Sessions

Evaluation of Therapeutic Drug Monitoring Reporting in a Teaching Hospital in Taiwan

[Speaker] Yuhong Lin:1
[Co-author] Hsinhui Huang:1
1:Pharmacy, Kaohsiung Veterans General Hospital Tainan Branch, Taiwan

Protein abundance of clinically relevant drug transporters in the human liver and along the intestine: a comparative analysis in paired tissue specimens

[Speaker] Marek Drozdzik:1
[Co-author] Janett Muller:2, Joanna Lapczuk:1, Diana Busch:2, Sylwia Szelag-Pieniek:1, Justyna Grzegolkowska:1, Marek Ostrowski:3, Mateusz Kurzawski:1, Stefan Oswald:2
1:Pharmacology, Pomeranian Medical University, Poland, 2:Department of Clinical Pharmacology, University Medicine of Greifswald, Greifswald, Germany, 3:Surgery, Pomeranian Medical University, Poland

Drug-Drug Interaction by CYP Metabolism Is Not a Major Determinant of Attenuation of Anti-platelet Function of Clopidogrel by Coadministration with Vonoprazan

[Speaker] Mitsuhiro Nishihara:1
[Co-author] Hitomi Yamasaki:2, Richard Czerniak:3, Helen Jenkins:4
1:Global Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., USA, 2:Drug Disposition & Analysis, Research Division, Axcelead Drug Discovery Partners, Inc., Japan, 3:Quantitative Clinical Pharmacology, Takeda Pharmaceuticals International Co., USA, 4:d3 Medicine, A Certara Company, UK

Effect of genetic polymorphism on the inhibition of CYP2D6-mediated dopamine formation from p-tyramine by steroid hormones and related compounds including typical CYP2D inhibitors and antidepressants

[Speaker] Toshiro Niwa:1
[Co-author] Marina Shizuku:1, Kaori Yamano:1, Mayumi Yanai:1
1:School of Pharmacy, Shujitsu University, Japan

Proteomics-based analytical method for the absolute quantitation of cetuximab in human serum and its clinical application

[Speaker] Kaito Shibata:1
[Co-author] Takafumi Naito:1, Jun Okamura:2, Seiji Hosokawa:2, Hiroyuki Mineta:2, Junichi Kawakami:1
1:Department of Hospital Pharmacy, Hamamatsu University School of Medicine, Japan, 2:Department of Otorhinolaryngology/Head & Neck Surgery, Hamamatsu University School of Medicine, Japan

NanoBRET to monitor ligand engagement to beta-2 adrenergic receptor in a highly metastatic breast cancer cell model

[Speaker] Diana C Alcobia:1,3
[Co-author] Sarah Mistry:2, Alexander Kondrashov:2, Jeanette Woolard:1, Erica K Sloan:3, Stephen J Hill:1
1:Physiology, Pharmacology and Neuroscience Department, University of Nottingham, UK, 2:School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK, 3:Drug Discovery Biology Department, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia

Genotype-specific effects of cytochrome P450 inducers and inhibitors on CYP2C19 enzyme activity

[Speaker] Chiaki Kamiya:1
[Co-author] Keiichi Odagiri:2, Sachiko Miyakawa:3, Akio Hakamata:1, Naoki Inui:1, Shimako Tanaka:4, Shinya Uchida:4, Noriyuki Namiki:4, Hiroshi Watanabe:1
1:Clinical Pharmacology and Therapeutics, Hamamatsu University of Medicine, Japan, 2:Center for Clinical Research, Hamamatsu University School of Medicine, Japan, 3:Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Japan, 4:Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences Universitty of Shizuoka, Japan

The absorptive property of Paeoniflorin-6-O'-benzenesulfonate (CP-25) in peripheral blood mononuclear cells

[Speaker] Chun Wang:1,2,3
[Co-author] Min-Yi Zhao:1,2,3, Jian Wang:1,2,3, Yi-Jin Wu:1,2,3, Wei Wei:1,2,3
1:Institute of Clinical Pharmacology, Anhui Medical University, China, 2:Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, China, 3:Collaborative Innovation Center of Anti-inflammatory and Immune Medicine in Anhui Province, China

Development and validation of a method for epidermal growth factor receptor tyrosine kinase inhibitors quantification in dried blood spots: practices of pharmacist assisted self-blood sampling

[Speaker] Kei Irie:1,2,3
[Co-author] Shigeki Nanjo:4, Katsuhiro Masago:4, Akito Hata:4, Chiyuki Kokan:4, Reiko Kaji:4, Shiro Fujita:4, Yutaka Okada:1, Nobuyuki Katakami:4, Shoji Fukushima:2
1:Division of pharmacy, Institute of Biomedical Research and Innovation, Japan, 2:Department of Pharmaceutics, Faculty of Pharmaceutical Science, Kobe Gakuin University, Japan, 3:*Current affiliation: Department of Pharmacy, Kobe City Hospital Organization Kobe City Medical Center General Hospital, Japan, 4:Division of Integrated Oncology, Institute of Biomedical Research and Innovation Hospital, Japan

Disruption of Slc52a3 gene causes abnormalities of energy metabolism and brain development in mice with riboflavin deficiency

[Speaker] Congyun Jin:1,2
[Co-author] Hiroki Yoshimatsu:1,2, Atsushi Yonezawa:1,2, Kaori Yamanishi:1,2, Yoshiaki Yao:1,2, Shunsaku Nakagawa:1, Satoshi Imai:1, Tomohiro Omura:1, Takayuki Nakagawa:1, Kazuo Matsubara:1
1:Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan, 2:Graduate School of Pharmaceutical Sciences, Kyoto University, Japan

Pharmacokinetics of fentanyl after dermal administration to arthritis model rats

[Speaker] Tsutomu Shimada:1
[Co-author] Akari Maeda:1, Gaku Akashita:1, Yoshimichi Sai:1
1:Department of Hospital Pharmacy, University Hospital, Kanazawa University, Japan

Relationship between plasma concentration and efficacy of rituximab in the patient with non-Hodgkin's lymphoma

[Speaker] Mayuko Mori:1,2
[Co-author] Atsushi Yonezawa:1,2, Yuki Otani:2, Yui Isomoto:2, Masahiro Tsuda:1,2, Satoshi Imani:2, Toshiyuki Kitano:3, Akifumi Takaori:3, Makoto Hayakari:2, Kazuo Matsubara:2
1:Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2:Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan, 3:Department of Hematology / Oncology, Graduate School of Medicine, Kyoto University, Japan

Biomarkers to predict the efficacy of Infliximab in the Patients with Inflammatory Bowel Disease

[Speaker] Sho Masui:1,2
[Co-author] Atsushi Yonezawa:1,2, Yasuaki Ikemi:2, Yuki Otani:2, Makoto Hayakari:2, Noriko Iwamoto:4, Takashi Shimada:4, Minoru Matsuura:3, Hiroshi Nakase:3, Kazuo Matsubara:2
1:Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2:Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan, 3:Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan, 4:Leading Technology of Bioanalysis and Protein Chemistry, SHIMADZU Corporation, Japan

A microsensing system for the in vivo real-time monitoring of local drug kinetics

[Speaker] Genki Ogata:1,2
[Co-author] Kai Asai:3, Yamato Sano:4, Madoka Takai:5, Hiroyuki Kusuhara:4, Yasuaki Einaga:3,6, Hiroshi Hibino:1,2
1:Department of Molecular Physiology, Niigata University School of Medicine, Japan, 2:Center for Transdisciplinary Research, Niigata University, Japan, 3:Department of Chemistry, Faculty of Science and Technology, Keio University, Japan, 4:Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan, 5:Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Japan, 6:JST-ACCEL, Tokyo, Japan

Investigating the mode of action of intracellular loop 1 pepducins at the CXCR4 receptor

[Speaker] Birgit Caspar:1,2
[Co-author] Leigh A Stoddart:1,2, Joelle Goulding:1,2, Stephen J Briddon:1,2, Stephen J Hill:1,2
1:Division of Pharmacology, Physiology and Neuroscience, University of Nottingham, UK, 2:Centre of Membrane Proteins and Receptors (COMPARE), University of Nottingham, UK

Important role of organic anion transporting polypeptide in disposition of flavonoid

[Speaker] Jianqing Ruan:1
[Co-author] Hui Zhi:1, Linghua Kong:1
1:College of Pharmaceutical Sciences, Soochow University, Suzhou, China

Celecoxib loaded polymeric nanoparticles characterization and invitro evaluation

[Speaker] Abhishek K Sah:1
[Co-author] Preeti K Suresh:2, Sanjay Singh:1
1:Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University)Varanasi (U P) 221005 India, 2:University Institute of Pharmacy Faculty of Technology Pt Ravishankar Shukla University Raipur (CG) India

Cycloserine amount emanating from terizidone metabolism in patients with multi-drug resistant tuberculosis

[Speaker] Mwila Mulubwa:1
[Co-author] Pierre Mugabo:1
1:School of Pharmacy, University of the Western Cape, South Africa

A Design Principle for an Autonomous Post-translational Pattern Formation

[Speaker] Shuhei S Sugai:1
[Co-author] Koji L Ode:1,2, Hiroki R Ueda:1,2
1:Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Japan, 2:Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, Japan

Drug-drug interaction between TAS-303 and simvastatin/midazolam in healthy subjects

[Speaker] Yuji Kumagai:1
[Co-author] Tomoe Fujita:2, Masako Aso:1, Hideki Amano:1, Yoshinobu Sasaki:1, Masaki Kawai:3, Toru Takenaka:4, Makoto Nagaoka:3, Koichiro Hoashi:3
1:Clinical Trial Center, Kitasato University Hospital, Japan, 2:Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan, 3:Clinical Development II, TAIHO PHARMACEUTICAL CO., LTD., Japan, 4:Pharmacokinetics Research Laboratories, TAIHO PHARMACEUTICAL CO., LTD., Japan

Prediction of Warfarin-Sorafenib Interaction in Japanese Patients Using a Population Pharmacokinetic-Pharmacodynamic Model

[Speaker] Kazuhiko Asari:1
[Co-author] Harumi Takahashi:1
1:Department of Biopharmaceutics, Meiji Pharmaceutical University, Japan

A study to investigate the reduction in exposure to selected cigarette smoke constituents in healthy Japanese smokers who switched to a novel tobacco vapor product

[Speaker] Takeshi Kurachi:1
[Co-author] Kyoko Nakaya:1, Yuki Takeshige:1, Yasuyuki Futamura:1
1:Japan Tobacco Inc., Japan

Inhibitory effect of Polypodium leucotomos extract on CYP3A-mediated midazolam metabolism

[Speaker] Yurika Gomi:1
[Co-author] Yuki Nishimura:1, Norimitsu Kurata:2, Mariko Iwase:1, Yuji Kiuchi:1
1:Department of Pharmacology, Showa University, School of Medicine, Japan, 2:Faculty of Arts and Sciences at Fujiyoshida, Showa University, Japan

No clinically relevant interaction of voriconazole with microdosed apixaban, edoxaban and rivaroxaban

[Speaker] Gerd Mikus:1
[Co-author] Marlene Schaumaeker:1, Kathrin Foerster:1, Marie-Louise Lehmann:1, Walter E Haefeli:1
1:Clinical Pharmacology and Pharmacoepidemiology, Universtity of Heidelberg, Germany

Relationship between gastric pH and plasma concentrations of gefitinib, erlotinib and osimertinib after oral administrations in rat

[Speaker] Takaaki Sasaki:1
[Co-author] Shinya Uchida:1, Ayae Suzuki:1, Osamu Yasumuro:1, Yasuharu Kashiwagura:1, Shimako Tanaka:1, Naoki Inui:2, Hiroshi Watanabe:2, Noriyuki Namiki:1
1:Department of Pharmacy Practice and Science, University of Shizuoka, School of Pharmaceutical Sciences, Japan, 2:Department of Clinical Pharmacology & Therapeutics, Hamamatsu University School of Medicine, Japan

The 21st century puzzle of ethnomedical representatively bioactive compounds (ERBCs) has been deciphered: a novel approach and its significances

[Speaker] Xi Huang:1
[Co-author] Ping Ren:1
1:Institute of TCM-related Depressive comorbidity, nan jing university of chinese medicine, China

Insights into the metabolic characteristics of aminopropanediol analogues of SYLs as S1P1 modulators: from structure to metabolism to druggability

[Speaker] Jinping Hu:1,2
[Co-author] Manman Zhao:1,2, Jiaqi Mi:1,2, Baolian Wang:1,2, Li Sheng:1,2, Hui Chen:1,2, Yan Li:1,2
1:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study, Beijing, 2:Key Laboratory of Active Substances Discovery and Drug Ability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, China

Pharmacokinetics Pharmacodynamics and PK/PD modelling of danofloxacin in Sahiwal cattle

[Speaker] Zahid Manzoor:1,2
[Co-author] Zahid Iqbal:1, Naima Batool:3
1:Pharmacology, Al-Nafees Medial College, Isra University, Pakistan, 2:King Edward Medical University, Lahore, Pakistan, 3:Nishtar Medical College, Multan, Pakistan

Relationship between initial vancomycin trough levels and early-onset vancomycin-associated nephrotoxicity in critically ill patients

[Speaker] Masayuki Chuma:1,5
[Co-author] Makoto Makishima:2, Toru Imai:1, Naohiro Tochikura:1, Shinichiro Suzuki:1, Tsukasa Kuwana:3, Nami Sawada:3, Norikazu Kikuchi:4, Yoshikazu Yoshida:1, Kosaku Kinoshita:3
1:Department of pharmacy, Nihon university Itabashi hospital, Japan, 2:Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Japan, 3:Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Japan, 4:Department of Pharmacy, Nihon University Hospital, Japan, 5:Current affiliation : Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Japan

New enantiomeric chromone derivatives AU-1a and AU-1b from Aspergillus udagawae inhibit collagen-induced platelet activation by impairing GPVI-dependent signaling pathway

[Speaker] Naomasa Yamamoto:1,6
[Co-author] Shou Nakadate:2, Hiroshi Iijima:3, Hiromasa Nagase:4, Takashi Yaguchi:5, Katsuyuki Kumano:6
1:Biochemistry, School of Pharmaceutical Sciences, Ohu University, Japan, 2:Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima, Japan, 3:School of Pharmacy, Nihon University, Funabashi, Chiba, Japan, 4:Center for Fundamental Laboratory Research, Hoshi University, Shinagawa, Japan, 5:Medical Mycology Research Center, Chiba University, Chiba, Japan, 6:JSP Life Sceience Laboratory, Shibuya, Japan

Construction of a physiologically-based pharmacokinetic model of coproporphyrin I, a putative endogenous probe for hepatic OATP1Bs and MRP2

[Speaker] Takashi Yoshikado:1,2
[Co-author] Kota Toshimoto:2, Kazuya Maeda:3, Hiroyuki Kusuhara:3, Koji Chiba:1, Yuichi Sugiyama:2
1:Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy, Japan, 2:Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Japan, 3:Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Japan

Rapid attainment to target trough concentrations of tacrolimus for early improvement of clinical symptoms in patients with ulcerative colitis

[Speaker] Yuto Yamada:1,2
[Co-author] Takashi Niwa:2, Hiroko Katoh:2, Akio Suzuki:2, Takashi Ibuka:3, Hiroshi Araki:3, Hideki Hayashi:1,2,4, Yoshinori Itoh:2, Tadashi Sugiyama:1,4
1:Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Japan, 2:Department of Pharmacy, Gifu University Hospital, Japan, 3:First Department of Internal Medicine, Gifu University Graduate School of Medicine, Japan, 4:Community Healthcare Pharmacy, Gifu Pharmaceutical University, Japan

Development and characterization of human immortalized cell-based multicellular spheroidal blood-brain barrier model

[Speaker] Kenta Umehara:1
[Co-author] Naohiko Anzai:2, Hidetaka Akita:1, Tomomi Furihata:1,2
1:Drad Sch Pharmaceut Sci, Chiba University, Japan, 2:Grad Sch Med, Chiba University, Japan

nlmx : Nonlinear mixed effect modeling software using AUTO_DERIV and LSODA Library

[Speaker] Mingul Kim:1,2
[Co-author] Jijin Lee:1
1:Center for Clinical Pharmacology and Biomedical Research Institute, Jeonbuk National University Hospital, Korea, 2:Jeonbuk National University, Korea

UFT-induced myelosuppression and its pharmacokinetic-toxicodynamic model in rats

[Speaker] Megumi Matsui:1
[Co-author] Shinji Kobuchi:1, Yukako Ito:1, Toshiyuki Sakaeda:1
1:Pharmacokinetics, Kyoto Pharmaceutical University, Japan

Rationale on the decision-making process for opicapone's bedtime regimen in Parkinson's disease

[Speaker] Patricio Soares-da-Silva:1,2,3
[Co-author] Amilcar Falcao:1,4, Paulo Magalhaes:1, Ana Santos:1, Francisco Rocha:1, Joaquim Ferreira:5
1:Department of Research & Development, BIAL, Portugal, 2:Dept. Biomedicine, Unit of Pharmacology & Therapeutics, Faculty of Medicine, University of Porto, 4200 Porto, Portugal, 3:MedInUp - Center for Drug Discovery and Innovative Medicines, University of Porto, 4200 Porto, Portugal, 4:Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, 3000 Coimbra, Portugal, 5:Laboratory of Pharmacology & Therapeutics, Faculty of Medicine, University of Lisbon, 1600 Lisbon, Portugal

COMPARATIVE BIOEQUIVALENCE OF CARBAMAZEPINE BRANDS SOLD IN SOKOTO

[Speaker] Ezekiel O. Ogbolu:1
[Co-author] Chika Aminu:1, S. O. Bello:1, Mohammed Achor:1
1:PHARMACOLOGY AND THERAPEUTICS, USMAN DAN FODIO UNIVERSITY, SOKOTO STATE, NIGERIA

Clinical Laboratory Reference Values for Caucasian Studies in Japan

[Speaker] Nozomu Miyawaki:1
[Co-author] Ayumi Mugitani:2, Takuma Yonemura:2, Yoichiro Ogama:2, Harumi Murakami:2, Masaharu Takeshima:2, Shigeki Kan:2, Midori Yokoyama:2, Takeshi Chiyoda:2, Shin Irie:3
1:SOUSEIKAI Global Clinical Research Center, Japan, 2:SOUSEIKAI Sumida Hospital, Japan, 3:SOUSEIKAI, Japan

Pharmacokinetic interaction of Thymoquinone with ethanolic and acetonic extract of seeds of Nigella sativa Linn

[Speaker] Jayachandran Nair CV:1
[Co-author] Ujjalkumar Das:2, Rajani Mathur:1, Thirumurthy Velpandian:2
1:Department of Pharmacology, Delhi Institute of Pharmaceutical Science and Research, New Delhi, India, 2:Ocular Pharmacology and Pharmacy Division, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India

Evaluation of the antioxidant effects of Imvusankunzi (a herbal remedy used in the treatment of erectile dysfunction) using neutrophils

[Speaker] Rebone Molobane M. Maboa:1
[Co-author] Tsakani L Rasakanya:1, Tebogo Mdaka:1
1:Pharmacology & Therapeutics, SASBCP, South Africa

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