Sessions

Apolipoprotein E deletion protects prostacyclin receptor agonist-induced relaxations in mouse aorta

[Speaker] Yanhua Cheng:1
[Co-author] Paul M Vanhoutte:1, Susan Ws Leung:1
1:Pharmacology & Pharmacy, The University of Hong Kong, Hong Kong

Apremillast (AP), a PDE 4 inhibitor, worsens the injury induced by Isoproterenol in murine heart

[Speaker] Susrutha P Narayanan:1
[Co-author] Vipin Kumar Verma:1, Dharamvir S Arya:1, Jagriti Bhatia:1
1:Pharmacology, All India Institute of Medical Sciences (AIIMS), New Delhi, India

Promotion of Oral Anticoagulation in Patients with Atrial Fibrillation: Absolute Impact of Interventions attained in the IMPACT-AF trial

[Speaker] Cyrus R Kumana:1
[Co-author] Bernard M Cheung:1
1:Medicine, The Unversity of Hong Kong, Hong Kong

MONITORING OF PLASMA WARFARIN IN ATRIAL FIBRILLATION AT A MAIN REFERENCE HOSPITAL IN WEST SUMATRA, INDONESIA

[Speaker] Rahmatini Rahmatini:1
[Co-author] Aliska G:1, Usman E:1, Yanni M:2
1:Department of pharmacology, Faculty of medicine andalas university, Indonesia, 2:Department of Cardiology and Vascular Medicine, Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia

TRPC3 channel inhibitor pyrazole-3 suppresses atrial fibrillation in rats with aorto-venocaval shunt as a pathological condition of chronic volume overload

[Speaker] Megumi Aimoto:1
[Co-author] Xin Cao:1, Yoshinobu Nagasawa:1, Akira Takahara:1
1:Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan

Advantageous antiarrhythmic and cellular electrophysiological effect of the metabolite of amiodarone (desethylamiodarone)

[Speaker] Andras Varro:1
1:Department of Pharmacology and Pharmacotherapy, University of Szeged, Hungary

Activation of spinal nociceptin receptors induces cardiovascular depression and antinociception in an independent manner in mice

[Speaker] Ya-Hui Huang:1
[Co-author] Yan-Yuen Poon:1,2, Ching-Yi Tsai:1
1:Institute for Translational Research in Biomedine, Chang Gung Memorial Hospital, Taiwan, 2:Department of Anesthesiology, Chang Gung Memorial Hospital, Taiwan

Therapeutic effects of voluntary wheel running on cardiac dysfunction induced by cancer cachexia

[Speaker] Susumu Ueno:1
[Co-author] Miki Nonaka:2, Ryo Kakigi:3, Nagomi Kurebayashi:4, Takashi Murayama:4, Kiyoshi Terawaki:5, Takashi Sakurai:4, Yasuhito Uezono:2,6
1:Department of Occupational Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, 2:Division of Cancer Pathophysiology, National Cancer Center Research Institute, Japan, 3:Department of Physiology, Juntendo University Graduate School of Medicine, Japan, 4:Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Japan, 5:Tsumura Kampo Research Laboratories, Kampo Research & Development Division, Tsumura & Co., Japan, 6:Division of Supportive Care Research, National Cancer Center, Exploratory Oncology Research & Clinical Trial Center, Japan

Rabbit a reliable human like model in preclinical cardiac electrophysiological safety testing

[Speaker] Norbert Jost:1,2
[Co-author] Laszlo Virag:1, Istvan Baczko:1, Andras Varro:1,2
1:Department of Pharmacology and Pharmacotherapy, University of Szeged, Hungary, 2:MTA-SZTE Research Group of Cardiovascular Pharmacology, Hungary

The mechanism of βAR stimulation-induced IL-6 production in cardiac fibroblast

[Speaker] Shota Tanaka:1
[Co-author] Kota Tonegawa:1, Shota Fuchigami:1, Atsuki Imaeda:1, Masanori Obana:1, Makiko Maeda:1, Yasushi Fujio:1, Hiroyuki Nakayama:1
1:Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmacological Sciences, Osaka University, Japan

Resolvin D1and E1 decreases spleen mononuclear cells adhesion LPS-induced to cardiac fibroblast by reducing ICAM-1 and VCAM-1 expression levels

[Speaker] Guillermo Diaz-Araya:1
[Co-author] Natalia Munoz:1, Ninoska Ramirez:1, Pablo Sepulveda:1, Felipe Ruz:1, Raul Vivar:1, Victor Velarde:1, Aimee Salas:1
1:Chemical Pharmacology and Toxicology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Chile

Up-regulation of NOX1/NADPH oxidase following myocardial cell injury plays a critical role in the development of cardiac fibrosis

[Speaker] Kazumi Iwata:1
[Co-author] Kuniharu Matsuno:1, Chihiro Yabe-Nishimura:1
1:Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan

Pyridostigmine improved macrophage polarization and cardiac fibrosis induced by isoproterenol in mice

[Speaker] Dong-Ling Li:1
[Co-author] Su-Yun Yong:1, Run-Qing Xue:1, Xiao-Jiang Yu:1, Wei-Jin Zang:1
1:Department of Pharmacology, School of Basic Medical Sciences, Xian Jiaotong University Health Science Center, China

A multidisciplinary approach for pharmacological assessment using human iPS-derived cardiomyocytes

[Speaker] Junko Kurokawa:1
[Co-author] Masami Kodama:2, Yasunari Kanda:3, Takashi Ashihara:4, Shushi Nagamori:5, Yui Suzuki:1, Kohei Sakatoku:1, Nanami Iwasaki:1, Yusuke Sano:1, Kazuho Sakamoto:1
1:Department of Bio-informational Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, Japan, 2:Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan, 3:Division of Pharmacology, National Institute of Health Sciences, Japan, 4:Department of Cardiovascular Medicine, Shiga University of Medical Science, Japan, 5:Laboratory of Bio-Molecular Dynamics, Department of Collaborative Research, Nara Medical University, Japan

The mechanism underlying the role of CaMKII-mediated phosphorylation of Cav1.2 channel in cardiac hypertrophy and the effects of new-type peptide

[Speaker] Jingyuan Li:1
[Co-author] Songlin Li:1, Zhuo Li:1, Ze Kang:1, Siqi Wang:1, Xudong Zhu:1, Zhengnan Zhu:1, Meimi Zhao:1, Huiyuan Hu:1, Liying Hao:1
1:Dept. of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, China

Protective effects and mechanisms of hydrogen sulfide on isoproterenol-induced cardiac hypertrophy in mice

[Speaker] Guoliang Meng:1
[Co-author] Yun Chen:1, Shengju Yang:1,2, Mengting Xu:1, Wei Zhang:1
1:School of Pharmacy, Nantong University, China, 2:Affiliated Hospital of Nantong University, China

Melatonin enhances therapeutic efficacy of cardiac progenitor cells for myocardial infarction via targeting miR-98/STAT3 signal

[Speaker] Benzhi Cai:1,2,3
[Co-author] Wenya Ma:1,2,3, Fengzhi Ding:1,2, Lai Zhang:1,2, Fan Yang:1,2, Ye Yuan:1,2,3, Yanjie Lu:1,2, Zhimin Du:1,2,3
1:Pharmacy, Department of Pharmacy of The Second Affiliated Hospital, Harbin Medical University (the Heilongjiang Provincial Key Laboratory of Drug Research, Harbin Medical University), Harbin, China, 2:Department of Pharmacology (Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China, 3:Department of Clinical Pharmacy of The Second Affiliated Hospital, Harbin Medical University, Harbin, China

Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling in Cardiomyocytes Initiates Inflammatory Gene Expression, Inflammasome Activation and Macrophage Accumulation Leading to Adverse Cardiac Remodeling in Response to Pressure Overload

[Speaker] Takeshi Suetomi:1
[Co-author] Andrew Willeford:1, Michelle Li:1, Shigeki Miyamoto:1, Joan Heller Brown:1
1:Pharmacology, University of California San Diego, USA

Roles of heat shock protein 90 in cardiac remodeling

[Speaker] Shoko Tamura:1
[Co-author] Tetsuro Marunouchi:1, Yoshihiko Mino:1, Kouichi Tanonaka:1
1:Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences, Japan

Mechanisms for cardiomyocyte generation by adult sinoatrial node cells in culture

[Speaker] Shigeki Kiuchi:1
[Co-author] Tae Shimoyama:2, Fuminori Otsuka:2, Shigeto Suzuki:1, Kageyoshi Ono:1
1:Laboratory of Molecular Physiology and Pharmacology, Faculty of Pharma-Sciences, Teikyo University, Japan, 2:Laboratory of Molecular Environmental Health, Faculty of Pharma-Sciences, Teikyo University, Japan

A role of coagulation factor XI as a regulator of vascular smooth muscle migration

[Speaker] Wenhua Liu:1
[Co-author] Takeshi Hashimoto:1, Tetsuo Yamashita:1, Katsuya Hirano:1
1:Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Japan

Cellular Mechanism of the QT Prolongation Induced by Combretastatin A4-phosphate

[Speaker] Xiaoyuan Guan:1
[Co-author] Lu Hua:1
1:Peking Union Medical College, Chinese Academy of Medical Sciences., Fuwai Hospital, Chinese Academy of Medical Sciences., China

Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice

[Speaker] Hamish Al Lemmey:1
[Co-author] Xi Ye:1, Christopher J Garland:1, Kim A Dora:1
1:Department of Pharmacology, University of Oxford, UK

Dihydromyricetin ameliorates transverse aortic constriction induced myocardial hypertrophy in mice via inhibition of oxidative stress

[Speaker] Yun Chen:1
[Co-author] Guoliang Meng:1, Wei Zhang:1
1:School of Pharmacy, Nantong University, China

Despite Modifications of Dabigatran Pharmacokinetics, P-gp Antagonists Do Not Increase Bleeding Occurrence In the elderly

[Speaker] Milou-Daniel Drici:1
[Co-author] Marjorie Bernier:2, Guillaume Bardy:2, Elise Van Obberghen:2, Anne Spreux:2, Thibaud Lavrut:1, Fanny Rocher:2
1:Pharmacology Bat J4, University of Nice Medical Center, France, 2:Centre Regional de Pharmacovigilance de Nice - Hopital de Cimiez, NICE, France

(-)-Epigallocatechin-3-O-gallate (EGCG) attenuates the hemodynamics stimulated by caffeine through decrease of catecholamine release

[Speaker] Ki-Wan Oh:1
[Co-author] Jong-Myeong Hong:1, Jin Tae Hong:1
1:Chunbuk National University, Korea

PIEZO1 as Mechanosensor for Protecting Vascular Cells from Fibrosis

[Speaker] Sheng-Nan Chang:1,2
[Co-author] Chia-Ti Tsai:3, Jou-Wei Lin:2, Juey-Jen Hwang:3, Pei-Wen Cheng:4
1:National Taiwan University College of Medicine, Graduate Institute of Clinical Medicine, Taipei, Taiwan, 2:Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City, Taiwan, 3:Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 4:Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Small molecule activators of Ca2+-activated K+ channels can enhance endothelium-dependent responses in isolated resistance arteries

[Speaker] Frances Plane:1
[Co-author] Stephanie E Lunn:1, Ran Wei:1, Stephen L Gust:1, Paul M Kerr:2
1:Pharmacology, University of Alberta, Canada, 2:MacEwan University, Canada

Concentration-QTc analysis integrated into a Phase 1 Japanese bridging study

[Speaker] Jorg Taubel:1,2
[Co-author] Ulrike Lorch:1, Simon Coates:1, Dilshat Djumanov:1, Georg Ferber:3
1:Richmond Pharmacology Ltd, UK, 2:St Georges University of London, UK, 3:Statistik Georg Ferber, Switzerland

Comparison of ECG parameters using GE GETEMED continuous ECG Holter and MAC-1200 bedside ECG

[Speaker] Jorg Taubel:1,2
[Co-author] Dilshat Djumanov:1
1:Richmond Pharmacology, St George's University of London, UK, 2:St George's University of London, UK

Clinical Factors associated with QTc interval prolongation in patients treated with beta-lactam antibiotics plus inhibitors of beta-lactamase

[Speaker] Guillermo Di Girolamo:1,2
[Co-author] Guillermo A Keller:1,2, Maria C Villa Etchegoyen:1,2, Sebastian Mirad:2, Roberto A Diez:3
1:Centro de Vigilancia y Seguridad de los Medicamento, Segunda Cátedra de Farmacología, Department of Pharmacology, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina, 2:Instituto de Investigaciones Cardiologicas Prof Dr Alberto C Taquini, Facultad de Medicina, UBA, Buenos Aires, Argentina, 3:Segunda Catedra de Farmacologia, Departamento de Farmacologia, Facultad de Medicina, UBA, Buenos Aires, Argentina

Unexpected role of the telomere-associated protein Rap1 in protecting against mitochondrial defects and cardiac dysfunction during aging

[Speaker] Yin Cai:1
[Co-author] Michael G. Irwin:1, Zhengyuan Xia:1
1:Anaesthesiology, The University of Hong Kong, China

Chemerin-9-induced contraction of isolated pulmonary artery is enhanced in monocrotaline-induced pulmonary hypertensive rat

[Speaker] Makoto Goshima:1
[Co-author] Chiharu Kakuda:1, Muneyoshi Okada:1, Hideyuki Yamawaki:1
1:Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Japan

A Novel Porcine Model of Thrombotic Myocardial Infarction with Cardiac Dysfunction for the Evaluation of Antiplatelet Agents

[Speaker] Makoto Mizuno:1
[Co-author] Yusuke Ito:1, Atsuhiro Sugidachi:1
1:Rare Disease & LCM Laboratories, Daiichi Sankyo Co., Ltd., Japan

Identification of a Novel Gene that is involved in Pulmonary Arterial Hypertension Development

[Speaker] Gusti Rizky Teguh Ryanto:1
[Co-author] Koji Ikeda:2, Kazuya Miyagawa:2, Keiko Yagi:2, Yoko Suzuki:1,2, Ken-Ichi Hiirata:1, Noriaki Emoto:1,2
1:Cardiovascular Medicine, Internal Medicine, Kobe University Graduate School of Medicine, Japan, 2:Clinical Pharmacy, Kobe Pharmaceutical University, Japan

Rivaroxaban attenuates vascular remodeling of heart and lung in PAH through suppression of ERK1/2 and NF-kB phosphorylation

[Speaker] Ayasa Tanihata:1
[Co-author] Shota Matsumoto:1, Hideki Imano:1, Ryuji Kato:1, Yoshio Ijiri:1, Takehiro Yamaguchi:2, Yasukatsu Izumi:2, Minoru Yoshiyama:2, Michio Asahi:3, Tetsuya Hayashi:1
1:Department of Cardiovascular Pharmacotherapy and Toxicology, Osaka University of Pharmaceutical Sciences, Japan, 2:Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Japan, 3:Department of Pharmacology, Osaka Medical College, Japan

Vascular smooth muscle NCX1 is involved in the pathogenesis of pulmonary arterial hypertension

[Speaker] Hideaki Tagashira:1
[Co-author] Asahi Nagata:1,2, Satomi Kita:1,3, Sari Suzuki:1, Kohtaro Abe:4, Akinori Iwasaki:2, Takahiro Iwamoto:1
1:Department of Pharmacology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan, 2:Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan, 3:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan, 4:Department of Anesthesiology and Critical Care Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

A novel p38-alpha MAPK inhibitor (LASSBio-1824) reverses Sugen/Hypoxia-induced pulmonary arterial hypertension in rats

[Speaker] Gisele Zapata-Sudo:1
[Co-author] Grazielle F. Silva:1, Allan K. Alencar:1,2, Jaqueline S. Da Silva:1, Josenildo S. Araujo:1, Marina M. Silva:1, Rosana C. Freitas:1, Tadeu L. Montagnoli:1, Carlos A. Fraga:1, Roberto T. Sudo:1
1:Universidade Federal do Rio de Janeiro, Brazil, 2:Faculdade de Medicina de Petropolis, Brazil

Role of secretory phospholipase A2 in rhythmic contraction of pulmonary artery of experimental pulmonary hypertension

[Speaker] Yoshiyuki Tanabe:1
[Co-author] Maki T Saito:2, Koichi Nakayama:2,3
1:Laboratory of Pharmacology, Yokohama University of Pharmacy, Japan, 2:Department of Molecular and Cellular Pharmacology, Iwate Medical University, Japan, 3:University of Shizuoka, Japan

Evaluation of a combination therapy using riociguat and a TAK-1 inhibitor in the Sugen 5416/hypoxia rat model of pulmonary arterial hypertension

[Speaker] Laura Moreno:1,2,3
[Co-author] Daniel Morales-Cano:1,2,3, Jose Luis Izquierdo:2,4, Bianca Barreira:1,2,3, Sergio Esquivel-Ruiz:1,2,3, Maria Callejo:1,2,3, Gema Mondejar-Parreno:1,2,3, Angel Cogolludo:1,2,3, Jesus Ruiz-Cabello:2,5, Francisco Perez-Vizcaino:1,2,3
1:Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid (UCM), Spain, 2:Ciber Enfermedades Respiratorias (CIBERES), Madrid, Spain, 3:Gregorio Maranon Biomedical Research Institution (IiSGM), Madrid, Spain, 4:National Center for Cardiovascular Research (CNIC), Madrid, Spain, 5:School of Pharamacy, Universidad Complutense de Madrid (UCM), Spain

Upregulation of Ca2+-sensing receptors by PDGF signal in idiopathic pulmonary arterial hypertension

[Speaker] Aya Yamamura:1
[Co-author] Rie Takahashi:1, Hisaki Hayashi:1, Motohiko Sato:1
1:Department of Physiology, Aichi Medical University, Japan

Intracellular calcium and membrane potential oscillations in the pulmonary vein myocardium

[Speaker] Iyuki Namekata:1
[Co-author] Masahiko Iie:1, Haruna Kanae:1, Yayoi Tsuneoka:1, Shogo Hamaguchi:1, Hikaru Tanaka:1
1:Department of Pharmacology, Toho University, Faculty of Pharmaceutical Sciences, Japan

The Exploration and Practice of Remote Ischemic Preconditioning Through Intermittent Seiza

[Speaker] Shaojian Ye:1
1:Pharmacology, Medical College, Jianghan University, China

Effect of remote ischemic preconditioning on myocardial injury after off-pump coronary artery bypass graft: unicentric randomized trial

[Speaker] Teresa tejerina:1
[Co-author] Monica Bouza:2, Bunty Ramchandani:3, Manuel Carnero:3, Victoria Acedo:3, Fernando Reguillo:3, Luis Maroto:3
1:Departament of Pharmacology, School of Medicne. U Complutense Madrid, Spain, 2:Servicio de Cirugía Cardiaca, Hospital Clínico San Carlos. Madrid. Departament of Pharmacology, School of Medicne. U Complutense Madrid, Spain, 3:Servicio de Cirugía Cardiaca, Hospital Clínico San Carlos. Madrid., Spain

Soluble Guanylate Cyclase Redox State and Usefulness of Nitric Oxide-Enhancing Drugs in Monocrotaline-Induced Pulmonary Hypertensive Rats

[Speaker] Masashi Tawa:1,2
[Co-author] Takahide Furukawa:2, Hiroko Tongu:2, Mai Sugihara:2, Satoko Taguwa:2, Misaki Yamanaka:2, Yoko Yano:2, Hiroaki Matsumori:2, Tatsuya Sawano:2,3, Ryosuke Tanaka:2, Mamoru Ohkita:2, Yasuo Matsumura:2
1:Department of Pharmacology, Kanazawa Medical University, Japan, 2:Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, Japan, 3:Division of Molecular Pharmacology, Department of Medicine, Tottori University, Japan

Sex Difference of Cardiovascular Death in the 2/3 Nephrectomized-Nitric Oxide Synthases Deficient Mice: Involvement of Androgen

[Speaker] Mayuko Sakanashi:1,2
[Co-author] Yuji Taira:1, Toshihiro Matsuzaki:1, Junko Nakasone:1, Haruaki Kubota:1, Katsuhiko Noguchi:1, Masato Tsutsui:1
1:Department of Pharmacology, Graduate school of medicine, University of the Ryukyus, Japan, 2:Department of Pharmacy, Kinjo Gakuin University, Japan

Effect of methotrexate on pteridine-contents and relaxation response of the aorta from quinonoid-dihydropteridine reductase (QDPR) knockout mice

[Speaker] Chiho Sumi-Ichinose:1
[Co-author] Yui Suganuma:1, Taiki Kano:1, Noriko Ihira:1, Kazuhisa Ikemoto:1, Hiroshi Ichinose:2, Kazunao Kondo:1
1:Department od Pharmacology, Fujita Health University, School of Medicine, Japan, 2:Graduate school of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan

Protective Effects of Histidine-rich Glycoprotein on Barrier Dysfunction of Vascular Endothelial Cells

[Speaker] Shangze Gao:1
[Co-author] Yuan Gao:1, Hidenori Wake:1, Keyue Liu:1, Kiyoshi Teshigawara:1, Shiji Mori:2, Masahiro Nishibori:1
1:Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, Japan, 2:Shujitsu University School of Pharmacy, Japan

MDM2 induces vascular calcification through its E3 ligase activity

[Speaker] Duk-Hwa Kwon:1
[Co-author] Nakwon Choe:1, Sera Shin:1, Hosouk Joung:1, Taewon Kook:1, Yeong-Un Lee:1, Yun-Gyeong Lee:1, Hyun Kook:1
1:Chonnam National University Medical School, Korea

Biased activation of soluble guanylyl cyclase by quinones causes contractions of isolated arteries: Role of NADPH: quinone oxidoreductase-1

[Speaker] Susan WS Leung:1
[Co-author] Charlotte Ms Detremmerie:1, Paul M Vanhoutte:1
1:Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong

Febuxostat ameliorates angiotensin II-induced aortic fibrosis via suppressing macrophage-derived TGF-β expression

[Speaker] Masaki Imanishi:1
[Co-author] Masateru Kondo:1,2, Yoshito Zamami:1,2, Kenshi Takechi:3, Yuya Horinouchi:4, Yuki Izawa-Ishizawa:4, Yasumasa Ikeda:4, Koichiro Tsuchiya:5, Toshiaki Tamaki:4, Keisuke Ishizawa:1,2
1:Department of Pharmacy, Tokushima University Hospital, Japan, 2:Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, 3:Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan, 4:Department of Pharmacology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, 5:Department of Medical Pharmacology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan

Protective effects of Histidine-rich glycoprotein on human vascular endothelial cells

[Speaker] Yuan Gao:1
[Co-author] Hidenori Wake:1, Keyue Liu:1, Kiyoshi Teshigawara:1, Shuji Mori:2, Masahiro Nishibori:1
1:Pharmacology, Okayama University, Japan, 2:Dept. Pharmacy., Shujitsu Univ., Japan

Poly (I: C) impairs nitric oxide donor-mediated relaxation through increased NF-kappa B/iNOS pathway in rat superior mesenteric artery

[Speaker] Takayuki Matsumoto:1
[Co-author] Makoto Ando:1, Kumiko Taguchi:1, Tsuneo Kobayashi:1
1:Physiology and Morphology, Hoshi University, Japan

Vasorelaxant effects of cromakalim on the rat aorta via Na-Ca exchange

[Speaker] Katsuharu Tsuchida:1
[Co-author] Akiko Takase:1, Seiichiro Nishida:1,2, Hiroyasu Satoh:3
1:Faculty of Pharmaceutical Sciences, Doshisha Women's College, Japan, 2:Internal Medicine, Koriyama Seiran Hospital, Japan, 3:Health Science, Shitennoji University, Japan

Functional molecular complexes of junctophilin-2 and caveolin-1 provide a structural/functional basis for Ca2+-microdomain formation in vascular smooth muscle cells

[Speaker] Takanori Saeki:1
[Co-author] Yoshiaki Suzuki:1, Hisao Yamamura:1, Hiroshi Takeshima:2, Yuji Imaizumi:1
1:Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan, 2:Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan

PDGF induces migration of synthetic vascular smooth muscle cells through c-Src-dependent activation of full-length CaV1.2 L-type Ca2+ channels

[Speaker] Toshihide Kashihara:1
[Co-author] Xiaoguang Guo:1, Tsutomu Nakada:1, Mitsuhiko Yamada:1
1:Department of Molecular Pharmacology, Shinshu University School of Medicine, Japan

Enhancing endothelial cell signaling in resistance arteries to reverse vasospasm

[Speaker] Joshua Smith:1
[Co-author] Hamish Lemmey:1, Kim Dora:1, Christopher Garland:1
1:Department of Pharmacology, University of Oxford, UK

The functional role of YAP1 on cell proliferation and cell death in vascular smooth muscle cell

[Speaker] Takashi Kubo:1
[Co-author] Akira Takaguri:1, Kumi Satoh:1
1:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Japan

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