Sessions

Protective Effects of Antrodia Cinnamomea on Alcoholic Fatty Liver Disease

[Speaker] Yini Cao:1
[Co-author] Lu Xu:1, Qinyu Wang:1, Yunxia Wang:1, Rong Qi:1
1:Peking University Health Science Center, China

Alcohol-induced hepatocyte pyroptosis results from miR-148a dysregulation through FoxO1

[Speaker] Mi Jeong Heo:1
[Co-author] Tae Hyun Kim:1, Sang Geon Kim:1
1:College of Pharmarcy, Seoul National University, Korea

Serotonin-induced DNA synthesis and proliferation are mediated by autocrine secretion of transforming growth factor-α in primary cultures of adult rat hepatocytes

[Speaker] Kota Naito:1
[Co-author] Kazuki Kurihara:1, Hajime Moteki:1, Mitsutoshi Kimura:1, Masahiko Ogihara:1
1:Faculty of Pharmaceutical Sciences, Josai University, Japan

Beta-arrestin2 deficiency protects against hepatic fibrosis in mice and prevents synthesis of extracellular matrix

[Speaker] Wu-Yi Sun:1,2
[Co-author] Yuan-Jing Gu:1,2, Xin-Ran Li:1,2, Wen-Ting Peng:1,2, Jing-Yu Chen:1,2, Yang Ma:1,2, Qing-Tong Wang:1,2, Wei Wei:1,2
1:Institute of Clinical Pharmacology, Anhui Medical University, China, 2:Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, China

Development of transrepression-selective liver X receptor (LXR) ligands

[Speaker] Sayaka Nomura:1,2
[Co-author] Kaori Endo-Umeda:3, Makoto Makishima:3, Yuichi Hashimoto:2, Toshiaki Ishizuka:1, Minoru Ishikawa:2
1:Pharmacology, National Defense Medical College, Japan, 2:The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan, 3:Nihon University School of Medicine, Japan

Role of endogenous PGE2 in liver repair after hepatic ischemia/reperfusion

[Speaker] Yoshiya Ito:1
[Co-author] Nobuyuki Nishizawa:1,2, Koji Eshima:3, Hirotoki Ohkubo:4, Tomoyoshi Inoue:1, Hideki Amano:1, Masataka Majima:1
1:Pharmacology, Kitasato University School of Medicine, Japan, 2:Surgery, Kitasato University School of Medicine, Japan, 3:Immunology, Kitasato University School of Medicine, Japan, 4:Cardiiovascular Surgery, Kitasato University School of Medicine, Japan

The Hepatoprotective Effects Of Coptisine On Carbon Tetrachloride Induced Acute Liver Damage In Mice

[Speaker] Yun-Chieh Chen:1
[Co-author] Chih-Ming Hsu:2, Yu-Shih Lin:3, Keng-Fan Liu:4, Jen-Chieh Tsai:5, Wen-Huang Peng:4, Wei-Sung Li:6
1:School of Pharmacy, College of Pharmacy, China Medical University, Taiwan, 2:Biotechnology Research Center, Da-Yeh University, 168 University Rd, Dacun, Chang-Hua, Taiwan, R. O. C. 5 No 6, Sec. West, Jiapu Rd., Puzi City, Chiayi County, Taiwan, 3:Department of Pharmacy, Chaiyi Chang Gung Memorial Hospital, Chiayi, Taiwan, 4:Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Biopharmaceutical and Food Sciences, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404, Taiwan, 5:Department of Medicinal Botanicals and Health Applications, College of Biotechnology and Bio-resources, Da-Yeh University, 168 University Rd, Dacun, Chang-Hua, Taiwan, 6:Plant Pathology Division, Taiwan Agricultural Research Institute (TARI), Council of Agriculture (COA), Executive Yuan, Wufeng 413, Taiwan

Effect of endoplasmic reticulum stress and acid-sensing ion channel 1a on the process of liver fibrosis

[Speaker] Yan Huang:1
[Co-author] Long Quan Zuo:1, Ying Hong Wang:1, Ya Min Hu:1, Yue Qin Zhu:1
1:School of Pharmacy, Anhui Medical University, Hefei, Anhui Province, China

Mitophagy and oxidative stress in early stage acetaminophen-induced liver injury

[Speaker] Yan Gao:1
[Co-author] Naihong Chen:2, Lei Sha:1
1:China Medical University, China, 2:Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, China

Biochemical and histological changes in a mouse model of nonalcoholic steatohepatitis

[Speaker] Hirokazu Wakuda:1
[Co-author] Li Li:1,2, Takuya Kuramoto:1, Warinda Susutlertpanya:1, Naoyuki Otani:1, Naoto Uemura:1
1:Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine, Oita University, Japan, 2:Faculty of Medicine, Hebei Medical University, China

Signal Transduction Mechanism for 5-HT2B Receptor-Stimulated Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes

[Speaker] Hajime Moteki:1
[Co-author] Kota Naito:1, Kazuki Kurihara:1, Mitsutoshi Kimura:1, Masahiko Ogihara:1
1:Faculty of Pharmaceutical Sciences, Josai University, Japan

Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-mediated inhibition of CCR2

[Speaker] Tian Lan:1
[Co-author] Jiao Guo:1, Changzheng Li:1, Guizhi Yang:1, Yue Sun:1
1:GUANGDONG PHARMACEUTICAL UNIVERSITY, China

5-HT3 receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of Y1 and GLP-1 receptors

[Speaker] Shu-ichi Kojima:1
[Co-author] Ken Kojima:1, Tomoe Fujita:1
1:Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan

Tris-hydroxymethyl-aminomethane conjugation reduces the gastrointestinal side-effects of acetylsalicylic acid. Characterization of a novel anti-inflammatory compound

[Speaker] Mihaly Boros:1
[Co-author] Gabriella Varga:1, Miklos Ghyczy:3, Gabor Toth:2, Daniel Erces:1
1:Institute of Surgical Research, University of Szeged, Hungary, 2:Department of Medical Chemistry, Faculty of Medicine, University of Szeged, Hungary, 3:Cologne, Germany

Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-kB and PPAR-r signaling pathways

[Speaker] Lipeng Xu:1
[Co-author] Yali Yang:1, Hui Yan:1, Mei Jing:1, Pei Yu:1
1:Institute of New Drug Research, Jinan University College of Pharmacy, China

Pharmacological study of β-adrenoceptor subtypes that mediate isoprenaline-induced relaxation of guinea pig colonic longitudinal smooth muscles

[Speaker] Fumiko Yamaki:1
[Co-author] Daisuke Chino:1,2, Tomoyo Sone:1, Kumi Yamazaki:1, Yuri Tsuruoka:1, Risa Yamagishi:1, Shunsuke Shiina:1, Keisuke Obara:1, Koji Higai:3, Yoshio Tanaka:1
1:Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Japan, 2:Department of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Nihon Pharmaceutical University, Japan, 3:Laboratory of Medical Biochemistry, Faculty of Pharmaceutical Sciences, Toho University, Japan

Detection of stress in the gastrointestinal smooth muscle of wakeful rats by electromyography

[Speaker] Kalman F Szucs:1
[Co-author] Gyorgy Grosz:2, Miklos Sule:2, Anita Sztojkov-Ivanov:1, Eszter Ducza:1, Arpad Marki:1, Anna Kothencz:1, Robert Gaspar:1
1:University of Szeged, Hungary, 2:MDE GmbH, Germany

M10, a novel derivative of Myricetin, prevents colitis and colorectal tumorigenesis through attenuating robust endoplasmic reticulum stress

[Speaker] Shuxiang Cui:1
[Co-author] Feng Wang:1, Zhiyu Song:2, Wenbao Li:3
1:Beijing Key Laboratory of Environmental Toxicology, Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, China, 2:Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China, 3:Marine Biomedical Research Institute of Qingdao, Qingdao, China

Berberine Chloride Suppresses the Development of Murine Acute Colitis due to the Enhancement of IL-10 Production in Macrophages

[Speaker] Shusaku Hayashi:1
[Co-author] Nonoka Wakabayashi:1, Ai Hertati:1, Makoto Kadowaki:1
1:Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Japan

Effect of indomethacin on TNBS-induced colitis in mice

[Speaker] Yumiko Mizukawa:1
[Co-author] Aya Matsumura:1, Mizuki Maeda:1, Wako Tanigawa:1, Yoko Amagase:1, Tetsuro Urushidani:1
1:Department of pathophysiology, Department of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Japan

Chronic cyclooxygenase-2 inhibition does not cause gastrointestinal damage in the rat

[Speaker] Bernadette Lazar:1
[Co-author] Gabor Brenner:1, Mihaly Balogh:1, Szilvia Laszlo:1, Mahmoud Al-Khrasani:1, Terezia Laszlo:2, Zsuzsanna Helyes:3, Peter Ferdinandy:1, Klara Gyires:1, Zoltan S Zadori:1
1:Pharmacology and Pharmacotherapy, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvarad ter 4, 1089, Budapest, Hungary, 2:Department of Pathology, University of Pecs, Szigeti ut 12, 7624, Pecs, Hungary, 3:Department of Pharmacology and Pharmacotherapy, University of Pecs, Szigeti ut 12, 7624, Pecs, Hungary

Rofecoxib, in contrast to celecoxib, does not have direct antimicrobial effect and does not cause small intestinal dysbiosis in the rat

[Speaker] Zoltan S. Zadori:1
[Co-author] Bernadette Lazar:1, Gabor Brenner:1, Szilvia Laszlo:1, Emese Bato:2, Eszter Ostorhazi:3, Janos Juhasz:4, Dora Szabo:3, Peter Ferdinandy:1, Klara Gyires:1
1:Department of Pharmacology and Pharmacotherapy, Semmelweis University, Hungary, 2:Second Department of Internal Medicine and Cardiology Center, University of Szeged, Hungary, 3:Institute of Medical Microbiology, Semmelweis University, Hungary, 4:Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Hungary

Microbiota and uremic toxin contribute to intestinal motility dysregulation induced by renal impairment

[Speaker] Kazuhiro Nishiyama:1,2
[Co-author] Yasu-Taka Azuma:2, Hidemitsu Nakajima:2, Tadayoshi Takeuchi:2
1:Department of Translational Pharmaceutical Sciences Graduate School of Pharmaceutical Sciences, Kyushu University, Japan, 2:Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Japan

Guinea-pig ghrelin: its structure, distribution and function in the gastrointestinal tract

[Speaker] Takio Kitazawa:1
[Co-author] Yuji Okuhara:1, Hiroyuki Kaiya:2, Hiroki Teraoka:1
1:School of Veterinary Medicine, Rakuno Gakuen University, Japan, 2:Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Japan

Relationship between GLP-2 dynamics and tissue injury in rat intestine after anti-cancer drugs administration

[Speaker] Saki Shiga:1
[Co-author] Takuji Machida:1, Maiko Machida:2, Masahiko Hirafuji:1
1:Health Sciences University of Hokkaido, Japan, 2:Hokkaido Pharmaceutical University School of Pharmacy, Japan

Carbachol-induced contractile responses in rat colon are influenced by protein kinase C-inhibition in TNBS-induced colitis model

[Speaker] Hiromi Nobe:1
[Co-author] Koji Nobe:2
1:Bunkyo Gakuin University, Japan, 2:Showa University, Japan

Rapid LPS transport during lipid absorption in rat small intestine

[Speaker] Yasutada Akiba:1,2
[Co-author] Jonathan D Kaunitz:1,2
1:Med, UCLA, USA, 2:West LA VAMC, USA

A comparative study on the efficacy of NLRP3 inflammasome signaling inhibitors in a pre-clinical model of bowel inflammation

[Speaker] Carolina Pellegrini:1
[Co-author] Luca Antonioli:1, Rocchina Colucci:2, Daniela Gentile:1, Laura Benvenuti:1, Gianfranco Natale:3, Federica Fulceri:1, Massimo Bertinaria:4, Corrado Blandizzi:1, Matteo Fornai:1
1:Department of Clinical and Experimental Medicine, University of Pisa, Italy, 2:Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy, 3:Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, 4:Department of Pharmaceutical Sciences and Technologies, University of Torino, Torino, Italy

Protective effect of Ocimum basilicum essential oil against acetic acid-induced colitis in rats

[Speaker] Vahid Nikoui:1
[Co-author] Amir Rashidian:2, Saeed Mehrzadi:1, Parnia Roohi:3, Ali Reza Ghannadi:4, Mohsen Minaiyan:3, Muhammad Imran Khan:5
1:Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran, 2:Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 3:Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran, 4:Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran, 5:Department of Pharmacy, Kohat University of Science and Technology, 26000 Kohat, KPK, Pakistan

PLX-R18- Placenta-derived Mesenchymal-like Stromal Cells are efficacious in reducing lethality in Gastrointestinal Acute Radiation Syndrome (GI-ARS) Mouse Model

[Speaker] Yoshiyuki Soeda:1
[Co-author] Racheli Ofir:2, Noa Sher:2, Yoshiyuki Suzuki:3, Zami Aberman:2, Akihiro Inano:1
1:Medical Research Center/Clinical Research Center, Fukushima Medical University, Fukushima, Japan, 2:Pluristem Therapeutics Inc., Israel, 3:Department of Radiation Oncology, Japan

Up-regulation of colonic Th1/Th17 cytokines is associated with increased severity of experimental colitis in mice lacking microsomal prostaglandin E synthase-1

[Speaker] Hiroki Sekiya:1,2
[Co-author] Masaki Nakamura:3, Shotaro Maehana:3, Hitoshi Kashiwagi:4, Yoshitaka Imamichi:4, Koh-Ichi Yuhki:4, Fumitaka Ushikubi:4, Takafumi Ichikawa:2, Hidero Kitasato:3, Fumiaki Kojima:1,2
1:Department of Pharmacology, Kitasato University School of Allied Health Sciences, Japan, 2:Department of Regulation Biochemistry, Kitasato University Graduate School of Medical Sciences, Japan, 3:Department of Environmental Microbiology, Kitasato University Graduate School of Medical Sciences, Japan, 4:Department of Pharmacology, Asahikawa Medical University, Japan

Involvement of peripheral alpha2A adrenoceptor in the acceleration of gastrointestinal transit and abdominal pain induced by intermittent sleep deprivation

[Speaker] Fukie Yaoita:1
[Co-author] Keigo Kawanami:1, Hiroki Imaizumi:1, Takeshi Tadano:2, Koichi Tan-No:1
1:Department of Pharmacology, Faculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, Japan, 2:Department of Complementary and Alternative Medicine, Clinical R&D Kanazawa University Graduate School of Medical Science, Japan

Involvement of TRPV4 in the regulation of angiogenesis in colitis-associated cancer in mice

[Speaker] Kenjiro Matsumoto:1
[Co-author] Daichi Utsumi:1, Kikuko Amagase:1, Makoto Tominaga:2, Shinichi Kato:1
1:Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Japan, 2:Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, Japan

Contractile response to TRPA1 activation by allyl-isothiocyanate in isolated mouse distal colon: role of substance P and CGRP released from TRPA1-expressing neurons

[Speaker] Kimihito Tashima:1
[Co-author] Yuki Goto:1, Yukiko Noma:1, Kazuki Hashimoto:1, Syunji Horie:1
1:Lab. of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International Univ., Japan

Zinc transporter SLC39A7/ZIP7 contributes to the tumorigenic potentials of human colorectal cancer cells

[Speaker] Ryusuke Horaguchi:1
[Co-author] Wakana Ohashi:1, Naoki Yamamine:1, Tetsuro Oda:1, Yuichi Hattori:1
1:Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan

Zinc transporter SLC39A7/ZIP7 is essential for intestinal homeostatic self-renewal

[Speaker] Wakana Ohashi:1
[Co-author] Koji Hase:2, Toshiyuki Fukada:3
1:Department of Molecular and Medical Pharmacology, Graduate School and Pharmaceutical Sciences, University of Toyama, Japan, 2:Division of Biochemistry, Faculty of Pharmacy, Keio University, Japan, 3:Molecular and Cellular Physiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan

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