Sessions

Analgesic activity of first-time obtained compounds - bis (3, 4-dihydroquinoxalin-2 (1H)-one) and bis (3, 4-dihydro-2H-1, 4-benzoxazin-2-one)

[Speaker] Zarina Shulgau:1
[Co-author] Ivan Kulakov:2, Anastasiya Karbainova:2, Tatyana Krivoruchko:1
1:Toxicology and Pharmacology Laboratory, National Center for Biotechnology, Kazakhstan, 2:F. M. Dostoevskii Omsk State University, Russia

Transdermal delivery of novel terpenoid esters in pain management

[Speaker] Mariia V. Nesterkina:1,2
[Co-author] Iryna A. Kravchenko:1,2
1:Department of Organic and Pharmaceutical Technologies, Odessa National Polytechnic University, Ukraine, 2:I. I. Mechnikov Odessa National University, Ukraine

Antinociceptive and antioxidant activities of Hunteria umbellata stem bark: possible role of the serotonergic, opioidergic and dopaminergic pathways

[Speaker] Osaze O Edosuyi:1
[Co-author] Ighodaro Igbe:1, Loretta O Iniaghe:1
1:University of Benin, Nigeria

Inhibition of Rho-kinase provides optimal protection of the rat ureter from Bradykinin induced ureteric spasm

[Speaker] Aisha Alfituri:1
[Co-author] Theodor Burdyga:1
1:University of liverpool, UK

Molecular characterization and comparison of the effects of several opioid agonists clinically used in Japan - Using the CellKey™ and internalization assays with stable cells expressing opioid μ, δ or μ/δ dimerized receptors

[Speaker] Yuriko Fujii:1,2
[Co-author] Kanako Miyano:1, Kaori Oshima:1,3, Sei Manabe:1,4,5, Ryoto Someya:6, Kazumi Yoshizawa:3, Hiroshi Morimatsu:4, Masako Iseki:2, Eiichi Inada:2, Yasuhito Uezono:1,7
1:Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, Japan, 2:Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo, Japan, 3:Department of Pharmacology and Therapy, Faculty of Pharmaceutical Science, Tokyo University of Science, Chiba, Japan, 4:Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama, Japan, 5:Department of Anesthesiology & Critical Care Medicine, National Cancer Center Hospital, Tokyo, Japan, 6:Laboratory of Medicinal Chemistry, Kitasato University School of Pharmacy, Tokyo, Japan, 7:Division of Supportive Care Research, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Tokyo, Japan

Characterization of the properties of four opioid analgesics approved in Japan with cells stably expressing μORs using the CellKey™ and GloSensor™ cAMP assay systems

[Speaker] Sei Manabe:1,2,3
[Co-author] Kanako Miyano:2, Takumi Ogino:2,4, Kaori Oshima:2,5, Miaki Uzu:2, Miki Nonaka:2, Yoshikazu Matsuoka:6, Tetsufumi Sato:3, Hiroshi Morimatsu:1, Yashihito Uezono:2,7
1:Anesthesiology and Resuscitology, Okayama University Medical School, Japan, 2:Division of Cancer Pathophysiology, National Cancer Center Research Institute, Japan, 3:Department of Anesthesiology & Critical Care Medicine, National Cancer Center Hospital, Japan, 4:Laboratory of Medicinal Chemistry, Kitasato University School of Pharmacy, Japan, 5:Department of Pharmacology and Therapy, Faculty of Pharmaceutical Science, Tokyo University of Science, Japan, 6:Department of Intensive Care Unit, Okayama University Hospital, Japan, 7:Division of Supportive Care Research, Exploratory Oncology & Clinical Trial Center, National Cancer Center Hospital, Japan

Specific action mediated by spinal HMGB1 receptors in the induction of central post-stroke pain

[Speaker] Wataru Matsuura:1
[Co-author] Shinichi Harada:1, Keyue Liu:2, Masahiro Nishibori:2, Shogo Tokuyama:1
1:Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Japan, 2:Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmacological Sciences, Okayama University, Japan

Chronic pain induced by social defeat stress: a possible mechanism underlying free fatty acid-GPR40/FFAR1 in the brain

[Speaker] Fuka Aizawa:1
[Co-author] Takuya Yamashita:2, Kazuo Nakamoto:1, Fumiyo Kasuya:2, Shogo Tokuyama:1
1:Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Japan, 2:Biochemical Toxicology Laboratory, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan

Therapeutic efficacy of TNF-a neutralizing antibody in Complex Regional Pain Syndrome (CRPS) model mice

[Speaker] Shiho Shibata:1,2
[Co-author] Hideaki Tagashira:1, Satomi Kita:1,3, Sari Suzuki:1, Ken Yamaura:2, Takahiro Iwamoto:1
1:Department of Pharmacology, Faculty of Medicine, Fukuoka University, Japan, 2:Department of Anesthesiology, Faculty of Medicine, Fukuoka University, Japan, 3:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan

Intermittent psychological (Empathy) stress-induced generalized pain syndrome in mice mimics pathophysiological and pharmacotherapeutic characters in fibromyalgia in clinic

[Speaker] Naoki Dozono:1
[Co-author] Hiroyuki Neyama:1, Hiroshi Ueda:1
1:Department of Pharmacology and Therapeutic Innovation, Nagasaki University Institute of Biomedical Sciences, Japan

Spinal synaptic mechanisms of pain relief by GABA transporter inhibitors

[Speaker] Misa Oyama:1,2
[Co-author] Shun Watanabe:1,2, Takashi Iwai:1,2, Mitsuo Tanabe:1,2
1:Laboratory of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Japan, 2:Medicinal Research Laboratories, School of Pharmacy, Kitasato University, Japan

Glycosphingolipids involved in pain signaling: The contribution of sialic acids to mechanical allodynia

[Speaker] Shun Watanabe:1,2
[Co-author] Mami Sagawa:1,2, Motoki Morita:1,2, Natsumi Nomura:1,2, Misa Oayama:1,2, Takashi Iwai:1,2, Hideyoshi Higashi:3, Mitsuo Tanabe:1,2
1:Laboratory of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Japan, 2:Medicinal Research Laboratories, School of Pharmacy, Kitasato University, Japan, 3:Division of Glyco-Signal Research Institute of Molecular Biomembrane and Glycobiology Tohoku Medical and Pharmaceutical University, Japan

The bilateral change of the spinal cord and dorsal root ganglion glycosyltransferase expression involved in glycosphingolipids biosynthesis during inflammatory pain

[Speaker] Motoki Morita:1,2
[Co-author] Shun Watanabe:1,2, Natsumi Nomura:1,2, Misa Oyama:1,2, Takashi Iwai:1,2, Mitsuo Tanabe:1,2
1:Laboratory of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Japan, 2:Medicinal Research Laboratories, School of Pharmacy, Kitasato University, Japan

Middle molecular weight heparinylphenylalanine is an analgesic with reduced risk of hemorrhage

[Speaker] Hiroyuki Nishikawa:1,2
[Co-author] Kiriko Uenoyama:2, Fumiko Sekiguchi:2, Maho Tsubota:2, Atsufumi Kawabata:2
1:Research and Development Center, Fuso Pharmaceutical Industries, Ltd., Japan, 2:Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Japan

Molecular mechanisms for the recombinant soluble thrombomodulin-induced suppression of HMGB1-dependent allodynia in mice: Roles of the N-terminal domains of thrombomodulin

[Speaker] Yusuke Hayashi:1
[Co-author] Maho Tsubota:1, Ryuichi Tsujita:1,2, Goichi Honda:2, Atsufumi Kawabata:1
1:Lab. Pharmacol. Pathophysiol Fac. Pharm Kindai Univ, Japan, 2:Asahi Kasei Pharma, Tokyo, Japan

Contribution of polysulfides to the synergistic action of Hydrogen sulfide (H2S) and nitric oxide (NO) on TRPA1

[Speaker] Ryo Miyamoto:1,2
[Co-author] Shin Koike:3, Yoko Takano:4, Norihiro Shibuya:2, Yuka Kimura:2, Kenjiro Hanaoka:4, Yasuteru Urano:4, Yuki Ogasawara:3, Hideo Kimura:2
1:Tsuruoka Metabolomics Laboratory, National Cancer Center, Japan, 2:Department of Molecular Pharmacology, National Center of Neurology and Psychiatry, Japan, 3:Department of Analytical Chemistry, Meiji Pharmaceutical University, Japan, 4:Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan

Evaluation of anti-pruritic effects of ITCs that inhibit TLR3 signaling

[Speaker] Masaki Moriyama:1
[Co-author] Mitsuhiro Konno:1, Kanako Serizawa:1, Natsumi Yuzawa:1, Yuki Majima:1, Ikuo Hayashi:1, Tomohiko Suzuki:1, Mie Kainoh:1
1:Pharmaceutical Research Laboratories, Toray Industries, Inc., Japan

Brain allopregnanolone is involved in itch-associated scratching in atopic dermatitis mice

[Speaker] Masanori Fujii:1
[Co-author] Sayaka Ohgami:1, Erika Asano:1, Susumu Ohya:1,2
1:Department of Pharmacology, Kyoto Pharmaceutical University, Japan, 2:Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Japan

Engagement of kappa opioid system in the right amygdala diminishes diffuse noxious inhibitory controls (DNIC)

[Speaker] Megumi Ikegami:1
[Co-author] Kelsey Nation:1, Edita Navratilova:1, Daigo Ikegami:1, Frank Porreca:1
1:Department of Pharmacology, University of Arizona, College of Medicine, USA

Ketamine in chronic pain : a multicenter observational study

[Speaker] Gisele P Pickering:1
[Co-author] V Morel:1, M Voute:1, E Martin:1, A Coquerel:1
1:Clinical Pharmacology Dpt, Inserm CIC1405, University Hospital and Medical Faculty, France

Ketamine in chronic pain : a randomised clinical trial

[Speaker] Gisele P Pickering:1
[Co-author] M Voute:1, E Martin:1, C Duale:1
1:Clinical Pharmacology Dpt, Inserm CIC1405, University Hospital and Medical Faculty, France

Brain opioid-mediated analgesia by systemic administration of dipeptide kyotorphin analog

[Speaker] Hiroyuki Neyama:1
[Co-author] Yusuke Hamada:2, Minoru Narita:2, Hiroshi Ueda:1
1:Department of Pharmacology and Therapeutic Innovation, Nagasaki University, Institute of Biomedical Sciences, Japan, 2:Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan

Lysophosphatidic acid (LPA) involvement in central post-stroke pain (CPSP)

[Speaker] Chiho Miyama:1
[Co-author] Ryusei Iwamoto:1, Hiroshi Ueda:1
1:Department of Pharmacology and Therapeutic Innovation, Nagasaki University Institute of Biomedical Sciences, Japan

The development of mirror image pain in a mouse model of inflammatory pain

[Speaker] Chizuko Watanabe:1
[Co-author] Takafumi Sato:1, Akira Otowa:1, Tsukasa Sakurada:2, Shinobu Sakurada:1, Hirokazu Mizoguchi:1
1:Physiology and Anatomy, Tohoku Medical and Pharmaceutical University, Japan, 2:First Department of Pharmacology, Daiichi College of Pharmaceutical Sciences, Japan

Analgesic effects of a novel monoclonal antibody against Nav1.7 sodium channel

[Speaker] Sosuke Yoneda:1
[Co-author] Erika Kasai:1, Tatsuya Takahashi:1, Mai Yoshikawa:1, Junji Onoda:1, Takaya Izumi:1, Shoji Yamane:1, Kazuhiko Maekawa:1, Toshiyuki Asaki:1, Minoru Hasegawa:1
1:SHIONOGI & CO., LTD., Japan

The Use of Non-steroidal Anti-inflammatory Drugs in an Australian Elite Athlete Population

[Speaker] Alison Shield:1
[Co-author] Thomas Eason:1, Julie Cooke:2
1:Pharmacy, University of Canberra, Australia, 2:Sport and Exercise Science, University of Canberra, Australia

Tyrosyl-tRNA synthetase: a potential kyotorphin synthetase in mammals

[Speaker] Hiroshi Ueda:1
[Co-author] Tamotsu Tsukahara:1
1:Department of Pharmacology and Therapeutic Innovation, Nagasaki University Institute of Biomedical Sciences, Japan

The role of endogenous chaperone protein RTP4 in Opioid Receptor Heteromer Regulation

[Speaker] Wakako Fujita:1
[Co-author] Mini Yokote:2, Hiroshi Ueda:2, Lakshmi A Devi:3
1:Department of Frontier Life Science, Nagasaki University Graduate School of Biomedical Sciences, Japan, 2:Department of Pharmacology and Therapeutic Innovation, Nagasaki University Graduate School of Biomedical Sciences, Japan, 3:Department of Pharmacology, Icahn School of Medicine at Mount Sinai, NY, USA

The contribution of macrophage/monocyte to cyclooxygenase-independent pain in advanced osteoarthritis model in rats

[Speaker] Yusuke Sakurai:1
[Co-author] Masahide Fujita:1, Takao Sanaki:2, Takeshi Yoshioka:3, Kenichi Higashino:3, Kiyotaka Mochizuki:4, Tatsuya Takahashi:4, Toshiyuki Asaki:1, Minoru Hasegawa:1, Yasuhide Morioka:1
1:Pain & Neuroscience, Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Japan, 2:Infectious Diseases, Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Japan, 3:Translational Research Unit, Biomarker R&D Department, Shionogi & Co., Ltd., Japan, 4:Biotechnology-Based Medicine, Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Japan

Pharmacological evaluation of novel PAC1 receptor antagonist on oxaliplatin-induced cold allodynia in mice

[Speaker] Takahiro Ueda:1
[Co-author] Ryota Nagashima:1, Ai Watanabe:1, Takuya Okada:1, Naoki Toyooka:1, Atsuro Miyata:2, Takashi Kurihara:2, Ichiro Takasaki:1
1:Grad. Sch. Sci. & Eng. Res., Univ. Toyama, Japan, 2:Grad. Sch. Med. & Dent. Sci., Univ. Kagoshima, Japan

Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia in rats

[Speaker] Nobuaki Egashira:1,2
[Co-author] Shota Yamamoto:2, Satohiro Masuda:1,2
1:Department of Pharmacy, Kyushu University Hospital, Japan, 2:Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan

Plasma oxycodone and its metabolites concentrations in labouring women and their newborns

[Speaker] Merja Kokki:1
[Co-author] Mari Kinnunen:2, Kaisa Tuovinen:2, Hautajärvi Heidi:3, Veli-Pekka Ranta:4, Hannu Kokki:2
1:Anaesthesia and Operative Services, Kuopio University Hospital, Finland, 2:School of Medicine, University of Eastern Finland, Kuopio, Finland, 3:Admescope Ltd, Oulu, Finland, 4:School of Pharmacy, University of Eastern Finland, Kuopio, Finland

PACAP-induced pain responses are mediated by spinal Cyr61-chemokine signaling pathway

[Speaker] Tomoki Ogata:1
[Co-author] Tatsunori Maeda:1, Masafumi Yokai:2, Atsuro Miyata:2, Takashi Kurihara:2, Ichiro Takasaki:1
1:Grad. Sch. Sci. & Eng. Res., univ. Toyama, Japan, 2:Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., Japan

Novel PAC1 receptor antagonist inhibits nitroglycerin-induced migraine-like pain responses in mice

[Speaker] Ayaka Shimodaira:1
[Co-author] Chika Shibasaki:1, Ai Watanabe:1, Naoki Toyooka:1, Takuya Okada:1, Atsuro Miyata:2, Takashi Kurihara:2, Ichiro Takasaki:1
1:Grad. Sch. Sci. & Eng. Res., Univ. Toyama, Japan, 2:Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., Japan

Effect of hyperbaric oxygenation therapy on nociceptive pain

[Speaker] Sheila B Cruz Martinez:1
[Co-author] Ignacio Valencia Hernandez:1, Hernández María del Carmen Castillo:1
1:Posgraduate, Instituto Politecnico Nacional, Mexico

Next generation of paracetamol-related analgesics

[Speaker] Johan Nilsson:1
[Co-author] Love Flood Johansson:1, Lars Grundemar:1
1:Laboratory medicine, Department of Clinical Chemistry and Pharmacology, Lund University, Lund, Sweden

Impact of World Health Organisation's guidelines for the treatment of pain and the European Medicines Agency's safety recommendations on non-steroidal anti-inflammatory drugs use in analgesics utilization in Lithuania and other European countries. Observational study

[Speaker] Skaiste Kasciuskeviciute:1
[Co-author] Gintautas Gumbrevicius:1, Kestutis Petrikonis:1, Edmundas Kadusevicius:1
1:Lithuanian University of Health Sciences, Lithuania

Pharmacokinetic and Pharmacodynamics assessment of the anti-nociceptive effect of propofol and thiopenthal in rat

[Speaker] Nima Bakhtiari:1
[Co-author] Saeed Rezaee:2, Ali Reza Malayeri:1, Aliasghar Hemmati:1
1:Basic Pharmacology, Faculty of Pharmacy, Ahvaz Jundishapur University of medical science, Iran, 2:Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of medical science, Iran

Brain activation and pain-related behavior in a nonhuman primate model of experimental postoperative pain

[Speaker] Kurumi Yamoto:1
[Co-author] Takahiro Natsume:1, Shinya Ogawa:1, Yuji Awaga:1, Aldric Hama:1, Ikuo Hayashi:2, Akihisa Matsuda:1
1:Hamamatsu Pharma Research, Inc., Japan, 2:Hamamatsu Pharma Research USA, Inc., USA

Anti-inflammatory and analgesic effects of the total conjugated cholic acid extracted from Pulvis Fellis Suis

[Speaker] Jiao He:1,2
[Co-author] Bing Yin:1,2, Le Lv:1,2, Xin Wen:1,2, Zhaoyue Wang:1,2, Ziyang Chen:1,2, Yang Yang:1,2
1:Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, China, 2:Biomedicine Key Laboratory of Shaanxi Province, College of Life Science, Northwest University, China

Identification of the μ-opioid receptor splice variants involved in the lack of rewarding effect for amidino-TAPA

[Speaker] Hirokazu Mizoguchi:1
[Co-author] Maya Yoshioka:1, Chizuko Watanabe:1, Akira Otowa:1, Shinobu Sakurada:1
1:Physiology and Anatomy, Tohoku Medical and Pharmaceutical University, Japan

Sensitization of kappa opioid system in the amygdala in rat model of stress-induced medication overuse headache

[Speaker] Daigo Ikegami:1
[Co-author] Jennifer Y Xie:1, Milena De Felice:2, Caroline M Kopruszinski:1, Megumi Ikegami:1, Edita Navratilova:1, Frank Porreca:1
1:Pharmacology, University of Arizona, USA, 2:School of Clinical Dentistry, University of Sheffield, UK

Lornoxicam and Phloroglucinol Treat for Acute Abdominal Pain in Patients with Gallstone: A Meta analysis

[Speaker] Lili Yao:1
[Co-author] Boda Shi:1, Jinlong Xu:2
1:Ningbo Yinzhou Fuming Hospital, China, 2:Ningbo Yinzhou Sceond Hospital, China

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