Sessions

Late-onset depressive-like behaviors in rats experienced pharmacological stress during early postnatal period

[Speaker] Taku Yamaguchi:1
[Co-author] Kazuki Baba:1, Fumi Maeda:1, Hidenori Matsumoto:1, Ryo Fukumori:1, Tsuneyuki Yamamoto:1
1:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki International University, Japan

The role of the brain FKBP5 in depression

[Speaker] Takeshi Izumi:1
[Co-author] Robel Ghebreab:2, Ce Wang:2, Takayuki Yoshida:2, Hiroki Shikanai:1, Akitoyo Hishimoto:3, Mitsuhiro Yoshioka:2
1:Department of Pharmacology, Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan, 2:Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan, 3:Department of Psychiatry, Kobe University Graduate School of Medicine, Japan

Anti-depressant fluoxetine reveals its therapeutic effect via astrocytes

[Speaker] Manao Kinoshita:1
[Co-author] Kayoko Fujishita:1, Keisuke Shibata:1, Yuri Hirayama:1, Youichi Shinozaki:1, Eiji Shigetomi:1, Yoshinori Moriyama:2, Kazuhiro Ikenaka:3, Kenji F. Tanaka:4, Schuichi Koizumi:1
1:Neuropharmacology, University of Yamanashi, Japan, 2:Membrane Biochemistry, Okayama University, Japan, 3:Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Japan, 4:Neuropsychiatry, Keio University, Japan

Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI

[Speaker] Takahide Shuto:1
[Co-author] Mahomi Kuroiwa:1, Naoki Sotogaku:1, Yukie Kawahara:1, Yoshinori Ohnishi:1, Yuuki Hanada:1, Akinori Nishi:1
1:Department of Pharmacology, Kurume University School of Medicine, Japan

Pharmacological study of original low-molecular mimetic of BDNF, dimeric dipeptide GSB-106

[Speaker] Taissiia L Garibova:1
[Co-author] Anna V Tallerova:1, Tatyana A Gudasheva:1, Sergey B Seredenin:1
1:Research Zakusov Institute of Pharmacology, Russia

The role of desmoplakin in the mature dentate gyrus of the mouse hippocampus

[Speaker] Eri Segi-Nishida:1
[Co-author] Keisuke Ohtsubo:1
1:Department of Biological Science and Technology, Tokyo University of Science, Japan

Common blood-based markers in female patients and a model mouse of depression

[Speaker] Shigeo Miyata:1,2
[Co-author] Masahiko Mikuni:2, Yuchio Yanagawa:1, Masato Fukuda:2
1:Dept. of Genetic and Behavioral Neuroscience, Gunma University, Japan, 2:Dept. of Psychiatry and Neuroscience, Gunma University, Japan

Depression behaviors and sleep disturbance following corticosterone injection up to three weeks in rats: the effects on locus coeruleus

[Speaker] Xiangyu Cui:1
[Co-author] Suying Cui:1, Yonghe Zhang:1
1:Pharmacology, Peking University, School of Basic Medical Sciences, Beijing, China

Effect of neonatal hyperthermia on brain function

[Speaker] Toshimitsu Hiragi:1
[Co-author] Ryuta Koyama:1, Yuji Ikegaya:1
1:Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan

Pannexin-1 channel dysfunction in the medial prefrontal cortex mediates depressive-like behaviors in mice

[Speaker] Jin-Gang He:1
[Co-author] Ming Ni:1, Fang Wang:1, Zhuang-Li Hu:1, Jian-Guo Chen:1
1:Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, China

The Role of SNARE Complex in the Depression-like Behaviour of Prenatal Stress offspring Rats

[Speaker] Yan jun Cao:1
[Co-author] Kai Yuan Zhang:2, Xing Xing Zheng:1, Jia Hui Liu:1, Ying Cheng:1
1:Northwest University, China, 2:XiDian University, China

Combination in prenatal nicotine exposure with juvenile isolation rearing induces depressive behavior and change of tryptophan metabolism

[Speaker] Yuko Mori:1
[Co-author] Akihiro Mouri:2,4, Kazuo Kunisawa:3, Mami Hirakawa:2, Moe Niijima:2, Hisayoshi Kubota:2, Tomoaki Teshigawara:1, Yasuko Yamamoto:1, Toshitaka Nabeshima:3,4, Kuniaki Saito:1,4
1:Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Sciences, Japan, 2:Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Japan, 3:Advanced Diagnostic System Research Laboratory, Japan, 4:Japanese Drug Organization of Appropriate Use and Research, Japan

Reduction in basal plasma Adrenocorticotropic hormone (ACTH) and Prolactin during treatment with escitalopram for depression

[Speaker] Mamakhelelise A Matete:1
[Co-author] Makhotso Lekhooa:1, Andrew Walubo:1
1:Pharmacology and Psychiatry, Pharmacology South Africa, South Africa

Blockade of GAPDH nuclear translocation in the hippocampus contributes to anti-depressant-like action in stressed mice via HPA axis

[Speaker] Hidemitsu Nakajima:1
[Co-author] Sunao Nakamura:1, Mitsuru Kuwamura:2, Yasu-Taka Azuma:1, Takatoshi Hikida:3, Tadayoshi Takeuchi:1
1:Laboratory of Veterinary Pharmacology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan, 2:Laboratory of Veterinary Pathology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan, 3:Laboratory for Advanced brain Functions, Institute for Protein Research, Osaka University, Japan

Role of NMDA receptor GluN2D subunit in the antidepressant effects and the cognitive impairment effects of enantiomers of ketamine

[Speaker] Soichiro Ide:1
[Co-author] Yuiko Ikekubo:1, Masayoshi Mishina:2, Kenji Hashimoto:3, Kazutaka Ikeda:1
1:Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Japan, 2:Brain Science Laboratory, The Research Organization of Science and Technology, Ritsumeikan University, Japan, 3:Center for Forensic Mental Health, Chiba University, Japan

Liver hydrolysate produces antidepressant and antidementia effects in olfactory bulbectomized mice

[Speaker] Osamu Nakagawasai:1
[Co-author] Kotaro Yamada:2, Takayo Odaira:1, Wakana Sakuma:1, Wataru Nemoto:1, Hidetomo Sakurai:2, Koichi Tan-No:1
1:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Japan, 2:Consumer Healthcare Products Development, ZERIA Pharmaceutical Co., Ltd., Japan

The effect of lipid lowering agents on improving depression-like behavior in metabolic syndrome mice

[Speaker] Ching-Hua Yeh:1
[Co-author] Liang-Po Hsieh:1,2
1:Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, 2:Department of Neurology, Cheng Ching General Hospital, Taichung, Taiwan

Response to escitalopram in treatment of major depression does not correlate with escitalopram plasma concentration

[Speaker] Mamakhelelise A Matete:1
[Co-author] Zanele Bekker:1, Andrew Walubo:1
1:Pharmacology and Psychiatry, Pharmacology, South Africa

Antidepressant effect of BE360, a new selective estrogen receptor modulator, and its mechanism in ovariectomized mice

[Speaker] Wakana Sakuma:1
[Co-author] Osamu Nakagawasai:1, Wataru Nemoto:1, Takayo Odaira:1, Takumi Ogawa:2, Kiminori Ohta:2, Yasuyuki Endo:2, Koichi Tan-No:1
1:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Japan, 2:Laboratory of Organic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Japan

The role of innate immune pathway in repeated social defeat stress-induced behavioral changes in mice

[Speaker] Shiho Kitaoka:1,2
[Co-author] Xiang Nie:1,2, Kohei Tanaka:3, Atsubumi Ogawa:3, Fumitake Nakano:1, Yuki Imoto:4, Eri Segi-Nishida:5, Shuh Narumiya:2, Tomoyuki Furuyashiki:1,2
1:Pharmacology, Kobe University Graduate School of Medicine, Japan, 2:AMED-CREST, Japan, 3:Kyoto University Graduate School of Medicine, Japan, 4:Kyoto University Graduate School of Pharmaceutical Sciences, Japan, 5:Tokyo University of Science, Japan

Depression-like behavior, abnormal neuronal maturation and DNA hypomethylation in low folate diet-fed mice

[Speaker] Ryota Araki:1
[Co-author] Shoji Nishida:1, Ryo Takemura:1, Sota Asari:1, Shin Tachibana:1, Misato Tsuboi:2, Yoshitaka Nakamura:2, Takeshi Yabe:1
1:Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical sciences, Setsunan University, Japan, 2:Food Science & Technology Research Laboratories, R&D Division, Meiji Co., Ltd., Japan

K2P channels and NMDA receptor as new targets of fast onset antidepressants

[Speaker] Yang Li:1
[Co-author] Fei Guo:1, Yuqin Ma:1
1:Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of sciences, China

Effect of Yi-nao-jie-yu Prescription on post stroke depression

[Speaker] Xiaoli Li:1
[Co-author] Huiling Tian:1, Xinyue Sun:1, Haipeng Liu:1, Hongjing Chen:1, Liangyin Liang:1
1:The Third Affiliated Hospital, Beijing University of Chinese Medicine, China

The Role of Pentoxifylline as an Anti-Tumor Necrosis Factor-alpha in Improving the Outcome of Depressed Elderly Treated with Selective Serotonin Reuptake Inhibitors. A Proof-of-Concept Study

[Speaker] Ahmed M. Abdel-Tawab:1
[Co-author] Hany I. Ibrahim:2, Abeer M. Eissa:3, Mohammed H. El-Banoby:2
1:Pharmacology and Therapeutics, Faculty of Medicine, Ain Shams University, Cairo, Egypt, 2:Department of Geriatric Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt, 3:Department of Neuro-Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Involvement of the nitrergic system in the proconvulsant effect of social isolation stress in male mice

[Speaker] Muhammad Imran Khan:1
[Co-author] Vahid Nikoui:2, Jamal Ahmad:3, Bashir Ahmad:3, Ahmad-Reza Dehpour:4,5
1:Department of Pharmacy, Kohat University of Science and Technology, 26000 Kohat, KPK, Pakistan, 2:Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran, 3:Khyber Medical University, 28100, KPK, Pakistan, 4:Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran, 5:Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Effectivity of acute antidepressant treatment is determined by the valence of cognitive judgment bias in rats

[Speaker] Rafal Rygula:1
[Co-author] Michal Rychlik:1, Robert Drozd:1
1:Institute of Pharmacology Polish Academy of Sciences, Poland

The effect of soybean diet on interferon alpha induced depression in mice

[Speaker] Azadeh Mesripour:1
[Co-author] Yazdan Azimi Fashi:1, Valiollah Hajhashemi:1
1:Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical sciences, Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical sciences, Isfahan university of Medical Sciences, Isfahan, Iran

Investigation of antidepressant-like effect of dipyrone using chronic unpredictable mild stress model

[Speaker] Fazilet Aksu:1
[Co-author] Olcay Kiroglu:1, Kubra Demirkol:1, Fatih Berktas:1, Arash A Yegani:2, Erkan Maytalman:3, Mahmut Unverdi:4
1:Cukurova University Medical Faculty Pharmacology Department, Turkey, 2:Mustafa Kemal University Veterinary Faculty Pharmacology Department, Turkey, 3:Alaeddin Keykubat University Medical Faculty Alanya, Turkey, 4:Traumatic Brain Injury Reseach Lab., HCMC, USA

Allantoin Activates PI3K/Akt/mTOR pathway to Improve Symptoms of Unpredictable Chronic Mild Stress-Induced Depression in Rats

[Speaker] Keng Fan Liu:1
[Co-author] Chao-Lin Yang:1, Chuan-Sung Chiu:2, Ying-Chih Lin:3, Meng-Shiou Lee:1, Kai-Chun Cheng:4, Jen-Chieh Tsai:5, Juei-Tang Cheng:6, Wen-Huang Peng:1
1:China Medical University, Taiwan, 2:Hsin Sheng College of Medical Care and Management, Taoyuan, Taiwan, 3:Department of Optometry, Jen-Teh Junior College of Medicine, Nursing and Management, Taiwan, 4:Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Japan, 5:Biotechnology Research Center, Da-Yeh University, Taiwan, 6:Institute of Medical Sciences, Chang Jung Christian University, Taiwan

Withdrawn

Hippocampal AMPK activation suppresses depressive-like behavior in olfactory bulbectomized mice

[Speaker] Takayo Odaira:1
[Co-author] Osamu Nakagawasai:1, Wataru Nemoto:1, Kohei Takahashi:1, Wakana Sakuma:1, Ryotaro Ono:1, Koichi Tan-No:1
1:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Japan

Inhibition of caspase-1 improves the depressive-like behaviour via regulation of the stability of surface AMPARs

[Speaker] Jian-Guo Chen:1
[Co-author] Jin-Gang He:1, Zhuang-Li Hu:1, Peng-Fei Wu:1, Li-Hong Long:1, Fang Wang:1
1:Tongji Medical College, Huazhong University of Science and Technology, China

Effects of hydrogen sulfide on the depressive-like behavior of rats

[Speaker] Fang Wang:1
[Co-author] Zhuang-Li Hu:1, Jian-Guo Chen:1
1:Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, China

Nicotine modulates depression-like behaviors via regulating nAChR/Akt signalings in stressed mice

[Speaker] Mizuki Uchida:1
[Co-author] Akimi Kuwana:1, Rina Mizoguchi:1, Norio Ozaki:2, Akira Yoshimi:1, Yukihiro Noda:1
1:Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Faculty and Graduate School of Pharmacy, Japan, 2:Department of Psychiatry, Nagoya University Graduate School of Medicine, Japan

Combined glucocorticoid and mineralocorticoid receptor blockade in the hypothalamic paraventricular nucleus prevents the pathogenesis of depression induced by chronic corticosterone via drinking water

[Speaker] Yong-He Zhang:1
[Co-author] Hui Ding:1, Xiang-Yu Cui:1, Su-Ying Cui:1
1:Pharmacology, Peking University, School of Basic Medical Science, China

Whole-brain mapping of neuronal activity in mice after social defeat stress

[Speaker] Hisato Igarashi:1
[Co-author] Atsushi Kasai:1, Misaki Niu:1, Kaoru Seiriki:1,2, Takahiro Kuwaki:1, Masato Tanuma:1, Shun Yamaguchi:3, Takanobu Nakazawa:1,4, Hitoshi Hashimoto:1,5,6,7
1:Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 2:Interdisciplinary Program for Biomedical Sciences, Institute for Academic Initiatives, Osaka University, Japan, 3:Division of Morphological Neuroscience, Graduate School of Medicine, Gifu University, Japan, 4:Department of Pharmacology, Graduate School of Dentistry, Osaka University, Japan, 5:Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Japan, 6:iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 7:Division of Bioscience, Institute for Datability Science, Osaka University, Japan

Ubiquitination of EAAT2 is involved in the impairment of stress adaptation

[Speaker] Hiroko Miyagishi:1
[Co-author] Minoru Tsuji:1, Atsumi Saito:1, Kazuhiro Kurokawa:1, Kazuya Miyagawa:1, Hiroshi Takeda:1
1:Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Japan

INVESTIGATING THE EFFECT OF TIZANADINE IN DEPRESSION USING ANTIDEPRESSANT SCREENING TEST IN MICE

[Speaker] Esther PatricKBadugu:1
[Co-author] Ben A Chindo:1, Danjuma Mallam:1
1:Pharmacology & Toxicology, Kaduna State University, Nigeria

Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function

[Speaker] Zengliang Jin:1
[Co-author] Yunfeng Li:2, Huanli Xu:1, Yuanyuan Zheng:1
1:Department of Pharmacology, Capital Medical University, China, 2:Neuropsychopharmacology, Institute of Pharmacology and Toxicology, China

Role of ventral hippocampus in the modulation of impulsive aggression

[Speaker] Chih-Hua Chang:1
[Co-author] Po-Wu Gean:1
1:Department of Pharmacology, College of Medicine, National Cheng-Kung University, Taiwan

Single prolonged stress induces post-traumatic stress disorder-like characteristics in ICR mice

[Speaker] Ken-ichi Tanaka:1,2
[Co-author] Takao Yagi:2,3, Takeshi Nanba:2,3, Masato Asanuma:3,4
1:Physiology and Pharmacology, Saitama Prefectural University, Japan, 2:Department of Clinical Pharmacy, Shujitsu University School of Pharmacy, Japan, 3:Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan, 4:Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan

Activation of accumbal GABAB receptors inhibits δ1 and δ2 receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats

[Speaker] Tadashi Saigusa:1
[Co-author] Yuri Aono:1, Yuriko Watanabe:2
1:Department of Pharmacology, Nihon University School of Dentistry at Matsudo, Japan, 2:Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Japan

Susceptibility to juvenile isolation stress-induced aggressive behaviors in synaptic vesicle protein 2A (SV2A)-mutant rats

[Speaker] Kentaro Tokudome:1,2
[Co-author] Saki Shimizu:1, Kanako Ohnishi:1, Azusa Shimada:1, Toshihiro Tanaka:1, Tadao Serikawa:1, Yukihiro Ohno:1
1:Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan, 2:Division of Molecular and Cellular Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Japan

Roles of NOX1/NADPH oxidase in neuropathic pain and its related emotional behaviors

[Speaker] Masakazu Ibi:1
[Co-author] Chihiro Yabe-Nishimura:1
1:Pharmacology, Kyoto Prefectural University of Medicine, Japan

Withdrawn

Histamine H3 receptor inverse agonists alleviate methamphetamine-induced behavioral abnormalities in mice via histamine H1 receptors

[Speaker] Nobue Kitanaka:1
[Co-author] Junichi Kitanaka:1, Yukie Amatsu:1, Rena Ozawa:1, Miho Sato:1, Kotaku Hashimoto:1, Erina Hisatomi:1, Eri Kitao:1, Mari Mimura:1, Miyu Nakamura:1, Kenta Tagami:1, Koh-Ichi Tanaka:2, Kazuo Tomita:2,3, Takao Tsukahara:3, Tomoaki Sato:3, Nobuyuki Nishiyama:2, F. Scott Hall:4, George R. Uhl:5, Motohiko Takemura:1
1:Department of Pharmacology, Hyogo College of Medicine, Japan, 2:Division of Pharmacology, Department of Pharmacology, School of Pharmacy, Hyogo University of Health Sciences, Japan, 3:Department of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan, 4:Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, USA, 5:New Mexico VA Healthcare System/BRINM, USA

Social defeat stress modifies behaviors via the elevation of body temperature

[Speaker] Yutaka Hoshi:1
[Co-author] Koji Shibasaki:2, Ryuta Koyama:1, Yuji Ikegaya:1,3
1:Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan, 2:Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Japan, 3:Center for Information and Neural Networks, Japan

Less potent in the hypnotic effect of benzodiazepine associated with decreased GABAergic transmission in the chronic social defeat stress model mouse

[Speaker] Satoshi Imai:1
[Co-author] Masaru Miyayama:1, Yuumi Shimizu:1, Nozomi Asaoka:2, Naoya Nishitani:2, Shuji Kaneko:2, Takayuki Nakagawa:1, Kazuo Matsubara:1
1:Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan, 2:Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan

Neonatal maternal separation delays the GABA excitatory-to-inhibitory functional switch by inhibiting KCC2 expression and induces developmental disorders-like behaviors in mice

[Speaker] Minami Furukawa:1,2
[Co-author] Takao Tsukahara:1, Sayuri Yamanishi:1,2, Kazuo Tomita:1, Yuko Takashi:1,3, Koh-Ich Tanaka:4, Junichi Kitanaka:5, Nobue Kitanaka:5, Motohiko Takemura:5, Nobuyoshi Nishiyama:4, Yoshihiro Nishitani:3, Shouichi Miyawaki:2, Tomoaki Sato:1
1:Department of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan, 2:Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan, 3:Department of Restorative Dentistry and Endodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan, 4:Division of Pharmacology, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Japan, 5:Department of Pharmacology, Hyogo College of Medicine, Japan

Involvement of kynurenine 3-monooxygenase in the vulnerability to the PCP-induced behavioral abnormalities

[Speaker] Hisayoshi Kubota:1
[Co-author] Akihiro Mouri:1,4, Kazuo Kunisawa:2, Moe Niijima:1, Tomoaki Teshigawara:3, Mami Hirakawa:1, Yuko Mori:1, Yasuko Yamamoto:3, Toshitaka Nabeshima:2,4, Kuniaki Saito:3,4
1:Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, Japan, 2:Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Japan, 3:Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Science, Japan, 4:Japanese Drug Organization of Appropriate Use and Research, Japan

Repeated social defeat induces social interaction deficits associated with the alteration of kynurenine pathway activity in the prefrontal cortex

[Speaker] Kazuo Kunisawa:1
[Co-author] Akihiro Mouri:2,4, Aika Kosuge:2, Tsubasa Iida:2, Yasuko Yamamoto:3, Kuniaki Saito:3,4, Toshitaka Nabeshima:1,4
1:Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Japan, 2:Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, Japan, 3:Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Sciences, Japan, 4:Japanese Drug Organization of Appropriate Use and Research, Japan

Immediate and Lasting Effects of Early-Life Escitalopram, Venlafaxine, Exercise and Omega-3 Supplementation on Depressive-Like Behaviour in FSL Rats

[Speaker] Stephanus F Steyn:1
[Co-author] Brian H Harvey:1, Christiaan B Brink:1
1:Pharmacology, Division of Pharmacology, Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa

Variability of peripheral and central organ activity patterns of mice in an elevated plus maze

[Speaker] Toya Okonogi:1
[Co-author] Ryota Nakayama:1, Takuya Sasaki:1,2, Yuji Ikegaya:1
1:Lab. Chem. Pharmacol., Grad. Sch. Pharm. Sci., The Univ. Tokyo, Japan, 2:Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Japan

Memantine induces stereotyped behaviors in mice

[Speaker] Junichi Kitanaka:1
[Co-author] Nobue Kitanaka:1, Yoshiro Kubota:1, Yumi Mimura:1, Yukiya Okada:1, Sayaka Ogura:1, Koh-Ichi Tanaka:2, Kazuo Tomita:2,3, Takao Tsukahara:3, Tomoaki Sato:3, Nobuyuki Nishiyama:2, F. Scott Hall:4, George R. Uhl:5, Motohiko Takemura:1
1:Department of Pharmacology, Hyogo College of Medicine, Japan, 2:Division of Pharmacology, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Japan, 3:Department of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan, 4:Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, USA, 5:New Mexico VA Healthcare System/BRINM, USA

A role of NMDA receptor on stress related behavioral alternation in rats

[Speaker] Ji-Hye Park:1,3
[Co-author] Yong Cheon Na:2, Chang Yeob Han:3, Mi Jeong Han:3, Seong Bin Park:4, Seoul Lee:1,3
1:Wonkwang Brain Research Institute, Korea, 2:Wonkwang medical Institute, Korea, 3:Wonkwang University School of Medicine, Korea, 4:Korea Human Resource Development Institute for Health & Welfare, Korea

Involvement of Arhgef10 in social behaviour

[Speaker] Dai-Hua Lu:1
[Co-author] Houng-Chi Liou:1, Hsiao-Mei Liao:2, Chia-Hsiang Chen:2,3, Wan-Wan Lin:1, Susan Shur-Fen Gau:2, Wen-Mei Fu:1
1:Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, 2:Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, 3:Department and Graduate Institute of Biomedical Sciences, Chang Gung University, Taiwan

AMPA receptor-control essential for modulation of social behaviors

[Speaker] Edson Luck T. Gonzales:1
[Co-author] Ji-Woon Kim:1, Kwanghoon Park:2, Ri Jin Kang:1, Do Gyeong Kim:1, Hana Seung:1, Hyun Ah Oh:1, Mee Jung Ko:1, Chihye Chung:2, Chan Young Shin:1
1:Department of Neuroscience, Konkuk University, School of Medicine, Korea, 2:Department of Biological Sciences, Konkuk University, School of Medicine, Korea

Sansoninto, a traditional herbal medicine, attenuates aggressive behavior and regulates serotonergic and dopaminergic systems in hypothalamus of social isolation-reared mice

[Speaker] Hikari Iba:1
[Co-author] Kanae Matsuzawa:1, Maki Saimiya:1, Chika Aramaki:1, Sho Yoshida:1, Kaori Kubota:1,2, Shutaro Katsurabayashi:1, Takuya Watanabe:1,2, Katsunori Iwasaki:1,2
1:Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan, 2:A. I. G. Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University, Japan

The roles of KATP channels including Kir6.2 in regulation of emotional behaviors and stress responses

[Speaker] Atsumi Saito:1
[Co-author] Kazuya Miyagawa:1, Hiroko Miyagishi:1, Kazuhiro Kurokawa:1, Akira Umeda:2, Yasumasa Okada:3, Minoru Tsuji:1, Hiroshi Takeda:1
1:Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Japan, 2:Department of Internal Medicine, International University of Health and Welfare Shioya Hospital, Japan, 3:Department of Internal Medicine, National Hospital Organization Murayama Medical Center, Japan

Autism-like behaviors and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice

[Speaker] Jun Aruga:1,2
[Co-author] Naoko Morimura:2, Hiroki Yasuda:3, Kei-Ichi Katayama:2, Minoru Hatayama:1,2, Takeo Yoshikawa:4
1:Department of Medical Pharmacology, Nagasaki University Institute of Biomedical Sciences, Japan, 2:Laboratory for Behavioral and Developmental Disorders, RIKEN BSI, Japan, 3:Gunma University Graduate School of Medicine, Japan, 4:Laboratory for Molecular Psychiatry, RIKEN BSI, Japan

Tramadol modulates brain activity at seeing others' pain

[Speaker] Chihiro Suzuki:1
[Co-author] Yumiko Ikeda:2, Amane Tateno:3, Yoshiro Okubo:3, Haruhisa Fukayama:1, Hidenori Suzuki:2
1:Anesthesiology and Clinical Physiology, Tokyo Medical and Dental University, Japan, 2:Pharmacology, Nippon Medical School, Japan, 3:Neuropsychiatry, Nippon Medical School, Japan

The transgenerational inheritance of reduced memory and recognition in prenatal valproic acid-exposed mice model of autism spectrum disorder

[Speaker] Misato Yoshikawa:1
[Co-author] Hiroaki Aso:1, Masahiko Watanabe:1, Katsuya Suemaru:1
1:Department of Public Health, School of Pharmacy, Shujitsu University, Japan

Novel potential benefit of metformin on valproic acid-induced autism spectrum disorder in rats

[Speaker] Olufunmilayo O Adeyemi:1
[Co-author] Aishat O Balogun:1, Ismail O Ishola:1
1:Department of Pharmacology, Therapeutics and Toxicology, College of Medicine University of Lagos, Nigeria

Oxidative damage and mitochondrial dysfunction in valproic acid-exposed autism model rats

[Speaker] Kazuya Matsuo:1
[Co-author] Yasushi Yabuki:1, Kohji Fukunaga:1
1:Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan

Optogenetic manipulation of dorsal raphe serotonergic neurons modulates emotional behaviors in rodents

[Speaker] Naoya Nishitani:1
[Co-author] Nozomi Asaoka:1, Hiroyuki Kawai:1, Norihiro Shibui:1, Yuma Nagai:1, Chihiro Andoh:1, Kazuki Nagayasu:1, Hisashi Shirakawa:1, Takayuki Nakagawa:2, Shuji Kaneko:1
1:Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2:Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan

Transient Blockade of ERK Activation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice

[Speaker] Yasushi Satoh:1
[Co-author] Shinya Yufune:1, Shogo Endo:2, Toshiaki Ishizuka:1
1:Pharmacology, National Defense Medical College, Japan, 2:Aging Regulation Research Team, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Japan

Behavioral impairment associated with dysfunction of myelination by Shati/Nat8L deficit in mice

[Speaker] Hiroshi Noike:1
[Co-author] Kazuyuki Sumi:1, Kyosuke Uno:1, Takanori Tomohiro:2, Yasumaru Hatanaka:2, Yoshiaki Miyamoto:1, Atsumi Nitta:1
1:Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan, 2:Laboratory of Biorecognition Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan

Light-guided running behavior induces direction selective spikes of hippocampal neurons

[Speaker] Yuki Aoki:1
[Co-author] Hideyoshi Igata:1, Takuya Sasaki:1,2, Yuji Ikegaya:1
1:Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, Japan, 2:Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Japan

Noradrenergic system contributes to the maintenance of social hierarchy in mice

[Speaker] Yuiko Nishihara:1
[Co-author] Yuki Kurauchi:1, Hina Kawamoto:1, Risako Tanaka:1, Akinori Hisatsune:2, Takahiro Seki:1, Hiroshi Katsuki:1
1:Department of chemico-pharmacological sciences, graduate school of pharmaceutical sciences, Kumamoto university, Japan, 2:Priority organization for innovation and excellence, Kumamoto university, Japan

Contribution of GAPDH nuclear translocation in the hippocampus to depression and anxiety-Like behavior in social stressed mice

[Speaker] Sunao Nakamura:1
[Co-author] Mitsuru Kuwamura:3, Yasu-Taka Azuma:1, Tadayoshi Takeuchi:1, Takatoshi Hikida:2, Hidemitsu Nakajima:1
1:Laboratory of Veterinary Pharmacology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan, 2:Laboratory of Veterinary Pathology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan, 3:Laboratory for Advanced brain Functions, Institute for Protein Research, Osaka University, Japan

Vulnerability of social defeats in the overexpressed striatal SHATI/NAT8L in mice

[Speaker] Hajime Miyanishi:1
[Co-author] Kyosuke Uno:1, Toh Miyazaki:1, Kengo Sodeyama:1, Toshiyuki Fuziwara:1, Shin-Ichi Muramatsu:2,3, Yoshiaki Miyamoto:1, Atsumi Nitta:1
1:Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan, 2:Division of Neurology, Jichi Medical University, Shimotsuke, Japan, 3:Center for Gene & Cell Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

The perinatal mice administered prostaglandin E2 develop psychobehavioral and neuronal impairments in adults

[Speaker] Hirotake Hida:1,2
[Co-author] Akihiro Mouri:3, Kentaro Mori:1, Saori Takeuchi:1, Toshitaka Nabeshima:3, Kiyofumi Yamada:2, Norio Ozaki:4, Tomoyuki Furuyashiki:5, Shuh Narumiya:6, Yukihiro Noda:1
1:Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Faculty and Graduate School of Pharmacy, Japan, 2:Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan, 3:Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Sciences, Toyoake, Aichi, Japan, 4:Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan, 5:Division of Pharmacology, Kobe University Graduate School of Medicine, Kobe, Japan, 6:Medical Innovation Center, Kyoto Univ Sch Med, Kyoto University Graduate School of Medicine, Kyoto, Japan

Prostaglandin E receptor subtype EP1 deficiency elicits AD/HD-like behavior correlated with a dysfunction of dopamine D1 receptor-ERK signaling in the prefrontal cortex

[Speaker] Akihiro Mouri:1,8
[Co-author] Tomoyuki Furuyashiki:2, Kazuo Kunisawa:3, Yasuko Yamamoto:4, Kiyofumi Yamada:5,8, Yukihiro Noda:6,8, Kuniaki Saito:4,8, Shu Narumiya:7, Toshitaka Nabeshima:3,8
1:Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, Japan, 2:Division of Pharmacology, Kobe University Graduate School of Medicine, Japan, 3:Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science., Japan, 4:Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Science., Japan, 5:Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan, 6:Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, Japan, 7:Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan, 8:Japanese Drug Organization of Appropriate Use and Research, Japan

Functional analysis of Down's syndrome associated molecule in the cerebellum excitatory synapse formation

[Speaker] Ken-ichi Dewa:1,2
[Co-author] Nariko Arimura:2, Shin-Ichiro Taya:2, Kazuhisa Sakai:2, Noritaka Ichinohe:2, Schuichi Koizumi:1, Mikio Hoshino:2
1:Department of pharmacology, Yamanashi University, Japan, 2:National institute of Neurology and Psychiatry, Japan

Exposure to valproic acid during pregnancy induces autism endophenotypes in the male offspring

[Speaker] Mami Hirakawa:1
[Co-author] Akihiro Mouri:1,4, Kazuo Kunisawa:2, Yuko Mori:3, Moe Niijima:1, Hisayoshi Kubota:1, Tomoaki Teshigawara:3, Hidetsugu Fujigaki:3, Toshitaka Nabeshima:2,4, Kuniaki Saito:3,4
1:Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Sciences, Japan, 2:Advanced Diagnostic System Research Laboratory, Fujita Health Universuty Graduate School of Health Science, Japan, 3:Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Science, Japan, 4:Japanese Drug Organization of Appropriate Use and Research, Japan

Withania somnifera root extract ameliorates valproic acid induced neurochemical and histopathological impairment in autistic rats

[Speaker] Shrngika Soni:1
[Co-author] Rakesh Ruhela:1, Phulen Sarma:1, Ajay Prakash:1, Bikash Medhi:1
1:Departmento of Pharmacology, PGIMER, Chandigarh, India

Effects of intranasal oxytocin on autism-like behavioral abnormalities in valproic acid-induced mouse model of autism

[Speaker] Yuta Hara:1,2
[Co-author] Yukio Ago:2, Momoko Higuchi:2, Shigeru Hasebe:3, Takanobu Nakazawa:2,3, Hitoshi Hashimoto:2,4,5, Toshio Matsuda:6, Kazuhiro Takuma:3,4
1:Cell Biology Laboratory, Faculty of Pharmacy, Kindai University, Japan, 2:Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 3:Department of Pharmacology, Graduate School of Dentistry, Osaka University, Japan, 4:United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, University of Fukui, Japan, 5:Division of Bioscience, Institute for Datability Science, Osaka University, Japan, 6:Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan

Roles of 5-HT1A receptor in pathophysiological state of neuronal circuit at the prefrontal cortex in 15q11 -13 duplication autism model mice

[Speaker] Fumihito Saitow:1
[Co-author] Toru Takumi:2, Hidenori Suzuki:1
1:Pharmacology, Nippon Medical School, Japan, 2:RIKEN Brain Science Institute, Japan

Maternal and offspring P2X7 receptors drive autism-like behavior in mice

[Speaker] Beata Sperlagh:1
[Co-author] Gergely Horvath:1, Lilla Otrokocsi:1, Maria Baranyi:1, Agnes Kittel:1, Katinka Beko:1
1:Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

Role of IFITM3 in polyI: C-induced neuronal impairments

[Speaker] Norimichi Itoh:1
[Co-author] Taku Nagai:1, Daisuke Ibi:2, Akira Nakajima:3, Toshitaka Nabeshima:4, Kiyofumi Yamada:1
1:Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan, 2:Chemical Pharmacology, Faculty of Pharmaceutical Science, Meijo University, Japan, 3:Applied Biology and Food Sciences, Faculty of Agriculture and Life Science, Hirosaki University, Japan, 4:Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Japan

Experimental study on the analgesic and anti-seizure activity of newly synthesised hydrazide-hydrazone derivatives bearing 2H-chromene and coumarin scaffold

[Speaker] Stanislav Marchev:1
[Co-author] Andreeva-Gateva Pavlina:1, Tzonev Alex:1, Tchekalarova Jana:2, Angelova Violina:3, Vlaskovska Mila:1, Surcheva Slavina:1
1:Department of Pharmacology and Toxicology, Faculty of Medicine, Medical University, Sofia, Bulgaria, 2:Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria, 3:Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria

MODULATORY EFFECT OF PENTAZOCINE AND PETHIDINE ON ANTICONVULSANT ACTIVITY OF PHENOBARBITONE IN 4-AMINOPYRIDINE-INDUCED SEIZURES IN MICE

[Speaker] Ya'u Jamilu:1
[Co-author] Aishatu Shehu:1, Abdurrahman Adamu:1, Saadatu Ibrahim:1, Abdullahi H Yaro:2, Joseph A Anuka:1
1:Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria, 2:Department of Pharmacology, Bayero University Kano, Kano, Nigeria

CAN DEVELOPMENTAL, BEHAVIOURAL AND BIOCHEMICAL AND MOLECULAR PARAMETERS PREDICT LEVEL OF SUSCEPTIBILITY TO EPILEPTIC SEIZURES IN SUBJECTS WITH ASD: INSIGHT FROM A RAT MODEL OF ASD

[Speaker] Bikash Medhi:1
[Co-author] Rakesh Ruhela:1, Phulen Sarma:1, Shringika Soni:1, Ajay Prakash:1, Abhishek Mishra:1
1:Pharmacology, Post Graduate Institute of Medical Education and Research (PGIMER), India

A Combination of anti-epileptic drugs and valacyclovir ameliorated epileptic seizure in pentylenetetrazol-induced kindled mice

[Speaker] Shimon Takahashi:1,2
[Co-author] Natsumi Jyodukuri:1, Kenshi Takechi:3, Yoshito Zamami:1,2, Masaki Imanishi:1,2, Keisuke Ishizawa:1,2
1:Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 2:Department of Pharmacy, Tokushima University Hospital, Japan, 3:Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Japan

Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice

[Speaker] Masahiro Nishibori:1
[Co-author] Li Fu:1, Hidenori Wake:1, Dengli Wang:1, Kiyoshi Teshigawara:1, Keyue Liu:1, Hideo K Takahashi:2, Shuji Mori:3
1:Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan, 2:Dept of Pharmacology, Faculty of Medicine, Kinki University, Japan, 3:Dept of Pharmacology, School of Pharmacy, Shujitsu University, Japan

The role of interactions of platelets with brain- specific neuronal glycolipids in the modulation of neuronal functions during neurological disorders

[Speaker] Ekaterina Kopeikina:1
[Co-author] Eugene Ponomarev:1, Marina Dukhinova:1
1:School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong

Dysregulation of the CNS supporting vascular and glial cells induces the late posttraumatic epilepsy in mice with mild traumatic brain injury

[Speaker] Kenta Sakai:1
[Co-author] Fuyuko Takata:1, Shinya Dohgu:1, Mitsuhisa Koga:1, Ikuya Kimura:1, Atsushi Yamauchi:1, Yasufumi Kataoka:1
1:Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences Fukuoka University, Japan

Metformin reduces epileptogenic like events post status epilepticus in rats

[Speaker] Sree Lalitha Bojja:1
[Co-author] Ranjana W Minz:1, Bikash Medhi:2
1:Dept. of Immunopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, 2:Department of Pharmacology, PGIMER, India

Status epilepticus-induced changes in astrocytic Kir4.1 channel expression in pilocarpine model of temporal lobe epilepsy

[Speaker] Higor A. Iha:1
[Co-author] Takahiro Mukai:1, Haruna Imaura:1, Takayuki Nakamura:1, Satoko Yamashita:1, Tatsuya Yamamoto:1, Saki Shimizu:1, Kazuaki Sato:1,2, Akio Ikeda:2, Yukihiro Ohno:1
1:Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan, 2:Department of Epilepsy, Movement Disorders and Physiology, Kyoto University, Japan

Sevoflurane anesthesia in electroconvulsive therapy: a meta-analysis of randomized controlled trials

[Speaker] Yoshiteru Takekita:1
[Co-author] Taro Suwa:2, Hirotsugu Kawashima:3, Nobuatsu Aoki:1, Masaki Kato:1, Toshihiko Kinoshita:1
1:Department of Neuropsychiatry, Kansai medical university, Japan, 2:Department of Neuropsychiatry, Graduate School of Medicine, Kyoto University, Japan, 3:Department of Psychiatry, Toyooka Hospital, Japan

Npas4-Homer1a pathway regulates neuronal homeostasis in animal model of epilepsy

[Speaker] Taku Nagai:1
[Co-author] Wei Shan:1, Motoki Tanaka:2, Norimichi Itoh:1, Yoko Furukawa-Hibi:1, Toshitaka Nabeshima:3,4, Masahiro Sokabe:2, Kiyofumi Yamada:1
1:Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan, 2:Mechanobiology Laboratory, Nagoya University Graduate School of Medicine, Japan, 3:Advanced Diagnostic System Research Laboratory, Graduate School of Health Sciences, Fujita Health University, Japan, 4:Aino University, Japan

Evaluating the therapeutic potential of reversible acetylcholinesterase inhibitors in a mouse model of Dravet syndrome

[Speaker] Jennifer C. Wong:1
[Co-author] Andrew Escayg:1
1:Emory University, USA

Reversal of Schizophrenia-like Symptoms and Cholinergic Alterations by Melatonin In a Rodent Model

[Speaker] Mukhtar Ahmed Qasmi:1
[Co-author] Suhel Parvez:2, Md. Aslam:2
1:Ministry of AYUSH Government of India, not applicable, India, 2:Jamia Hamdard, New Delhi, India

Amotivation is associated with reduced ventral striatum volumes independently of dopamine receptor blockade by anti-psychotics in elderly schizophrenia patients

[Speaker] Fernando Caravaggio:1,2
[Co-author] Philip Gerretsen:1,2, Gary Remington:1,2, Ariel Graff-Guerrero:1,2
1:Department of Psychiatry, University of Toronto, Canada, 2:Centre for Addiction and Mental Health, Canada

The cerebellar α6 subunit-containing GABAA receptor: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders

[Speaker] Lih-Chu Chiou:1,2,3
[Co-author] Hsin-Jung Lee:1, Margot Ernst:4, Wei-Jan Huang:5, Akihiro Mouri:6,7, Marco Treven:4, Takayoshi Mamiya:6, James Cook:8, Werner Sieghart:4, Toshitaka Nabeshima:6,7,9
1:Department of Pharmacology, College of Medicine, National Taiwan University, Taiwan, 2:Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan, 3:Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung, Taiwan, 4:Center for Brain Research, Department of Molecular Neurosciences, Medical University Vienna, Austria, 5:Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan, 6:Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan, 7:Advanced Diagnostic System Research Laboratory, Fujita Health University, Graduate School of Health Sciences, Toyoake, Japan, 8:Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA, 9:Aino University, Ibaraki, Japan

Atypical Antipsychotics Regulate NMDA Receptor expression via GSK3beta/beta-catenin and GSK3beta/CREB1 Pathways in the Striatum of Young Rats

[Speaker] Bo Pan:1,2,3
[Co-author] Jiamei Lian:2,3, Chao Deng:2,3
1:Department of Pharmacy, Yangzhou University Medical Academy, China, 2:School of Medicine, University of Wollongong, Wollongong, NSW, Australia, 3:Antipsychotic Research Laboratory, Illawarra Health and Medical Research Institute, Wollongong, NSW, Australia

Involvement of kynurenine pathway in behavioral impairments in the offspring induced by the prenatal poly I: C injection

[Speaker] Moe Niijima:1
[Co-author] Akihiro Mouri:1,4, Tomoaki Teshigawara:2, Kazuo Kunisawa:3, Hisayoshi Kubota:1, Mami Hirakawa:1, Yuko Mori:2, Masato Hoshi:2, Toshitaka Nabeshima:3,4, Kuniaki Saito:2,4
1:Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Science, Japan, 2:Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Sciences, Japan, 3:Advanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Sciences, Japan, 4:Japanese Drug Organization of Appropriate Use and Research, Japan

NMDA Receptor Modulator Rescues Psychiatric Phenotypes in Mouse Model of Maternal Immune Activation

[Speaker] Yun Ting Hung:1
[Co-author] Shau Kwaun Chen:1, Jia Ming Chang:2, Hsiao Han Chiu:1, Ming Huan Chan:1
1:Institute of Neuroscience, National Chengchi University, Taiwan, 2:Department of Computer Science, National Chengchi University, Taipei, Taiwan

Effects of four atypical antipsychotics on autonomic nervous system activity in schizophrenia

[Speaker] Saki Hattori:1
[Co-author] Akira Suda:1, Ikuko Kishida:1,2, Masatoshi Miyauchi:1, Mami Fujibayashi:3, Natsuki Tsujita:4, Chie Ishii:2, Norio Ishii:2, Toshio Moritani:5, Yoshio Hirayasu:1
1:Department of Psychiatry, Yokohama City University School of Medicine, Japan, 2:Fujisawa Hospital, Japan, 3:Division of Physical and Health Education, Setsunan University, Japan, 4:Graduate School of Human and Environmental Studies, Kyoto University, Japan, 5:Faculty of General Education, Kyoto Sangyo University, Japan

GPR52 is a key regulator of corticostriatal signalling and function

[Speaker] Christopher J Langmead:1
[Co-author] Daisy L Spark:1, Cassandra J Hatzipantelis:1, Jess Nithianantharajah:2, Gregory D Stewart:1
1:Monash University, Australia, 2:Florey Institute of Neuroscience, University of Melbourne, Australia

Aberrant Neuronal Development Links to the Over-eating Behaviors in a Rodent Model of Schizophrenia

[Speaker] Chih-Hao Yang:1
[Co-author] Yu-Ning Wang:1, Hsing-Ni Li:1, Hsin-Wei Huang:1, Cheng-Ying Hsieh:1, Joen-Rong Sheu:1
1:Department of Pharmacology, Taipei Medical University, Taiwan

Behavioral and neurochemical analyses in the Piccolo knockdown mice as a new animal model for schizophrenia

[Speaker] Kohei Hamatani:1
[Co-author] Yoshiaki Miyamoto:1, Fu Kequan:1, Ryo Inagaki:1, Yuki Oketani:1, Shin-Ichi Muramatsu:2,3, Kyosuke Uno:1, Atsumi Nitta:1
1:Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan, 2:Division of Neurology, Department of Medicine, Jichi Medial University, Shimotsuke Tochigi, Japan, 3:Center for Gene & Cell Therapy, Institute of Medial Science, University of Tokyo, Tokyo, Japan

Antipsychotic-induced encephalopathy and re-examining the psychiatric disorders from the viewpoint of it

[Speaker] Satoshi A Hayama:1
1:Faculty of Integrated Human Studies, Kyoto University, Japan

VPAC2 receptor activation inhibits axon outgrowth and dendritic arborization in cultured mouse cortical neurons and its attenuation by clozapine but not haloperidol

[Speaker] Shuto Takeuchi:1
[Co-author] Ryosuke Yamauchi:1, Takuya Kawanai:1, Atsuko Hayata-Takano:1,2, James A. Waschek:3, Hitoshi Hashimoto:1,2,4, Yukio Ago:1,3
1:Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 2:United Graduate School of Child Development, Osaka University, Japan, 3:Psychiatry and Biobehavioral Sciences, University of California Los Angeles, USA, 4:Institute for Datability Science, Osaka University, Japan

DESIGN AND MECHANISM OF ANXIOLYTIC-LIKE EFFECT OF THE DIPEPTIDE TSPO LIGAND

[Speaker] Tatyana A Gudasheva:1
[Co-author] Olga A Deeva:1, Milada A Yarkova:2, Sergey B Seredenin:2
1:Department of Medicinal Chemistry, Federal State Budgetary Institution Research Zakusov Institute of Pharmacology, Russia, 2:Department of pharmacogenetics, Federal State Budgetary Institution Research Zakusov Institute of Pharmacology, Russia

Pharmacological validation and differentiation of anxiolytic effects of non-benzodiazepine from panicolytic effects of benzodiazepine in the induced anxiety animal model based on predator encounter

[Speaker] Raja Loganathan:1
[Co-author] Tapan K Mandal:1, Arivuchelvan Arivalagan:2, Birendra K Roy:3
1:Department of Veterinary Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences, India, 2:Department of Veterinary Pharmacology and Toxicology, Tamil Nadu Veterinary and Animal Sciences University, India, 3:Department of Veterinary Pharmacology and Toxicology, Birsa Agricultural University, India

EFFECT OF METHANOLIC LEAF EXTRACT OF Peristrophe bicalycuclata ON STRESS INDUCED ANXIETY IN MICE

[Speaker] Olasubomi F Sotunde:1
[Co-author] Adewale G Bakre:1, Ezekiel O Iwalewa:1
1:PHRMACOLOGY AND THERAPEUTICS, UNIVERSITY OF IBADAN, Nigeria

Evaluation of behavioral alterations and oxidative stress in the offspring of perinatally stressed rats

[Speaker] Margarita Lopez Martinez:1
[Co-author] M. Toledo-Blas:1, A. Guzman-Grenfell:1, A. Meneses-Ortiz:1, P. Lopez-Sanchez:1
1:Laboratorio de Farmacologia Experimental, Instituto Nacional de Perinatologia, Mexico

Fructose Causes Neuroinflammation in the Central Neuronal System may through CX3CL1-CX3CR1 axis to Mediate NO production in Fructose-fed Hypertensive Rat

[Speaker] Chiu-Yi Ho:1,2
[Co-author] Pei-Wen Cheng:1, Shin-Hung Chen:1, Ching-Jiunn Tseng:1,2
1:Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 2:Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan

Immunoreactive signals of GPR143 in the ventral tegmental area, substantia nigra and their trajectories

[Speaker] Kohtaro Takizawa:1
[Co-author] Motokazu Koga:1, Daiki Masukawa:1, Fumio Nakamura:1,2, Yoshio Goshima:1
1:Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Japan, 2:Department of Biochemistry, School of Medicine, Tokyo Women's Medical University, Japan

Role of NLRP3 Inflammasome in Cortical Spreading Depression-Induced Inflammatory Responses in Mice

[Speaker] Hsun-Ting Hsieh:1
[Co-author] Shih-Pin Chen:2,3, Shuu-Jiun Wang:3,4,5, Jiin-Cherng Yen:1
1:Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan, 2:Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, 3:Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, 4:Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, 5:Brain Research Center, National Yang-Ming University, Taipei, Taiwan

The Immunoreactivity of Calbindin on Cerebellum Cortex and Hippocampus of Mice Brain after One Week Exposure to Radiofrequency Radiation

[Speaker] Bijay Aryal:1
1:Department of Pharmacology, Gandaki Medical College, Nepal

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