Sessions

Potential therapeutic in preeclampsia: effect of resveratrol on endothelial cells incubated with plasma from pregnant before clinical onset of disease

[Speaker] Valeria C Sandrim:1
[Co-author] Mayara Dias-Caldeira:1, Heloisa Bettiol:2, Viviane Cardoso:2, Marco A Barbieri:2, Ricardo C Cavalli:3
1:Pharmacology, UNESP, Brazil, 2:Department of Pediatrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil, 3:Departmento de Ginecologia e Obstetricia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo (FMRP-USP), Ribeirao Preto, Brazil

Deletion of SIRT1 in the cardiomyocyte exacerbates doxorubicin-induced cardiotoxicity in mice

[Speaker] Ryusuke Hosoda:1
[Co-author] Atsushi Kuno:1, Yoshiyuki Horio:1
1:Department of Pharmacology, Sapporo Medical University School of Medicine, Japan

Pinacidil, a KATP channel opener stimulates a cardiac Na+/Ca2+ exchanger function through NO/cGMP/PKG pathways in guinea-pig cardiac myocytes

[Speaker] Keisuke Iguchi:1
[Co-author] Yasuhide Watanabe:2, Masao Saotome:1, Kanna Yamashita:2, Miyuki Sasaki:2, Yuichiro Maekawa:1
1:Internal Medicine III (Cardiology), Hamamatsu University School of Medicine, Hamamatsu, Japan, 2:Health Science, Hamamatsu University School of Medicine, Hamamatsu, Japan

Betulinic acid lessens oxidative stress and impairment of aortic contraction induced by lipopolysaccharide in rats

[Speaker] Ling-Bo Qian:1
[Co-author] Yao-Yao Bai:1, Hui-Ying Zhou:1, Dong Yan:1, Wei-Xin Li:1, Jin-Ting Yang:2, Xin-Ru Zhou:1
1:Department of Basic Medical Sciences, Hangzhou Medical College, China, 2:Department of Anesthesiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, China

SIRT1 plays a novel role in the regulation of cardiomyocyte terminal differentiation in the developing heart

[Speaker] Shumei Yang:1
[Co-author] Alexandra Shin:2, Limin Han:2, Chiranjib Dasgupta:2, Lei Huang:2, Lubo Zhang:2
1:Chemistry and Biochemistry, California State University San Bernardino, California, USA, 2:Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA

Some cardiovascular effect of benzenesulfinyltetrolcompound (az4-8) isolated from the leaves of aqueous extract of the leaves of Phyllanthusamarus (Schum and Thonn)

[Speaker] Fabian C. Amaechina:1
[Co-author] Eric I. Omogbai:1, Zuleika A. M. Nworgu:1, Buniyanmi A. Ayinde:2, Enitome E. Bafor:1, Ruangelie Edrada-Ebel:3
1:Department of Pharmacology and Toxicology, University of Benin, Nigeria, 2:Department of Pharmacognosy, University of Benin, Nigeria, 3:Department of Pharmaceutical Analysis, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK

Trimethylamine N oxide reflects cardiac remodeling in patients with heart disease and is useful as a prognostic biomarker

[Speaker] Kenichi Aizawa:1
[Co-author] Keita Negishi:1, Yasushi Imai:1, Kazuomi Kario:1, Ryozo Nagai:1, Toru Suzuki:1,2
1:Jichi Medical University, Japan, 2:University of Leicester, UK

Effects of canstatin on L-type Ca2+ channel activity in rat ventricular cardiomyocytes

[Speaker] Keisuke Imoto:1
[Co-author] Masaki Hirakawa:1, Muneyoshi Okada:1, Hideyuki Yamawaki:1
1:Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Japan

Carbonylation of protein phosphatases in hydrogen peroxide or PDGF-BB-treated mouse artery smooth muscle cells

[Speaker] Cheng-Ying Hsieh:1
[Co-author] Chi-Li Chung:2, Chieh-Min Chen:1
1:Department of Phamacology, Taipei Medical University, Taiwan, 2:School of Respiratory Therapy, Taipei Medical University, Taiwan

Vascular dysfunction in a sucrose induced metabolic complications ameliorates with essential oil (Citronellol)

[Speaker] Prakash V Diwan:1
[Co-author] Rahul Kshirsagar:2, G. Bhanuprakash Reddy:3
1:Director, Central Research laboratory, Belgaum-590010 Karnataka India, India, 2:Pharmacology, Yash Institute of Pharmacy, Aurangabad- 431134 Maharastra, India, 3:Biochemistry, National Institute of Nutrition, Hyderabad, Telengana 500007, India

The important role of phosphorylation of CPI-17 at threonine 38 on vascular smooth muscle contraction and maintain normal blood pressure using CPI-17 genetically modified mice

[Speaker] Qunhui Yang:1
[Co-author] Kaji Noriyuki:1, Kada Kodai:1, Hiroshi Ozaki:1, Masatoshi Hori:1
1:Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan

Vasodilatory Effect of a Rho Kinase Inhibitor DL0805 on the Rat Basilar Artery and its Potential Mechanisms

[Speaker] Li Li:1
[Co-author] Wendan Lu:1, Yanjia Shen:1, Xiaoping Wu:1, Tianyi Yuan:1, Lianhua Fang:1, Guanhua Du:1
1:National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, China

Dipeptidyl Peptidase-4 (DPP-4) Inhibition Attenuates Cardiac Dysfunction after Myocardial Infarction Independently of DPP-4

[Speaker] Takehiro Yamaguchi:1
[Co-author] Yasukatsu Izumi:1,2, Masayuki Shiota:1,3, Masako Tanaka:1,4, Mayuko Osada-Oka:1,5, Shinji Matsunaga:1, Shojiro Kitajima:1, Katsuyuki Miura:6, Hiroshi Iwao:1,7, Shuhei Tomita:1
1:Pharmacology, Osaka City University Graduate School of Medicine, Japan, 2:Takaishi-Kamo Hospital, Japan, 3:Research support platform, Osaka City University Graduate School of Medicine, Japan, 4:Life Science and Medical Bioscience, Waseda University School of Advanced Science and Engineering, Japan, 5:Food Hygiene and Environmental Health Division of Applied Life Science, Kyoto Prefectural University Graduate School of Life and Environmental Sciences, Japan, 6:Applied Pharmacology and Therapeutics, Osaka City University Graduate School of Medicine, Japan, 7:Shitennoji University, Japan

The interaction between Danshen and Nisoldipine on intestinal

[Speaker] Jie Yang:1
[Co-author] Junichi Hasegawa:1, Keiko Etou:1, Haruna Ogawa:1
1:Divison of Pharmacotherapeutics, Tottori University Faculty of Medicine, Japan

The mitochondria-targeting peptide Elamipretide preserves mitochondrial function and protects the heart against ischemia-reperfusion damage

[Speaker] Janis Kuka:1
[Co-author] Marina Makrecka-Kuka:1, Edijs Vavers:1, Reinis Vilskersts:1, Edgars Liepinsh:1, Maija Dambrova:1, Inese Smukste:2
1:Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Latvia, 2:Stealth BioTherapeutics, USA

Opposite Effects of Beta3 Adrenergic Receptor Agonists on Electrical Properties of Normal and Hyperglycemic Cardiomyocytes

[Speaker] Belma Turan:1
[Co-author] Aysegul Durak:1, Yusuf Olgar:1, Sinan Degirmenci:1, Erkan Tuncay:1
1:Biophysics, Ankara Univ. Faculty of Medicine, Turkey

EOFAZ suppresses the monocyte adhesion to endothelial cells by down ¯ regulating the expressions of VCAM ¯ 1 and ICAM ¯ 1 in TNF ¯ α treated HUVECs via inhibiting the activation of NF ¯ κ B and MAPKs Signaling

[Speaker] Xiang-chun Shen:1,2,3,4
[Co-author] Lin Tao:1,2,3,4, Dan Lin:1,2,3,4, Yan Lin:1,2,3,4, Hong Yang:1,2,3,4, Ni-Wen Huang:1,2,3,4, Yi-Ni Xu:1,2,3,4, Yu-Qi Chen:2,5
1:School of Pharmaceutical Science, GuiZhou Medical University, China, 2:The Key Laboratory of Optimal Utilizaiton of Natural Medicine Resources, School of Pharmaceutic Sciences, Guizhou Medical University, University Town, Guian New District, Guizhou, China, 3:The High Educational Key Laboratory of Guizhou province for Natural Medicianl Pharmacology and Druggability, Guizhou Medical University, University Town, Guian New District, Guizhou, China, 4:The Union Key Laboratory of Guiyang City-Guizhou Medical Univeristy, Guizhou Medical University, University Town, Guian New District, Guizhou, China, 5:Department of Traditional Chinese Medicine, Beijing Xiaotangshan Hospital, Beijing, China

Effect of PD-1 antibody on a mouse model for experimental autoimmune myocarditis

[Speaker] Kenjiro Tsuruoka:1
[Co-author] Shigeo Wakabayashi:2, Ninso Matsunaga:1, Hirofumi Morihara:2, Masaaki Ii:3, Yasuhito Fujisaka:1, Isao Goto:1, Michio Asahi:2
1:Division of Internal Medicine, Osaka Medical College Hospital, Japan, 2:Department of Pharmacology, Faculty of Medicine, Osaka Medical College, Japan, 3:Division of Research Animal Laboratory and Translational Medicine Research and Development Center, Osaka Medical College, Japan

The mechanism underlying the modulatory action of amniodarone on hERG K+ channels

[Speaker] Chung-Chin Kuo:1,2
[Co-author] Yung-Chen Lo:1
1:Department of Physiology, National Taiwan University College of Medicine, Taiwan, 2:Department of Neurology, National Taiwan University Hospital, Taiwan

The effect of extract solution from ginkgo leaf and halimasch on myocardial infarction in the dog

[Speaker] Xiali Tao:1
[Co-author] Jinhong Chen:1
1:Beijing RUINUO ZHONGDE Technology Co., Ltd, China

Determination of the effect of doxorubicin coupled to biosynthesized gold nanoparticles on cardiac function in vivo and ex vivo of rat

[Speaker] Ortega César Villegas:1
[Co-author] Villanueva-Ibáñez Maricela:1, Blanca Estela Jaramillo Loranca:1, Monroy Jazmín Flores:2, Aguilar Luisa Martínez:2, Hernández Genaro Vargas:3, García Rocío Álvarez:3, Munguía Bibiana Chávez:4, Vargas María del Rocío Ramírez:5
1:Laboratory of nanotechnology, biological systems and industrial applications, Universidad Politécnica de Pachuca, México, 2:Laboratory of pharmacology of the myocardium, Universidad Nacional Autónoma de México, México, 3:Laboratory of technology in bioactive compounds, Universidad Politécnica de Pachuca, México, 4:Laboratory of experimental pathology, Instituto Politécnico Nacional, México, 5:Laboratory of environmental biotechnology, Universidad Politécnica de Pachuca, México

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

[Speaker] Heikki J Ruskoaho:1,2
[Co-author] Jani Aro:2, Raisa Serpi:2, Lotta Pohjolainen:1, Virpi Talman:2, Antti Poso:3, Jaana Rysa:3, Sini Kinnunen:1,2, Marja Tolli:1,2, Mika Valimaki:1,2
1:Pharmacology and Pharmacotherapy, University of Helsinki, Faculty of Pharmacy, Finland, 2:Institute of Biomedicine, University Oulu, Finland, 3:School of Pharmacy, University of Eastern Finland, Finland

Endotheline-1 induces contraction in quiescent hepatic stellate cells mediated by myosin light chain kinase and Rho kinase

[Speaker] Shin-ya Saito:1
[Co-author] Ryosuke Suzuki:1, Yumeto Wakabayashi:1, Ryota Nishiyama:1, Momoka Yamaguchi:1, Tomohisa Ishikawa:1
1:Department of Pharmacology, University of Shizuoka, Japan

Memoryless Markov modelling as selection criteria for herbal agents in syndromic diseases: A case study of Dioscorea prehensile & Zingiber officinalis in rat models of Pre-eclampsia

[Speaker] Shaibu O Bello:1
[Co-author] Iyabo M Adebisi:1
1:Pharmacology & Therapeutics, College Of Health Sciences, Usmanu Danfodiyo University, Nigeria

Prothrombotic alteration of ecto-nucleotidase expression in endothelial cells by histone deacetylase inhibitors

[Speaker] Isao Matsuoka:1
[Co-author] Yuki Narita:1, Kazuki Yoshida:1, Masa-Aki Ito:1
1:Laboratory of Pharmacology, Takasaki University of Health and Welfare, Faculty of Pharmacy, Japan

High mobility group box 1 suppresses smooth muscle tension in rat aorta via Toll-like receptor 4-dependent upregulation of iNOS

[Speaker] Fumiko Sekiguchi:1
[Co-author] Ayano Yagura:1, Atsufumi Kawabata:1
1:Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Japan

Effect of Hu Jing formula on lowering blood fat and endothelial protection in a rat model of hyperlipidemia

[Speaker] Xinlou Chai:1
[Co-author] Houwang Jiang:1, Yubing Yan:1, Hongbo Yang:1
1:Beijing University of Chinese Medicine, School of Chinese Medicine, China

Hydrogen trisulfide induced modulation of vascular tone in mice aorta

[Speaker] Shigeto Suzuki:1
[Co-author] Shigeki Kiuchi:1, Hideo Kimura:2, Kageyoshi Ono:1
1:Laboratory of Molecular Physiology and Pharmacology, Faculty of Pharma-Science, Teikyo University, Japan, 2:Department of Molecular Pharmacology, National Center of Neurology and Psychiatry, National Institute of Neuroscience, Japan

Hydroxytyrosol improved changes in biomarkers of vascular and neuronal damage induced by an experimental model of diabetes mellitus

[Speaker] Jose A Gonzalez-Correa:1
[Co-author] Maria Dolores Rodriguez-Perez:1, Beatriz Villanueva-Torres:2, Juan A Lopez-Villodres:1, Leticia Vallejo-Carmona:2, Ursula Medina-Moreno:4, Teresa Tejerina-Sanchez:3, Jose P De La Cruz-Cortes:1
1:Pharmacology, University of Malaga (Spain), Spain, 2:School of Nursing. Metropolitan University, Puerto Rico, 3:Pharmacology. School of Medicine. Complutense University of Madrid., Spain, 4:Epidemiology. School of Medicine. Autonomous University of San Luis Potosi, Mexico

WNK1 is required for the proliferation induced by hypotonic challenge in vascular cells

[Speaker] Yong-Yuan Guan:1
[Co-author] Ya-Juan Zhang:1
1:Pharmacology, Zhongshan School of Medicine, Sun Yet-Sen University, China

ICA decreases myocardial hypertrophy injuries induced by isoproterenol by inhibiting endoplasmic reticulum stress

[Speaker] Qiufang Zhang:1
1:Department of Pharmaology, Department of Pharmaology, Hubei University of Medicine, China

Computational methods for safety pharmacology and anti-arrhythmic drug discovery: Towards in silico clinical trials in human

[Speaker] Alfonso Bueno-Orovio:1
[Co-author] Elisa Passini:1, Oliver J Britton:1, Blanca Rodriguez:1
1:Computer Science, University of Oxford, UK

Increment of indoxyl sulfate leads to impairment of vascular function in adenine-induced renal injury rats

[Speaker] Shuhei Kobuchi:1
[Co-author] Kazuhide Ayajiki:1
1:Department of Pharmacy, Pharmacology, Hyogo University of Health Sciences, Japan

Intermittent hypoxia-induced cell proliferation via upregulations of interleukin-6 and epiregulin

[Speaker] Yoji Kyotani:1
[Co-author] Jing Zhao:1, Asako Itaya-Hironaka:2, Akiyo Yamauchi:2, Sumiyo Sakuramoto-Tsuchida:2, Mai Makino:2, Shin Takasawa:2, Masanori Yoshizumi:1
1:Pharmacology, Nara Medical University, Japan, 2:Biochemistry, Nara Medical University, Japan

Implication of endogenous lysophosphatidic acid in intimal thickening in rat injured artery

[Speaker] Yoshiharu Takiguchi:1
[Co-author] Shin-Ichi Tani:1, Keisuke Furuta:1, Naoshi Yamazaki:1
1:Department of Clinical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan

Liu-Wei-Di-Huang-Fang protects endothelial cells from apoptosis by modulating the expression of ER

[Speaker] Huimin Bian:1
[Co-author] Xiang Wu:1, Qi Chen:1, Yu Li:1
1:Nanjing Uiversity of Chinese Medicine, China

Effect of Monascus Purpureus Rice on Electronegative LDL-Induced Mitochondrial Dysfunction in Cardiomyocytes

[Speaker] Wei-Yu Chen:1
[Co-author] Chih-Hsin Tang:1, Yun-Fang Chen:3, Chin-Hu Lai:4, Chu-Huang Chen:5, An-Sheng Lee:2
1:Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, 2:Department of Medicine, Mackay Medical College, New Taipei City, Taiwan, 3:Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan, 4:Nation defense medical center, Taichung Armed Forces General Hospital, Taichung, Taiwan, 5:Vascular and Medicinal Research, Texas Heart Institute, Houston, Texas, USA

Morin ameliorates isoproterenol induced myocardial necrosis in rats

[Speaker] Vipin K. Verma:1
[Co-author] Dharamveer Arya:1, Jagriti Bhatia:1
1:Pharmacology, All India Institute of Medical Sciences, India

Functional analysis of vascular Na+/Ca2+ exchangers using genetically engineered mice

[Speaker] Satomi Kita:1,2
[Co-author] Hideaki Tagashira:2, Takahiro Iwamoto:2
1:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan, 2:Department of Pharmacology, Faculty of Medicine, Fukuoka University, Japan

Plasma Neuregulin-1 Levels and Risk Factors of Acute Coronary Syndrome in Non-Diabetic Patients

[Speaker] Gestina Aliska:1
[Co-author] Muhammad Fadil:2, Yose Ramda Ilhami:2, Rahma Tsania Zhuhra:3, Syandrez Prima Putra:3
1:Pharmacology and Therapeutic, Faculty of Medicine, Andalas University, Indonesia, 2:Cardiology and Vascular Medicine, Faculty of Medicine, Andalas University, Indonesia, 3:Junior Lecturer, Faculty of Medicine, Andalas University, Indonesia

Nitric oxide modulates angiogenesis through an O2-dependent mechanism

[Speaker] Pilar D'Ocon:1
[Co-author] Cristina Arce:1, Diana Vicente:1, Laura Gonzalezcastillo:1, Fermi Monto:1, Maria Antonia Noguera:1, Maria Dolores Ivorra:1
1:Pharmacology, Facultad de Farmacia. Universidad deValencia, Spain

N-Methylberbamine extends the action potential of the cardiac ventricular myocytes of rabbits through inhibiting an outward rectifying current

[Speaker] Shi Zhou:1
[Co-author] Xiaodong Sun:1, Xuanxuan Sun:1, Shuai Lei:1, Ming Lei:1, Jinming Li:1, Xiaorong Zeng:2, Liying Hao:1, Huiyuan Hu:1
1:Department of Pharmaceutical Toxicology, China Medical University, China, 2:Key Laboratory of Medical Electrophysiology, Southwest Medical University, China

HORMONAL REPLACEMENT THERAPY MODULATES THE EXPRESSION OF Nrf2 AND THE ACTIVITY OF ANTIOXIDANT ENZYMES IN VASCULAR ORGANS IN A MODEL OF OVARIECTOMY

[Speaker] Lourdes G. Baeza-Perez:1
[Co-author] Claudia Calzada-Mendoza:1, Maria Elena Hernandez-Campos:1, Pedro Lopez-Sanchez:1, Liliana Anguiano-Robledo:1
1:Seccion de Estudios de Posgrados e Investigacion, Escuela Superior de Medicina del Instituto Politecnico Nacional, Mexico

The flavonoid compound luteolin prevents endothelial dysfunction in a mouse model of high fat diet-induced obesity

[Speaker] Rocchina Colucci:1
[Co-author] Daniela Gentile:2, Matteo Fornai:2, Carolina Pellegrini:2, Laura Benvenuti:2, Emiliano Duranti:2, Stefano Masi:2, Sara Carpi:3, Paola Nieri:3,4, Agostino Virdis:2, Laura Pistelli:4,5, Corrado Blandizzi:2, Luca Antonioli:2
1:Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy, 2:Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 3:Department of Pharmacy, University of Pisa, Pisa, Italy, 4:Interdepartmental Research Center Nutraceuticals and Food for Health, University of Pisa, Pisa, Italy, 5:Department of Agriculture, Food and Environment (DAFE), University of Pisa, Pisa, Italy

Protein tyrosine phosphatase inhibitor, orthovanadate, induces vasoconstriction and vasorelaxation in mouse thoracic aortas

[Speaker] Yuka Terada:1
[Co-author] Naoki Higashi:1, Yuki Hidaka:1, Yasumasa Isomoto:1, Katsutoshi Yayama:1
1:Cardiovascular Pharmacology, Kobe Gakuin University, Japan

Detrimental effects of PVAT derived PGE2 and H2S in human coronary arteries with atherosclerosis

[Speaker] Gulsev Ozen:1
[Co-author] Catherine Deschildre:2, Larissa Kotelevets:3, Eric Chastre:3, Dan Longrois:2,4, Gokce Topal:1, Jean-Etienne Fabre:2, Jean-Baptiste Michel:2, Xavier Norel:2
1:Istanbul University, Department of Pharmacology, Turkey, 2:INSERM U1148, Paris Nord University, Sorbonne Paris-Cite, Paris, France, 3:INSERM U1149, CNRS ERL8252, Paris Diderot University, Sorbonne Paris-Cite, Paris, France, 4:AP-HP CHU X. Bichat, Department of Anesthesia and Intensive Care, Paris, France

Pharmacokinetic Interaction Study of Danshen and Rosuvastatin in Rats and Volunteers

[Speaker] Jie Yang:1
[Co-author] Junichi Hasegawa:1, Yusuke Endo:2, Kazuhiko Iitsuka:1, Miwa Yamamoto:3, Akiko Matsuda:4
1:Division of Pharmacotherapeutics, Tottori University Faculty of Medical, Japan, 2:New Medical Research Promotion Center, Tottori University Faculty of Medical, Japan, 3:Department of Adult and Elderly Nursing, Tottori University Faculty of Medical, Japan, 4:Faculty of Nursing, Nara Medical University, Japan

Phospholamban is degraded by VHL E3 ubiquitin ligase in failing hearts

[Speaker] Shunichi Yokoe:1
[Co-author] Takatoshi Nakagawa:1, Michio Asahi:1
1:Osaka Medical College, Japan

Elucidation of PIEZO1 as Potential Therapeutic Target for Statin

[Speaker] Tzyy Yue Wong:1
[Co-author] Sheng-Nan Chang:2,3, Chia-Ti Tsai:4, Jou-Wei Lin:3, Juey-Jen Hwang:4, Pei-Wen Cheng:5
1:Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 2:National Taiwan University College of Medicine, Graduate Institute of Clinical Medicine, Taipei, Taiwan, 3:Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City, Taiwan, 4:Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 5:Department of Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Bradykinin regulates plasmin-induced endothelial Ca2+ response in PARs dependent pathway

[Speaker] Yukako Obata:1
[Co-author] Kazuhiko Takeuchi:2, Akio Hakamata:3, Keiich Odagiri:3, Yoshiki Nakajima:1, Hiroshi Watanabe:3
1:Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan, 2:Department of Home Medical Care, Hamamatsu Kita Hospital, Hamamatsu, Japan, 3:Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan

The Staphylococcus aureus collagen-binding protein A-region exerts inhibitory effect on type I collagen-mediated platelet aggregation

[Speaker] Chao-Zong Liu:1
[Co-author] Tsai Hui-Ling:1
1:Department of Pharmacology, Tzu Chi University, Taiwan

Investigating the behaviour of mitochondria following platelet activation

[Speaker] Harriet E Allan:1
[Co-author] Marilena Crescente:1, Timothy D Warner:1
1:Blizard Institute, Queen Mary University London, UK

Understanding the cardiovascular effects of low dose aspirin by using a platelet COX-1-/- mouse model

[Speaker] Marilena Crescente:1
[Co-author] Paul C Armstrong:1, Melissa V Chan:1, Matthew L Edin:2, Tania Maffucci:1, Nicholas S Kirkby:3, Jane A Mitchell:3, Darryl C Zeldin:2, Harvey R Herschman:4, Timothy D Warner:1
1:Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK, 2:NIH/NIEHS, USA, 3:Imperial College of London, UK, 4:UCLA, USA

VASORELAXANT EFFECT OF PROCYANIDIN B2 ON HUMAN INTERNAL MAMMARY ARTERY

[Speaker] Aleksandra N Novakovic:1
[Co-author] Marija Marinko:1, Goran Jankovic:1, Predrag Milojevic:2,3, Ivan Stojanovic:2,3, Dragoslav Nenezic:2,3, Vladimir Kanjuh:4, Qin Yang:5,6, Guo-Wei He:5,6
1:Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia, 2:Faculty of Medicine, University of Belgrade, Serbia, 3:Institute for Cardiovascular Diseases Dedinje, Belgrade, Serbia, 4:Academy of Sciences and Arts, Belgrade, Serbia, 5:Department of Surgery, The Chinese University of Hong Kong, Hong Kong, 6:TEDA International Cardiovascular Hospital, Medical College, Nankai University, China

Prorrenin/renin receptor expression in the solitary tract nucleus in a 5/6 nephrectomy-induced hypertension model in rats

[Speaker] Pedro Lopez-Sanchez:1
[Co-author] Gabriela Arteaga-Bravo:1, Ana V. Vega:2, Yumei Feng:3, Maria Elena Hernandez-Campos:1
1:Seccion de Estudios de Posgrados e Investigacion, Escuela Superior de Medicina del IPN, Mexico, 2:UBIMED, FES Iztacala-UNAM, Mexico, 3:Center for Cardiovascular Research. School of Medicine. University of Nevada, USA

Potentiating effect of prostaglandin F2α on platelet aggregation in mice

[Speaker] Hitoshi Kashiwagi:1
[Co-author] Koh-Ichi Yuhki:1, Yoshitaka Imamichi:1, Fumiaki Kojima:2, Shima Kumei:1, Shuh Narumiya:3, Fumitaka Ushikubi:1
1:Department of Pharmacology, Asahikawa Medical University, Japan, 2:Department of Pharmacology, Kitasato University School of Allied Health Sciences, Japan, 3:Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Japan

Changes in vasodilation via protease-activated receptor-2 with ageing differ between animal models of metabolic syndrome

[Speaker] Kana Maruyama:1
[Co-author] Satomi Kagota:1, John J. Mcguire:2, Noriko Yoshikawa:1, Kazuki Nakamura:1, Kazumasa Shinozuka:1
1:Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Japan, 2:Cardiovascular Research Group, Division of BioMedical Sciences, Memorial University, Canada

FBXO44-mediated RGS2 protein degradation uniquely depends on a novel Cullin 4B/DDB1 E3 ligase complex

[Speaker] Benita Sjogren:1
1:Medicinal Chemistry & Molecular Pharmacology, Purdue University, USA

mRNA deadenylation-guided control of Atg7-dependent cell death and heart function to maintain cardiac homeostasis

[Speaker] Keiji Kuba:1
[Co-author] Tomokazu Yamaguchi:1, Takashi Suzuki:1, Teruki Sato:1, Akinori Takahashi:2, Shigeomi Shimizu:3, Josef M Penninger:4, Tadashi Yamamoto:2, Yumiko Imai:5
1:Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, Japan, 2:OIST- Okinawa Institute of Science and Technology Graduate University, Japan, 3:Medical Research Institute, Tokyo Medical and Dental University, Japan, 4:IMBA -Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria, 5:National Institute of Biomedical Innovation, Health and Nutrition, Japan

Impacts of loss-of-function RyR2 mutations on Ca2+ signaling in non-cardiac and cardiac cells

[Speaker] Naoyuki Tetsuo:1
[Co-author] Nagomi Kurebayashi:1, Takashi Murayama:1, Takashi Sakurai:1
1:Department of Pharmacology, Juntendo University Faculty of Medicine, Japan

Hidden cardiotoxicity: paradigm change in cardiac safety testing in ischemic and comorbid conditions

[Speaker] Peter Ferdinandy:1,2
1:Department of Pharmacology and Pharmacotherapy, Semmelweis University, Hungary, 2:Pharmahungary Group, Szeged, Hungary

Differences on vascular reactivity and RNAm expression of Renin-Angiotensin and Kinin-Kallikrein systems components on acute and chronic myocardial infarction in male and female Wistar rats

[Speaker] Jazmin Flores-Monroy:1
[Co-author] Diana Ramirez-Hernandez:1,2, Diego Lezama-Martinez:1,2, Luisa Martinez-Aguilar:1
1:Biochemistry and Pharmacology, Universidad Nacional Autonoma de Mexico, Mexico, 2:Instituto Politecnico Nacional, Escuela Superior de Medicina, Mexico

Simulated clinical study in pharmacodynamic evaluation of new drug

[Speaker] Liu Jianxun:1
[Co-author] Ren Jianxun:1, Ren Junguo:1, Lin Chengren:1, Li Lei:1
1:Xiyuan hospital of China Academy of Chinese Medical Sciences, China

Statin Ameliorates Coronary Perivascular Fibrosis in Chronic Kidney Disease: An Experimental Study

[Speaker] Putu N. Cahyawati:1
[Co-author] Sri A. Aryastuti:1, Putu D. Witari:1
1:Department of Pharmacology and Pharmacy, Faculty of Medicine and Health Sciences, Warmadewa University, Bali, Indonesia

Sleep Deprivation-Induced Proteome Changes in the Rat Serum

[Speaker] Bo Ma:1
[Co-author] Jincheng Chen:1
1:China Academy of Chinese Medical Sciences, Xiyuan Hospital, China

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