Sessions

Involvement of transient receptor potential ankyrin 1 (TRPA1) on nociception and inflammation in a thermal lesion model in rats

[Speaker] Gabriela Trevisan:1,2
[Co-author] Caren Td Antoniazzi:1, Samira D De-Pra:2, Sara M Oliveira:1, Flavia K Rigo:2
1:Physiology and Pharmacology, Federal University of Santa Maria, Brazil, 2:Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (Unesc), Brazil

The inhibitory mechanisms of methylcobalamin on mechanical allodynia in mice infected with herpes simplex virus type-1

[Speaker] Takashi Kikukawa:1
[Co-author] Daisuke Uta:1, Tsugunobu Andoh:1
1:Department of Applied Pharmacology, University of Toyama, Japan

Effects of Chronic Anandamide Administration and The Role of Nitric Oxide on Cisplatin Induced Peripheral Neuropathy in Rats

[Speaker] Cigdem Cengelli Unel:1
[Co-author] Sule Aydin:1, Basak Donertas:1, Emel Ulupinar:2, Orhan Ozatik:3, Bilgin Kaygisiz:1, Engin Yildirim:1, Kevser Erol:1
1:Department of Medical Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey, 2:Department of Anatomy, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey, 3:Department of Histology and Embryology, Faculty of Medicine, Dumlupınar University, Eskisehir, Turkey

The acute effects of chlorogenic acid in cisplatin-induced peripheral neuropathy

[Speaker] Cigdem Cengelli Unel:1
[Co-author] Ezgi Bozkurt:1, Kevser Erol:1
1:Department of Medical Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey

Inhibitory effect of repeated oral administration of chondroitin sulfate on the formalin-induced tactile allodynia in mice

[Speaker] Wataru Nemoto:1
[Co-author] Kotaro Yamada:2, Osamu Nakagawasai:1, Yoshiki Ogata:1, Hidetomo Sakurai:2, Koichi Tan-No:1
1:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Japan, 2:Consumer Health Products Development, ZERIA Pharmaceutical Co., Ltd., Japan

Glucocorticoid regulation of ATP release from spinal astrocytes underlies circadian exacerbation of neuropathic pain

[Speaker] Naoki Kusunose:1
[Co-author] Satoru Koyanagi:1, Naoya Matsunaga:1, Shigehiro Ohdo:1
1:Kyushu University, Japan

Effect of Bone Marrow Derived Mesenchymal Stem Cells on Neuropathic Pain Induced by Cisplatin In Rats

[Speaker] Gulay Sezer:1,2
[Co-author] Arzu Yay:3, Zeynep Burcin Gonen:2, Zeynep Soyer Sarica:4, Gozde Ozge Onder:3, Berkay Saraymen:5, Alan Aydin:6, Emel Ozturk:3, Dilek Bahar:2, Yilmaz Secil:2
1:Pharmacology Department, Erciyes University, School of Medicine, Turkey, 2:Erciyes University, Betul Ziya Eren Genome and Stem Cell Centre, Kayseri, Turkey, 3:Histology and Embriology Department, School of Medicine, Kayseri, Turkey, 4:Erciyes University, Hakan Cetinsaya Experimental and Clinical Research Centre, Kayseri, Turkey, 5:Immunology Department, School of Medicine, Kayseri, Turkey, 6:Anatomy Department, Faculty of Veterinary Medicine, Kayseri, Turkey

Downregulation of spinal astrocytic connexin43 leads to mechanical hypersensitivity through upregulation of interleukin-6 and cyclooxygenase-2 in mice

[Speaker] Norimitsu Morioka:1
[Co-author] Syun Kondo:1, Yoki Nakamura:1, Kazue Hisaoka-Nakashima:1, Yoshihiro Nakata:1
1:Pharmacology, Hiroshima University Graduate School of Biomedical & Health Sciences, Japan

Differential sensory fiber specificity and LPA receptor-involvement between partial sciatic nerve injury-induced and high-fat diet-induced neuropathic pain

[Speaker] Noriko Izuka:1
[Co-author] Chiho Miyama:1, Shintaro Fukuzoe:1, Hiroshi Ueda:1
1:Department of Pharmacology and Therapeutic Innovation, Nagasaki University Institute of Biomedical Sciences, Japan

Analgesic and antiinflammatory activities of dimethoxyflavone, isolated from stereospermum kunthianum stem bark

[Speaker] Fidelis Poh Ching:1
[Co-author] Falodun Abiodun:2
1:Niger Delta University, Wilberforce Island, Yenagoa, Nigeria, 2:University of Benin, Nigeria

Novel enhancement mechanisms of the nociceptive response by serum exosomes in a mouse model of neuropathic pain

[Speaker] Kengo Hamamura:1
[Co-author] Soh Katsuyama:2, Yohei Toyofuku:1, Shunpei Watanabe:1, Yuri Nishimura:1, Nanami Sueishi:1, Taisei Tanaka:1, Takaaki Komatsu:3, Tsukasa Sakurada:4, Kosuke Aritake:1
1:Department of Chemical Pharmacology, Daiichi College of Pharmaceutical Sciences, Japan, 2:Center for Education of Clinical Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan, 3:Drug analysis laboratory, Daiichi College of Pharmaceutical Sciences, Japan, 4:Center for Supporting Pharmaceutical Education, Daiichi College of Pharmaceutical Sciences, Japan

Possible involvement of macrophages in the pathogenesis of HIV-induced distal sensory neuropathic pain

[Speaker] Mpumelelo Ntogwa:1
[Co-author] Satoshi Imai:1, Ren Hiraiwa:1, Madoka Koyanagi:1, Takayuki Nakagawa:1, Kazuo Matsubara:1
1:Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan

Rapid and selective inhibition of dorsal horn inhibitory interneurons induces morphine-resistant spontaneous nocifensive behaviors

[Speaker] Keisuke Koga:1
[Co-author] Kensho Kanehisa:1, Hidetoshi Tozaki-Saitoh:1, Kazuhide Inoue:2, Hidemasa Furue:3,4, Makoto Tsuda:1
1:Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan, 2:Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan, 3:Department of Neurophysiology, Hyogo College of Medicine, Japan, 4:Department of Information Physiology, National Institute for Physiological Sciences, Japan

Involvement of the long non-coding RNA Neat1 in the neuropathic pain and neurite outgrowth following nerve injury

[Speaker] Motoyo Maruyama:1,2
[Co-author] Atsushi Sakai:1, Takashi Okada:3, Hidenori Suzuki:1
1:Department of Pharmacology, Nippon Medical School, Japan, 2:Division of Laboratory Animal Science, Nippon Medical School, Japan, 3:Department of Biochemistry and Molecular Biology, Nippon Medical School, Japan

The analysis of anxiety- and depression-related behaviors in neuropathic pain of mice - possible involvement of brain inflammation

[Speaker] Kazue Hisaoka-Nakashima:1
[Co-author] Yoshiaki Tomimura:1, Toshiki Yoshii:1, Fang Fang Zhang:1, Yoki Nakamura:1, Keyue Liu:2, Masahiro Nishibori:2, Yoshihiro Nakata:1, Norimitsu Morioka:1
1:Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan, 2:Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan

Relationship between pharmacokinetics and the antihyperalgesic and anti-inflammatory effects of meloxicam in the rat

[Speaker] Francisco J. Flores-Murrieta:1,2
[Co-author] Miriam C. Carrasco-Portugal:1, Juan Rodriguez-Silverio:2, Hidemi Aguilar-Mariscal:3
1:Unidad de Investigacin; n en Farmacologia, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico, 2:Escuela Superior de Medicina del Instituto Politecnico Nacional, Mexico, 3:Universidad Juarez Autonoma de Tabasco, Villahermosa, Tabasco, Mexico

Menthol gel for the management of neuropathic pain after hand surgery - a case report

[Speaker] Hannu Kokki:1
[Co-author] Merja Kokki:2
1:Department of Anaesthesiology and Intensive Care, School of Medicine, University of Eastern Finland, Kuopio, Finland, 2:Department of Anaesthesia and Operative Services, Kuopio University Hospital, Finland

Secreted extracellular miRNA, let-7b-5p causes neuropathic pain via TLR7 in peripheral nerve injury

[Speaker] Naoyo Motoyama:1
[Co-author] Katsuya Morita:2, Sayaka Asano:3, Yui Jodo:2, Mayu Shigaki:2, Mari Sanai:4, Toshihiro Dohi:2
1:Biological Endodontics, Hiroshima University, Japan, 2:Pharmacology, Hiroshima Bunka Gakuen University, Japan, 3:Oral Diagnostic Science, Nihon University School of Dentistry, Japan, 4:Gerontology, Hiroshima Bunka Gakuen University, Japan

New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury

[Speaker] Tomohiro Yamashita:1,2
[Co-author] Sawako Kamikaseda:2, Aya Tanaka:2, Hidetoshi Tozaki-Saitoh:2,3, Makoto Tsuda:2,3, Kazuhide Inoue:2
1:Laboratory of Global Healthcare, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan, 2:Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan, 3:Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan

Role of miR-17-92 in the functional changes of primary sensory neurons following nerve injury

[Speaker] Atsushi Sakai:1
[Co-author] Fumihito Saitow:1, Motoyo Maruyama:1,2, Noriko Miyake:3, Koichi Miyake:3, Takashi Okada:3, Hidenori Suzuki:1
1:Department of Pharmacology, Nippon Medical School, Japan, 2:Division of Laboratory Animal Science, Nippon Medical School, Japan, 3:Department of Biochemistry and Molecular Biology, Nippon Medical School, Japan

Analgesic effect of GT-0198, a structurally novel glycine transporter 2 inhibitor, on a mouse model of neuropathic pain

[Speaker] Yu Omori:1
[Co-author] Mayumi Nakajima:1, Kazumi Nishimura:1, Eiki Takahashi:1, Tadamasa Arai:1, Masato Akahira:1, Tomohiko Suzuki:1, Mie Kainoh:1
1:Pharmaceutical Research Laboratories, Toray Industries, Inc., Japan

Antihyperalgesic and antiallodynic effects of alpha-terpineol in neuropathic pain induced by chronic constriction injury in rat sciatic nerve

[Speaker] Siavash Parvardeh:1
[Co-author] Mohsen Soleimani:1, Mohammad Abbas Sheikholeslami:1, Shiva Ghafghazi:1
1:Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Iran

Therapeutic effects of an NK1 receptor antagonist on mechanical hypersensitivity and bone loss in partial sciatic nerve ligated mice

[Speaker] Daisuke Kodama:1
[Co-author] Yoshiaki Ohi:1, Akira Haji:1
1:Laboratory of Neuropharmacology, School of Pharmacy, Aichi-Gakuin University, Japan

Anti-allodynic effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain

[Speaker] Ryota Yamagata:1
[Co-author] Wataru Nemoto:1, Yoshiki Ogata:1, Osamu Nakagawasai:1, Koichi Tan-No:1
1:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Japan

TRK-700, A NOVEL CENTRALLY ACTING ANALGESIC WITH NO SEDATIVE EFFECT IN ANIMAL MODELS OF NEUROPATHIC PAIN

[Speaker] Chihiro Kaneko-Yoshida:1
[Co-author] Takashi Morimoto:1, Naoki Izumimoto:1, Tatsuya Nishi:1, Tomohiko Suzuki:1, Mie Kainoh:1
1:Pharmaceutical Research Laboratories, Toray Industries, Inc., Japan

A major iridoid glycoside loganin protects against neuropathic pain via the suppression of TNF-α/NF-κB signaling pathway

[Speaker] Bin-Nan Wu:1
[Co-author] Yu-Chin Chang:1, Li-Wen Chu:1, Su-Ling Hsieh:2
1:Department of Pharmacology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 2:Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

Involvement of HVDCCs in oxymatrine suppressing neuropathic pain

[Speaker] Li Yang:1,2
1:School of Pharmaceutical Science and Technology, Dalian University of Technology, China, 2:Liaoning University of Traditional Chinese Medicine, China

To study the anti-hyperalgesic and anti-allodynic effects of Atorvastatin and Low Dose Naltrexone in Vincristine Induced Peripheral Neuropathic Pain Model in Rats

[Speaker] Saniya Mahendiratta:1
[Co-author] Amitava Chakrabarti:1, Debasish Hota:2
1:Pharmacology, PGIMER, India, 2:Department of Pharmacology, AIIMS, Bhubneshwar, India

A search for effective drugs for treating chemotherapy-induced peripheral neuropathy

[Speaker] Reiko Ishii-Nozawa:1
[Co-author] Yuya Umeda:1, Hidekazu Ikeya:1, Yoshihiko Haraguchi:1, Hajime Kagaya:1
1:Department of Clinical Pharmaceutics, Meiji Pharmaceutical University, Japan

Optogenetic activation of non-nociceptive Aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

[Speaker] Ryoichi Tashima:1
[Co-author] Keisuke Koga:1, Misuzu Sekine:1, Kensho Kanehisa:1, Yuta Kohro:1, Yugo Fukazawa:2, Kazuhide Inoue:3, Hiromu Yawo:4, Hidemasa Furue:5, Makoto Tsuda:1
1:Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan, 2:Department of Brain Structure and Function, Research Center for Child Mental Development, Faculty of Medical Sciences, Fukui University, Japan, 3:Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan, 4:Department of Developmental Biology and Neuroscience, Graduate School of Life Sciences, Tohoku University, Japan, 5:Division of Neural Signaling, National Institute for Physiological Sciences, Japan

Chemotherapy with consideration to biological rhythm reduce oxaliplatin- induced peripheral neuropathy

[Speaker] Yoshihiro Seto:1
[Co-author] Masashi Wanifuchi:1, Aya Takahara:1, Shunsuke Takakura:1, Fumiyasu Okazaki:1, Mari Tomonari:1, Hideto To:1
1:Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan

Role of spinal LPCAT2, an inducible PAF synthesis enzyme on development and maintenance of painful peripheral neuropathy models in mice

[Speaker] Katsuya Morita:1
[Co-author] Naoyo Motoyama:2, Tomoya Kitayama:3, Mari Sanai:4, Midori Hashimoto:5, Akiko Tsuchii:1, Kazuna Kato:1, Yuno Kawai:1, Toshihiro Dohi:1
1:Pharmacology, Hiroshima Bunka Gakuen University, Japan, 2:Biological Endodontics, Hiroshima University, Japan, 3:Pharmacy, Mukogawa Women's University, Japan, 4:Gerontology, Hiroshima Bunka Gakuen University, Japan, 5:Psychology, Hiroshima Bunka Gakuen University, Japan

Meningeal extravasation, efficacy of botulinum toxin or triptans is not specific for pathophysiology of migraine only

[Speaker] Zdravko Lackovic:1
[Co-author] Ivica Matak:1, Boris Filipovic:2, Visnja Drinovac-Vlah:3, Lidija Bach-Rojecky:3
1:Pharmacology, University of Zagreb, School of Medicine, Croatia, 2:Clinical Hospital ‘Sveti Duh’, Croatia, 3:Pharmacology, University of Zagreb, School of Pharmacy and Biochemistry, Croatia

Glycinergic dysfunction in a subpopulation of dorsal horn neurons in a neuropathic pain model

[Speaker] Wendy L Imlach:1
1:Physiology, Monash University, Australia

Critical role of the morphine-activated VTA neuron in pain relief

[Speaker] Naoko Kuzumaki:1
[Co-author] Moe Watanabe:1, Michiko Narita:1, Yusuke Hamada:1, Daisuke Sato:1, Vivianne L. Tawfik:2, Hideki Tamura:3, Akihiro Yamanaka:4, Minoru Narita:1,3
1:Dept. Pharmacol., Hoshi Univ., Tokyo, Japan, 2:Dept. Anesthesiol., Perioperative and Pain Med., Stanford Univ. Sch. Med., Palo Alto, USA, 3:L-StaR, Hoshi Univ., Tokyo, Japan, 4:Dept. Neurosci. II, RIEM, Nagoya Univ. Aichi, Japan

Abnormal expression patterns of nociceptors in Parkinson's disease-specific iPSC-derived sensory neurons

[Speaker] Chizuru Iwasawa:1
[Co-author] Naoko Kuzumaki:1, Reona Asano:1, Hideki Tamura:2, Nobutaka Hattori:3, Hideyuki Okano:2,4, Minoru Narita:1,2
1:Department of Pharmacology, Hoshi University, Japan, 2:L-StaR, Hoshi University, Japan, 3:Department of Neurology, Juntendo University School of Medicine, Japan, 4:Department of Physiology, Keio University School of Medicine, Japan

Social defeat stress arouse recurrence of pain in ameliorating state

[Speaker] Hidetoshi Saitoh:1
[Co-author] Takuya Hatta:1, Kazuhide Inoue:1, Makoto Tsuda:1
1:Kyushu University, Japan

Somatostatin receptor subtype 4 is a promising drug target for the treatment of neuropathic pain, neurogenic inflammation, anxiety and depression

[Speaker] Zsuzsanna Helyes:1
[Co-author] Erika Pinter:1, Eva Szoke:1, Balint Scheich:1, Agnes Hunyady:1, Eva Borbely:1, Valeria Tekus:1, Csaba Hetenyi:1, Monika Balint:1, Janos Szolcsanyi:1
1:Department of Pharmacology and Pharmacotherapy, Medical School & Szentagothai Research Centre, University of Pecs, Hungary

A pruritogen 5-HT-induced itching on synaptic transmission in spinal superficial dorsal horn neurons -In vivo patch-clamp recording analyse-

[Speaker] Daisuke Uta:1,2
[Co-author] Tsugunobu Andoh:1, Yasushi Kuraishi:1, Keiji Imoto:2, Hidemasa Furue:2,3
1:Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan, 2:Department of Information Physiology, National Institute for Physiological Sciences, Japan, 3:Department of Neurophysiology, Hyogo College of Medicine, Japan

Direct impairment of Schwann cells by taxanes and platinum derivatives participates in the chemotherapy-induced peripheral neuropathy pathogenesis

[Speaker] Madoka Koyanagi:1
[Co-author] Satoshi Imai:1, Mayuna Matsumoto:1, Takashi Ogihara:1, Yui Nakazato:1, Takayuki Nakagawa:1, Kazuo Matsubara:1
1:Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan

Unveiled cold sensitivity of TRPA1 by the prolyl hydroxylation inhibition-induced sensitization to ROS in oxaliplatin-induced acute peripheral neuropathy

[Speaker] Takayuki Nakagawa:1
[Co-author] Takahito Miyake:2, Saki Nakamura:2, Meng Zhao:2, Kanako So:2, Hisashi Shirakawa:2, Yasuo Mori:3, Shuji Kaneko:2
1:Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Japan, 2:Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 3:Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Enginnering, Kyoto University, Japan

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