Sessions

LIPOPOLYSACCHARIDE (LPS) CHANGES THE FUNCTIONAL ALPHA-1 ADRENOCEPTOR SUBTYPE IN THE CAUDA EPIDIDYMIS SMOOTH MUSCLE

[Speaker] Andre Mueller:1,2
[Co-author] Alan As Silva:1, Erick Jr Silva:1, Andre S Pupo:1
1:Department of Pharmacology, Bioscience Institute, Sao Paulo State University (Unesp), Botucatu-SP, Brazil, 2:Federal University of Mato Grosso, Institute of Health Sciences, Sinop-MT, Brazil

Novel pharmacological effects of a jungle ginger on prostate contractility

[Speaker] Nguok Ngie Eunice Su:1,3
[Co-author] Jamie S Simpson:2, Philip Thompson:2, Sabatino Ventura:1
1:Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia, 2:Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia, 3:Sarawak Biodiversity Centre, Kuching, Sarawak, Malaysia

Ibuprofen reduces spontaneous activity and enhances nerve evoked contractions to minimise mitomycin C induced bladder dysfunction

[Speaker] Russ Chess-Williams:1
[Co-author] Eliza West:1, Catherine Mcdermott:1
1:Centre for Urology Research, Bond University, Australia

Medicine candidates of rare earths nano-lanthanum hydroxide in preclinical studie: a novel phosphate binders

[Speaker] Zi-Xing Ma:1
[Co-author] Teng-Fei Yu:2, Yan Wu:3, Dan-Dan Liu:3, Gang Li:4
1:First author, China, 2:Second author, China, 3:Participate in the author, China, 4:Correspondence, China

The dysfunction of clock genes induces nocturia associated with disrupted gene expression rhythm of mechano-sensory channels in the mouse bladder urothelium

[Speaker] Tatsuya Ihara:1
[Co-author] Masayoshi Tanaka:1, Eiji Shigetomi:1, Yoichi Shinozaki:1, Shuichi Koizumi:1
1:Department of Neuropharmacology, University of Yamanashi, Japan

Essential role of CPI-17 for muscle force generation in urinary bladder using CPI-17 genetically modified mice

[Speaker] Chihiro Iga:1
[Co-author] Qunhui Yang:1, Noriyuki Kaji:1, Hiroshi Ozaki:1, Masatoshi Hori:1
1:Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan

Renoprotective effects of edoxaban, a factor Xa inhibitor

[Speaker] Yuya Horinouchi:1
[Co-author] Yasumasa Ikeda:1, Keijo Fukushima:2, Masaki Imanishi:3, Yuki Izawa-Ishizawa:1, Yoshito Zamami:3,4, Hiromichi Fujino:2, Keisuke Ishizawa:3,4, Koichiro Tsuchiya:5, Toshiaki Tamaki:1
1:Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 2:Department of Molecular Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 3:Department of Pharmacy, Tokushima University Hospital, Japan, 4:Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 5:Department of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan

A Retrospective Study of Semen Quality in Young Infertile Men with Androgenetic Alopecia after Discontinuation of Finasteride

[Speaker] Yumi Inoue:1
[Co-author] Makoto Yono:1,2, Megumi Kimura:1, Masaharu Hori:1, Shigeki Tsuji:1, Takanori Tanaka:1, Yukikuni Sakata:1, Shin Irie:1
1:Department of Clinical Pharmacology, Nishi-Kumamoto Hospital, SOUSEIKAI, Japan, 2:Department of Urology, Nishi-Kumamoto Hospital, SOUSEIKAI, Japan

XANTHINE OXIDASE INHIBITOR EFFECT OF 3-ETHYL-4HYDROXY- 5 METHYLBENZALDEHYDE ISOLATED FROM ROSELLE CALYX (HIBISCUS SABDARIFFA L.)

[Speaker] Sri Wahyuningsih:1
[Co-author] Elin Y Sukandar:2, Sukrasno Sukrasno:2
1:Pharmacology and Clinical Pharmacy, Universitas Jenderal Achmad Yani, Indonesia, 2:School of Pharmacy, Institut Teknologi Bandung, Indonesia

Endogenous hydrogen sulfide can function as a relaxation factor in the bladder and prostate of male rats

[Speaker] Suo Zou:1
[Co-author] Takahiro Shimizu:1, Shogo Shimizu:1, Youichirou Higashi:1, Hideaki Ono:1, Takaaki Aratake:1, Masaki Yamamoto:1, Tomoya Hamada:1, Yoshiki Nagao:1, Motoaki Saito:1
1:Department of Pharmacology, Kochi Medical School, Kochi University, Japan

PHARMACOLOGICAL SUBSTANTIATION OF DEVELOPMENT OF SUPPOSITORIES WITH INDOLE-3-CARBINOL AND MELOXICAM FOR TREATMENT OF UROLOGIC DISEASES

[Speaker] Ganna V. Zaychenko:1
[Co-author] Olena A. Ruban:2, Timur B. Ravshanov:3, Volodymyr S. Zaychenko:2, Dmytro V. Muzychko:1
1:Department of Pharmacology, Bogomolets National Medical University, Ukraine, 2:Department of Industrial Technology of Drugs, National University of Pharmacy, Ukraine, 3:Department of Clinical Pharmacology IPPQI, National University of Pharmacy, Ukraine

FUNCTIONAL CHARATERIZATION OF ZEBRAFISH TRANSIENT RECEPTOR POTENTIAL MELASTATIN 2 IN HEK 293 CELL LINE

[Speaker] Ha Nam Tran:1
[Co-author] Masayuki X Mori:5, Tomohiro Numata:3, Hiroshi Hosokawa:2, Shingo Maegawa:2,4, Shingo Tanaka:4, Yasuo Mori:1,5
1:Technology and Ecology, Graduate School of Global Environmental Studies - Kyoto University, Japan, 2:Graduate School of Informatics - Kyoto University, Japan, 3:Fukuoka University School of Medicine, Japan, 4:Graduate School of Biostudies - Kyoto University, Japan, 5:Graduate School of Engineering - Kyoto University, Japan

Nobiletin, a flavone from shekwasha (Citrus depressa), alleviates hypertensive bladder response

[Speaker] Yoshihiko Ito:1
[Co-author] Je T Woo:2, Saori Nishijima:3, Kimio Sugaya:3, Shizuo Yamada:1
1:Graduate School of Integrative Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan, 2:Okinawa Research Center Co., Ltd., Japan, 3:Southern Kinights' Laboratory, Japan

Mangiferin decreases uric acid by both inhibiting XOD activity and promoting diuresis in vivo

[Speaker] Xuechen Li:1
[Co-author] Zhenxin Yan:1, Fei Ye:1
1:Pharmacology, Institute of Material Medica, Chinese Academy of Medical Sciences, China

A role of Osp94, a hypertonic stress sensitive molecular chaperone, in microtubule transport and synthesis of tau alternative splicing variants

[Speaker] Ryoji Kojima:1
[Co-author] Misaki Inayoshi:1, Mariko Morisaki:1, Yuki Nakao:1, Yasuyoshi Mizutani:2
1:Analytical Pharmacology, Meijo University, Japan, 2:Pathology, Fujita Health University School of Medicine, Japan

Roles of brain nitric oxide in micturition of rats

[Speaker] Hideaki Ono:1
[Co-author] Takahiro Shimizu:1, Shogo Shimizu:1, Youichirou Higashi:1, Suo Zou:1, Masaki Yamamoto:1, Takaaki Aratake:1, Tomoya Hamada:1, Yoshiki Nagao:1, Motoaki Saito:1
1:Department of Pharmacology, Kochi Medical School, Kochi University, Japan

A Retrospective Clinical Comparison of Subtype Nonselective and Selective α1-Adrenoceptor Antagonists for Nocturia in Male Patients with Hypertension and Benign Prostatic Hyperplasia

[Speaker] Megumi Kimura:1
[Co-author] Makoto Yono:1,2, Yumi Inoue:1, Masaharu Hori:1, Shigeki Tsuji:1, Takanori Tanaka:1, Yukikuni Sakata:1, Shin Irie:1
1:Department of Clinical Pharmacology, Nishi-Kumamoto Hospital, SOUSEIKAI, Japan, 2:Department of Urology, Nishi-Kumamoto Hospital, SOUSEIKAI, Japan

Should overactive bladder symptoms be reported as means or medians? An exploratory study with propiverine

[Speaker] Martin C Michel:1
[Co-author] Marjan Amiri:2, Sandra Murgas:3
1:Pharmacology, Johannes Gutenberg University, Germany, 2:University of Duisburg-Essen, Germany, 3:Apogepha, Germany

Regulation of sodium-coupled monocarboxylate transporter 1 function by PDZ domain-containing RING finger 3

[Speaker] Yusuke Otsuka:1,2
[Co-author] Yuta Ohno:3, Naoyuki Otani:4, Promsuk Jutabha:5, Tomomi Furihata:1, Motoshi Ouchi:5, Shuichi Tsuruoka:2, Naohiko Anzai:1,5
1:Department of Pharmacology, Chiba University Graduate School of Medicine, Japan, 2:Department of Nephrology, Graduate School of Medicine, Nippon Medical School, Japan, 3:Department of Pharmacy, Gifu University Hospital, Japan, 4:Department of Clinical Pharmacology and Therapeutics, Oita University Faculty of Medicine, Japan, 5:Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan

5-HT2 and 5-HT2B inhibitors mitigate fibrotic phenotype of peritoneal fibroblasts via non-canonical signaling in patients on continuous ambulatory peritoneal dialysis

[Speaker] Saurabh Chaturvedi:1
[Co-author] Harshit Singh:1, Ravi Mishra:1, Vikas Agarwal:1, K C Rastogi:2, Narayan Prasad:3
1:Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, India, 2:Hygia Institute of Pharmaceutical Education and Research, India, 3:Nephrology, Sanjay Gandhi post graduate Institute of Medical Sciences, India

Verification of Pharmacodynamic Equivalence of Granule and Capsule Formulations of Bixalomer, A Non-absorbable Phosphate Binder

[Speaker] Yuki Nomura:1
[Co-author] Junichi Taguchi:2, Yusuke Yamaguchi:3, Kentaro Kuroishi:3, Toshifumi Hatta:4, Masataka Katashima:4, Taiji Sawamoto:1
1:Research Program Management, Drug Discovery Research, Astellas Pharma Inc., Japan, 2:Analytical Research Labs., Pharmaceutical Technology, Astellas Pharma Inc., Japan, 3:Japan-Asia Data Science, Development, Astellas Pharma Inc., Japan, 4:Clinical Pharmacology, Development, Astellas Pharma Inc., Japan

Glycolysis, but not Mitochondria, responsible for intracellular ATP distribution in cortical area of podocytes

[Speaker] Shota Ozawa:1,2
[Co-author] Shuko Ueda:1, Hiromi Imamura:3, Kiyoshi Mori:1,4, Katsuhiko Asanuma:1,5, Motoko Yanagita:1,6, Takahiko Nakagawa:1,7
1:TMK project, Medical Innovation Center, Kyoto University, Japan, 2:Research Unit/Innovative Medical Science, Mitsubishi Tanabe Pharma Corporation, Japan, 3:Laboratory of Functional Biology, Graduate School of Biostudies, Kyoto University, Japan, 4:School of Pharmaceutical Sciences, University of Shizuoka, Japan, 5:Department of Nephrology, Chiba University Graduate School of Medicine, Japan, 6:Department of Nephrology, Kyoto University Graduate School of Medicine, Japan, 7:Department of Future Basic Medicine, Nara Medical University, Japan

A role for the Rho-kinase pathway in mediating smooth muscle tone of the porcine prostate and corpus cavernosum

[Speaker] Donna J Sellers:1
[Co-author] Amelia Jack:1, Russ Chess-Williams:1
1:Centre for Urology Research, Faculty of Health Sciences and Medicine, Bond University, Australia

Body weight is a risk factor for hyperkalemia related with RAAS blockers treatments

[Speaker] Toshinori Hirai:1
[Co-author] Ryosuke Yamaga:1, Akiko Fujita:1, Toshimasa Itoh:1
1:Pharmacy, Tokyo Womens Medical University Medical Center East, Japan

Comparative research of affecting condition of SDS preparation in lipid per oxidation in the process of kidney inflammation which was formed by kanamycin

[Speaker] Narantungalag Dorjsuren:1
[Co-author] Gundegmaa Tserensonom:2, Khaliun Nyambayar:1, Sarnai Sukhbaatar:1
1:Mongolian National University of Medical Sciences, Mongolia, 2:Ach Medical University of Mongolia, Mongolia

Increased glucocorticoid hormone actions induce skin-specific Na+ and water loss in melanocortin 3 receptor knockout mice

[Speaker] Kento Kitada:1
[Co-author] Yahua Zhang:2, Janet D Klein:3, Adriana Marton:2, Steffen Daub:2, Akira Nishiyama:4, Friedrich C Luft:5, Jeff M Sands:3, Jens Titze:1,2
1:Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, 2:Division of Clinical Pharmacology, Vanderbilt University Medical Center, USA, 3:Renal Division, Department of Medicine, and Department of Physiology, Emory University, USA, 4:Department of Pharmacology, Kagawa University, Japan, 5:N/A, Germany

Possible involvement of TRPM4 channels in the cholinergic contractile responses in mouse detrusor and ileal smooth muscles

[Speaker] Firoj Alom:1
[Co-author] Hayato Matsuyama:2, Hiroshi Nagano:1, Yasuyuki Tanahashi:3, Toshihiro Unno:2
1:Department of Pathogenetic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, Japan, 2:Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Japan, 3:Department of Animal Medical Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Japan

A Design of Clinical Trial ; TARGET-UA (Trial of intensive UA-lowering therapy in CKD patients)

[Speaker] Masato Kasahara:1
[Co-author] Tetsuya Yamamoto:2, Masaya Ikezoe:3, Takahiko Nakagawa:4, Toshiki Moriyama:5, Toshiya Sato:6, Miyoko Hasebe:1, Sachie Matsuda:1, Yoshihiko Saito:7
1:Department of Clinical research, Nara Medical University Hospital, Japan, 2:Hyogo Medical College, Japan, 3:Department of Nephrology Saku Central Hospital, Japan, 4:Department of Future Basic Medicine started Nara Medical University, Japan, 5:Department of Health Promotion Medicine Osaka University Graduate School of Medicine, Japan, 6:Department of Biostatistics Kyoto University School of Public Health, Japan, 7:Department of Cardiology Nara Medical University, Japan

Muscarinic receptor alterations with ageing: The effectiveness of clinical antimuscarincs on the porcine urinary bladder

[Speaker] Christian Moro:1
[Co-author] Eleanor West:1, Zane Stromberga:1, Russ Chess-Williams:1
1:Bond University, Australia

Life span extension of xanthine oxidoreductase knockout mouse by increase of HPRT activity

[Speaker] Makoto Hosoyamada:1
[Co-author] Naoko H Tomioka:1, Tomoko Fukuuchi:2, Toshio Ohtsubo:3, Kiyoko Kaneko:2, Kimiyoshi Ichida:4
1:Department of Human Physiology and Pathology, Faculty of Pharma-Science, Teikyo University, Japan, 2:Department of Biomedical and Analytical Sciences, Faculty of Pharma-Science, Teikyo University, Tokyo, Japan, 3:Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 4:Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

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