Sessions

Sphingomyelin disrupts vesicular trafficking of cholesterol in Niemann-Pick disease type C

[Speaker] Hiroyuki Nakamura:1
[Co-author] Masahiro Wanikawa:1, Shunsuke Emori:1, Naohiro Hashimoto:1, Toshihiko Murayama:1
1:Chiba University, Japan

Developing new therapies for neuronal ceroid lipofuscinoses or Batten disease

[Speaker] Maija Dambrova:1,2
[Co-author] Sara Mole:3
1:Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Latvia, 2:Riga Stradins University, Latvia, 3:University College London, UK

Increase of phosphate enhances the cytotoxicity of osteoblasts by bisphosphonates

[Speaker] Masamichi Tajima:1
[Co-author] Akihiko Hasegawa:2
1:Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Japan, 2:Division of Internal Medicine, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, Japan

The effects of kaempferol against mutant copper-zinc superoxide dismutase-mediated toxicity via autophagy

[Speaker] Tomoyuki Ueda:1
[Co-author] Masatoshi Inden:1, Masanori Kiuchi:1, Yuta Asaka:1, Hisaka Kurita:1, Isao Hozumi:1
1:Laboratory of Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University, Japan

Effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells

[Speaker] Naoko Takase:1
[Co-author] Masatoshi Inden:1, Shin-Ichiro Sekine:1, Yuki Kaneko:1, Hisaka Kurita:1, Isao Hozumi:1
1:Laboratory of Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University, Japan

Recapitulating fabry disease with human induced pluripotent stem cells and CRISPR interference reveals a signaling axis involved in cardiac phenotypes

[Speaker] Hirofumi Morihara:1
[Co-author] Kiichiro Tomoda:1, Shigeo Wakabayashi:1, Michio Asahi:1
1:Pharmacology, Osaka Medical College, Japan

Tctex-1 promotes cell cycle re-entry by regulating branched actin remodeling, endocytosis and primary ciliary resorption

[Speaker] Masaki Saito:1
[Co-author] Wataru Otsu:2, Jen-Zen Chuang:2, Teruyuki Yanagisawa:1, Ching-Hwa Sung:2,3
1:Department of Molecular Pharmacology, Tohoku University School of Medicine, Japan, 2:Department of Ophthalmology, Margaret M. Dyson Vision Research Institute, Weill Medical College of Cornell University, USA, 3:Department of Cell and Developmental Biology, Weill Medical College of Cornell University, USA

GPR101 orphan receptor: a novel cause of growth hormone deregulation

[Speaker] Dayana Abboud:1,2
[Co-author] Adrian Daly:3, Patricia Molina:1,2, Nadine Dupuis:1,2, Celine Laschet:1,2, Pierre Geubelle:1,2, Bernard Pirotte:2, Albert Beckers:3, Julien Hanson:1,2
1:ULG, Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, Liege, Belgium, 2:ULG, Laboratory of Medicinal Chemistry, CIRM, Liege, Belgium, 3:Department of Endocrinology, CHU of Liege, Domaine Universitaire du Sart-Tilman, Liege, Belgium

Prediction of ferritin response to chelation in patients affected by transfusion-dependent haemoglobinopathies

[Speaker] Oscar Della Pasqua:1,3
[Co-author] Elisa Borella:2, Sean Oosterholt:1, Paolo Magni:2
1:Clinical Pharmacology & Therapeutics Group, School of Pharmacy, University College London, UK, 2:Universita' degli Studi di Pavia, Pavia, Italy, 3:GlaxoSmithKline, UK

Identification of therapeutic small molecule compound for cystic fibrosis by targeting pseudo exon-inclusion

[Speaker] Saiko Shibata:1
[Co-author] Masahiko Ajiro:1, Masatoshi Hagiwara:1,2
1:Department of Drug Discovery Medicine, Graduate school of Medicine, Kyoto University, Japan, 2:Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Japan

Molecular Dissections of the DNA Repair-Deficiency Disorders Using Induced Pluripotent Stem Cells and CRISPR Interference

[Speaker] Kiichiro Tomoda:1
[Co-author] Michio Asahi:1, Hirofumi Morihara:1, Marina Watanabe:1
1:Department of Pharmacology, Osaka Medical College, Japan

Intracerebroventricular 2-hydroxypropyl-β-cyclodextrin improves not only neurological symptoms but also hepatic abnormalities in Niemann-Pick disease type C model mice and patients

[Speaker] Madoka Fukaura:1
[Co-author] Yoichi Ishituka:1, Yuki Kondo:1, Naoki Ushihama:1, Toru Takeo:2, Naomi Nakagata:2, Takumi Era:3, Taishi Higashi:4, Keiichi Motoyama:4, Hidetoshi Arima:4, Yuki Kurauchi:5, Hiroshi Katsuki:5, Shunsuke Kamei:6, Tsuyoshi Shuto:6, Hirofumi Kai:6, Katsumi Higaki:7, Yoshio Sakiyama:8, Takafumi Sakakibara:9, Muneaki Matsuo:10, Tetsumi Irie:1
1:Departmant of Clinical and Chemistry Infomatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 2:Division of Reproductive Engineering, Center for Animal Resources and Development (CARD), Kumamoto University, Japan, 3:Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan, 4:Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 5:Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 6:Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 7:Research Center for Bioscience and Technology, Tottori University, Japan, 8:Saitama Medical Center, Jichi Medical University, Japan, 9:Department of Pediatrics, Nara Medical University, Japan, 10:Department of Pediatrics, Faculty of Medicine, Saga University, Japan

Effect of Maltosyl-Beta-cyclodextrin on in vitro and in vivo models of Niemann-Pick disease type C

[Speaker] Nushrat Yasmin:1
[Co-author] Yoichi Ishitsuka:1, Yusei Yamada:1, Madoka Fukaura:1, Shuichi Nakahara:1, Yuki Kondo:1, Toru Takeo:2, Naomi Nakagata:2, Taishi Higashi:3, Keiichi Motoyama:3, Hidetoshi Arima:3, Yasuyo Okada:4, Junichi Nishikawa:4, Atsushi Ichikawa:4, Katsumi Higaki:5, Muneaki Matsuo:6, Tetsumi Irie:1
1:Department of Clinical chemistry and informatics, Graduate School of pharmaceutical science, Kumamoto university, Japan, 2:Division of Reproductive Engineering, Center for Animal Resources and Development (CARD), Kumamoto University, Japan, 3:Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 4:School of Pharmacy and Pharmaceutical Science, Institute Biosciences, Mukogawa Women's University, Japan, 5:Research Center for Bioscience and Technology, Tottori University, Japan, 6:Department of Pediatrics, Faculty of Medicine, Saga University, Japan

Riboflavin assisted corneal collagen cross linking in patients with progressive Keratoconus: effect on visual and morphological changes

[Speaker] Anusuya Bhattacharyya:1
[Co-author] Phulen Sarma:2, Kalyan Das:1
1:Ophthalmology, Sri Sankaradeva Nethralaya, Guwahati Assam, India, 2:Pharmacology PGIMER Chandigarh, India

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