Sessions

The effect of CYP2C19*17 on platelet aggregation in patients with acute coronary syndrome and percutaneous coronary intervention in Russian population

[Speaker] Kristina Ryzhikova:1
[Co-author] Karin Mirzaev:1, Elena Grishina:1, Denis Andreev:2, Dmitrij Sychev:1
1:Russian Medical Academy of Continuous Professional Education, Moscow, Russia, 2:First Moscow State Medical University, Russia

Physiologically based pharmacokinetic modelling of atomoxetine in the different CYP2D6 genotypes

[Speaker] Seok-Yong Lee:1
[Co-author] Se-Hyung Kim:1, Ji-Young Byeon:1, Young-Hoon Kim:1, Choong-Min Lee:1, Eui-Hyun Jung:1, Won-Ki Chae:1, Choon-Gon Jang:1, Yun Jeong Lee:2
1:School of Pharmacy, Sungkyunkwan University, Korea, 2:College of Pharmacy, Dankook University, Korea

Influence of CYP1A2, adenosine A2A receptor and dopamine D2 receptor polymorphisms on the changes of blood pressure and calculation speed by caffeine intake

[Speaker] Tatsuya Yoshihara:1,2
[Co-author] Fumie Shiraishi:2, Fumi Takahashi:3, Shunichi Kajioka:2, Toshiyuki Sasaguri:2
1:Clinical Research Center, SOUSEIKAI Fukuoka Mirai Hospital, Japan, 2:Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Japan, 3:School of Medicine, Department of Pharmacology, University of Occupational and Environmental Health, Japan

Haplotype analyses of CYP2C19*2 and CYP2C19*17 genetic polymorphisms in clopidogrel non-responsiveness after percutaneous coronary intervention with stent implantation

[Speaker] Faruk Saydam:1
[Co-author] Cansu Ozbayer:2, Taner Ulus:3, Mahmut Ozdemir:4, Necmi Ata:3, Hasan Veysi Gunes:5
1:Department of Medical Biology and Genetics, Recep Tayyip Erdogan University Faculty of Medicine, Turkey, 2:Department of Midwifery, Dumlupinar University Kutahya School of Health, Turkey, 3:Department of Cardiology, Eskisehir Osmangazi University Faculty of Medicine, Turkey, 4:Department of Pharmacology, Eskisehir Osmangazi University Faculty of Medicine, Turkey, 5:Department of Medical Biology, Eskisehir Osmangazi University Faculty of Medicine, Turkey

ASSOCIATION OF POLYMORPHISMS IN CYP3A5 and SLC22A1 WITH IMATINIB RESPONSE IN THAI PATIENTS WITH CHRONIC MYELOID LEUKEMIA

[Speaker] Att Khampho:1
[Co-author] Saengsuree Jootar:2, Pimjai Niparuck:2, Pornpimol Kijsanayotin:1
1:Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand, 2:Division of Hematology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand

Impact of CYP3A5 and SLCO1B1 polymorphisms on atazanavir/ritonavir trough concentrations in Thai HIV-infected patients

[Speaker] Baralee Punyawudho:1
[Co-author] Noppaket Singkham:1, Narukjaporn Thammajaruk:2, Kiat Ruxrungtham:2,3, Torsak Bunupuradah:2, Sasisopin Kiertiburanakul:4, Ploenchan Chetchotisakd:5, Anchalee Avihingsanon:2,3
1:Pharmaceutical Care, Chiang Mai University, Thailand, 2:HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand, 3:Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, 4:Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 5:KhonKaen University, KhonKaen, Thailand

Examination of CYP3A5 gene polymorphisms was useful for adjusting doses of tacrolimus in outpatients with rheumatic diseases

[Speaker] Shinji Horibata:1,2
[Co-author] Miho Takahashi:2, Kennosuke Yorihuji:1,2,3, Miwa Nishida:2,4, Goh Tuji:2,4, Shunichi Kumagai:2,4
1:Pharmacy, Shinko Hospital, Japan, 2:The Shinko Institute for Medical Research, Japan, 3:Clinical Pharmacy, Kobe Pharmaceutical University, Japan, 4:Center for Rheumatic Diseases, Shinko Hospital, Japan

Metabolic characterization of the opioid analgesic meperidine and pharmacogenetic implications for generation of the neurotoxic metabolite normeperidine

[Speaker] Jessica L Murray:1
[Co-author] Susan L Mercer:1,2, Klarissa D Jackson:1,2
1:Lipscomb University College of Pharmacy, USA, 2:Vanderbilt University, USA

First-generation antihistamine-induced drowsiness and the CYP2D6 genotype

[Speaker] Jun Miura:1
[Co-author] Jun Itahashi:1, Takuya Ogata:1, Hiromi Motomura:1, Kaori Yama:1, Shigenori Tadokoro:2, Haruki Sasaki:2, Maiko Machida:2, Nobumasa Hayase:1
1:Pharmacotherapy, Hokkaido Pharmaceutical University, Japan, 2:Health Administration Center, Muroran Institute of Technology, Japan

Influence of CYP2D6 polymorphisms on steady state plasma concentrations and therapeutic outcome of donepezil in Thai patients with Alzheimer's disease

[Speaker] Thitipon Yaowaluk:1
[Co-author] Vorapun Senanarong:2, Chanin Limwongse:3, Rasda Boonprasert:4, Pornpimol Kijsanayotin:1
1:Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences Chulalongkorn University, Thailand, 2:Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand, 3:Division of Medical Genetics, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand, 4:Clinical Toxicology Laboratory, Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand

Risk of fall injuries with concomitant use of antidepressants and CYP2D6 inhibitors

[Speaker] Karin Soderberg-Lofdal:1,2
[Co-author] Max Vikstrom:3, Karin Leander:3, Marja-Liisa Dahl:1,2
1:Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Sweden, 2:Department of Clinical Pharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden, 3:Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Effect of BCRP, OATP1B1, and CYP2C9 polymorphisms on the pharmacokinetics of extended-release and immediate-release fluvastatin

[Speaker] Qian Xiang:1
[Co-author] Xia Zhao:1, Yi Min Cui:1
1:Pharmacy, Peking University Frist Hospital, China

Correlation between voriconazole dosage regimen at steady state and CYP3A4 rs4646437 polymorphism

[Speaker] Thikhumporn Areesinpitak:1
[Co-author] Suda Vannaphasaht:1, Sumonrat Chuwongwattana:2, Chonlaphat Sukasem:2, Wichittra Tassaneeyakul:1
1:Department of Pharmacology, Khon Kaen University, Thailand, 2:Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand

THE CYP2C19*2 (G681A, rs4244285), CYP2C19*3 (G636A, rs4986893) POLYMORPHISMS ASSOCIATED WITH RESISTANCE TO CLOPIDOGREL IN PATIENTS WITH ACS IN THE YAKUT AND RUSSIAN ETHNIC GROUPS

[Speaker] Denis Fedorinov:1,2
[Co-author] Karin Mirzaev:1, Dmitriy Sychev:1, Nadezda Maksimova:3, Yana Chertovskih:4, Nyurguiana Popova:4, Ksenia Tayurskaya:3, Zoya Rudykh:3
1:Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare, Moscow, Russia, 2:Sechenov First Moscow State Medical University, Moscow, Russia, 3:Ammosov North-Eastern Federal University, Yakutsk, Russia, 4:Republican hospital No. 3, Yakutsk, Russia

Effects of cytochrome b5 expression and its genetic variant on the activity of CYP2C9, CYP2C19 and CYP3A4

[Speaker] DuckHoon Kim:1
[Co-author] Sung-Eun Yoo:1, Myeongjin Yi:1, Woo-Young Kim:1, Sun-A Cho:1, Sangseop Lee:1, Su-Jun Lee:1, Ho-Sook Kim:1, Jong-Lyul Ghim:1,2, Jae-Gook Shin:1,2
1:Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Korea, 2:Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Korea

Assessment of hepatic cytochrome P450 3A activity using steroid metabolic markers in patients with renal impairment

[Speaker] Andrew Hyoungjin Kim:1
[Co-author] Dong Ki Kim:2, Seunghwan Lee:1, Kyung-Sang Yu:1, In-Jin Jang:1, Joo-Youn Cho:1
1:Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Korea, 2:Department of Internal Medicine, Seoul National University College of Medicine and Hospital, Korea

Inhibition of CYP2B6, CYP2C8, CYP2C9, and CYP3A4 by Sophorea Radix extracts in human liver microsomes

[Speaker] DuckHoon Kim:1
[Co-author] Daeun Lim:1, Min Jung Kim:1, Su-Jun Lee:1, Jae Gook Shin:1,2, Ho-Sook Kim:1, Jong-Lyul Ghim:1,2, Dong Hyun Kim:1
1:Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Korea, 2:Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Korea

Effect of CYP2C19 *2 and *3 variants on sulphonylurea monotherapy treatment failure in Chinese patients with Type 2 diabetes

[Speaker] Elaine Chow:1,2
[Co-author] Guozhi Jiang:2, Katie Kh Chan:2, Andrea Oy Luk:1,2, Ronald Cw Ma:1, Brian Tomlinson:2, Juliana Cn Chan:2
1:Phase 1 Clinical Trial Centre, The Chinese University of Hong Kong, Hong Kong, 2:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong

Unique Profile of Pharmacogenetics Variants Associated With Warfarin Response In Black Africans: Looking Beyond VKORC1 and CYP2C9 Polymorphisms

[Speaker] Collet C Dandara:1
[Co-author] Arinao A Ndadza:1, Sarudzai S Muyambo:2, Alice A Matimba:3, Charles B Nhachi:2, Emile E Chimusa:1, Ambroise A Wonkam:1, Collen M Masimirembwa:4
1:Department of Pathology, University of Cape Town, South Africa, 2:Department of Clinical Pharmacology, University of Zimbabwe, Zimbabwe, 3:Advanced Courses and Conferences, UK, 4:AiBST, Zimbabwe

Genotype-guided warfarin dosing

[Speaker] Ksenija Makar-Ausperger:1
[Co-author] Kristina Krzelj:2, Martina Lovric Bencic:1,2, Matea Radacic- Aumiler:1, Viktorija Erdeljic Turk:1, Nada Bozina:1,2
1:University Hospital Center Zagreb, Croatia, 2:University of Zagreb School of Medicine, Croatia

A study to determine Pharmacogenomic predictors of efficacy and safety of Azathioprine therapy in patients with IBD

[Speaker] Phulen Sharma:1
[Co-author] Gaurav Muktesh:2, Shringika Soni:1, Abhishek Mishra:1, Rahul Singh:2, Narender Dhaka:2, Ajay Prakash:1, Usha Dutta:2, Rakesh Kochhar:2, Bikash Medhi:1
1:Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), India, 2:Gastroenterology, PGIMER, Chandigarh, India

Integrative genomic analysis for the functional roles of ITPKC in bone mineral density

[Speaker] Hsing Fang Lu:1
[Co-author] Henry Sung-Ching Wong:1,2, Yu-Wen Hsu:3, Er-Chieh Cho:1, Kuo-Sheng Hung:4, Wei-Chiao Chang:1,2,5,6
1:School of Pharmacy, Taipei medical university, Taiwan, 2:Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taiwan, 3:The Ph. D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taiwan, 4:Department of Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taiwan, 5:Department of Pharmacy, Taipei Medical University-Wanfang Hospital, Taiwan, 6:Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Taiwan

Identification of the genomic biomarkers of bosentan-induced liver dysfunction

[Speaker] Kennosuke Yorifuji:1,2,3
[Co-author] Yuko Uemura:2, Shinji Horibata:2,3, Goh Tsuji:2,4, Yoko Suzuki:1,5, Kazuya Miyagawa:1,5, Kazuhiko Nakayama:5, Ken-Ichi Hirata:5, Shunichi Kumagai:2,4, Noriaki Emoto:1,5
1:Clinical Pharmacy, Kobe Pharmaceutical University, Japan, 2:The Shinko Institute for Medical Research, Japan, 3:Department of Pharmacy, shinko hospital, Japan, 4:Center for Rheumatic Diseases, shinko hospital, Japan, 5:Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe Graduate School of Medicine, Japan

Integrative analysis of electric health records and pharmacogenomic information for identifying factors related to the efficacy of DPP-IV inhibitors

[Speaker] Yuya Suzumura:1
[Co-author] Shiko Okabe:1, Akira Kakimoto:1, Atsumu Toyoshima:1, Kaname Nakatani:2, Yuhei Nishimura:1
1:Department of Integrative Pharmacology, Mie University Graduate School of Medicine, Japan, 2:Division of Personalized Medicine, Mie University Graduate School of Medicine, Japan

Genome data mining, annotation and comparative analysis of P450s in Cryptococcus species

[Speaker] Moleboheng E Binyane:1
[Co-author] Sitheni S Mashele:1, Khajamohiddin Syed:2
1:Department of Biomedical Technology, Central University of Technology, South Africa, 2:University of Zululand, South Africa

Sigma-1 receptor ligand Fabomotizole attenuates genotoxicity in experiments and clinical trial

[Speaker] Aliy K Zhanataev:1
[Co-author] Andrey D Durnev:1
1:Pharmacological genetics, Federal state institution “Research Zakusov named institute of pharmacology”, Russia

GENOTYPING OF VOLUNTEERS FOR NAPROXEN PHARMACOKINETIC ASSAYS AND MOBILE PHASE STANDARDIZATION IN UHPLC

[Speaker] Adriana Calvo:1
[Co-author] Thiago Dionisio:1, Flavio Faria:1, Carlos Santos:1
1:Biological Sciences, Bauru School of Dentistry University of Sao Paulo, Brazil

Influence of OATP1B1 and BCRP polymorphisms on the Pharmacokinetics and Pharmacodynamics of Rosuvastatin in young and elderly Korean subjects

[Speaker] Yun Kim:1
[Co-author] Ki Young Huh:1, Seunghwan Lee:1, Seonghae Yoon:2, Jae-Yong Chung:2
1:Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Korea, 2:Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Korea

Genotype - Phenotype correlations for Thiopurine Methyltransferase in Thai patients

[Speaker] Thawinee Jantararoungtong:1
[Co-author] Santirat Prommas:1, Supaporn Wiwattanakul:1, Monpat Chamnanphon:1, Apichaya Puangpetch:1, Chonlaphat Sukasem:1
1:Pathology, Division of Pharmacogenomics and Personalized Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Effect of ABCB1 C3435T Polymorphism on Creatinine levels in Kenyan HIV Patients on Lopinavir-Based Regimens

[Speaker] Richard Kagia:1
[Co-author] Okalebo Faith:1, Oluka Margaret:1, Njoroge Anne:1, Bulimo Wallace:1
1:Dept. of Pharmacology & Pharmacognosy, College of Health Sciences, University of Nairobi, Kenya

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