Sessions

Anandamide induced autophagy and apoptosis in human hepatoma cells

[Speaker] Chun Chien Yang:1
[Co-author] Chia Ming Chang:1, Yun Hong Wong:1, Meng Hsuan Cheng:2, Yu Chiao Yang:1, Hsiao Mei Kuo:3, Hun Lung Yuan:4, Hui Fen Chiu:1
1:Pharmacology, Kaohsiung Medical University, Taiwan, 2:Department of Internal Medicine, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Taiwan, 3:Department of Neuroscience, Marine Biotechnology and Resources, National Sun Yat-sen University, Taiwan, 4:Deparment of Chemistry, R. O. C. Military Academy, Kaohsiung, Taiwan

A new andrographolide derivative exhibited anti-colon cancer effects via anti-angiogenic and pro-apoptotic pathways

[Speaker] Jingjing Li:1
[Co-author] Simonming-Yuen Lee:2, Georgr Pak-Heng Leung:1
1:Department of Pharmacology and Pharmacay, Li Ka Shing Faculty of Medicine, The University of HongKong, Hong Kong, 2:The Institute of Chinese Medical Sciences, University of Macao, Macao

Novel Benzimidazole Derivatives Effectively Inhibit vascular endothelial growth factor induced angiogenesis and tumor angiogenesis

[Speaker] Shiu-Wen Huang:1
[Co-author] Tur-Fu Huang:2
1:Department of Medical Research, Taipei Medical University Hospital, Taiwan, 2:Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taiwan

Involvement of microRNA 27a in a novel Antrodia cinnamomeia inhibits colorectal cancer proliferation, suppresses cancer stem-like phenotype and re-sensitized KRAS mutant colorectal cancer

[Speaker] Ching-Hu Chung:1
[Co-author] Chun-Ho Chu:2, Tsung Jen Lin:3, Kuo Chu Lai:3, Te-Chang Lee:4
1:Department of Medicine, Mackay Medical College, Taiwan, 2:Institute of Pharmacology, National Yang-Ming University, and the Department of Surgery, Koo Foundation, Sun Yat-Sen Cancer Center, Taiwan, 3:Institute of Pharmacology and Toxicology, Department of Medicine, School of Medicine, Tzu Chi University, Taiwan, 4:Institute of Pharmacology, National Yang-Ming University, and the Institute of Biomedical Sciences, Academia Sinica, Taiwan

Anti-carcinogenic effects of arctigenin on human breast cancer cells

[Speaker] Kyung-Soo Nam:1
[Co-author] Thressi Maxwell:1, Kyu-Shik Lee:1, Soyoung Kim:1
1:Department of Pharmacology, School of Medcine, Dongguk University, Korea

Growth inhibitory effect of beta-eudesmol on cholangiocarcinoma cells is associated with suppression of heme oxygenase-1 production and STAT3 phosphorylation

[Speaker] Kesara Na-Bangchang:1,2
[Co-author] Vivek Bhakta Mathema:1,2, Wanna Chailaroenkul:1,2
1:Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Phahonyothin Rd, Khlong Luang, Pathum Thani Thailand 12120, Thailand, 2:Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University, Phahonyothin Rd, KHlonglung, Pathum Thani Thailand 12120, Thailand

Catalpol suppressed proliferation, growth and invasion of CT26 colon cancer by inhibiting inflammation and tumor angiogenesis

[Speaker] Pingting Zhu:1
[Co-author] Ping Mao:1, Jiaojiao Zhou:1
1:School of Medicine, Yangzhou University, China

Celastrol suppresses mTOR signaling by altering its association with chaperones and inducing its ubiquitination in breast cancer cells

[Speaker] Weiying Zhou:1,2
[Co-author] Xiaoli Li:1,2, Xintong Yao:1,2, Duanfang Zhou:1,2, Liangyuan Long:1,2
1:College of Pharmacy, Chongqing Medical University, China, 2:Research Center of Pharmacodynamics Evaluation Engineering Technology of Chongqing, China

Curcumin attenuates Rab coupling protein-induced cancer cell invasion through downregulation of β1 integrin expression

[Speaker] Hoi Young Lee:1
[Co-author] So Ra Choe:1, Kyung Hwa Cho:1, Bo Young Jeong:1, Jin Young Kim:1, Chang Gyo Park:1
1:Pharmacology, College of Medicine, Konyang University, Korea

Gold nanostructures for gambogic acid delivery

[Speaker] Xiao-Ming Zhu:1
[Co-author] Hong-Ye Wan:1, Jian-Li Chen:1
1:State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau

Betulinic acid sensitizes temozolomide-resistant glioblastoma cells through downregulation of Sp1

[Speaker] Wen-Bin Yang:1
[Co-author] Tsung-I Hsu:2,3, Jian-Ying Chuang:2,3, Chiung-Yuan Ko:2,3
1:Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan, 2:The Ph. D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, Taiwan, 3:Center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

Regulation of PKB/Akt-pathway in the chemopreventive effect of lactoferrin against diethylnitrosamine-induced hepatocarcinogenesis in rats

[Speaker] Rehab R Hegazy:1
[Co-author] Abeer A Salama:1, Dina F Mansour:1, Rehab F Abdel-Rahman:1, Azza M Hassan:2
1:Pharmacology, National Research Centre, Egypt, 2:Pathology, Faculty of Veterinary Medicine, Cairo University, Egypt

An NQO1 dependent ROS and RIP1/RIP3 mediated necroptosis induced in glioma cancer cells by MAM

[Speaker] Jie Yu:1
[Co-author] Xiaxia Wu:1, Changxi Wang:1, Wen Sun:1, Ying Hou:1, Yiying Zhang:1, Zhiwei Li:1, Jin-Jian Lu:1, Xiuping Chen:1
1:Institute of Chinese Medical Sciences, University of Macau, Macao

ABCB1-mediated multi-drug resistance in leukemic K562/ADR cells was reversed by Matrine, the main ingredient from Sophora alopecuroides

[Speaker] Zhi Chen:1,2
[Co-author] Nobuhiro Nishimura:1, Takayuki Okamoto:2, Koichiro Wada:2, Kohji Naora:1
1:Department of Pharmacy, Shimane University Hospital, Japan, 2:Department of Pharmacology, Faculty of Medicine, Shimane University, Japan

Solanum incanum extract (SR-T100) induces melanoma cell apoptosis and inhibits established lung metastasis

[Speaker] Chih-Hung Lee:1,2
[Co-author] Hamm-Ming Sheu:3, Sebastian Yu:4
1:Kaohsiung Chang Gung Memorial Hospital, Taiwan, 2:Dermatology, Chang Gung University, Taiwan, 3:Dermatology, National Cheng Kung University, Taiwan, 4:Dermatology, Kaohsiung Medical University, Taiwan

A novel coumarin-based compound inhibits invasion and migration of murine osteosarcoma cells in vitro

[Speaker] Yuki Sugiyama:1
[Co-author] Seikou Nakamura:1, Hiroki Fukuda:2, Masato Yoshizawa:1, Shiori Tamai:1, Yuki Toda:1, Kazuyuki Takata:1, Eishi Ashihara:1
1:Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Japan, 2:Department of Pharmacognosy, Kyoto Pharmaceutical University, Japan

Downregulation of Cyclin B1 Mediated Nagilactone E-Induced G2 Phase Cell Cycle Arrest in Non-Small Cell Lung Cancer Cells

[Speaker] Jin-Jian Lu:1
[Co-author] Le-Le Zhang:1, Zhe-Ling Feng:1, Min-Xia Su:1, Xiuping Chen:1, Ao Li:2, Li-Gen Lin:1
1:University of Macau, China, 2:Chongqing University of Technology, China

Process in the Experimental Researches of Traditional Chinese Medicine Combined with Chemotherapy for the Treatment of Non - small Cell Lung Cancer

[Speaker] Jie Li:1
[Co-author] Jia Feng Wang:1, Jin Qi Li:1,2,3
1:School of medicine, University of Electronic Science and Technology of China, China, 2:Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China, 3:Sichuan Key Laboratory for individualized drug therapy, Chengdu, China

Artocarpin, an isoprenyl flavonoid, induced apoptosis and inhibited cell migration in osteosarcoma

[Speaker] Ju-Fang Liu:1
[Co-author] Pei-Wen Peng:2, Wei-Fang Lee:2
1:Central Laboratory, Shin-Kong Wu Ho-Su Memorial Hospital, Taiwan, 2:School of Dental technology. Taipei Medical University, Taiwan

CS5931, a novel marine polypeptide, inhibits migration and invasion of cancer cells via interacting with enolase 1

[Speaker] Xiukun Lin:1
[Co-author] Huanli Xu:1, Shuonan Su:1, Xiaoliang Chen:1, Xiaohui Liu:1, Zengliang Jin:1, Ye Tian:1
1:Department of Pharmacology, Capital Medical University, Beijing, China

Beta-elemene inhibits glycolysis leading to suppression of breast cancer metastasis dependent on blocking nuclear import of PKM2 and GLUT1 expression

[Speaker] Wenxing Chen:1
[Co-author] Yin Lu:1
1:School of Pharmacy, and Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, China

Phospholipase C-related catalytically inactive protein enhances cisplatin-induced apoptosis

[Speaker] Satoshi Asano:1
[Co-author] Yuka Maetani:1, Yasuka Ikura:1, Takashi Kanematsu:1
1:Department of Cellular and Molecular Pharmacology, Division of Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Japan

Targeting cancer cells with combinations of small molecule inhibitors of the heat shock protein activity and expression: tumor sensitization to chemotherapy and radiotherapy

[Speaker] Anna V. Khokhlova:1
[Co-author] Vera A. Mosina:1, Alexander E. Kabakov:1
1:Medical Radiological Research Center, Obninsk, Russia

USP24 Induces IL-6 in Tumor-associated Microenvironment through Stabilizing p300 and beta-TrCP to Promote the Malignancy of Lung Cancer

[Speaker] Jan-Jong Hung:1
1:Department of Biotechnology and Bioindustry Science, NCKU, Taiwan

Matrix metalloproteinase 3 (MMP3) regulates expression of Hsp gene in high-metastatic cell line of colon cancer

[Speaker] Yuka Okusha:1
[Co-author] Takanori Eguchi:1,2, Chiharu Sogawa:1, Kuniaki Okamoto:1, Ken-Ichi Kozaki:1
1:Dept Dent Pharmacol, Okayama Univ Grad Sch Med Dent Pharm Sci, Japan, 2:Adv Res Ctr Oral Craniofacial Sci, Okayama Univ Grad Sch Med Dent Pharm Sci, Japan

The effect of tumor suppressor Pdcd4 knockdown on the malignancy of mouse melanoma cells

[Speaker] Eriko Kinoshita:1
[Co-author] Noriko Yoshikawa:1, Mayuko Hatai:1, Satomi Kagota:2, Kazumasa Shinozuka:2, Kazuki Nakamura:1
1:Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Japan, 2:Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Japan

Inhibition of UCHL1 enhances the sensitivity of estrogen receptor negative breast cancer cells to endocrine therapy

[Speaker] Yan Cheng:1
[Co-author] Xisha Chen:1, Kuansong Wang:1
1:Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, China

DNA Methylation and Telomerase Linked Mechanisms Potentially Underlie the Effects of Bisphenol A and Its Analogues (Bisphenol F and Bisphenol S) in Breast Cancer Cells

[Speaker] Nathalie Zgheib:1
[Co-author] Zainab Awada:1, Reem Akika:1, Rihab Nasr:1, Akram Ghantous:2
1:Department of Pharmacology and Toxicology, American University of Beirut, Lebanon, 2:International Agency for Research on Cancer, France

Development and characterisation of a triple-negative breast cancer multicellular spheroidal model

[Speaker] Keith N Ncube:1
[Co-author] Vanessa Steenkamp:1, Duncan A Cromarty:1, Iman Van Den Bout:2, Werner Cordier:1
1:Department of Pharmacology, University of Pretoria, South Africa, 2:Centre for Neuroendocrinology, University of Pretoria, South Africa

Transcriptional repression of HER2 by Cl- channel blockade in human breast cancer cells

[Speaker] Susumu Ohya:1,2
[Co-author] Mayu Fujimoto:2, Hiroaki Kito:1, Takahiro Inoue:2
1:Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Japan, 2:Department of Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Japan

Analysis of oxidative stress response in clinically relevant radioresistant cells

[Speaker] Kazuo Tomita:1,6
[Co-author] Yoshikazu Kuwahara:1,2, Yuko Takashi:1,3, Sayuri Yamanishi:1,4, Hideki Nabika:5, Koh-Ich Tanaka:6, Junichi Kitanaka:7, Nobue Kitanaka:7, Motohiko Takemura:7, Nobuyoshi Nishiyama:6, Shouichi Miyawaki:4, Manabu Fukumoto:8, Yoshihiro Nishitani:3, Akihiro Kurimasa:2, Tomoaki Sato:1
1:Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan, 2:Radiation Biology and Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan, 3:Restorative Dentistry and Endodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan, 4:Orthodontics and Dentofacial Orthpedics, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan, 5:Material and Biological Chemistry, Faculty of Science, Yamagata University, Japan, 6:Division of Pharmacology, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Japan, 7:Department of Pharmacology, Hyogo College of Medicine, Japan, 8:Department of Molecular Pathology, Tokyo Medical University, Japan

Copper-imidazo[1, 2-a]pyridines induce apoptosis in colorectal cancer cell lines

[Speaker] Nadia Gangat:1
[Co-author] Jean Dam:2, Charles De Koning:2, Leonie Harmse:1
1:Department of Pharmacy and Pharmacology, University of the Witwatersrand, South Africa, 2:Department of Chemistry, University of the Witwatersrand, Johannesburg, South Africa

The cytotoxic effects of VE-3N, a novel 1, 4-dihydropyridine derivative, involve the mitochondrial bioenergetic disruption via uncoupling mechanisms

[Speaker] Gilberto L. Pardo-Andreu:1
[Co-author] Javier Marin-Prida:1, Michael Gonzalez:1, Estael Ochoa-Rodriguez:2, Yamila Verdecia-Reyes:2, Roberto Fernandez-Acosta:3, Luciane C Alberici:4
1:Center for Research and Biological Evaluation, University of Havana, Cuba, 2:Faculty of Chemistry. University of Havana, Cuba, 3:Pharmacy Department, University of Havana, Cuba, 4:School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Brazil

Copper imidazo[1, 2-a]pyridine complexes induce apoptosis in K562 and HL-60 leukaemic cells

[Speaker] Zeenat Ismail:1
[Co-author] Charles De Koning:2, Jean Dam:2, Clement Penny:3, Leonie Harmse:1
1:Pharmacy and Pharmacology, University of the Witwatersrand, South Africa, 2:School of Chemistry, University of the Witwatersrand, South Africa, 3:Department of Internal Medicine, University of the Witwatersrand, South Africa

A novel derivative of quinazolinone, HoLu-12 induces G2/M arrest and apoptosis in human oral squamous cell carcinoma cells

[Speaker] Kuo-Chu Lai:1
[Co-author] Yi-Ting Chia:2, Mann-Jen Hour:3
1:Department of pharmacology, Tzu Chi University, Hualien, Taiwan, 2:Institute of Pharmacology and Toxicology, Department of Medicine, School of Medicine, Tzu Chi University, Hualien, Taiwan, 3:School of Pharmacy, China Medical University, Taichung, Taiwan

Arsenite regulates prolongation of glycan residues of membrane glycoprotein: a pivotal study via wax physisorption kinetics and FTIR imaging

[Speaker] Chien-Hui Hong:1,2
[Co-author] Chia-Yen Hsu:3, Pei-Yu Huang:3, Yao-Chang Lee:3, Chih-Hung Lee:4, Hsin-Su Yu:5
1:Dermatology, Kaohsiung Veterans General Hospital, Taiwan, 2:Dermatology, National Yang Ming University, Taiwan, 3:Biomedical and Molecular Imaging Lab, X-ray and IR Imaging Group, National Synchrotron Radiation Research Center, Taiwan, 4:Kaohsiung Chang Gung Memorial Hospital, Taiwan, 5:Kaohsiung Medical University, Taiwan

Effect of α, β-unsaturated carbonyl compounds in cigarette smoke extract on the growth of mouse Colon-26 cancer cells

[Speaker] Mayuko Hatai:1
[Co-author] Noriko Yoshikawa:1,3, Eriko Kinoshita:1, Shizuyo Horiyama:3, Satomi Kagota:2, Kazumasa Shinozuka:2, Kazuki Nakamura:1
1:Department of Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Japan, 2:Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Japan, 3:Institute for Bioscience, Mukogawa Women's University, Japan

HS10296, a novel irreversible EGFR TKI, attenuates epithelial-mesenchymal transition facilitated by M2-polarizedtumor-associated macrophages in Non-Small Cell Lung Cancer

[Speaker] Fang Wei:1
[Co-author] Jing Zhou:1, Zhi Rui Zhang:1, Hao Liu:1
1:School of Pharmacy, vice director of the department of pharmacology, China

Targeting the PI3K/AKT/mTOR signaling pathway in cancer by new quinoline/chalcone hybrids

[Speaker] Amer A. Abd El-Hafeez:1,2,3
[Co-author] Heba A. Hassan:4, Sammar H. Abbas:4, Toru Hosoi:1, Koichiro Ozawa:1, Mai E. Shoman:4
1:Pharmacotherapy Department, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, 2:Global Career Design Center, Hiroshima University, Hiroshima, Japan, 3:Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt, 4:Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

New triazole-chalcone hybrids as potent apoptosis inducers through caspase activation in A549 human lung adenocarcinoma cells

[Speaker] Amer A. Abd El-Hafeez:1,2,3
[Co-author] Fatma F. Ahmed:4, Samar H. Abbas:4, Dalia Abdelhamid:4, Toru Hosoi:1, Koichiro Ozawa:1, Mohamed Abdel-Aziz:4
1:Pharmacotherapy Department, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, 2:Global Career Design Center, Hiroshima University, Hiroshima, Japan, 3:Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt, 4:Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

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