Sessions

The role of cAMP signaling in the regulation of interleukin-33 production by RAW264.7 macrophages in response to various doses of lipopolysaccharide

[Speaker] Yoshiki Yanagawa:1
[Co-author] Shizuka Sato:1, Sachiko Hiraide:1, Kenji Iizuka:1
1:Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan

Prostaglandin E2-EP2-NF-kB signaling in macrophages mediates chronic inflammation during intracranial aneurysm formation and becomes a potential therapeutic target

[Speaker] Tomohiro Aoki:1,2,3
[Co-author] Juhana Frosen:4,5, Shuh Narumiya:2,3
1:Department of Molecular Pharmacology, Research Institute, National Cerebral and Cardiovascular Center, Japan, 2:Alliance Laboratory for Advanced Medical Research, Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan, 3:Core Research for Evolutional Science and Technology (CREST), Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan, 4:Neurosurgery Research Group, Biomedicum Helsinki, Finland, 5:NeuroCenter, Kuopio University Hospital, Finland

Decrease in two-pore domain K+ channel K2P5.1 activity caused by pre-mRNA splicing inhibition in T lymphocytes

[Speaker] Kyoko Endo:1
[Co-author] Natsumi Kurokawa:1, Kazutaka Tagishi:1, Ayaka Shimizu:1, Hiroaki Kito:1,2, Masanori Fujii:1, Susumu Ohya:1,2
1:Pharmacology, Kyoto Pharmaceutical University, Japan, 2:Nagoya City University, Japan

Post-transcriptional regulation of Ca2+-activated K+ channel KCa3.1 by histone deacetylase in CD4+ cells of the inflammatory bowel disease model mice

[Speaker] Miki Matsui:1
[Co-author] Kyoko Terasawa:1, Hiroaki Kito:2, Masanori Fujii:1, Susumu Ohya:1,2
1:Department of Pharmacology, Kyoto Pharmaceutical University, Japan, 2:Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Japan

Investigation of Japanese encephalitis virus infection-induced neuroinflammation and pharmacological intervention

[Speaker] Chun-Jung Chen:1
[Co-author] Su-Lan Liao:1, Cheng-Yi Chang:1, Yu-Ting Hung:1
1:Department of Medical Research, Taichung Veterans General Hospital, Taiwan

The effect of lapatinib on lymphocyte activation and transcription factors in T cell differentiation

[Speaker] Ryuta Makino:1
[Co-author] Hideto Okamoto:1, Makoto Osabe:1, Masahiro Tohkin:1
1:Regulatory science, Graduate School of Pharamaceutical Science, Nagoya City University, Japan

Anti-Dectin-2 monoclonal antibodies suppress DerP-induced IL-5 and IL-13 production in DC and monocyte-depleted PBMC coculture from asthma patients

[Speaker] Shie-Liang Hsieh:1,2
[Co-author] Ming-Han Chen:2
1:Genomics Research Center, Academia Sinica, Taiwan, 2:Taipei Veteran's General Hospital, Taiwan

Biosynthesis of N-acylethanolamine and lysophosphatidic acid by glycerophosphodiesterase GDE4 and GDE7

[Speaker] Kazuhito Tsuboi:1,2
[Co-author] Iffat As Rahman:2, Zahir Hussain:2, Ryouhei Yamashita:3, Toru Uyama:2, Yasuhiro Takenouchi:1, Tamotsu Tanaka:3, Yasuo Okamoto:1, Akira Tokumura:4, Natsuo Ueda:2
1:Department of Pharmacology, Kawasaki Medical School, Japan, 2:Department of Biochemistry, Kagawa University School of Medicine, Japan, 3:Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 4:Faculty of Pharmacy, Yasuda Women's University, Japan

Further in vitro and in vivo studies of newly discovered LPA2 agonists against radiation-induced damages

[Speaker] Kazuhiko Kawata:1
[Co-author] Yoshiki Iwanaga:1, Hiroshi Ueda:1
1:Department of Pharmacology and Therapeutic Innovation, Institute of Biomedical Sciences, Nagasaki University, Japan

Effects of Kaponane Diterpenoids Compound PV006 on M1 Polarization of THP1 derived Macrophages

[Speaker] Xinyu Li:1
[Co-author] Jiafen Zhang:1, Shasha Song:1, Yongfang Wang:1
1:Department of Skin Pharmacology, Institute of Dermatology, Chinese Academy of Medical Sciences, China

Lithium carbonate inhibited the histamine release induced by bradykinin, substance P, compound 48/80 and GlcNAc-specific lectin Datura stramonium agglutinin

[Speaker] Tamiko Suzuki-Nishimura:1
[Co-author] Masayoshi Baba:1, Shiori Otani:1, Arisa Yamamoto:1, Yasushi Kodama:1
1:Pharmacology 2, Pharmacy School, Shujitsu Univ., Japan

Zoledronate and clodronate inhibited RBL-2H3 cells degranulation without disturbing Rab27a-Doc2a interaction

[Speaker] Muhammad N. A. Sahid:1,2
[Co-author] Shuang Liu:2, Takeshi Kiyoi:2, Kazutaka Maeyama:2
1:Pharmaceutical Chemistry, Universitas Gadjah Mada, Indonesia, 2:Graduate School of Medicine, Ehime University, Japan

Synergistic effect of ATP and prostaglandin E2 on mast cell degranulation

[Speaker] Kazuki Yoshida:1
[Co-author] Masa-Aki Ito:1, Makoto Tajima:1, Tomoki Nagano:1, Isao Matsuoka:1
1:Laboratory of Pharmacology, Takasaki University of health and welfare, Faculty of pharmacy, Japan

Suppression of IgE-independent degranulation of murine mast cells by dexamethasone

[Speaker] Satoshi Tanaka:1
[Co-author] Keiko Yamada:1, Kazuma Sakamaki:1, Hitomi Sato:1, Mayumi Kamada:2, Yasushi Okuno:2, Nobuyuki Fukuishi:3, Kazuyuki Furuta:1
1:Department of Immunobiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan, 2:Department of Biomedical Data Intelligence, Graduate School of Medicine, Kyoto University, Japan, 3:Department of Pharmacology, College of Pharmacy, Kinjo Gakuin University, Japan

Study of the function of metabotropic P2Y receptors in mast cells

[Speaker] Haruhisa Nishi:1
[Co-author] Niyonsaba François:2
1:Pharmacology, The Jikei University School of Medicine, Japan, 2:Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Japan

The impact of ATP binding cassette subfamily A member 1 and 7 on the degranulation of mast cells

[Speaker] Haruka Asai:1
[Co-author] Yui Fukami:1, Risako Fujii:1, Yuuki Mio:1, Sumiko Dohmae:2, Nobuyuki Fukuishi:1
1:Department of Pharmacology, College of Pharmacy, Kinjo Gakuin University, Japan, 2:College of Bioscience and Biotechnology, Chubu University, Japan

Mechanism of TSCS promote anti-Fas antibody-induced FLS apoptosis via Blocking MC-Tryptase-PAR-2-Rho-FLS Signaling Pathway

[Speaker] Shi-gang Li:1
1:Medical School, China Three Gorges University, China

MAST CELLS DEPLETION IMPROVES BONE MARKERS EXPRESSION ON MANDIBLE OF SPONTANEOUSLY HYPERTENSIVE RATS WITH PERIODONTAL DISEASE

[Speaker] Sandra Oliveira:1,2
[Co-author] Victor Brito:1,2, Ayna Barreto:1,2, Mariana Patrocinio:1, Maria Carolina Sousa:1, Carluci Beltan:1,2, Dayane Queiroz:1,2, Leticia Vieira:1,2, Vanessa Lara:4, Carlos Santos:3
1:Basic Science, São Paulo State University (UNESP), School of Dentistry, Brazil, 2:Multicenter Graduate Program in Physiological Sciences, SBFis, Brazil, 3:Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Brazil, 4:Department of Oral Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Brazil

Metformin promotes the proliferation and differentiation of murine preosteoblast by regulating the expression of sirt6 and oct4

[Speaker] Zhao Wang:1
[Co-author] Wei Mu:1,2, Liyuan Li:1, Qingfei Liu:1, Yong Ju:3
1:School of Pharmaceutical Sciences, Tsinghua University, Beijing, China, 2:Department of Orthopedics, Clinical Bone Research Center, PLA 101 Hospital, Wuxi, China, 3:Department of Chemistry, Tsinghua University, Beijing, China

Identification of P2Y receptors with oleamide suppressing microglial inflammatory response

[Speaker] Masahiro Kita:1
[Co-author] Yasuhisa Ano:1, Asuka Inoue:2, Junken Aoki:2
1:Research Laboratories for Health Science & Food Technologies, Research & Development Division, Kirin Company, Limited, Japan, 2:Department of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan

Postprandial dietary fatty acids regulate microglia M1/M2 polarization. Implications in neuroinflammation

[Speaker] Sergio Montserrat-de la Paz:1
[Co-author] Rocio Toscano:1, Maria E. Martin:2, Maria C. Millan-Linares:3, Francisco Jg. Muriana:3, Victor Sanchez-Margalet:1, Beatriz Bermudez:2
1:Department of Medical Biochemistry, Molecular Biology and Immunology. School of Medicine, University of Seville, Spain, 2:Department of Cell Biology. Faculty of Biology, University of Seville, Spain, 3:Department of Food & Health. Spanish National Research Council, Spain

Mild electrical stimulation exerts immunosuppressive effect via hydrogen peroxide production

[Speaker] Mariam Piruzyan:1,2
[Co-author] Ihori Shitanda:1, Yuichiro Shimauchi:1, Marry Ann Suico:1, Tsuyoshi Shuto:1, Hirofumi Kai:1,2
1:Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 2:HIGO Program, Kumamoto University, Japan

Anti-inflammatory properties of the β2-receptor agonist salbutamol and the PDE4 inhibitor rolipram are mediated by MKP-1

[Speaker] Keränen Tiina:1,2
[Co-author] Hömmö Tuija:1,2, Leppänen Tiina:1,2, Hämäläinen Mari:1,2, Eeva Moilanen:1,2, Riku Korhonen:1,2
1:The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere, Finland, 2:Tampere University Hospital, Finland

Cytotoxicity and genotoxicity of macrophages induced by Manganese nitrite via CAPASEs activation and ROS generation

[Speaker] Yu-Hsiang Kuan:1
[Co-author] Yi-Ting Hsieh:2, Chen-Yu Chiang:2, Min-Weu Lee:2, Kun-Lin Yeh:2, Shiuan-Shinn Lee:2, Rosa Huang Liu:3, Ming-Ling Yang:4
1:Department of Pharmacology, Chung Shan Medical University, Taiwan, 2:School of Public Health, Chung Shan Medical University, Taiwan, 3:School of Nutrition, Chung Shan Medical University, Taiwan, 4:Department of Anatomy, School of Medicine, Chung Shan Medical University, Taiwan

The expression of IL-10 on lymphocytes attenuates the response to glucocorticoid therapy in myasthenia gravis patients

[Speaker] Sachiko Tanaka:1
[Co-author] Masayuki Masuda:2, Chisato Ogimura:1, Reika Hashimoto:1, Yuki Ueta:2, Hitoshi Aizawa:2, Kenji Onda:1, Kentaro Sugiyama:1, Toshihiko Hirano:1
1:Tokyo University of Pharmacy and Life Sciences, Japan, 2:Tokyo Medical University, Japan

The efficacy of mycophenolate mofetil in Japanese patients with systemic lupus erythematosus

[Speaker] Mai Kawazoe:1
[Co-author] Kaichi Kaneko:1, Shinichi Kawai:2, Toshihiro Nanki:1
1:Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Japan, 2:Department of Inflammation and Pain Control Research, School of Medicine, Toho University, Japan

Lansoprazole prevents the progression of liver fibrosis in nonalcoholic steatohepatitis model rats

[Speaker] Toshio Nishi:1
[Co-author] Yuta Yamamoto:1, Naoko Yamagishi:1, Mikitaka Iguchi:2, Hideyuki Tamai:2, Takao Ito:1, Yoshihiro Tsuruo:3, Masao Ichinose:2, Masayuki Kitano:2, Takashi Ueyama:1
1:Department of Anatomy and Cell Biology, Wakayama Medical University School of Medicine, Japan, 2:2nd Department of Internal Medicine, Wakayama Medical University Graduate School of Medicine, Japan, 3:Department of Anatomy and Cell Biology, Tokushima University Graduate School of Medical Science, Japan

Efficacy of Novel Therapeutics in Psoriatic Arthritis: A Network Meta-analysis of Randomised Controlled Trials

[Speaker] Man Fung Tsoi:1
[Co-author] Yue Fei:1, Adrian Ch Chu:1, Bernard My Cheung:1, Chak Sing Lau:1, Tommy T Cheung:1
1:Department of Medicine, The University of Hong Kong, Hong Kong

Airway nociceptor neurons detect allergens after sensitization

[Speaker] Sebastien Talbot:1
1:Pharmacology and Physiology, Universite de Montreal, Canada

Development of a new Neuromyelitis Optica model mice

[Speaker] Simon H Chau:1
[Co-author] Yoichiro Abe:1, Masato Yasui:1
1:Pharamacology, Keio University, Japan

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