Sessions

Development of Novel Delta Opioid Receptor Inverse Agonists and Their Antitussive Effects

[Speaker] Shigeto Hirayama:1,2
[Co-author] Eika Higashi:1, Jun Nikaido:3, Toru Nemoto:1, Hiroko Ikeda:3, Junzo Kamei:3, Hideaki Fujii:1,2
1:Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University, Japan, 2:Medicinal Research Laboratories, School of Pharmacy, Kitasato University, Japan, 3:Department of Pathophysiology and Therapeutics, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan

Atypical antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive unfavourable effects

[Speaker] Daisuke Ibi:1,2,3
[Co-author] Mario De La Fuente Revenga:2, Masayuki Hiramatsu:1, Javier Gonzalez-Maeso:2,3
1:Chemical Pharmacology, Meijo University, Japan, 2:Physiology and Biophysics, Virginia Commonwealth University School of Medicine, USA, 3:Psychiatry, Icahn School of Medicine at Mount Sinai, USA

Molecular mechanism responsible for the neurotropic effects of cognition enhancer Noopept

[Speaker] Yulia V. Vakhitova:1
[Co-author] Liana F. Zainullina:1, Tatyana V. Ivanova:1, Rita U. Ostrovskaya:1, Tatyana A. Gudasheva:1, Sergey B. Seredenin:1
1:Zakusov Institute of Pharmacology, Russia

Cholinergic inputs to cortical cholinergic neurons facilitate disinhibition of excitatory neurons in the rat cerebral cortex

[Speaker] Keisuke Kaneko:1
[Co-author] Sachie Matsumura:2, Yoshiyuki Oi:1, Masayuki Kobayashi:3
1:Department of Anesthesiology, Nihon University School of Dentistry, Japan, 2:Department of Pediatric Dentistry, Nihon University School of Dentistry, Japan, 3:Department of Pharmacology, Nihon University School of Dentistry, Japan

High-content imaging analysis for detecting the status of synapse using drebrin in cultured neurons

[Speaker] Kenji Hanamura:1
[Co-author] Yuko Sekino:2, Tomoaki Shirao:1
1:Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Japan, 2:Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan

Curcumin in combination with piperine attenuates MPTP induced dopaminergic neuron injury in rats: Impact from behavioral to neurotransmitter alterations

[Speaker] Puneet Kumar:1
[Co-author] Shamsher Singh:2
1:Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, India, 2:ISF College of Pharmacy, Moga, India

Drebrin regulates sub-spine localization of Calcium/calmodulin-dependent kinase II β

[Speaker] Hiroyuki Yamazaki:1
[Co-author] Tomoaki Shirao:1
1:Neurobiology and Behavior, Gunma University Graduate School of Medicine, Japan

Effects of angiotensin II on excitatory synaptic transmission in rat nucleus tractus solitarius neurons

[Speaker] Yoshiaki Ohi:1
[Co-author] Misaki Tanimoto:1, Daisuke Kodama:1, Akira Haji:1
1:Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University, Japan

GABAB receptor in the hypothalamic paraventricular nucleus mediates β-adrenoceptor activation-induced elevation of plasma noradrenaline in rats

[Speaker] Naoko Yamaguchi:1
[Co-author] Kaoru Mimura:1, Shoshiro Okada:1
1:Department of Pharmacology, School of Medicine, Aichi Medical University, Japan

ZhikeShaoyao-induced chronic antidepressant and prokinetic in CUMS rats via polypharmacology and identification of absorbed bioactive compounds

[Speaker] Qiuyue Xu:1
[Co-author] Ping Ren:1, Xi Huang:2, Yun Wang:3
1:Nanjing University of Chinese Medicine, China, 2:Xi HUANG, China, 3:Yun WANG, China

Benzophenone-3 affects glutaminergic system in the rat brain

[Speaker] Weronika A. Krzyzanowska:1
[Co-author] Bartosz S. Pomierny:1, Beata Starek-Swiechowicz:1, Zaneta Broniowska:1, Beata Strach:1, Beata Bystrowska:2, Boguslawa Budziszewska:1
1:Department of Biochemical Toxicology, Faculty of Pharmacy, Jagiellonian University-Medical College, Poland, 2:Department of Toxicology, Faculty of Pharmacy, Jagiellonian University-Medical College, Poland

Estrogen increases glutathione level in brain endothelial cells exposed to ischemic injury by repression of ABCG2 activity

[Speaker] Eun-Mi Park:1,2
[Co-author] Jin A Shin:1,2, Sae Im Jeong:1,2, Hye Won Kim:1,2, Gyeonghui Jang:1,2
1:Ewha Womans Univ. School of Med. Dept. Pharmacolog, Korea, 2:Ewha Womans Univ. School of Med. Tissue Injury Defense Research Center, Korea

Comprehensive Study on the Potential Therapeutic Use of Brevetoxin-2 to Aid Post-stroke Recovery

[Speaker] Erica Sequeira:1
[Co-author] Marsha Pierce:1, Dina Gomez:1, Thomas Murray:1
1:Pharmacology, Creighton University, USA

Activation and potentiation of GIRK channel activity by ivermectin

[Speaker] I-Shan Chen:1,3
[Co-author] Michihiro Tateyama:1,3, Yuko Fukata:2,3, Motonari Uesugi:4,5, Yoshihiro Kubo:1,3
1:Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Japan, 2:Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Japan, 3:Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Japan, 4:Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Japan, 5:Institute for Chemical Research, Kyoto University, Japan

IN VITRO ASSEMENT OF POTENTIAL DRUG INTERACTION OF OPICAPONE, A NOVEL COMT INHIBITOR

[Speaker] Ana i Loureiro:1
[Co-author] Carlos Fernandes-Lopes:1, Paul Moser:1, Patricio Soares-da-Silva:1,2
1:Department of Research and Development, BIAL, Portela & Companhia, SA, 4745-457 S. Mamede do Coronado, Portugal, 2:Dept Biomedicine, Unit of Pharmacology & Therapeutics, Faculty of Medicine, University of Porto, 4200 Porto, Portugal; 3MedInUp - Center for Drug Discovery and Innovative Medicines, University of Po, Portugal

Peripheral and central effects of dexibuprofen on APP/PS1 mice fed with an obesogenic diet

[Speaker] Antoni Camins:1
[Co-author] Miren Ettcheto:1,4,5, Elena Sanchez-Lopez:5,6, Oriol Busquets:1,4,5, Patricia R Manzine:1,2,5, Shagar Rabieipoor:1,5, Ruben D Castro-Torres:1,5, Marisa Garcia:6, Carme Auladell:3,5, Jaume Folch:5
1:Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Spain, 2:Department of Gerontology, Federal University of San Carlos, San Carlos, SP, Brazil, 3:Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain, 4:Departament de Bioquimica, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain, 5:Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain, 6:Unitat de Farmacia Tecnologia Farmaceutica i Fisico-quimica. Universitat de Barcelona, Spain

Pharmacological study of new compounds - the translocator protein 18kDa ligands

[Speaker] Milada Yarkova:1
[Co-author] Grigoriy Mokrov:1, Tatyana Gudasheva:1, Sergey Seredenin:1
1:Zakusov Institute of Pharmacology, Russia

Implication of HCN channels in the frontal cortex on the emotional abnormality of mice induced by exposure to a single restraint stress

[Speaker] Kazuhiro Kurokawa:1
[Co-author] Kazuya Miyagawa:1, Atsumi Saito:1, Hiroko Miyagishi:1, Minoru Tsuji:1, Hiroshi Takeda:1
1:Pharmacology, School of Pharmacy International University of Health and Welfare, Japan

Paraxanthine elevates cysteine uptake in hippocampus slice

[Speaker] Nobuko Matsumura:1
[Co-author] Koji Aoyama:1, Toshio Nakaki:1
1:Pharmacology, Teikyo University, School of Medicine, Japan

Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons

[Speaker] Hiroyuki Kawai:1
[Co-author] Nozomi Asaoka:1, Takahito Miyake:1, Kazuki Nagayasu:1, Hisashi Shirakawa:1, Shuji Kaneko:1
1:Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan

The effect of curcumin on morphine addiction in male rats: role of cerebral inflammatory cytokines

[Speaker] Mohammad Abbas Sheykholeslami:1
[Co-author] Masoomeh Sabetkasaie:1, Siavash Parvardeh:1, Shiva Ghafghazi:1
1:Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Low sensitivity of porcine α2A-adrenoceptor subtype to α2-agonists

[Speaker] Taisuke Kitano:1
[Co-author] Soichiro Yamaguchi:1, Takeshi Kobayashi:1, Ken-Ichi Otsuguro:1
1:Graduate School of Veterinary Medicine, Hokkaido University, Japan

The production and role of hydrogen sulfide and hydrogen polysulfides in mammalian cells

[Speaker] Norihiro Shibuya:1
[Co-author] Shin Koike:2, Ryo Miyamoto:1, Yuka Kimura:1, Kenjiro Hanaoka:3, Noriyuki Nagahara:4, Kiyoshi Fukui:5, Yasuteru Urano:3, Yuki Ogasawara:2, Hideo Kimura:1
1:National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan, 2:Analytical Chemistry, Meiji Pharmaceutical University, Japan, 3:Graduate School of Pharmeutical Sciences, The University of Tokyo, Japan, 4:Isotope Research Center, Nippon Medical School, Japan, 5:Institute for Enzyme Research, The University of Tokushima, Japan

Pyrazolo[1, 4]diazepine-based small molecule oxytocin receptor partial agonists

[Speaker] Eryn L Werry*:1
[Co-author] William T Jorgensen*:2, Tristan A Reekie:2, Kiyan Afzali:3, Taylor Garrett:2, Erick CN Wong:3, Oludamilola Awofala:3, Damien W Gulliver:3, Mark Connor:4, Michael Kassiou:2
1:Faculty of Health Sciences, The University of Sydney, Australia, 2:School of Chemistry, The University of Sydney, Australia, 3:School of Medical Sciences (Pharmacology), The University of Sydney, Australia, 4:Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Australia

Actin polymerization factor Fhod3 formin protein in the mouse cerebrocortical neurons

[Speaker] Takayuki Nemoto:1
[Co-author] Hikmawan Wahyu Sulistomo:1, Ryu Takeya:1
1:Pharmacology, Faculty of Medicine, University of Miyazaki, Japan

Beta Guanidinopropionic Acid Extends the Lifespan of Drosophila Melanogaster via AMPK-dependent Autophagy

[Speaker] Li-Hong Long:1,2,3,4
[Co-author] Fang Wang:1,2,3,4, Jian-Guo Chen:1,2,3,4
1:Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, 2:The Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, 430030, China, 3:Hubei Key Laboratory of Drug Target Researches and Pharmacodynamic Evaluation (HUST), Wuhan, 430030, China, 4:The Laboratory of Neuropsychiatric Diseases, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, 430030, China

The role and mechanisms of sphingosine kinase 2 in cerebral preconditioning-induced autophagy activation

[Speaker] Rui Sheng:1
[Co-author] Dan-Dan Song:1, Tong-Tong Zhang:1, Jia-Li Chen:1, Yun-Fei Xia:1, Zheng-Hong Qin:1, Christian Waeber:2
1:Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, China, 2:Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland

DISTRIBUTION, METABOLISM AND ELIMINATION OF OPICAPONE IN THE RAT AND NON-HUMAN PRIMATE

[Speaker] Ana I. Loureiro:1
[Co-author] Carlos Fernandes-Lopes:1, Paul Moser:1, Patricio Soares-da-Silva:1,2
1:Department of Research and Development, BIAL, Portela & Companhia, SA, 4745-457 S. Mamede do Coronado, Portugal, 2:Dept Biomedicine, Unit of Pharmacology & Therapeutics, Faculty of Medicine, University of Porto, 4200 Porto, Portugal; 3MedInUp - Center for Drug Discovery and Innovative Medicines, University of Po, Portugal

Functional left/right hemispheric difference of dopamine D2 neurons in rat dorsolateral striatum

[Speaker] Yukitoshi Sakaguchi:1
[Co-author] Yoshio Sakurai:1
1:Graduate School of Brain Science, Doshisha University, Japan

Activation of hypothalamic μ-opioidergic system enhances the anti-tumor immune response

[Speaker] Yusuke Hamada:1
[Co-author] Naomi Kanao:1, Sara Yoshida:1, Michiko Narita:1, Hideki Tamura:2, Hiroyuki Tezuka:2, Masami Suzuki:3, Akihiro Yamanaka:4, Naoko Kuzumaki:1, Minoru Narita:1,2
1:Dept. Pharmacology, Hoshi University, Japan, 2:L-StaR, Hoshi University, Japan, 3:Div. Cancer Genomics, NCCRI, Japan, 4:Dept. Neuroscience II, RIEM, Nagoya University, Japan

The role of nesfatin-1 in the regulation of feeding and emesis in Suncus murinus (House Musk Shrew)

[Speaker] Sze Wa Chan:1
[Co-author] Zengbing Lu:1,2, Ichiro Sakata:3, Takafumi Sakai:3, Julia Yh Liu:1,2, Ge Lin:2, John A Rudd:2,4
1:School of Health Sciences, Caritas Institute of Higher Education, Hong Kong, 2:School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, 3:Graduate School of Science and Engineering, Saitama University, Japan, 4:Brain and Mind Institute, The Chinese University of Hong Kong, Hong Kong

The role of brain 5-HT7 receptor-ERK system in the formation of stress adaptation in mice

[Speaker] Minoru Tsuji:1
[Co-author] Kotaro Takeda:1, Hiroko Miyagishi:1, Atsumi Saito:1, Kazuhiro Kurokawa:1, Hideaki Kato:1, Kazuya Miyagawa:1, Hiroshi Takeda:1
1:Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Japan

Ferulic acid represents Danchuanhong for antidepression, prokinetic and vasodilation following cerebroprotection via shared ghrelin system in comorbid TBI rat

[Speaker] Wan Zheng:1
[Co-author] Tian Zhang:1, Hongbin Yan:1, Dan Wu:1, Ping Ren:1, Xi Huang:1, Xia Zi'an:2
1:Nanjing University of Chinese Medicine, China, 2:Xiangya Hospital Central South University, China

A new generation of arachidonic acid analogues targeting cytosolic phospholipase A2

[Speaker] Chian-Ming Low:1,2
[Co-author] Cheng Yang Ng:3, Srinivasaraghavan Kannan:4, Yong Jun Chen:5, Francis Chee Kuan Tan:2, Wee Yong Ong:3, Mei Lin Go:5, Chandra S. Verma:4, Yulin Lam:3
1:Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 2:Department of Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 3:Department of Chemistry, Faculty of Science, National University of Singapore, Singapore, 4:Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, 5:Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore

ALS remedy candidates from natural resources

[Speaker] Kuniko Kusama-Eguchi:1
[Co-author] Yuta Yanai:1,4, Megumi Furukawa:2, Mitsuko Makino:2, Kazuko Watanabe:1, Keiichi Matsuzaki:2, Dai Hirose:3, Ayumi Ohsaki:4, Fumio Ikegami:5
1:Laboratory of Biochemistry, School of Pharmacy, Nihon University, Japan, 2:Laboratory of Pharmacognosy, School of Pharmacy, Nihon University, Japan, 3:Laboratory of Medical Microbiology, Japan, 4:College of Humanities and Sciences, Nihon University, Japan, 5:Center for Environment, Health and Field Sciences, Chiba University, Japan

FABP3 in the Anterior Cingulate Cortex Mediates Methylation Status of glutamic acid decarboxylase 67 Promoter Region

[Speaker] Yui Yamamoto:1
[Co-author] Hiroyuki Kida:2, Dai Mitsushima:2, Keiju Kamijo:1, Yuji Owada:3, Koji Fukunaga:4
1:Dept. Anatomy, Tohoku Med. and Pharm. Univ., Japan, 2:Dept. Physiology, Yamaguchi Univ. Grad. Sch. Med., Japan, 3:Dept. Organ Anatomy, Tohoku Univ. Grad. Sch. Med., Japan, 4:Dept. Pharmacology, Tohoku Univ. Grad. Sch. Pharm., Japan

New highly active pyrrolo[1, 2-a]pyrazine TSPO ligand

[Speaker] Grigory V Mokrov:1
[Co-author] Milada A Yarkova:2, Tatiana A Gudasheva:1, Sergey B Seredenin:2
1:Department of Medicinal Chemistry, Research Zakusov Institute of Pharmacology, Russia, 2:Department of pharmacogenetics, Research Zakusov Institute of Pharmacology, Russian Federation, Russia

Effect of glucocorticoids on chaperone-mediated autophagy and microautophagy

[Speaker] Masahiro Sato:1
[Co-author] Takahiro Seki:1, Ayumu Konno:2, Hirokazu Hirai:2, Yuki Kurauchi:1, Akinori Hisatsune:3,4, Hiroshi Katsuki:1
1:Chemico-Pharmacological Sciences, Kumamoto University, Japan, 2:Dept. Neurophysiol. Neural repair, Gunma Univ. Grad. Sch. Med., Japan, 3:Priority Organization for Innovation and Excellence, Kumamoto Univ., Japan, 4:Program for Leading Grad. Sch. HIGO Program, Kumamoto Univ., Japan

Possible involvement of histone acetylation in the resistance and adaptation to stress in mice

[Speaker] Hiroshi Takeda:1
[Co-author] Kazuya Miyagawa:1, Atsumi Saito:1, Hiroko Miyagishi:1, Kazuhiro Saito:1, Kazuhiro Kurokawa:1, Hideaki Kato:1, Minoru Tsuji:1
1:Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Japan

Presynaptic targeting g-CC reveals localized cAMP dynamics in hippocampal culture

[Speaker] Seiko Kawata:1
[Co-author] Tetsuya Hori:1, Naoto Saitoh:1
1:Department of Life and Medical Sciences, Doshisha University, Japan

IL-1b release and pore formation induced by the human antimicrobial peptide LL-37 may be P2Y13 receptor-mediated

[Speaker] Erick C. N Wong:1
[Co-author] Eryn L Werry:2, Shane M Wilkinson:3, O'Brien-Brown James:3, Alexander Jackson:1, Michael Kassiou:3
1:Sydney Medical School (Pharmacology), University of Sydney, Australia, 2:Faculty of Health Sciences, University of Sydney, Australia, 3:School of Chemistry, University of Sydney, Australia

Interaction of POMC with GTRAP3-18 in the brain

[Speaker] Koji Aoyama:1
[Co-author] Wattanaporn Bhadhprasit:1, Masahiko Watabe:2, Fan Wang:1, Nobuko Matsumura:1, Toshio Nakaki:1
1:Department of Pharmacology, Teikyo university School of Medicine, Japan, 2:General Medical Education Center (G-MEC), Teikyo University, Japan

Oncostatin M downregulates the brain endothelial barrier integrity through long-lasting activation of JAK/STAT3 pathway

[Speaker] Fuyuko Takata:1
[Co-author] Shinya Dohgu:1, Junichi Matsumoto:1, Takashi Machida:1, Ikuya Kimura:1, Atsushi Yamauchi:1, Yasufumi Kataoka:1
1:Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Care and Health Sciences, Fukuoka University, Japan

Development and characterization of human immortalized cell-based in vitro BBB tri-culture model

[Speaker] Keita Kitamura:1
[Co-author] Kenta Umehara:1, Shota Suzuki:1, Kan Chiba:1, Naohiko Anzai:2, Hidetaka Akita:1, Tomomi Furihata:1,2
1:Grad Sch Pharmaceut Sci, Chiba University, Japan, 2:Grad Sch Med, Chiba University, Japan

Benzophenone-3 concentration and its effect on oxidative stress markers in rat brain

[Speaker] Boguslawa Budziszewska:1
[Co-author] Zaneta Broniowska:1, Bartosz Pomierny:1, Beata Starek-Swiechowicz:1, Weronika Krzyzanowska:1, Beata Bystrowska:2, Beata Strach:1
1:Department of Biochemical Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, Poland, 2:Department of Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, Poland

AMPK activation by P2X7 through ROS-CaMKK pathway regulates mitophagy and lysosomal biogenesis in macrophages

[Speaker] Ponarulselvam Sekar:1
[Co-author] Duenyi Huang:2, Wan-Wan Lin:1,2
1:Graduate institute of medical sciences, Taipei Medical university, Taipei, Taiwan, 2:Graduate institute of pharamacology, National taiwan university, Taipei, Taiwan

MAPK-mediated phosphorylation of MKL2 regulates nuclear localization and transcriptional activity in striatal neurons

[Speaker] Anthony Ariza:1
[Co-author] Yasuhiro Funahashi:1, Keiichiro Okuda:1, Sachi Kozawa:1, Kozo Kaibuchi:1
1:Cell Pharmacology, Nagoya University Graduate School of Medicine, Japan

Prolyl oligopeptidase alters cortical glutamate and function of metabotropic glutamate receptor mGluR5 in mice and in cells

[Speaker] Ulrika H Julku:1
[Co-author] Reinis Svarcbahs:1, Timo Myohanen:1
1:Division of Pharmacology and Pharmacotherapy, University of Helsinki, Faculty of Pharmacy, Finland

Susceptibility to methamphetamine-induced hyperactivity in synaptic vesicle protein 2A (SV2A)-mutant rats

[Speaker] Saki Shimizu:1
[Co-author] Kentaro Tokudome:1, Ayako Ikari:1, Yumiko Iguchi:1, Takafumi Sugahara:1, Tadao Serikawa:1, Yukihiro Ohno:1
1:Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan

Development of a tag-probe based cell labeling technique for in vivo fluorescence imaging

[Speaker] Hiroyuki Okamoto:1
[Co-author] Daisuke Asanuma:1,2, Shigeyuki Namiki:1, Kenzo Hirose:1
1:Neurobiology, Graduate School of Medicine, The University of Tokyo, Japan, 2:PREST, JST, Japan

Investigating the functional-compulsive continuum in animals: Contextual lever-pressing in the deer mouse model of obsessive-compulsive disorder (OCD)

[Speaker] De Wet Wolmarans:1
[Co-author] Geoffrey De Brouwer:1, Brian H Harvey:1,2
1:Division of Pharmacology, North-West University, Potchefstroom, South Africa, 2:MRC Unit on Risk and Resilience in Mental Disorders, South Africa

Role of Mammalian Formin Fhod3 in Neural Tube Closure

[Speaker] Hikmawan W Sulistomo:1
[Co-author] Yohko Kage:1, Takayuki Nemoto:1, Ryu Takeya:1
1:Pharmacology, University of Miyazaki, Japan

Protein kinase D2 (PRKD2) regulates embryonic neural development

[Speaker] Baba Masayuki:1
[Co-author] Kensuke Matsumura:1, Takanobu Nakazawa:1,2, Kazuki Nagayasu:1,3, Atsushi Kasai:1, Kazuhiro Takuma:2,4, Hitoshi Hashimoto:1,4,5,6
1:Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 2:Department of Pharmacology, Graduate School of Dentistry, Osaka University, Japan, 3:Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 4:Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Japan, 5:iPS Cell-Based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 6:Division of Bioscience, Institute for Datability Science, Osaka University, Japan

Pathogenic role of EP2 receptors up-regulation in motor neuron-like NSC-34 cells and lumbar motor neurons in ALS model mice

[Speaker] Yasuhiro Kosuge:1
[Co-author] Hiroshi Nango:1, Kumiko Ishige:1, Yoshihisa Ito:1
1:Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan

Hydrophilic antioxidant ergothioneine promotes neuronal differentiation through activation of mTORC1 and NT5/TrkB signaling in neural stem cells

[Speaker] Noritaka Nakamichi:1
[Co-author] Takahiro Ishimoto:1, Yusuke Masuo:1, Yukio Kato:1
1:Faculty of Pharmacy, Kanazawa University, Japan

Prostaglandin E2 induces differentiation of NSC-34 cells with neuron-like features

[Speaker] Hiroshi Nango:1
[Co-author] Yasuhiro Kosuge:1, Masaki Sato:2, Yoshiyuki Shibukawa:2, Masakazu Tazaki:2, Yoshihisa Ito:1, Kumiko Ishige:1
1:Laboratory of Pharmacology, School of Pharmacy, Nihon University, Japan, 2:Department of Physiology, Tokyo Dental College, Japan

Lysosomal ubiquitin ligase RNF182 regulates mTORC1 signaling and neuronal differentiation

[Speaker] Masayuki Kaneko:1
[Co-author] Soshi Kanemoto:1, Xiao Peng Guo:1, Kazunori Imaizumi:1
1:Department of Biochemistry, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan

Hippocampal neuronal viability via CRMP-2 expression is mediated by PI3K-mTOR-S6K signaling pathways

[Speaker] Hwa-Jung Kim:1
[Co-author] Eun Jung Na:1, Hyeyeon Nam:1, Myung Ah Chung:1, In-Ja Kim:1
1:Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Korea

Efect of nicorandil on survival of patients with cardiac arrest using large-scale medical claims database

[Speaker] Takahiro Niimura:1
[Co-author] Yoshito Zamami:1,2, Yuki Izawa-Ishizawa:3, Kenshi Takechi:4, Masaki Imanishi:2, Yuya Horinouchi:3, Yasumasa Ikeda:3, Koichiro Tsuchiya:5, Toshiaki Tamaki:3, Keisuke Ishizawa:1,2
1:Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 2:Department of Pharmacy, Tokushima University Hospital, Japan, 3:Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 4:Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Japan, 5:Department of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan

Involvement of glycine binding site of NMDA receptor in the prefrontal cortex of SHRSP/Ezo as an AD/HD animal model

[Speaker] Hiroki Shikanai:1
[Co-author] Nobuhiro Oshima:2, Hidekazu Kawashima:2, Shin-Ichi Kimura:1, Sachiko Hiraide:1, Kenji Iizuka:1, Takeshi Izumi:1
1:Department of Pharmacology, Health Science University of Hokkaido, Japan, 2:Department of Biophysical Sciences, Health Science University of Hokkaido, Japan

Effect of botulinum toxin type-A treatment on non-motor symptoms and cognitive functions in patients with isolated adult-onset cervical dystonia

[Speaker] Maja Relja:1
[Co-author] Vladimir Miletic:1
1:Department of Neurology, Medical School, University of Zagreb, Croatia

Orexinergic neurons hyperfunction causes sleep disorders and hypertension in SHR

[Speaker] Su-Ying Cui:1
[Co-author] Yuan-Li Huang:1, Xiang-Yu Cui:1, Yong-He Zhang:1
1:Department of pharmacology, School of Basic Medical Science, Peking University Health Science Center, China

Stimulation of brain nicotinic acetylcholine receptors induces activation of central adrenomedullary outflow through protein S-nitrosylation in the rat brain

[Speaker] Takahiro Shimizu:1
[Co-author] Youichirou Higashi:1, Masaki Yamamoto:1, Kenjiro Tanaka:2, Kumiko Nakamura:1, Toshio Yawata:3, Suo Zou:1, Tetsuya Ueba:3, Kazunari Yuri:2, Motoaki Saito:1
1:Pharmacology, Kochi Medical School, Kochi University, Japan, 2:Neurobiology and Anatomy, Kochi Medical School, Kochi University, Japan, 3:Neurosurgery, Kochi Medical School, Kochi University, Japan

The effects of dopamine on the synaptic transmission in the rhomboid nucleus of the bed nucleus of the stria terminalis

[Speaker] Taiju Amano:1,2
[Co-author] Kazuki Ito:1, Haruka Uki:1, Kumi O Kuroda:2, Masabumi Minami:1
1:Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan, 2:Laboratory for Affiliative Social Behavior, RIKEN Brain Science Institute, Japan

The involvement of ceramide kinase / ceramide-1-phosphate in NGF-induced differentiation and neurotransmission in PC12 cells

[Speaker] Mayuko Hori:1
[Co-author] Midori Gokita:1, Hiroyuki Nakamura:1, Toshihiko Murayama:1
1:Chiba University, Japan

The de novo Q1042R POGZ mutation in sporadic ASD disrupts the neuronal differentiation

[Speaker] Kensuke Matsumura:1
[Co-author] Takanobu Nakazawa:1,2, Shota Okada:1, Kazuki Nagayasu:1,3, Hiroki Miura:1, Atsushi Kasai:1, Kazuhiro Takuma:2,4, Hidenaga Yamamori:5, Yuka Yasuda:5,6, Ryota Hashimoto:4,5, Hitoshi Hashimoto:1,4,7,8
1:Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 2:Department of Pharmacology, Graduate School of Dentistry, Osaka University, Japan, 3:Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 4:Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Japan, 5:Department of Psychiatry, Graduate School of Medicine, Osaka University, Japan, 6:Oncology Center, Osaka University Hospital, Japan, 7:iPS Cell-Based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 8:Division of Bioscience, Institute for Datability Science, Osaka University, Japan

Sigma1R intracellular translocation in mice brain after «Open field» test and afobazole treatment

[Speaker] Elena V. Abramova:1
[Co-author] Mikhail V. Voronin:1, Sergey B. Seredenin:1
1:Pharmacogenetics, FSBI Zakusov Institute of Pharmacology, Russia

The effect of environmental enrichment on hippocampus gene expression and blood corticosterone concentration in Hatano rats

[Speaker] Airi Nakayama:1
[Co-author] Hasuka Okawa:1, Hikaru Asano:1, Hideyo Tokuoka:1, Meihua Zheng:3, Shaoxia Pu:3, Gen Watanabe:3,4, Ryo Ohta:2, Maiko Kawaguchi:1
1:Meiji University, Japan, 2:Hatano Research Institute Food and Drug Safety Center, Japan, 3:Gifu University, Japan, 4:Tokyo University of Agriculture and Technology, Japan

Evaluation of the effect of benzodiazepines on cognitive status in rats

[Speaker] Youness Kadil:1
[Co-author] Houda Filali:1, Farid Hakkou:1
1:Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, Morocco

Evidence for the involvement of PAX4 transcription factor behind the chronic consequences of single-dose MDMA treatment in the rat hippocampus

[Speaker] Peter Petschner:1,2
[Co-author] Marton Gratzer:1, Sahel K Kapoor:1, Noemi Balogh:1, Viola Tamasi:3, Csaba Adori:1,4, Gabriella Juhasz:1,5,6, Gyorgy Bagdy:1,2,6
1:Department of Pharmacodynamics, Semmelweis University, Hungary, 2:MTA-SE Neuropsychopharmacology & Neurochemistry Research Group, Semmelweis University, Hungary, 3:Department of Genetics, Cell- and Immunobiology, Semmelweis University, Hungary, 4:Retzius Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden, 5:MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Semmelweis University, Hungary, 6:NAP-A-SE New Antidepressant Tartgets Research Group, Semmelweis University, Hungary

Spike timing regularity depends on the firing time scale under propofol-induced anesthetic condition

[Speaker] Mie Kajiwara:1
[Co-author] Risako Kato:2, Yoshiyuki Oi:1, Masayuki Kobayashi:2
1:Department of Anesthesiology, Nihon University School of Dentistry, Japan, 2:Department of Pharmacology, Nihon University School of Dentistry, Japan

Can remyelination be enhanced by immunomodulatory therapeutic modality?

[Speaker] Rina Aharoni:1
[Co-author] Michael Sela:1, Ruth Arnon:1
1:The department of immunology, The weizmann Institute of Science, Israel

Pharmacological exploration of peptide ligands with short residence-time at the oxytocin receptor

[Speaker] Damien Gulliver:1
[Co-author] Timothy Katte:1, Eryn Werry:1, William Jorgensen:1, Tristan Reekie:1, Michael Kassiou:1
1:Faculty of Medicine, School of Medical Sciences (Pharmacology), The University of Sydney, Australia

Availability of aged C57BL/6J mice as an aging model

[Speaker] Akiko Pawlak:1
[Co-author] Hiroyasu Murasawa:1, Hiroyuki Kobayashi:1, Yukiko Kawasaki:1, Masami Kato:1
1:Nihon Bioresearch Inc., Japan

Genetically-Encoded Green Fluorescent cAMP indicator for Multi-Color Cell Imaging

[Speaker] Yuki Mukai:1
[Co-author] Seiko Kawata:1, Hiroki Ishikawa:1, Tetsuya Hori:1, Naoto Saitoh:1
1:Life Med Sci, Doshisha Univ., Japan

Prolyl oligopeptidase (PREP) is a novel regulator for protein phosphatase 2A (PP2A)

[Speaker] Reinis Svarcbahs:1
[Co-author] Maria Jantti:1, Ulrika Julku:1, Timo Myohanen:1
1:Division of Pharmacology and Pharmacotherapy, University of Helsinki, Finland

Deleterious Effect of All Nitric Oxide Synthases in Cerebral Infarction in Male Mice: Involvements of Sex Difference and Testosterone

[Speaker] Masato Tsutsui:1
[Co-author] Haruaki Kubota:1,4, Mayuko Sakanashi:1, Katsuhiko Noguchi:1, Toshihiro Matsuzaki:1, Junko Nakasone:1, Hiroaki Shimokawa:2, Yusuke Ohya:3, Kazuhiro Sugahara:4, Manabu Kakinohana:4
1:Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Japan, 2:Department of Cardiovasc Med, Tohoku Univ Grad Sch Med, Japan, 3:Third Dept Intern Med, Ryukyu University Graduate School of Medicine, Japan, 4:Department of Anesthesiology, Ryukyu University Graduate School of Medicine, Japan

Pharmacodynamic differences of afobazole and its active metabolite

[Speaker] Sergey Seredenin:1
[Co-author] Milada Yarkova:1
1:Zakusov Institute of Pharmacology, Russia

Hydrogen Sulfide (H2S) and polysulfides (H2Sn) as signaling molecules

[Speaker] Hideo Kimura:1
[Co-author] Shin Koike:2, Yuka Kimura:1, Norihiro Shibuya:1, Ryo Miyamoto:1, Yukiko Toyofuku:1, Kenjiro Hanaoka:3, David Lefer:4, Noriyuki Nagahara:5, Yuki Ogasawara:2
1:National Institute of Neuroscience, Japan, 2:Meiji Pharmaceutical University, Japan, 3:University of Tokyo, Pharmaceutical Sciences, Japan, 4:LSU Health Science Center, USA, 5:Nippon Medical School, Japan

EFFECTS OF ATP AND ADENOSINE ON THE CONTRACTIONS OF RAT AND MOUSE FAST SKELETAL MUSCLE AT LOW TEMPERATURE CONDITIONS

[Speaker] Ayrat U Ziganshin:1,2
[Co-author] Adel E. Khairullin:1, Azat I. Gabdrakhmanov:2, Liliya E. Ziganshina:2, Sergey N. Grishin:1
1:Kazan State Medical University, Russia, 2:Kazan (Volga region) Federal University, Russia

Selective elimination of slow motor neurons in mice progressively induces a kinetic tremor that resembles patients with essential tremor

[Speaker] Lisa Ohgaki:1
[Co-author] Daijiro Inomata:1, Tenkei Koyama:1, Tomoyuki Yamanaka:2, Shigeyoshi Itohara:3, Hidemi Misawa:1
1:Division of Pharmacology, Faculty of Pharmacy, Keio University, Japan, 2:Laboratory of Structural Neuropathology, Graduate School of Brain Science, Doshisha University, Japan, 3:Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Japan

Functional characterization of AMPA receptor positive allosteric modulators PF-04958242 and LY-451395

[Speaker] Toshiyuki Ishii:1,2
[Co-author] Jacob R Stolz:1, Geoffrey T Swanson:1
1:Pharmacology, Northwestern University Feinberg School of Medicine, USA, 2:Physiology, Nippon Medical School, Tokyo, Japan

An adenosine A2A receptor antagonist, istradefylline, improves multiple symptoms reflecting obsessive-compulsive disorder in a novel murine model

[Speaker] Nozomi Asaoka:1
[Co-author] Naoya Nishitani:1, Haruko Kinoshita:1, Yuma Nagai:1, Kazuki Nagayasu:1, Hisashi Shirakawa:1, Takayuki Nakagawa:2, Shuji Kaneko:1
1:Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2:Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan

Phosphorylation of Shank3 by Rho-Kinase regulates surface translocation of NMDA and AMPA receptors in PSD

[Speaker] Rijwan Uddin Ahammad:1,2
[Co-author] Yasuhiro Funahashi:2, Md. Omar Faruk:1,2, Emran Hossen:1,2, Kozo Kaibuchi.:2
1:Cell Pharmacology, Doctoral Student, Japan, 2:Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Japan

Mechanism of thymidine incorporation into acid insoluble fraction via nucleoside transporters on oxidative stress DNA injury

[Speaker] Koh-ichi Tanaka:1,2,3
[Co-author] Nobue Kitanaka:2, Junichi Kitanaka:2, Kazuo Tomita:1,3, Takao Tsukahara:3, Tomoaki Sato:3, Motohiko Takemura:2, Nobuyoshi Nishiyama:1
1:Division of Pharmacology, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Japan, 2:Department of Pharmacology, Hyogo College of Medicine, Japan, 3:Department of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan

Withdrawn

Histamine opposite actions in dorsal and ventral pontine tegmentum regions involved in sleep-wake regulation

[Speaker] Miguel Garzon:1
[Co-author] Andrea Diez-Garcia:1, Angel Nunez:1
1:Department of Anatomy, Histology and Neuroscience, Medical School, Universidad Autonoma de Madrid, Spain

Re-covering blood vessels by astrocytic endfeet after laser ablation

[Speaker] Hideaki Kubotera:1
[Co-author] Hiroko Ikeshima-Kataoka:1, Anna L Allegra Mascaro:2,3, Francesco Pavone:2, Takafumi Inoue:1
1:Department of Life Science and Medical Bioscience, Faculty of Science and Engineering, Waseda University, Tokyo, Japan, 2:European Laboratory for Non-Linear Spectroscopy, University of Florence, Florence, Italy, 3:Neuroscience Institute, National Research Council, Pisa, Italy

Cell-type-specific targeting of viral vectors in the mammalian brain

[Speaker] Toshiaki Suzuki:1
[Co-author] Yuji Masaki:1, Taiki Hara:1, Nao Morimoto:1,2, Fumitaka Osakada:1,2,3
1:Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University, Japan, 2:Laboratory of Neural Information Processing, Institute for Advanced Research, Nagoya University, Japan, 3:PRESTO, Japan Science and Technology Agency, Japan

High doses of vitamin D3 improve affective-related state in menopausal women treated with hormonal replacement therapy

[Speaker] Julia Fedotova:1,2
[Co-author] Tatayna Dudnichenko:3
1:Neuroendocrinology, I. P. Pavlov Institute of Physiology RASci, Russia, 2:ITMO University, Russia, 3:North-Western State Medical University named after I. I. Mechnikov, Russia

Marine-derived compound-A suppresses zinc-enhanced pro-inflammatory M1 phenotype of microglia via inhibition of ROS generation

[Speaker] Youichirou Higashi:1
[Co-author] Takaaki Aratake:1, Takahiro Shimizu:1, Shogo Shimizu:1, Yusuke Ueba:1, Tomoya Hamada:1, Zou Suo:1, Masaki Yamamoto:1, Yoshiki Nagao:1, Motoaki Saito:1
1:Pharmacology, Kochi Medical School, Kochi University, Japan

Altered monoamine dynamics and abnormal behaviors in Lrtm2-deficient mice

[Speaker] Misato Ichise:1
[Co-author] Keiichi Katayama:2, Kazuto Sakoori:2, Naoko Morimura:2, Minoru Hatayama:1,2, Jun Aruga:1,2
1:Dept Med Pharmacol, Nagasaki Univ Grad Sch Biomed Sci, Nagasaki, Japan, 2:Lab Behav Dev Disorder, RIKEN BSI, Saitama, Japan

Ammonium-induced GS degradation undergo proteasome independent pathways

[Speaker] Sari Kishikawa:1
[Co-author] Miho Terunuma:1
1:Division of Oral Biochemistry, Graduate School of Medical and Dental Sciences, Niigata University, Japan

Inhibition of Kv3.1 currents by sertraline

[Speaker] Bok Hee Choi:1
[Co-author] Hyang Mi Lee:1, Sang June Hahn:2
1:Pharmacology, Institute for Medical Sciences, Chonbuk National University Medical School, Korea, 2:Department of Physiology, Medical Research Center, College of Medicine, The Catholic University of Korea, Korea

Disturbance of intracellular lipid storage in cell models of several types of spinocerebellar ataxias

[Speaker] Takahiro Seki:1
[Co-author] Mutsumi Oshima:1, Yuki Kurauchi:1, Akinori Hisatsune:2,3, Hiroshi Katsuki:1
1:Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 2:Priority Organization for lnnovation and Excellence, Kumamoto University, Japan, 3:Program for Leading Graduate Schools “HIGO Program”, Kumamoto University, Japan

The circulating TGF-beta contributes to the remyelination in CNS

[Speaker] Machika Hamaguchi:1
[Co-author] Rieko Muramatsu:1, Toshihide Yamashita:1
1:Department of molecular neuroscience, Graduate school of medicine, Osaka University, Japan

Discovery of a novel regulator of neuroinflammation: differential roles of SNS-1 in experimental autoimmune encephalomyelitis and lipopolysaccharide-induced neuroinflammation

[Speaker] Donggun Seo:1
[Co-author] Youngpyo Nam:1, Kyoungho Suk:1
1:Department of Pharmacology, Department of Pharmacology, Brain Science and Engineering Institute, and Department of Biomedical Sciences, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, 41944, Korea

VOLTAGE-GATED SODIUM CHANNEL ACTIVATION TRIGGERS CALCIUM INFLUX AND HIPPOCAMPAL NEURON COMPLEXITY

[Speaker] Dina A Gomez:1
[Co-author] Thomas F Murray:1
1:Pharmacology, Creighton University, USA

GTRAP3-18 regulated by RNA-binding proteins under the control of microRNA

[Speaker] Chisato Kinoshita:1
[Co-author] Toshio Nakaki:1
1:Department of Pharmacology, Teikyo University School of Medicine, Japan

Tankyrase participates in neurite growth and synapse formation via poly (ADP-ribosy) lation in hippocampal neurons

[Speaker] Moe Nii:1
[Co-author] Aina Uno:1, Takeshi Fujii:1, Masato Mashimo:1
1:Department of Pharmacology Faculty of Pharmacentical Sciences, Doshisha Women's College, Japan

Tyrosine hydroxylase and/or rBAT positive neuron in primary afferent innervates in the nucleus tractus solitarii

[Speaker] Daiki Masukawa:1
[Co-author] Yuka Nakao:1, Yoshio Goshima:1
1:Molecular Pharmacology and Neurobiology, Yokohama City University, Japan

An interaction between PAC1 receptor and serotonin 2A receptor involved in receptor trafficking and signal transduction

[Speaker] Yusuke Shintani:1
[Co-author] Atsuko Hayata-Takano:1,2, Naoki Encho:1, Keita Moriguchi:1, Hitoshi Hashimoto:1,2,3
1:Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 2:United Graduate School of Child Development, Osaka University, Osaka, Japan, 3:Institute for Datability Science, Osaka University, Osaka, Japan

KANPHOS Platform: A comprehensive database for kinase-associated neural phosphorylation signaling

[Speaker] Mutsuki Amano:1
[Co-author] Junichiro Yoshimoto:2, Takayuki Kannon:3, Tomoki Nishioka:1, Shiro Usui:4, Kozo Kaibuchi:1
1:Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Japan, 2:Graduate School of Information Science, Nara Institute of Science and Technology, Japan, 3:Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan, 4:Neuroinformatics Japan Center, RIKEN Brain Science Institute, Japan

Psychotropic activity of new thietan-phenol thiazolium bromide's derivates

[Speaker] Elizaveta Volkova:1
[Co-author] Olesya Lazovaya:1, Irina Nikitina:1
1:Bashkir State Medical University, Russia

Dissection of corticothalamic feedback pathway from V1 to dLGN in mouse

[Speaker] Sayumi Okigawa:1
[Co-author] Nao Morimoto:1,2, Fumitaka Osakada:1,2,3
1:Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University, Japan, 2:Laboratory of Neural Information Processing, Institute for Advanced Research, Nagoya University, Japan, 3:PRESTO, Japan Science and Technology Agency, Japan

A new aspect of cholinergic transmission in central nervous system

[Speaker] Ikunobu Muramatsu:1
[Co-author] Takayoshi Masuoka:1, Matomo Nishio:1, Takaharu Ishibashi:1
1:Department of Pharmacology, School of Medicine, Kanazawa Medical University, Japan

Memantine Nitrate Ester Derivatives MN-08 Improves Cognitive and Attenuates Alzheimer's Disease-Like Neuropathology in Transgenic mice

[Speaker] Xinhua Zhou:1
[Co-author] Xifei Yang:2, Zaijun Zhang:3, Yuqiang Wang:3, Maggie Pui Man Hoi:1
1:State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, China, 2:Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen, China, 3:Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy; Guangzhou, China

Characterization of the SOD1-G93A mouse model of Amyotrophic lateral sclerosis and a promising treatment for the disease

[Speaker] Sara Figuerola Santamonica:1
[Co-author] Francesca De Lorenzo:1, Michael Sendtner:2, Mart Saarma:1, Merja Voutilainen:1
1:Mart Saarma laboratory, Institute of Biotechnology, Finland, 2:Institute for Clinical Neurobiology, University of Wurzburg, Germany

Bradykinin excites intracardiac ganglion neurons by activating non-selective cation channels and inhibiting M-currents

[Speaker] Shiho Arichi:1
[Co-author] Sachie Hamada:1, Hitoshi Ishibashi:1
1:Kitasato University, Japan

The network Regulation of Yiqi Jiedu Formulae against Cerebral Ischemia Based on Central-periphery Inflammation System

[Speaker] Shaojing Li:1
1:Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, China

The role of RP58 in the maintenance of cognitive function

[Speaker] Tomoko Tanaka:1
[Co-author] Haruo Okado:1
1:Neural development project, Neural Development and Brain Regeneration, Tokyo Metropolitan Institute of Medical Science, Japan

Fingolimod, a spingosine-1-phosphate agonist, modulates P-glycoprotein activity in PTZ kindling induced Phenobarbital resistant model of epilepsy in rats: Possible involvement of spingolipid endothelin pathway

[Speaker] Nitika Garg:1
[Co-author] Rupa Joshi:1, Bikash Medhi:1
1:Post Graduate Institute of Medical Education and Research, India

EVALUATION OF GRANISETRON INFLUENCE ON SEROTONINE'S EFFECT ON ORGAN BATH ISOLATED INTESTINE HARVESTED FROM RATS THAT WERE PRETREATED WITH PCPA ADMINISTERED INTRAPERITONEALLY IN ORDER TO EXHAUST ENDOGENE SEROTONINE DEPOSITS

[Speaker] Mihnea Costescu:1
[Co-author] Ion Fulga:1, Oana-Andreia Coman:1, Aurelian Zugravu:1, Horia Paunescu:1
1:Pharmacology, University Of Medicine And Pharmacy Carol Davila Bucharest, Romania

Spike properties of granule retrosplenial cortex L2/3 neurons

[Speaker] Mengxuan Gao:1
[Co-author] Yuji Ikegaya:1
1:Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan

Pharmacological analysis of sleep/wake consolidation mechanisms in mammals

[Speaker] Qianhui Zhang:1
[Co-author] Hiroki R Ueda:1,2
1:Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Japan, 2:QBiC, RIKEN, Japan

The protective effects of levetiracetam on spinal muscular atrophy models

[Speaker] Shiori Ando:1,2
[Co-author] Kazuki Ohuchi:1,2, Michinori Funato:2, Shinsuke Nakamura:1, Masamitsu Shimazawa:1, Hideo Kaneko:2, Hideaki Hara:1
1:Molecular Pharmacology, Gifu Pharmaceutical University, Japan, 2:Department of Clinical Research, National Hospital Organization, Nagara Medical Center, Jordan

Functional role of Bcl-2-associated athanogene (BAG) 3 as a regulator of Bak1 protein level in N1E115 cells

[Speaker] Atsushi Sanbe:1
[Co-author] Yui Inomata:1, Sachi Tamada:1, Shintaro Takahashi:1, Rieko Higashio:1, Yu Tezuka:1
1:Pharmacotherapeutics, Iwate Medical University, Japan

3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteineand glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S

[Speaker] Yuka Kimura:1
[Co-author] Shin Koike:2, Norihiro Shibuya:1, David Lefer:3, Yuki Ogasawara:2, Hideo Kimura:1
1:National Center of Neurology and Psychiatry, Japan, 2:Dept. Anal. Chem, Meiji Pharma Univ, Japan, 3:Dept. Pharmacol. Exp. Ther., LSU Health Sci. Center, USA

Influence of the maternal immunoactivation on the neuron-microglia interactions in young offspring

[Speaker] Agnieszka Basta-Kaim:1
[Co-author] Boguslawa Budziszewska:1, Katarzyna Kotarska:1, Katarzyna Chamera:1, Ewa Trojan:1, Natalia Bryniarska:1
1:Experimental Neuroendocrinology, Institute of Pharmacology PAS, Poland

Effect Of Artesunate, Esomeprazole And Coffee Intake On Prodromal Parkinson's Disease Features In Adult Men

[Speaker] Stephen E Oriaifo:1
[Co-author] Isa M Abdul-Aguye:2, Hubert O Omeife:3, Ray I Ozolua:4
1:Dept of Pharmacology, Ambrose Alli University, Ekpoma, Edo State, Nigeria, 2:Dept of Pharmacology, Ambrose Alli University, ABU, Zaria, Nigeria, 3:Dpet of Medicine, ISTH, Irrua, Nigeria, 4:Dept of Pharmacology, Ambrose Alli University, UNIBEN, Benin-City, Nigeria

Reduction of the mitochondria-localized protein p13 protects against experimental parkinsonism

[Speaker] Norihito Shintani:1
[Co-author] Naoki Inoue:1, Sae Ogura:1, Yohei Morota:1, Hitoshi Hashimoto:1,2,3
1:Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 2:United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan, 3:Institute for Datability Science, Osaka University, Japan

Is there relationship between Toxoplasma gondii IgG seropositivity and idiopathic Parkinsonism and does it have correlation with cortisol blood level ?

[Speaker] Ahmed AR. Daoud:1
[Co-author] Nabila A. Yassin:3, Hazem A. Fayed:2, Wesam M. Elgendy:2, Marwa A. Hasby:2
1:Clinincal Parasitology Faculty of Medicine Tanta University, Tanta University Faculty of Medicine, Egypt, 2:Clinincal Parasitology Faculty of Medicine Tanta University, Egypt, 3:Neurology Department Faculty of Medicine Tanta University, Egypt

Identification of mechanisms leading to blood-brain barrier dysfunction in Parkinson's disease

[Speaker] Sarka Lehtonen:1
[Co-author] Tuuli-Maria Sonninen:1, Marja Koskuvi:1, Anastasia Shakirzyanova:1, Minna Oksanen:1, Maria Lagarkova:2, Sergey Kiselev:2, Katja A Puttonen:1, Pasi Tavi:1, Jari Koistinaho:1
1:A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Finland, 2:Russian Academy of Sciences, Vavilov Institute of General Genetics, Moscow, Russia

The machanism of neuroinflammation in Parkinson's disease: the involvement of integrin

[Speaker] Dan Zhang:1
[Co-author] Liyan Hou:2, Qingshan Wang:2, Xiuqi Bao:1
1:Institute of Materia Medica, Chinese Academy of Medical Scienses & Peking Union Medical College, China, 2:Dalian Medical University, China

Carnosic acid attenuated 6-hydroxydopamine-induced apoptosis through mediation of the mitochondrial biogenesis by parkin in SH-SY5Y cells

[Speaker] Chia-Wen Tsai:1
[Co-author] Yan-Ning Huang:1, Chia-Yuan Lin:1
1:Department of Nutrition, China Medical University, Taiwan.

Reduced cAMP/CREB signaling in the dentate gyrus is involved in facilitation of fear extinction in the MPTP-induced mouse model of Parkinson's disease

[Speaker] Toshiaki Ishii:1
[Co-author] Ken-Ichi Kinoshita:1, Yoshikage Muroi:1
1:Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Japan

Opicapone improves the effects of L-DOPA on the MPTP-induced Parkinson's-like syndrome in cynomolgus monkeys

[Speaker] Maria-Joao Bonifacio:1
[Co-author] Filipa Sousa:1, Patricio Soares-da-Silva:1,2,3
1:Research Department, BIAL-Portela & Cia SA, Portugal, 2:Dept. Biomedicine, Unit of Pharmacology & Therapeutics, Faculty of Medicine, University of Porto, 4200 Porto, Portugal, 3:MedInUp-Center for Drug Discovery and Innovative Medicines, University of Porto, 4200 Porto, Portugal

Neuroprotective potential of Thymoquinone in MPTP Model of Parkinson's Disease

[Speaker] M Emdadul Haque:1
[Co-author] Nisha R. Dhanushkodi:1, Madiha Mohieldine Merghani:1, Mustafa T. Ardah:1
1:Dept. of Biochemistry, CMHS, UAE University, UAE

A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesia in Parkinsonian Monkeys

[Speaker] Shunsuke Maehara:1
[Co-author] Goichi Beck:2, Phat Ly Chang:2, Stella M Papa:2,3
1:Pharmacology, Research Center, Mochida Pharmaceutical Co., Ltd., Japan, 2:Yerkes National Primate Research Center, Emory University, USA, 3:Department of Neurology, Emory University School of Medicine, USA

Midnolin is a novel risk factor for Parkinson's Disease and regulates expression of parkin and other causative genes

[Speaker] Yutaro Obara:1
[Co-author] Toru Imai:1, Hidenori Sato:2, Yuji Takeda:3, Takeo Kato:4, Kuniaki Ishii:1
1:Department of Pharmacology, Yamagata University School of Medicine, Japan, 2:Genome Informatics Unit, Institution for Promotion of Medical Science Research, Yamagata University School of Medicine, Japan, 3:Department of Immunology, Yamagata University School of Medicine, Japan, 4:Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Japan

Synergistic effect of Epicathechine and Edaravone in an in vitro Model of parkinson with 6-OHDopamine

[Speaker] Ramin Ataee:1
[Co-author] Hashem Javanmard:1, Mohammad Shokrzadeh:1, Mona Modanloo:1, Hossein Asgarian Omran:2
1:Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran, 2:Immunology Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Modulators targeting fast-activating transient K+ conductance shape subthalamic burst discharges

[Speaker] Ya-Chin Yang:1,2
[Co-author] Chen-Syuan Huang:1, Guan-Hsun Wang:1, Ai-Yu Chuang:1
1:Chang Gung University, Taiwan, 2:Chang Gung Memorial Hospital, Linkou, Taiwan

Protective effect of an Nrf2-ARE activator identified from a chemical library on 6-hydroxydopamine-induced dopaminergic neuronal death

[Speaker] Yuri Inose:1
[Co-author] Yasuhiko Izumi:1,2, Harue Kataoka:1, Akinori Akaike:1, Yutaka Koyama:2, Toshiaki Kume:1
1:Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2:Department of Pharmacology, Kobe Pharmaceutical University, Japan

Investigation of the effect of Agmatine in Rotenone induced Parkinson's Disease Model in Rats

[Speaker] Caner Gunaydin:1
[Co-author] Mehmet Emin Onger:2, Bahattin Avci:3, Ayhan Bozkurt:4, Nihan Cankara:5, Suleyman Sirri Bilge:1
1:Pharmacology, Ondokuz Mayis University School of Medicine, Turkey, 2:Histology and Embryology, Ondokuz Mayis University School of Medicine, Turkey, 3:Biochemistry, Ondokuz Mayis University School of Medicine, Turkey, 4:Physiology, Ondokuz Mayis University School of Medicine, Turkey, 5:Pharmacology, Suleyman Demirel University School of Medicine, Turkey

Inosine halts disease progression and also neuroprotective effects of though up-regulation of urate levels in Parkinson's disease

[Speaker] Mohammad Emamussalehin Choudhury:1
[Co-author] Hirotaka Iwaki:2, Rina Ando:2, Kyaw Win Thiri:2, Noriko Nishikawa:2, Masahiro Nagai:2, Junya Tanaka:1, Masahiro Nomoto:2
1:Department of Molecular and cellular Physiology, Ehime University Graduate School of Medicine, Japan, 2:Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Japan

Prion-like behaviour of α-synuclein

[Speaker] Hiroyuki Oshikane:1
[Co-author] Masahiko Watabe:1,2, Naoya Tochio:3, Fumio Arisaka:4, Naoko Tate:3, Toshio Nakaki:1
1:Department of Pharmacology, Teikyo University School of Medicine, Japan, 2:General Medical Education and Research Center (G-MEC), Teikyo University, Japan, 3:Laboratory of Basic Chemistry and Molecular Structure, Faculty of Pharma Sciences, Teikyo University, Japan, 4:Tokyo Institute of Technology, Japan

RTP801 functions in chronic restraint stress accelerated neurodegeneration of Parkinson's disease

[Speaker] Zhao Zhang:1
[Co-author] Shi-Feng Chu:1, Nai-Hong Chen:1
1:Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, China

Novel potential of NADPH-oxidase and RHO-kinase pathways inhibition in a genetic in-vitro Parkinson's disease model

[Speaker] Ismaila O Ishola:1
[Co-author] Njedika U Okubadejo:2, Konrad Klockmeier:3, Erich E Wanker:3, Sunday A Omilabu:4
1:Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos, Lagos, Nigeria, 2:Department of Medicine, Neurology Division, College of Medicine, University of Lagos, Nigeria, 3:Max delbruck Centre for Molecular Medicine, Neuroproteomics division, Berlin, Germany, 4:Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Nigeria

Role of ubiquitin ligase HRD1 in a cellular model of Parkinson's disease

[Speaker] Tomohiro Omura:1
[Co-author] Hiroki Matsuda:1, Luna Nomura:1, Masato Naito:1, Shunsaku Nakagawa:1, Satoshi Imai:1, Atsushi Yonezawa:1,2, Takayuki Nakagawa:1, Kazuo Matsubara:1
1:Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan, 2:Graduate School of Pharmaceutical Sciences, Kyoto University, Japan

Dopamine D2 receptors in the CNS regulate blood glucose levels through the sympathetic and parasympathetic nerves

[Speaker] Hiroko Ikeda:1
[Co-author] Risa Mikami:1, Naomi Yonemochi:1, Junzo Kamei:1
1:Department of Pathophysiology and Therapeutics, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan

Evaluation of metabolic and hemodynamic alterations in the offspring of perinatally stressed rats

[Speaker] Mireille Toledo-Blas:1
[Co-author] M. Lopez-Martinez:1, P. Lopez-Sanchez:1, A. Guzman-Grenfell:1, A. Meneses-Ortiz:1, Antonio Franco Vadillo:1
1:Laboratorio de Farmacologia Experimental Instituto Nacional de Perinatologia, Mexico

Continuous inhibition of secretase regulates synapse formation

[Speaker] Yuji Kamikubo:1
[Co-author] Kazue Niisato:1, Koichi Jingo:1, Hao Jin:1, Takashi Sakurai:1
1:Pharmacology, Juntendo University, Japan

Oxytocin signaling in the dorsal raphe nucleus is required for displaying maternal care under negative energy conditions

[Speaker] Yoshikage Muroi:1
[Co-author] Motoyuki Fujisaki:1, Toshiaki Ishii:1
1:Department of Vetrinary Medicine, Obihiro University of Aguriculture and Veterinary Medicine, Japan

Comprehensive protein analysis of the transport system in a connective tissue of the inner ear

[Speaker] Seishiro Sawamura:1
[Co-author] Yoriko Nonomura:1,2, Fumiaki Nin:1, Satoru Uetsuka:3, Hidenori Inohara:3, Arata Horii:2, Sugata Takahashi:2, Shushi Nagamori:4, Yoshikatsu Kanai:5, Hiroshi Hibino:1
1:Department of Molecular Physiology, Niigata University School of Medicine, Japan, 2:Department of Otorhinolaryngology, Head and Neck Surgery, Niigata University School of Medicine, Japan, 3:Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Osaka University, Japan, 4:Department of Collaborative Research for Bio-Molecular Dynamics, Nara Medical University, Japan, 5:Department of Pharmacology, Graduate School of Medicine, Osaka University, Japan

A simple method for simultaneous monitoring of respiratory and cardiac function in mice

[Speaker] Motoshige Sato:1
[Co-author] Nobuyoshi Matsumoto:1, Asako Noguchi:1, Toya Okonogi:1, Takuya Sasaki:1, Yuji Ikegaya:1
1:Laboratory of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Japan

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