[Speaker] Shinichi Nakamura:1
[Co-author] Kimie Terayama:1, Masaaki Nishida:1, Masahiko Suzuki:2, Kazuo Sugita:1, Yutaka Suzuki:1, Shigeki Sasaki:1, Masakazu Yoshida:1, Norimasa One:1, Kei Maruyama:2
1:Kumagaya General Hospital, Japan, 2:Saitama Medical University, Japan

A new pulmonary fibrosis mouse model

[Speaker] Hideki Mikami:1,2,3
[Co-author] Kento Yoshioka:1,2, Masahiko Hatano:2, Koichiro Tatsumi:3, Yoshitoshi Kasuya:1,2
1:Department of Biochemistry and Molecular Pharmacology, Graduate School of medicine, Chiba University, Chiba, Japan, 2:Department of Biomedical Science, Japan, 3:Department of Respirology, Japan

Role of HONO in the relationship between NO2 and mild asthma attacks

[Speaker] Masayuki Ohyama:1
[Co-author] Takae Nakajima:1, Chika Minejima:2, Kenichi Azuma:3, Yasuyuki Itano:4, Norimichi Takenaka:5
1:Department of Environmental Health, Osaka Institute of Public Health, Japan, 2:International Christian University, Japan, 3:Kindai University, Japan, 4:Osaka City Research Center of Environmental Science, Japan, 5:Osaka Prefecture University, Japan

Microarray analysis in bleomycin-induced lung fibrosis

[Speaker] Yasuo Okamoto:1
[Co-author] Masahiro Komi:1, Yasuhiro Takenouchi:1, Kazuhito Tsuboi:1
1:Department of Pharmacology, Kawasaki Medical School, Japan

The long-term inhibition of Orai-STIM coupling alleviates airways remodeling changes in experimental conditions

[Speaker] Martina Sutovska:1
[Co-author] Michaela Kocmalova:1, Ivana Kazimierova:1, Marta Joskova:1, Marian Adamkov:2, Sona Franova:1
1:Department of Pharmacology and BioMed (Martin's Biomedical Center), Jessenius Faculty of Medicine, Comenius University, Mala Hora, 11161 4D, 036 01 Martin, Slovakia, 2:Institute of Histology and Embryology, Jessenius Faculty of Medicine, Comenius University, Mala Hora 4, 03601, Martin, Slovakia

Unspliced X-box-binding protein 1 Protects Against Fibroblast Differentiation via Activating Nrf2 Signal during Pulmonary Fibrosis

[Speaker] Jian Gao:1,2,3
[Co-author] Xiaoting Mo:1,2, Wencheng Zhou:1,2, Wenhui Cui:1,2, Zhihui Zhang:1,3, Liucheng Li:1,2, Liang Xu:1, Cheng Zheng:1,3, Jiao Qu:3, Hongwei Yao:4
1:The First Affiliated Hospital of Anhui Medical University, China, 2:School of Pharmacy, Anhui Medical University, China, 3:The Second Affiliated Hospital of Dalian Medical University, China, 4:Department of Molecular Biology, Cell Biology & Biochemistry, Brown University Alpert Medical School, Providence, RI, USA

Inhibition of viral infection-induced inflammatory responses by targeting the CLOCK regulator casein kinase 1 δ/&epsilon

[Speaker] Meina Li:1
[Co-author] Shenna Y. Langenbach:1, Yuxiu C. Xia:1, Trudi Harris:1, Alastair G. Stewart:1
1:1Lung Health Research Centre, Department of Pharmacology & Therapeutics, School of Biomedical Science, University of Melbourne, Parkville, Victoria 3010, Australia

Protective Effect of Nrf2 Against Pulmonary Fibrosis through Targeting HMGB1-mediated Epithelial-mesenchymal Transition

[Speaker] Jiao Qu:1
[Co-author] Zhihui Zhang:3, Panpan Zhang:1,2, Cheng Zheng:3, Wencheng Zhou:4, Wenhui Cui:4, Xiaoting Mo:4, Liucheng Li:3, Liang Xu:3, Jian Gao:1
1:The Second Affiliated Hospital of Dalian Medical University, China, 2:School of Pharmacy, Dalian Medical University, China, 3:The First Affiliated Hospital of Anhui Medical University, China, 4:School of Pharmacy, Anhui Medical University, China

AMPK-FOXO3a pathway inhibits fibroblast-myofibroblast differentiation by activating autophagy during pulmonary fibrosis

[Speaker] Cheng Zheng:1
[Co-author] Zhihui Zhang:1, Jiao Qu:2,3, Panpan Zhang:3, Hua Wang:3, Rong Si:3, Yuhan Chao:2, Wenhui Cui:4, Liucheng Li:1, Jian Gao:1
1:The First Affiliated Hospital of Anhui Medical University, China, 2:The Second Affiliated Hospital of Dalian Medical University, China, 3:School of Pharmacy, Dalian Medical University, China, 4:School of Pharmacy, Anhui Medical University, China

HMGB1 Induces Epithelial-mesenchymal Transition in Pulmonary Fibrosis by Inhibiting FOXO1

[Speaker] Panpan Zhang:1,2
[Co-author] Jiao Qu:1,2, Cheng Zheng:3, Zhihui Zhang:3, Rong Si:1,2, Hua Wang:1,2, Liang Xu:4, Wenhui Cui:4, Liucheng Li:4, Jian Gao:1
1:The Second Affiliated Hospital of Dalian Medical University, China, 2:School of Pharmacy, Dalian Medical University, China, 3:The First Affiliated Hospital of Anhui Medical University, China, 4:School of Pharmacy, Anhui Medical University, China

Riot control agent oleoresin capsicum triggers acute lung injury via TLR cascade independently of the TRPV1 pathway

[Speaker] Pompy Patowary:1,2
[Co-author] Manash P Pathak:1,2, Kamaruz Zaman:2, Ps Raju:1, Pronobesh Chattopadhyay:1
1:Division of Pharmaceutical Technology, Defence Research Laboratory, Post Bag No. 2, Solmara, Tezpur-784001, Assam, India, 2:Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786 004, Assam, India

Antioxidant defense mechanism of sesamol and attenuation of bleomycin induced pulmonary toxicity in experimental animals

[Speaker] Swati Kaushik:1
[Co-author] Ameesha Tomar:1, Jagriti Bhatia:1, Dharamvir Singh Arya:1, Sudheer Arava:2
1:Deprtment of Pharmacology, All India Institute of Medical Sciences, New Delhi, India, 2:Department of Pathology, All India Institute of Medical Sciences, New Delhi-110029, India

Clinical benefit of pulmonary hypertension using statin therapy: a population-based cohort study

[Speaker] Chung-Yu Chen:1,2
1:Kaohsiung Medical University, Taiwan, 2:Kaohsiung Medical University Hospital, Taiwan

Screening of new inhibitors against idiopathic pulmonary fibrosis by virtue of human myofibroblast dedifferentiation

[Speaker] Kenichi Suzuki:1,2
[Co-author] Keita Ugai:1, Kento Yoshioka:1, Toshihiko Murayama:3, Masahiko Hatano:4, Koichiro Tatsumi:2, Yoshitoshi Kasuya:1
1:Department of Biochemistry and Molecular Pharmacology, Graduate School of Medicine, Chiba University, Chiba, Japan, 2:Department of Respirology, Graduate School of Medicine, Japan, 3:Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Japan, 4:Department of Biomedical Science, Graduate School of Medicine, Japan

Entrapment of Gold Nanoparticles in Liposomes for Controlled Intracellular Self-assembly

[Speaker] Ananth S Pannala:1
[Co-author] Gennaro A Dichello:1, Prabal K Chatterjee:1
1:University of Brighton, UK

Budesonide and Theophylline Co-encapsulated PLA Nanoparticles for Pulmonary Drug Delivery

[Speaker] Ananth S Pannala:1
[Co-author] Mira D Buhecha:1, Alison Lansley:1
1:School of Pharmacy and Biomolecular Sciences, University of Brighton, UK

Varenicline, a smoking cessation drug, inhibited the alveolar expansion in mice intratracheally administrated porcine pancreatic elastase

[Speaker] Mitsuhisa Koga:1
[Co-author] Yuki Kanaoka:1, Nozomi Kobayashi:1, Kohsyun Inada:1, Mai Eto:1, Aya Takagi:1, Yasufumi Kataoka:1, Atsushi Yamauchi:1
1:Department of Pharmaceutical Care and Health Sciences, Fukuoka University, Japan

Transforming Growth Factor Induces Collagen Expression in Human Nasal Mucosa-derived Fibroblasts: Role of Connective Tissue Growth Factor Induction

[Speaker] Wen-Bin Wu:1
[Co-author] Jiunn-Min Shieh:2,3, Yih-Jeng Tsai:1,4
1:School of Medicine, Fu Jen Catholic University, Taiwan, 2:Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan, 3:Department of Recreation and Healthcare Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, 4:Department of Otolaryngology Head and Neck Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan

Coleus Forskolin Briq. Extract inhibits inflammatory via NF-kappa B signaling in cough and asthma model

[Speaker] Yanwen Liu:1
[Co-author] Chaozhi Ma:1, Pengtao You:1, Yanfang Yang:1, Hezhen Wu:1, Xiaochun Ye:1, Xin Chen:1
1:Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine, China

Airway epithelial-to-mesenchymal transition: Compartmentalized cyclic AMP

[Speaker] Martina Schmidt:1
[Co-author] Haoxiao Zuo:1,2, Melissa Van Der Veen:1,2, Lennard Ringnalds:1,2
1:Molecular Pharmacology, University Groningen, the Netherlands, 2:University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, GRIAC, Groningen, the Netherlands

A novel DMARD, Iguratimod disrupts TGF-b signaling in epithelial cells and attenuates bleomycin-induced interstitial lung disease in mice

[Speaker] Qiong Luo:1
[Co-author] Xuelong Qian:1, Dongmei Hong:1, Yang Sun:1, Qiang Xu:1
1:Nanjing University, China

The effects of different fractions of garlic extracts on allergen-induced asthma

[Speaker] Jen-Chieh Tsai:1
[Co-author] Keng-Fan Liu:2, Hsien-Hao Tseng:1, Wen-Huang Peng:2, Chi-Rei Wu:2, Chia-Chen Hsieh:3
1:Da-Yeh University, Taiwan, 2:China Medical University, Taiwan, 3:Department of Medicine Division of Chest Medicine, Cheng Ching Hospital, Taiwan

Whole lung image-based quantification of alveolar airspace histological parameters identifies diffuse emphysematous phenotype in a mouse model of obstructive lung diseases

[Speaker] Ryunosuke Nakashima:1
[Co-author] Hirofumi Nohara:1,2, Shunsuke Kamei:1,2, Haruka Fujikawa:1,2, Kasumi Maruta:1, Taisei Kawakami:1, Yuka Eto:1, Mary Ann Suico:1, Hirofumi Kai:1, Tsuyoshi Shuto:1
1:Department of Molecular Medicine, Graduate School of Pharmaceutical Science, Kumamoto University, Japan, 2:Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Global Oriented) Program”, Kumamoto University, Japan

Antifungal effects of topical treatment of posaconazole on Aspergillus fumigatus infection in immunocompromised mice

[Speaker] Genki Kimura:1
[Co-author] Takahiro Nakaoki:1, Yuki Nishimoto:1, Yuto Suzuki:1, Takashi Masuko:1, Kazuhiro Ito:2, Yasuo Kizawa:1
1:Physiol. & Anat., Nihon Univ. Sch. Pharm., Japan, 2:Pulmocide Ltd., UK

Targeting TNF-α signaling pathway with ligand-specific antibody reverses corticosteroid insensitivity and/or airway inflammation in mice

[Speaker] Yuki Nishimoto:1
[Co-author] Genki Kimura:1, Keitaro Ueda:1, Kazuhiro Ito:2, Yasuo Kizawa:1
1:Physiol. & Anat., Nihon Univ. Sch. Pharm., Japan, 2:NHLI, Imperial College London, UK

Involvement of cysteinyl leukotriene 2 receptors in airway allergic inflammation in mice

[Speaker] Hiroyuki Tanaka:1,2
[Co-author] Atsushi Noguchi:1, Shunji Irino:1, Daiki Yamakoshi:1, Tomohiko Sekioka:3, Hirotaka Yamashita:1,2, Naoki Inagaki:1,2
1:Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan, 2:Medical information Science Division, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Japan, 3:Ono Pharmaceutical Co, Ltd., Japan

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