Sessions

A lupane-type triterpene LS-PH inhibits neutrophil activation and protects against acute lung injury by blocking FPR1

[Speaker] Yi-hsuan Wang:1
[Co-author] Yung-Fong Tsai:2, Tsong-Long Hwang:1,2
1:Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan, 2:Department of Anesthesiology, Chang Gung Memorial Hospital, Taiwan

Fucoxanthin suppress GATA-3 positive immuno-responses

[Speaker] Kosuke Tanaka:1
[Co-author] Chika Natsume:1, Yasutaka Azuma:2, Takashi Fujita:1
1:Molecular toxicology lab., Ritsumeikan University, Japan, 2:Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Japan

The expression levels of PD-L1 in cancer cells affect γδT cell cytotoxicity

[Speaker] Mako Tomogane:1
[Co-author] Teruki Shimizu:1,2, Masatsugu Miyashita:1,2, Yusuke Sano:1, Daiki Shimizu:1, Keigo Amari:1, Ryosuke Wakabayashi:1, Yuki Toda:1, Kazuyuki Takata:1, Eishi Ashihara:1
1:Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Japan, 2:Department of Urology, Kyoto Prefectural University of Medicine, Japan

Cell cycle and apoptosis in gingival fibroblasts exposed to nifedipine

[Speaker] Reiri Takeuchi:1
[Co-author] Hiroko Matsumoto:2, Chieko Taguchi:3, Kazumune Arikawa:3, Ko Ito:4, Akinobu Aoki:4, Kosuke Takahashi:4, Toshirou Kondoh:4, Koichi Hiratsuka:1
1:Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Japan, 2:Pharmacology, Nihon University School of Dentistry at Matsudo, Japan, 3:Preventive and Public Oral Health, Nihon University School of Dentistry at Matsudo, Japan, 4:Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo, Japan

The mechanism of phenytoin-induced gingival overgrowth on mitogen-activated protein kinase pathway

[Speaker] Hiroko Matsumoto:1
[Co-author] Reiri Takeuchi:2, Makiko Ono:3, Hitoshi Nishimura:3, Masamichi Komiya:3
1:Pharmacology, Nihon University School of Dentistry at Matsudo, Japan, 2:Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Japan, 3:Oral Surgery, Nihon University School of Dentistry at Matsudo, Japan

Molecular biochemical characterization of selective glucocorticoid receptor activities of GSK866 analogues with cysteine reactive warheads

[Speaker] Wim Vanden Berghe:1
[Co-author] Chandra S. Chirumamilla:1, Ajay Palagani:1,2, Marinus Verbeeck:1, Ryabtsova Oksana:3, Balu Kamaraj:4, Karolien De Bosscher:5, Nadia Bougarne:5, Bart Ruttens:6, Kris Gevaert:6, Rene Houtman:7, Winnok H. De Vos:8, Jurgen Joossens:3, Pieter Van Der Veken:3, Koen Augustyns:3, Xaveer Van Ostade:1, Annemie Bogaerts:4, Hans De Winter:3
1:Laboratory of Protein Chemistry, Proteomics and Epigenetic Signalling, Department of Biomedical Sciences, University of Antwerp (UA), Belgium, 2:Radiation Oncology Department, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA, 3:Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium, 4:Research group PLASMANT, Department of Chemistry, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk-Antwerp, Belgium, 5:Nuclear Receptor Signaling Unit, CRL, VIB-UGent Department of Medical Protein Research, Ghent, Belgium, 6:Center for Medical Biotechnology, VIB-UGent Department of Biochemistry, Ghent, Belgium, 7:PamGene International B.V., Den Bosch, the Netherlands, 8:Laboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium

The Effect of the Immunosuppressive Agent on Scleroderma in a Graft Versus Host Disease (GVHD) Model Using an X-ray Irradiation Device in Mice

[Speaker] Shiruku Hosoi:1
[Co-author] Shinichi Ozato:1, Tatsumi Wada:1, Takumi Yamazawa:1, Shinichiro Tsunesumi:1, Seiichi Katayama:1, Katsuhide Nishi:1, Naoyuki Hironaka:1
1:Pharmacology Department, Kumamoto Laboratory, LSI Medience Corporation, Japan

GRK2 contributes to LPS-induced M1 polarization of microglia through STAT signaling

[Speaker] Sailesh Palikhe:1
[Co-author] Wakana Ohashi:1, Masaaki Kawakami:1, Yuichi Hattori:1
1:Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan

Anti-inflammatory effect of Haloperidol in Rat: inhibit Activation of TLR/MD-2

[Speaker] Nima Bakhtiari:1
[Co-author] Amir Abbasnezhad:2, Siamak Asri Rezaei:3, Razie Choghakhori:2, Amin Hasanvand:2
1:Basic Pharmacology, Faculty of Pharmacy, Ahvaz Jundishapur University of medical science, Iran, 2:Nutritional Health Research Center, Department of Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran, 3:Department of Internal medicine and Clinical pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Human Macrophage derived Myeloperoxidase exacerbates Nonalcoholic steatohepatitis (NASH) in Diet-induced Obesity

[Speaker] Lalage A Katunga:1,2,3
[Co-author] Jacob D Franke:1,2,3, Kevin A Schulte:1,2,3, David A Ford:1,2,3
1:Saint Louis University, USA, 2:Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, USA, 3:Center for Cardiovascular Research, Saint Louis University School of Medicine, St Louis, USA

The in vitro inhibition and stimulation of isolated diabetic human neutrophils by commercial herbal medicines used as African traditional medicines

[Speaker] Mmamosheledi E Mothibe:1
[Co-author] Christina Kahler-Venter:2, Elzbieta Osuch:2
1:School of Pharmacy, Department of Pharmaceutical Sciences, Sefako Makgatho Health Sciences University, South Africa, 2:School of Medicine, Department of Pharmacology and Therapeutics, Sefako Makgatho Health Sciences University, South Africa

A SUPPRESSIVE EFFECT OF HISPIDULIN ON ALLERGIC CONTACT DERMATITIS IN MICE

[Speaker] Premrutai Thitilertdecha:1,2
[Co-author] Panwadee Pluangnooch:3, Sunita Timalsena:3, Kitipong Soontrapa:3
1:Department of Research and Development, Faculty of Medicine Siriraj Hospital, Thailand, 2:Siriraj Research Group in Immunobiology and Therapeutic Sciences, Faculty of Medicine Siriraj Hospital, Thailand, 3:Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Thailand

Characterization of histidine-rich glycoprotein (HRG) production under the experimental pathological conditions

[Speaker] Kiyoshi Teshigawara:1
[Co-author] Atsuko Niwa:2, Hidenori Wake:1, Dengli Wang:1, Keyue Liu:1, Shuji Mori:3, Hideo Takahashi:2, Masahiro Nishibori:1
1:Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan, 2:Department of Pharmacology, Faculty of Medicine, Kinki University, Japan, 3:School of Pharmacy, Shujitsu University, Japan

The effects of histidine-rich glycoprotein on neutrophil-like differentiated cell lines

[Speaker] Yukinori Yoshii:1
[Co-author] Hidenori Wake:1, Kiyoshi Teshigawara:1, Keyue Liu:1, Dengli Wang:1, Yohei Takahashi:1, Masahiro Nishibori:1
1:Pharmacology, Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, Japan

Negative regulation of JNK-mediated monocyte adhesion to human pulmonary microvascular endothelial cells by p38 MAPK

[Speaker] Tokiko Suzuki:1
[Co-author] Sailesh Palikhe:1, Kimimasa Sakata:1, Natsumi Mizuno:1, Yuichi Hattori:1
1:Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

Suppression of the expression of ubiquitin ligase RNF183 ameliorates dextran sodium sulfate-induced colitis

[Speaker] Yan Wu:1
[Co-author] Kazunori Imaizumi:1, Masayuki Kaneko:1
1:Department of Biochemistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan

Efficacy and safety of iguratimod in patients with rheumatoid arthritis

[Speaker] Satoshi Mizutani:1,2,3
[Co-author] Yoshiko Sato:2, Toshihiro Nanki:1, Shunji Yoshida:3
1:Division of Rheumatology, Department of Internal Medicine. School of Medicine, Faculty of Medicine, Toho University, Japan, 2:Department of Internal Medicine, Yokkaichi Hazu Medical Center, Japan, 3:Division of Infectious Disease and Rheumatology, Department of Internal Medicine. Fujita Health University School of Medicine, Japan

Pharmacokinetics, pharmacodynamics and tolerability of HL2351, a hybrid Fc-fused human Interleukin-1 receptor antagonist, in healthy subjects

[Speaker] Ki Young Huh:1
[Co-author] Jaeseong Oh:1, Eunwoo Kim:1, Ji-Eun Cha:2, Se-Jin Kim:2, Young-Gyu Cho:2, Kyung-Sang Yu:1, Seo Hyun Yoon:1, Howard Lee:1,3
1:Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea, 2:HANDOK Inc., Seoul, Korea, 3:Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea

Interleukin-19 is a negative regulator in TNBS-induced experimental colitis

[Speaker] Yasu-Taka Azuma:1
[Co-author] Yukiko Matsuo:1, Hidemitsu Nakajima:1, Tadayoshi Takeuchi:1
1:Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Japan

IL-19 plays an important role in the hepatic fibrosis induced by choline-deficient and high-fat (60%) diet with 0.1% methionine and 2% cholesterol

[Speaker] Yumi Ushikai:1
[Co-author] Kana Hirota:1, Hidemitsu Nakajima:1, Tadayoshi Takeuchi:1, Yasu-Taka Azuma:1
1:Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Japan

Interleukin-19 reduces inflammation in DSS-induced acute colitis

[Speaker] Kimiya Aono:1
[Co-author] Yukiko Matsuo:1, Hidemitsu Nakajima:1, Tadayoshi Takeuchi:1, Yasu-Taka Azuma:1
1:Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Japan

Interleukin-19 protects mice from oxazolone-induced colonic inflammation

[Speaker] Mariko Miki:1
[Co-author] Yasuyuki Fujimoto:1, Hidemitsu Nakajima:1, Tadayoshi Takeuchi:1, Yasu-Taka Azuma:1
1:Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Japan

IL-33 expression is regulated by YKL-40 in airway epithelial cells

[Speaker] Yutaka Hirata:1
[Co-author] Yoshitaka Oku:1, Hisako Matsumoto:2
1:Physiology, Hyogo College of Medicine, Japan, 2:Respiratory Medicine, Kyoto University, Japan

The effects of immunoglobulin D on T cell activation and differentiation in human

[Speaker] Yujing Wu:1
[Co-author] Hengshi Chen:1, Xiaojie Dong:1, Wensheng Chen:1, Jin Dong:1, Xing Dai:1, Qiong Huang:1, Wei Wei:1
1:Institute of Clinical Pharmacology, Anhui Medical University, China

Magnesium Isoglycyrrhizinate Ameliorates Hepatocytes Against Cyclophosphamide-Induced Hepatotoxicity By Promoting Activation Of The NF-KB/MAPK Signaling Pathway

[Speaker] Aiyun Wang:1,2
[Co-author] Jinqiu Zhong:1, Yin Lu:1,2, Yuzhu Cao:1
1:Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, China, 2:Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, China

Pathophysiological role of a factor affecting AGEs-RAGE interaction on endothelial cell responses

[Speaker] Shuji Mori:1
[Co-author] Masahiro Watanabe:1, Hidenori Wake:2, Keyue Liu:2, Kiyoshi Teshigawara:2, Hideo Takahashi:3, Masahiro Nishibori:2, Takao Toyomura:1
1:Department of Pharmacology, School of Pharmacy, Shujitsu University, Japan, 2:Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan, 3:Department of Pharmacology, Faculty of Medicine, Kindai University, Japan

Role of cAMP/cGMP-PDE inhibitors and their interactions with L-arginine & L-NAME in adjuvant induced rheumatoid arthritis in rats

[Speaker] Rishi Pal:1
[Co-author] Prafulla C Tiwari:1, Rajendra Nath:1, Kamlesh K Pant:1
1:KING GEORGE'S MEDICAL UNIVERSITY, UP, India

Involvement of purinoceptor expressed on M1 like macrophage in neuropathic pain

[Speaker] Daichi Kobayashi:1
[Co-author] Norikazu Kiguchi:1, Fumihiro Saika:1, Shinsuke Matsuzaki:1, Shiroh Kishioka:1
1:Department of Pharmacology, Wakayama Medical University, Japan

Inhibition of LPS-induced inflammatory cytokine expression with a new immunosuppressive compound

[Speaker] Ryusuke Sin:1
[Co-author] Naoki Sotogaku:1, Akinori Nishi:1
1:Department of Pharmacology, Kurume University School of Medicine, Japan

Fucoxanthin inhibits PM2.5-induced inflammatory response in MH-S cells

[Speaker] Yuan Yen Chang:1
[Co-author] Yi Chen Chen:2, Chin Lin Hsu:3, Hui Wen Lin:4
1:Department of Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taiwan, 2:Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan, 3:School of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan, 4:Department of Optometry, Asia University, Taichung 413, Taiwan

Fisetin inhibits viral-induced inflammatory response in MH-S cells

[Speaker] Hui Wen Lin:1
[Co-author] Yi Chen Chen:2, Chin Lin Hsu:3, Yuan Yen Chang:4
1:Department of Optometry, Asia University, Taiwan, 2:Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan, 3:School of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan, 4:Department of Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan

Consideration in developing new anti-inflammatory immune drugs- Soft regulation of inflammatory immune responses

[Speaker] Wei Wei:1
1:Anhui Medical University, China

Constitutive Activation of Integrin α9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis

[Speaker] Takashi Emori:1,2
[Co-author] Jun Hirose:2, Michiko Kasahara:1, Hiroyuki Yoshitomi:1, Hiromu Ito:3, Motomu Hashimoto:4, Shingo Sugahara:2, Hirotada Fujita:2, Nobuchika Yamamoto:2, Shuh Narumiya:1, Ichiro Aramori:1,2
1:Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Japan, 2:Drug Discovery Research, Astellas Pharma Inc., Japan, 3:Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Japan, 4:Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Japan

Inhibitory effects of an orally active small molecule alpha4beta1/alpha4beta7 integrin antagonist, TR-728, on DSS-induced experimental colitis in mice and spontaneous colitis in HLA-B27 transgenic rats

[Speaker] Yoko Koga:1
[Co-author] Rie Sasaki:1, Hiroe Hirokawa:1, Sunao Hara:1, Kenichi Hayashi:1, Hiroyuki Meguro:1, Mie Kainoh:1
1:Pharmaceutical Research Laboratories, Toray Industries, Inc., Japan

Inhibitory effects of an orally active small molecule alpha4beta1/alpha4beta7 integrin antagonist, TR-728, on TNBS-induced colitis in rats

[Speaker] Rie Sasaki:1
[Co-author] Yoko Koga:1, Hiroe Hirokawa:1, Shoichi Itaba:1, Hiroyuki Meguro:1, Mie Kainoh:1
1:Pharmaceutical Research Laboratories, Toray Industries, Inc., Japan

Pharmacological effect by the combination of molecular target medicine and interferon gamma

[Speaker] Hiromichi Tsuchiya:1
[Co-author] Shotaro Kamijyo:1, Toshihiko Gocho:1, Yoshitaka Yamazaki:2, Yui Akita:3
1:Medical pharmacology, Showa university, Japan, 2:Department of Hospital Pharmaceutics, Showa university, Japan, 3:School of Pharmacy, Showa university, Japan

A key role of CUG-binding protein 1 in HSC activation and liver fibrogenesis revealed by fraxinellone

[Speaker] Xingxin Wu:1,2
[Co-author] Xudong Wu:1,2, Yang Sun:1,2, Xuefeng Wu:1,2, Qiang Xu:1,2
1:School of Life Sciences, Nanjing University, China, 2:State Key Laboratory of Pharmaceutical Biotechnology, China

Anti-allergy medicine tranilast inhibits IL-33 production by macrophages with concomitant suppression of Akt activity

[Speaker] Sachiko Hiraide:1
[Co-author] Yoshiki Yanagawa:1, Kenji Iizuka:1
1:Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan

Interleukin-19 contributes to T cell-mediated contact hypersensitivity

[Speaker] Yasuyuki Fujimoto:1
[Co-author] Hidemitsu Nakajima:1, Tadayoshi Takeuchi:1, Yasu-Taka Azuma:1
1:Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Japan

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