Usefulness of chymase inhibitor for prevention of abdominal adhesion in rats

[Speaker] Maiko Ozeki:1
[Co-author] Denan Jin:2, Yuta Miyaoka:1, Fumitoshi Hirokawa:1, Michihiro Hayashi:1, Keitaro Tanaka:1, Kazuhisa Uchiyama:1, Shinji Takai:2
1:Department of General and Gastroenterological Surgery, Osaka medical college, Japan, 2:Department of Innovative Medicine, Graduate school of Medicine, Osaka medical college, Japan

FA-5, a novel AMP-activated protein kinase (AMPK) activator, as a new pharmacological tool for the management of bowel inflammation

[Speaker] Luca Antonioli:1
[Co-author] Matteo Fornai:1, Carolina Pellegrini:1, Laura Benvenuti:1, Concettina La Motta:2, Luca Quattrini:2, Francesco Angelucci:2, Vito Coviello:2, Won Keun Oh:3, Thi Kim Quy Ha:3, C. Blandizzi:1, R. Colucci:4
1:Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 2:Department of Pharmacy, University of Pisa, Pisa, Italy, 3:Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea, 4:Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy


[Speaker] Theresa A John:1
[Co-author] Victoria I Onanubi:2
1:Pharmacology, Therapeutics and Toxicology, Lagos State University College of Medicine, Nigeria, 2:Medical Research Center, Lagos State University College of Medicine, Nigeria

Protective effect of artesunate and aspirin in experimental model of colorectal cancer

[Speaker] Sneh Verma:1
[Co-author] Prasenjit Das:2, Vijay L. Kumar:1
1:Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India, 2:Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

Artesunate affords gastroprotection by modulating oxidative stress and NFκB mediated proinflammatory signaling

[Speaker] Vijay L. Kumar:1
[Co-author] Sneh Verma:1
1:Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India

Beneficial effects of combination of tissue transglutaminase inhibitor and interleukin-15 inhibitor in ameliorating mucosal immune inflammatory response in experimental model of Celiac Disease

[Speaker] Rahul Singh:1
[Co-author] Ashutosh Singh:2, Kaushal K Prasad:1, Bikash Medhi:2, Rakesh Kochhar:1

IRE1α is an essential regulator for unconventional secretion of CFTR via its kinase activity

[Speaker] He Piao:1
[Co-author] Min Goo Lee:1
1:Department of Pharmacology, Yonsei University College of Medicine, Korea

Post-translational Modification of GRASP Is a Essential for Unconventional Secretion of CFTR

[Speaker] Jiyoon Kim:1
[Co-author] Min-Goo Lee:1
1:Pharmacology, Yonsei University College of Medicine, Korea

Effects of histamine H4 receptor antagonist on the chemotherapy-induced anorexia in mice

[Speaker] Kouichi Yamamoto:1
[Co-author] Rikuya Okui:1, Atsushi Yamatodani:1
1:Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan

Antidiarrheal Activity of Ethanolic Stem Bark Extract of Newbouldia laevis in Castor oil Induced Diarrhea in Rats

[Speaker] Adeyinka A. Aderinola:1
[Co-author] Jane I. Ejiofor:2
1:Department of Pharmacology, Olabisi Onabanjo university, Ago-iwoye, Nigeria, 2:Department of Pharmacology and Therapeutic, Ahmadu Bello University, Zaria., Nigeria

The Central Actions of the Glucagon-like Peptide-1 Receptor Agonist, Exendin-4, in Suncus murinus: A telemetric study

[Speaker] Zengbing Lu:1,2
[Co-author] Sze Wa Chan:1, Longlong Tu:2, Man Piu Ngan:2, John A Rudd:2,3
1:School of Health Sciences, Caritas Institute of Higher Education, Hong Kong, 2:School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, 3:Brain and Mind Institute, The Chinese University of Hong Kong, Hong Kong

The Signaling pathways involved in Fluoxetine-induced apoptosis in human gastric adenocarcinoma cell line (AGS)

[Speaker] Uy Dong Sohn:1
[Co-author] Jeong Hoon Han:1, Wah Wah Po:1
1:Pharmacology, College of Pharmacy, Chung-Ang University, Korea

Inhibition of IgE/antigen- and ionophore-induced mucosal mast cells degranulation by Alpinia galangal and acetoxychavicol acetate

[Speaker] Syed Faisal Zaidi:1,2
[Co-author] Ji-Hyun Kim:2, Takeshi Yamamoto:2, Kanwal Ahmed:1, Khan Usmanghani:3, Makoto Kadowaki:2
1:Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia, 2:Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan, 3:Department of Clinical Pharmacy and Health Care, Jinnah University for Women, Karachi, Pakistan

Diet-induced mislocalization of the ATP-binding cassette transporters is involved in the development of cholesterol crystal in bile from gallstone disease model mouse

[Speaker] Yasuhiro Yamazaki:1
[Co-author] Chiaki Ono:1, Kazuki Saegusa:1, Ayumi Ohnishi:1, Junko Kurokawa:1
1:School of Pharma Science, University of Shizuoka, Department of Bio-informational pharmacology, Japan


[Speaker] Ezgi Bozkurt:1
[Co-author] Selcen Koca Yildiz:1, Kevser Erol:1, Bugra Koca:2
1:Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University, Turkey, 2:Biochemistry, Faculty of Medicine, Afyon Kocatepe University, Turkey

Topical pharmacological treatment of hemorrhoids during pregnancy and congenital malformations - a nation-wide cohort study

[Speaker] Espen Jimenez-Solem:1,2
[Co-author] Kasper Meidahl Petersen:1, Henrik Enghusen Poulsen:1,2, Morten Petersen:1, Thomas Bo Jensen:1, Mikkel Christensen:1,2, Andersen Jon Trærup:1,2
1:Bispebjerg and Frederiksberg Hospital, Department of Clinical Pharmacology, Denmark, 2:Department of Clinical Medicine, Copenhagen University, Denmark

Effect of 5-HT6 receptor antagonists on stress-induced defecation in rat: possible relevance for the treatment of irritable bowel syndrome

[Speaker] Melker Hagsater:1
[Co-author] Alexander Lisinski:1, Robert Pettersson:1, Elias Eriksson:1
1:Department of Pharmacology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Sweden

The gut hormone INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells

[Speaker] Sheng Yu Ang:1
[Co-author] Bronwyn A Evans:1, Daniel P Poole:1, Romke Bron:1, Jesse J Dicello:1, Ross Ad Bathgate:2, Martina Kocan:2, Dana S Hutchinson:1, Roger J Summers:1
1:Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Australia, 2:The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia

Novel method for evaluating leaky gut syndrome induced by NSAIDs/PPI and ischemia with health food-derived reagents

[Speaker] Haruki Usuda:1
[Co-author] Tomomi Niibayashi:1, Tetsuya Tanaka:1, Takayuki Okamoto:1, Koichiro Wada:1
1:Department of pharmacology, Faculty of medicine, Shimane University, Japan

The Research Progress of Clinical Applications of Human Menstrual Blood-Derived Mesenchymal Stem Cells

[Speaker] Yunke Huang:1
[Co-author] Yu Kang:1
1:The Obstetrics & Gynecology Hospital of Fudan University, China

Human motilin transgenic mice are useful for evaluation of motilin receptor agonists as gastric prokinetic drugs

[Speaker] Shinichi Kato:1
[Co-author] Aoi Takahashi:1, Mai Shindo:1, Kenjiro Matsumoto:1, Kikuko Amagase:1, Bunzo Matsuura:2
1:Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Japan, 2:Department of Lifestyle-related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Japan

DHA supplementation prevent the progression of NASH via GPR120 signaling

[Speaker] Kazuo Nakamoto:1
[Co-author] Akira Hirasawa:2, Shogo Tokuyama:1
1:Department of Clinical Pharmacy, Kobe Gakuin University, Japan, 2:Department of Genomic Drug Discovery Science, Kyoto University, Japan

Association between polymorphisms in SLC15A1 and PLA2G16 genes and development of obesity susceptibility in Chinese subjects

[Speaker] Yang C Wang:1,2
[Co-author] Rong Z Tan:1,2, Shu Liu:1,2, Nv X Xie:1,2, Ying Z Luo:1,2, Li Yang:1,2
1:Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China/ Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 2:Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China

Proton Pump Inhibitor Involves Abnormality of Iron Metabolism through Hepcidin Regulation

[Speaker] Hirofumi Hamano:1,2
[Co-author] Yasumasa Ikeda:3, Yuya Horinouchi:3, Yoshito Zamami:1,2, Masaki Imanishi:1, Yuki Izawa-Ishizawa:3, Licht Miyamoto:4, Koichiro Tsuchiya:4, Keisuke Ishizawa:1,2, Toshiaki Tamaki:3
1:Department of Pharmacy, Tokushima University Hospital, Japan, 2:Department of Clinical Pharmacy, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 3:Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 4:Department of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

Can probiotics prevent acute radiation-induced diarrhoea among cervical cancer patients?: the result from a randomized double-blinded placebo-controlled study

[Speaker] Ye Htut Linn:1
[Co-author] K Khine Thu:1, Nang Hla Hla Win:1
1:Department of Pharmacology, University of Medicine 1, Yangon, Myanmar

Pharmacological characterization of Protease-Activated Receptor signaling in the human enteric nervous system

[Speaker] Carla Cirillo:1,2
[Co-author] Laurent Alric:3, Nathalie Vergnolle:1
1:Pathophysiology of intestinal epithelium, Digestive Health Research Institute (IRSD), INSERM UMR 1220, INRA UMR 1416, ENVT, University of Toulouse Paul Sabatier, Toulouse, France, 2:Laboratory for Enteric Neuroscience, TARGID, University of Leuven, Leuven, Belgium, 3:Department of Internal Medicine, Toulouse Hospital, Toulouse, France

Potential causes of different gastric stability of original and generic proton pump inhibitors

[Speaker] Daria Kurguzova:1
[Co-author] Svetlana Serebrova:1,2, Alexey Prokofiev:1,2, Ludmila Krasnykh:2, Galina Vasilenko:2, Marina Zhuravleva:1,2, Elena Smolyarchuk:1, Anton Barkov:1
1:Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Russia, 2:Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products” of the Ministry of Health of the Russian Federation, Russia

Rifaximin prevents diclofenac-induced enteropathy in rats through antibacterial and anti-inflammatory activities

[Speaker] Matteo Fornai:1
[Co-author] Rocchina Colucci:2, Carolina Pellegrini:1, Erika Tirotta:1, Luca Antonioli:1, Cecilia Renzulli:3, Emilia Ghelardi:4, Elena Piccoli:4, Daniela Gentile:1, Laura Benvenuti:1, Gianfranco Natale:4, Federica Fulceri:1, Gloria Lopez-Castejon:5, Pablo Palazon-Riquelme:5, Corrado Blandizzi:1, Carmelo Scarpignato:6
1:Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 2:Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy, 3:Reasearch & Development Department, Alfasigma SpA, Bologna, Italy, 4:Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, 5:Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, UK, 6:Clinical Pharmacology & Digestive Pathophysiology Unit, Department of Clinical & Experimental Medicine, University of Parma, Parma, Italy

Role of thromboxane prostanoid (TP) receptor in the facilitation of angiogenesis and the healing of gastric ulcers

[Speaker] Sakiko Yamane:1,2
[Co-author] Hideki Amano:2, Tomohiro Betto:1,2, Tomoyoshi Inoue:1,2, Yoshiya Ito:2,3, Yuki Shimizu:1,2, Nobuyuki Nishizawa:2,3, Shuh Narumiya:4, Wasaburo Koizumi:1, Masataka Majima:2
1:Department of Gastroenterology, Kitasato University School of Medicine, Japan, 2:Department of pharmacology, Kitasato university, Japan, 3:Department of surgery, Kitasato university, Japan, 4:Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan

Real-world analysis of drug treatment for ulcerative colitis using medical claims database

[Speaker] Motohiro Okayasu:1
[Co-author] Yuji Yoshiyama:1
1:Community Pharmacy, Kitasato University School of Pharmacy, Japan

VEGFR1-TK signaling protects exacerbation of dextran sulfate sodium-induced colitis in mice

[Speaker] Tomohiro Betto:1,2
[Co-author] Hideki Amano:2, Sakiko Yamane:1,2, Tomoyoshi Inoue:1,2, Yuki Shimizu:1,2, Yoshiya Ito:2,3, Tutomu Yoshida:4, Masabumi Shibuya:5, Wasaburo Koizumi:1, Masataka Majima:2
1:Department of Gastroenterology, Kitasato university school of medicine, Japan, 2:Department of Pharmacology, Kitasato University School of Medicine, Japan, 3:Department of Surgery, Kitasato University School of Medicine, Japan, 4:Department of Pathology, Kitasato University School of Medicine, Japan, 5:Department of Research and Education, Jobu University, Japan

Identification of existing drugs effective for visceral pain relevant to irritable bowel syndrome through phenotypic screening in rats

[Speaker] Teita Asano:1
[Co-author] Mitsuko Takenaga:1
1:St. Marianna University School of Medicine, Japan

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