Sessions

Novel kainoid analogs as inhibitors of neuroinflammation

[Speaker] Andis Klegeris:1
[Co-author] Morgan Alford:1, Frederic Menard:2
1:Department of Biology, University of British Columbia Okanagan Campus, Canada, 2:Department of Chemistry, University of British Columbia Okanagan Campus, Canada

Nicotine promotes cerebral angiogenesis after intracerebral hemorrhage in mice

[Speaker] Kosei Matsumoto:1
[Co-author] Yuki Kurauchi:1, Akinori Hisatsune:2,3, Takahiro Seki:1, Hiroshi Katsuki:1
1:Chemico-Pharmacological Sciences, Kumamoto University, Japan, 2:Priority Organization for Innovation and Excellence, Kumamoto University, Japan, 3:Program for Leading Grad. Sch. HIGO Program, Kumamoto University, Japan

YQTLs improve Qi-deficiency and blood stasis in multiple cerebral infarction rats by increasing the expression of VEGFR2 and CD31

[Speaker] Bing Jie Xue:1
[Co-author] Ji Sheng Huang:2, Bo Ma:1, Ting Ting Hao:1, Jian Xun Liu:1
1:Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences, China, 2:Research Institute of Shineway Pharmaceutical Group, Hebei 065201, China

Blockade of endothelin ETB receptor ameliorates blood-brain barrier disruption through increase of angiopoietin-1 after traumatic brain injury in mice

[Speaker] Shotaro Michinaga:1
[Co-author] Ryusei Nakaya:1, Chihiro Fukutome:1, Anna Inoue:1, Aya Iwane:1, Ayami Tanabe:1, Yutaka Koyama:2
1:Osaka ohtani university, Japan, 2:Kobe Pharmaceutical University, Japan

Taurine supplementation ameliorates D-galactose-induced oxidative damage in brain

[Speaker] Yi-Chen Chen:1
[Co-author] Yao-Ling Chang:1, Sheng-Yao Wang:1, Yuan-Yen Chang:2, Chin-Lin Hsu:3, Hui-Wen Lin:4
1:Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan, 2:Department of Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan, 3:School of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan, 4:Department of Optometry, Asia University, Taichung 413, Taiwan

Preconditioning LPS ameliorates stroke-induced brain injury via a reduction of brain matrix metalloproteinases

[Speaker] Cheng Wei Huang:1
[Co-author] Alice Y. W. Chang:1
1:Institute of Physiology, National Cheng Kung University, Tainan, Taiwan

Neuroprotection by VNUT-mediated microglial ATP exocytosis in the ischemic brain

[Speaker] Ha P. N Le:1
[Co-author] Yuri Hirayma:1,2, Schuichi Koizumi:1
1:Neuropharmacology, Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Japan, 2:Department of Pharmacy, University of Yamanashi Hospital, Japan

Furin inhibitors protect central nervous system neurons from ischemic damage

[Speaker] Mariko Yamada:1
[Co-author] Hideki Hayashi:1, Yui Iwatani:1, Kaori Suzuki:1, Bo Yuan:1, Norio Takagi:1
1:Applied Biochemistry, Tokyo University of Pharmacy and Life Sciences, Japan

FAD012, a ferulic acid derivative, protects against middle cerebral artery occlusion (MCAO)-induced ischemic stroke by preserving cerebral blood flow in rats

[Speaker] Takashi Asano:1
[Co-author] Ryo Endo:1, Kosuke Hayashi:2, Yosuke Kato:2, Naohiro Iwata:3, Hirokazu Matsuzaki:1, Takeshi Sakamoto:2, Yasuhide Hibino:3, Mari Okazaki:1
1:Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Japan, 2:Laboratory of Organic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Josai University, Japan, 3:Laboratory of Immunobiochemistry, Faculty of Pharmaceutical Sciences, Josai University, Japan

Xuesaitong injection protects against ischemic stroke by inhibiting the polarization of microglia to M1 phenotype

[Speaker] Fangfang Li:1
[Co-author] Haiping Zhao:1, Zhibin Fan:1, Rongliang Wang:1, Zhen Tao:1, Guangwen Li:1, Yumin Luo:1
1:Neurology, Xuanwu Hospital of Capital Medical University, China

Brain-derived neurotrophic factor induction by low intensity pulsed ultrasound protects against experimental cerebral ischemia/reperfusion injury

[Speaker] Shing H. Liu:1
[Co-author] Cheng-Tien Wu:1, Feng-Yi Yang:2, Chang-Mu Chen:1
1:National Taiwan University, Taiwan, 2:National Yang-Ming University, Taiwan

Withdrawn

Macrophage TRPM2 channel plays a critical role in CXCL2-induced neutrophil recruitment and inflammation in the central nervous system of experimental autoimmune encephalomyelitis mouse

[Speaker] Hisashi Shirakawa:1
[Co-author] Masato Tsustui:1, Ryo Hirase:1, Sakie Miyamura:1, Kazuki Nagayasu:1, Shuji Kaneko:1
1:Department of Molecular Pharmacology, Kyoto University, Graduate School of Pharmaceutical Sciences, Japan

Protective effect of duloxetine against cerebral ischemia-reperfusion injury through TRPM2 inhibition

[Speaker] Takahiro Toda:1
[Co-author] Shinichiro Yamamoto:1, Yasuo Mori:2, Shunichi Shimizu:1
1:Division of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Japan, 2:Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan

FAD012, a ferulic acid derivative, improves cerebral blood flow and enhances swallowing reflux in a rat chronic cerebral hypoperfusion model

[Speaker] Takashi Asano:1
[Co-author] Hirokazu Matsuzaki:1, Yosuke Kato:2, Kosuke Hayashi:2, Meiyan Xuan:2, Naohiro Iwata:3, Jun Takayama:2, Takeshi Sakamoto:2, Yasuhide Hibino:3
1:Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, Japan, 2:Laboratory of Organic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Josai University, Japan, 3:Laboratory of Immunobiochemistry, Faculty of Pharmaceutical Sciences, Josai University, Japan

Effects of betulinic acid on ameliorating cerebral ischemia/reperfusion injury in rats

[Speaker] Shuying Dong:1
[Co-author] Xuhui Tong:1, Yuanyuan Tang:1, Meiling Yu:1, Guojun Jiang:1
1:Pharmacology, School of Pharmacy, Bengbu Medical College, China

Protective effect of an apelin receptor agonist on retinal ganglion cell death induced by retinal ischemia-reperfusion injury in mice

[Speaker] Yuki Ishimaru:1
[Co-author] Akihide Sumino:1,2, Mayumi Fujimoto:1, Fumiya Shibagaki:1, Akiko Yamamuro:1, Yasuhiro Yoshioka:1, Sadaaki Maeda:1
1:Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan, 2:Department of Pharmacology, Yokohama University of Pharmacy, Japan

Intranasal Administration of the SUR1 inhibitor Glibenclamide for the Treatment of Traumatic Brain Injury

[Speaker] Mingke Song:1
[Co-author] Ju Wang:1, Jin Chen:1, Xin-Lu Xu:1, Qi Yu:1
1:Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, China

Activation of protease-activated receptor 1 causes Rho kinase pathway-dependent suppression of proliferation of neural progenitor cells generated in injured hippocampal dentate gyrus

[Speaker] Masanori Yoneyama:1
[Co-author] Taro Yamaguchi:1, Yusuke Onaka:1, Kiyokazu Ogita:1
1:Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, SETSUNAN UNIVERSITY, Japan

Morphine pre- and post-conditioning exacerbates apoptosis in rat hippocampus cells in a model of homocysteine-induced oxidative stress

[Speaker] Amin Ataie:1
[Co-author] Ramin Ataee:2, Ahmad Karkhah:1
1:pharmacology, Babol Medical science University, Department of Pharmacology, Iran, 2:Mazandaran Medical Science University, Department of Toxicology and Pharmacology, Iran

Neurological diseases and risk of suicide attempt: A case-control study

[Speaker] Kim P. Dalhoff:1
[Co-author] Astrid Eliasen:1, Henrik Horwitz:1
1:Clinical Pharmacology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Denmark

Inhibition of HDAC3 preconditions the brain against ischemic

[Speaker] Linyin Feng:1
[Co-author] Xiaoyu Yang:1, Lei Zhang:1
1:Dept. of Neuropharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

Restoration of neuronal cognition and memory by Sirtuins in 3 nitro propanoic acid induced neurodegeneration in rat

[Speaker] Navita:1
[Co-author] Anchal Chandel:1, Rohit Goyal:1
1:School Of Pharmaceutical Sciences, Shoolini University, Solan (H. P.) india, India

Upregulating the formation of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion

[Speaker] Shifeng Chu:1
[Co-author] Zhao Zhang:1, Zhenzhen Wang:1, Naihong Chen:1
1:Institute of materia medica, Chinese academy of medical sciences, China

Neuroprotective effect of recombinant human soluble thrombomodulin against cerebral ischemic stroke via regulation of high-mobility group box 1 in mice

[Speaker] Takafumi Nakano:1,2
[Co-author] Keiichi Irie:1, Yoshihiko Nakamura:1, Kazunori Sano:1, Yuta Yamashita:1, Takayuki Myose:1, Koichi Matsuo:1,2, Hiroyasu Ishikura:3, Takashi Egawa:1,2, Kenichi Mishima:1
1:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan, 2:Department of Pharmaceutical and Health Care Manargement, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan, 3:Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, Japan

Preclinical studies of T-type calcium channel enhancer in Alzheimer's disease therapy

[Speaker] Kohji Fukunaga:1
[Co-author] Hisanao Izumi:1, Yasuharu Shinoda:1, Yasushi Yabuki:1
1:Pharmacology, Tohoku University Graduate School of Pharmaceutical Sciences, Japan

Roles of sphingosine 1-phosphate in blood-brain barrier using in vitro and in vivo ischemia-reperfusion injury model

[Speaker] Shinsuke Nakagawa:1
[Co-author] Jun Aruga:1
1:Department of Medical Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Japan

Minoxidil suppressed mitochondrial depolarization and subsequent neuronal cell death by decreasing intracellular potassium level

[Speaker] Hiroshi Higashi:1
[Co-author] Miki Shintaku:1, Toshihiko Kinjo:1, Nobuyuki Kuramoto:1
1:Laboratory of Molecular Phamacology, Faculty of Pharmaceutical Sciences, Setsunan University, Japan

Metabolomics analysis indicates noninvolvement of the kynurenine pathway neurotoxins in the interferon-γ-induced neurotoxicity of adult human astrocytes

[Speaker] Sadayuki Hashioka:1
[Co-author] Hideyuki Suzuki:2, Daisuke Nakajima:2, Tsuyoshi Miyaoka:1, Rei Wake:1, Maiko Hayashida:1, Jun Horiguchi:1, Andis Klegeris:3
1:Psychiatry, Shimane University, Japan, 2:Kazusa DNA Research Institute, Japan, 3:The University of British Columbia Okanagan Campus, Canada

Potential role of G protein-coupled receptor 3 in mast cells following brain ischemia

[Speaker] Shigeru Tanaka:1
[Co-author] Yuhki Yanase:2, Masahiro Yamamoto:1, Tatsuhiro Miyagi:1, Hiroko Shiraki:1, Izumi Hide:1, Norio Sakai:1
1:Department of Molecular and Pharmacological Neuroscience, Hiroshima University Graduate School of Biomedical & Health Sciences, Japan, 2:Department of Dermatology, Hiroshima University Graduate School of Biomedical & Health Sciences, Japan

Effect of olanzapine on trimethyltin-induced cognitive dysfunction and neurodegeneration

[Speaker] Yusuke Onaka:1
[Co-author] Shota Wada:1, Masanori Yoneyama:1, Taro Yamaguchi:1, Kiyokazu Ogita:1
1:Laboratory of Pharamacology, Faculty of Pharmaceutical Sciences, Setsunan University, Japan

Microglial apoptosis is involved in neuronal cell death after ischemic stroke

[Speaker] Hong-Wen Wang:1
[Co-author] Alice Y. W. Chang:1
1:Institute of Physiology, National Cheng Kung University, Tainan 701, Taiwan

Acteoside-induced PKM2 secretion from skeletal muscle is associated with functional recovery of chronic spinal cord injury

[Speaker] Chihiro Tohda:1
[Co-author] Atsushi Kodani:1
1:Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Japan

Effects of mEPO on neurogenesis and gliogenesis after cerebral ischemia in mice

[Speaker] Sijia Zhang:1
[Co-author] Rongliang Wang:1, Haiping Zhao:1, Zhen Tao:1, Jincheng Li:1, Fei Ju:1, Yumin Luo:1
1:Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, China

mPGES-1 inhibitor ameliorates ischemic brain injury by suppression of neuronal / microglial PGE2 production and inflammation

[Speaker] Yuri Ikeda-Matsuo:1,2
[Co-author] Ayako Ouchi:2, Mika Shikuri:2, Yasuhito Naito:2, Takashi Iwai:2, Syun Watanabe:2, Misa Oyama:2, Per-Johan Jakobsson:3, Mitsuo Tanabe:2
1:Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Hokuriku University, Japan, 2:Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Kitasato University, Japan, 3:Department of Medicine, Karolinska Institute, Sweden

Intranasal delivery of recombinant MANF protein is neuroprotective in cortical ischemia-reperfusion injury in rats

[Speaker] Jenni E Anttila:1
[Co-author] Mätlik Kert:1, Olli S Mattila:2, Lindholm Päivi:1, Perttu J Lindsberg:2, Mikko Airavaara:1
1:Institute of Biotechnology, University of Helsinki, Finland, 2:Research Program for Molecular Neurology, University of Helsinki, Finland

Leukotriene B4-BLT1 axis exacerbates neutrophil invasion and motor dysfunction after intracerebral hemorrhage in mice

[Speaker] Masanori Hijioka:1
[Co-author] Yuki Kurauchi:2, Akinori Hisatsune:2, Takahiro Seki:2, Tomoaki Koga:2,3, Yoshihisa Kitamura:1, Takehiko Yokomizo:3, Takao Shimizu:4, Hiroshi Katsuki:1
1:College of Pharmaceutical Sciences, Ritsumeikan University, Japan, 2:Kumamoto University, Japan, 3:Juntendo University, Japan, 4:National Center for Global Health and Medicine, Japan

Glial activation via the phosphorylation of nuclear factor kappa B is involved in the NMDA-induced neuronal damage in the rat retina

[Speaker] Kenji Sakamoto:1
[Co-author] Tatsuya Okuwaki:1, Hiroko Ushikubo:1, Asami Mori:1, Tsutomu Nakahara:1, Kunio Ishii:1
1:Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., Japan

Effect of hypothalamic orexin-A on the regulation of hepatic inflammatory and insulin signaling after cerebral ischemia

[Speaker] Shinichi Harada:1
[Co-author] Shogo Tokuyama:1
1:Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Japan

Monomethyl fumarate improves ischemia reperfusion damage and reduces oxidative stress in experimental model of ischemic stroke in rat

[Speaker] Reeta KH:1
[Co-author] Devendra Singh:1, Uma Sharma:2, N R Jagannathan:2, Y K Gupta:1
1:PHARMACOLOGY, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, INDIA, 2:Department of NMR & MRI Facility, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, India

Haptoglobin attenuates haemoglobin associated neurotoxicity in the brain

[Speaker] William H Haskins:1
[Co-author] Patrick Garland:1, John More:2, Ian Galea:1
1:Clinical Neurosciences, Faculty of Medicine, University of Southampton, UK, 2:Bioproducts Lab Ltd, UK

Synaptic loss predominates neuronal loss in a PD model of AAV-mediated alpha-synuclein overexpression in hippocampus and striatum

[Speaker] Elif Cinar:1
[Co-author] Gul Yalcin-Cakmakli:2, Ayse Ulusoy:3, Esen Saka:2, Bulent Elibol:2, Banu Cahide Tel:1
1:Pharmacology, Faculty of Pharmacy, Turkey, 2:Hacettepe University, Departmant of Neurology, Turkey, 3:Research Institute for Neurodegenerative Disease, Germany

Mitochondrial protective effect of Neferine through the modulation of Nrf2 signaling in ischemic stroke

[Speaker] Chuanhong Wu:1,2
[Co-author] Shaojing Li:1, Xiuping Chen:2
1:Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, China, 2:State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China

Golgi body is regulated by COPI vesicle transport via Scyl1 methylation under ER stress

[Speaker] Shinsuke Matsuzaki:1,2
[Co-author] Genki Amano:2, Yasutake Mori:3, Daichi Kobayashi:1, Hironori Takamura:2, Ko Miyoshi:2, Takeshi Yoshimura:2, Fumihiro Saika:1, Norikazu Kiguchi:1, Taiichi Katayama:2, Shiroh Kishioka:1
1:Department of Pharmacology, Wakayama Medical University, Japan, 2:Molecular Brain Science, Osaka University, United Graduate School of Child Development, Japan, 3:Department of Anatomy, International University of HEALTH and WELFARE School of Medicine, Japan

Hyaluronan, the backbone of perineuronal nets, supports glutamate transporter activity

[Speaker] Mariko Hayashi:1,2
[Co-author] Kaoru Sato:2
1:Medical School, International University of Health and Welfare, Japan, 2:National Institute of Health Sciences, Japan

Leukemia Inhibitory Factor Diferentially Regulates the post-stroke Immune Response in Aged Male and Female Rats

[Speaker] Stephanie M Davis:1
[Co-author] Lisa A Collier:1, Sarah R Martha:1, David K Powell:3, Douglas Lukins:2, Christopher C Leonardo:4, Craig T Ajmo:4, Keith R Pennypacker:1
1:Neurology, University of Kentucky, USA, 2:Radiology, University of Kentucky, USA, 3:Biomedical Engineering, University of Kentucky, USA, 4:Molecular Pharmacology and Physiology, University of South Florida, USA

Icariside II alleviates oxygen-glucose deprivation and reoxygenation-induced PC12 cell injury and mitochondrial dysfunction via Nrf2/SIRT3 signaling pathway

[Speaker] Linying Feng:1
[Co-author] Nana Chen:2, Fan Xu:2, Long Long:2, Jianmei Gao:2, Qihai Gong:1
1:Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, China, 2:College of pharmacy, Zunyi Medical University, China

Protective effect of trilobatin on hydrogen peroxide-induced injury in PC12 cells

[Speaker] Jianmei Gao:1
[Co-author] Linying Feng:2, Nana Chen:1, Yan Deng:2, Chun Lv:2
1:Department of Clinical Pharmacotherapeutics, School of Pharmacy, Zunyi Medical University, China, 2:Department of Pharmacology, Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, China

Novel receptor mechanisms of prothymosin alpha, a neuroprotective DAMPs molecule

[Speaker] Ryusei Iwamoto:1
[Co-author] Shiori Maeda:1, Hiroshi Ueda:1
1:Department of Pharmacology and Therapeutic Innovation, Nagasaki University Institute of Biomedical Sciences, Japan

Wnt5a, produced in mechanically stimulated PDL cells via MEK (1/2) and/or PI3K pathways, promotes neurite elongation

[Speaker] Kaori Takahashi:1
[Co-author] Takashi Yoshida:1, Minoru Wakamori:1
1:Div. Mol. Pharmacol. Cell Biophys., Dept. Oral Biol., Grad Sch. Dent., Tohoku Univ. , Japan

Role of Lrrn3, a brain-enriched transmembrane protein in neural development

[Speaker] Maiko Nakamura:1
[Co-author] Minoru Hatayama:1, Hayato Matsunaga:1, Shinsuke Nakagawa:1, Jun Aruga:1
1:Department of Medical Pharmacology, Nagasaki University Institute of Biomedical Sciences, Japan

GDNF, CDNF and MANF have divergent effects on nigrostriatal dopamine neurochemistry in rats

[Speaker] Juho-Matti Renko:1
[Co-author] Petteri Piepponen:1, Ilkka Reenila:1, Mart Saarma:2, Raimo Tuominen:1
1:Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland, 2:Institute of Biotechnology, University of Helsinki, Finland

CORIOLUS VERSICOLOR BIOMASS INCREASES HIPPOCAMPAL DENTATE GYRUS NEWLY-GENERATED NEURONS COMPLEXITY IN MICE

[Speaker] Frederico Pereira:1,2
[Co-author] Elisabete Ferreiro:2,3,4, Pita Inês:1,2, Nuno R Ferreira:5, Carlos A. Fontes-Ribeiro:1,2, Tito Fernandes:7,8, Vittorio Calabrese:9, Cristina Rego:2,3,6
1:Institute of Pharmacology and Experimental Therapeutics, IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal, 2:CNC. IBILI-University of Coimbra, Coimbral, Portugal, 3:CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, 4:III-Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Portugal, 5:Faculty of Pharmacy, University of Coimbra, Portugal, 6:Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Portugal, 7:Ministry of Education, Maputo, Mozambique, Mozambique, 8:Faculty of Veterinary Medicine, Lisbon University, Lisbon, Portugal, 9:Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy

Antioxidant and Neuroprotective Effects of N-((3, 4-Dihydro-2H-Benzo[h]chromen-2-yl) methyl)-4-Methoxyaniline in the Primary Cultured Rat Cortical Cells: Involvement of CREB Signaling

[Speaker] Jungsook Cho:1
[Co-author] Kyeongjun Lee:1, Heesoon Lee:2
1:Pharmacology, Dongguk University College of Pharmacy, Korea, 2:Medicinal Chemistry, Chungbuk National University College of Pharmacy, Korea

Activation of LPA1 signaling mediates antidepressant-induced neuroprotection from apoptosis triggered by pro-inflammatory cytokines

[Speaker] Maria C Olianas:1
[Co-author] Simona Dedoni:1, Pierluigi Onali:1
1:Biomedical Sciences, Sect. Neuroscience, University of Cagliari, Italy

Nerve growth factor facilitates metabotropic glutamate receptor agonist-induced calcium elevation in dorsal root ganglion neurons

[Speaker] Takayoshi Masuoka:1
[Co-author] Yuka Yamashita:1, Junko Yoshida:1, Masashi Tawa:1, Matomo Nishio:1, Takaharu Ishibashi:1
1:Department of Pharmacology, Kanazawa Medical University, Japan

The neuroprotective effect of desferrioxamine is mediated by hypoxia-inducible factor-1 (HIF-1) in rat organotypic hippocampal slices

[Speaker] Nicole M Jones:1
[Co-author] Thomas Fath:2, Hong L Nguyen:1
1:Pharmacology, School of Medical Sciences, UNSW Sydney, Australia, 2:Neurodegeneration and Repair Unit, UNSW Sydney, Australia

Ecklonia radiata-derived phlorotannin extract inhibits beta-amyloid fibril formation and neurotoxicity

[Speaker] Scott D Smid:1
[Co-author] Dylan Whan:1, Wei Zhang:2, Masaya Fujitani:3, Ryuji Kato:3
1:Discipline of Pharmacology, The University of Adelaide, Australia, 2:Centre for Marine Bioproducts Development, Flinders University, Australia, 3:Laboratory of Cell and Molecular Bioengineering, Graduate School of Pharmaceutical Sciences, Nagoya University, Japan

A NEUROPROTECTIVE ACTION OF CANNABINOIDS IN THE BOVINE ISOLATED RETINA: ROLE OF HYDROGEN SULFIDE

[Speaker] Sunny E Ohia:1
[Co-author] Leah Bush:1, Jenaye Robinson:1, Catherine Opere:2, Ya Fatou Njie-Mbye:1
1:Pharmaceutical Sciences, Texas Southern University, USA, 2:Pharmacy Sciences, Creighton University, Omaha, USA

The role of L-DOPA as a neurotransmitter

[Speaker] Yoshio Goshima:1
[Co-author] Daiki Masukawa:1, Motokazu Koga:1, Tatsuo Hashimoto:1
1:Molecular Pharmacology & Neurobiology, Yokohama City University Graduate School of Medicine, Japan

The neurotrophic and antidepressant actions of BDNF and VEGF require interactive signaling

[Speaker] Satoshi Deyama:1,2
[Co-author] Eunyoung Baing:2, Taro Kato:2,3, Xiao-Yuan Li:2, Ronald S. Duman:2
1:Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan, 2:Department of Psychiatry, Yale University School of Medicine, USA, 3:Drug Development Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd., Japan

An essential role of astrocytic mGluR5 in the somatosensory cortex in regulation of synaptogenesis and neuropathic pain

[Speaker] Yosuke Danjo:1
[Co-author] Yukiho Hirayama:1, Eiji Shigetomi:1, Keisuke Shibata:1, Kenta Takanashi:1, Youichi Shinozaki:1, Sung Kwang Kim:2, Junichi Nabekura:2, Schuichi Koizumi:1
1:Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Japan, 2:Division of Homeostatic Development, National Institute for Physiological Sciences, Japan

The mechanism of neuroprotection mediated by bibenzyl compound 20C against rotenone-induced oxidative insulting

[Speaker] Nuo Liu:1
[Co-author] Xiaoling Zhang:1, Zhenzhen Wang:1, Naihong Chen:1
1:State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, China

Noradrenaline protect motor neurons from hydrogen peroxide-induced cell death by increasing the supply of GSH from astrocytes via β3-adrenoreceptor stimulation

[Speaker] Yasuhiro Yoshioka:1
[Co-author] Mamiko Nakako:1, Sayuri Koyama:1, Akiko Yamamuro:1, Yuki Ishimaru:1, Sadaaki Maeda:1
1:Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ., Japan

Effects of asenapine and paliperidone on depression, anxiety and analgesy in mice: Alterations in brain neurotrophic factors, neurogenesis and blood enzyme levels

[Speaker] Guner Ulak:1
[Co-author] Esen Gumuslu:2, Oguz Mutlu:3, Sibel Kokturk:4, Firuzan Akar:3, Faruk Erden:3
1:Pharmacology, Kocaeli University Faculty of Medicine, Turkey, 2:Medical Genetics, Kocaeli University, Turkey, 3:Pharmacology, Kocaeli University, Turkey, 4:Histology, Ordu University, Turkey

Protective effects of apolipoprotein E-containing lipoproteins against glaucomatous optic neuropathy

[Speaker] Hideki Hayashi:1
[Co-author] Mariko Yamada:1, Misuzu Mori:1, Mio Kobayashi:1, Hikaru Koide:1, Takuya Kojima:1, Chihaya Mukaigaito:1, Bo Yuan:1, Norio Takagi:1
1:Applied Biochemistry, Tokyo University of Pharmacy and Life Sciences, Japan

Protective effects of thymol against neurodegeneration in rotenone induced rat model of Parkinson's disease

[Speaker] Shreesh K Ojha:1
[Co-author] Fizur N Meeran:1, Azimullah Sheikh:1, Hayate Javed:2
1:PHARMACOLOGY AND THERAPEUTICS, UNITED ARAB EMIRATES UNIVERSITY, UAE, 2:Department of Anatomy, United Arab Emirates University, Al Ain, UAE

Dimeric dipeptide mimetics of the neurotrophins NGF and BDNF: design, synthesis and pharmacological properties

[Speaker] Sergey B Seredenin:1
[Co-author] Tatyana A Gudasheva:2
1:Department of Pharmacogenetics, Federal State Budgetary Institution Research Zakusov Institute of Pharmacology, Russia, 2:Department of Medicinal Chemistry, Federal State Budgetary Institution Research Zakusov Institute of Pharmacology, Russia

Dimeric dipeptide mimetic of nerve growth factor GK-2 is a promising anti-stroke drug

[Speaker] Polina Povarnina:1
[Co-author] Tatyana A Gudasheva:1, Sergey B Seredenin:2
1:Department of Medicinal Chemistry, Federal State Budgetary Institution Research Zakusov Institute of Pharmacology, Russia, 2:Department of Pharmacogenetics, Federal State Budgetary Institution Research Zakusov Institute of Pharmacology, Russia

Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors

[Speaker] Naoya Yamashita:1,2
[Co-author] Rejji Kuruvilla:2
1:Department of Pharmacology, Juntendo University School of Medicine, Japan, 2:Department of Biology, Johns Hopkins University, USA

Downregulation of astrocytic connexin43 leads to enhancement of neurotrophic factor production in cortical astrocytes

[Speaker] Syun Kondo:1
[Co-author] Kazue Hisaoka-Nakashima:1, Yoshihiro Nakata:1, Norimitsu Morioka:1
1:Department of Pharmacology, Hiroshima University Graduate School of Biomedical & Health Sciences, Japan

Neural projection dynamics underlying motivated behaviors in a conflicting context

[Speaker] Natsuko Hitora-Imamura:1
[Co-author] Takuji Soga:1, Masabumi Minami:1
1:Department of Pharmacology, Hokkaido University, Japan

Protective effect of the general anesthetic: Propofol on the intracranial hemorrhage

[Speaker] Xiao-Chun Zhao:1
[Co-author] Ping An:2
1:Department of Anesthesiology, China Medical University Shengjing Hospital, China, 2:Department of Neurobiology, China Medical University, China

The expression regulation and protective role of Pnn in neural cells exposed to ischemic stress

[Speaker] Steve Leu:1
[Co-author] Sujira Mukda:2
1:Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan, 2:Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Thailand

Neuroprotective Effects of a Combination of Panax ginseng and Ginkgo biloba Extracts on Multiple Cerebral Embolism via Modulating NMDA Receptor Pathway in Rats

[Speaker] Aimei Zhao:1
[Co-author] Li Xu:1, Mingjiang Yao:1, Dennis Chang:2, Jianxun Liu:1
1:Institute of Basic Medical Sciences, Xiyuan Hospital of China Academy of Chinese Medical Sciences, China, 2:NICM, Western Sydney University, Penrith, NSW 2751, Australia

Valproic acid up-regulates p75NTR and sortilin expression to induce neuronal cell death

[Speaker] Pierluigi Onali:1
[Co-author] Simona Dedoni:1, Maria C Olianas:1
1:Biomedical Sciences, Sect. Neurosciences and Clinical Pharmacology, University of Cagliari, Italy

Analysis of activated cells in the dopaminergic neuron by ethanol

[Speaker] Masahiro Shibasaki:1
[Co-author] Chizuru Iwasawa:1, Yusuke Hamada:1, Michiko Narita:1, Naoko Kuzumaki:1, Minoru Narita:1
1:Department of Pharmacology, Hoshi University, Japan

Complex Dose Related Ketamine Analgesic, Antidepressant, Anesthetic and Toxic Mechanisms of Actions

[Speaker] Edward F. Domino:1
[Co-author] Mika Hirasawa-Fujita:1
1:Pharmacology, University of Michigan, USA

History Impacts the Aversive Effects of Drugs

[Speaker] Vanessa Minervini:1,3
[Co-author] Angelo Casalez:1,3, Charles P France:1,2,3
1:Pharmacology, University of Texas Health Science Center at San Antonio, USA, 2:Psychiatry, University of Texas Health Science Center at San Antonio, USA, 3:Addiction Research Treatment and Training Center of Excellence, University of Texas Health Science Center at San Antonio, USA

Environmental metabolite, 1, 2-diacetylbenzene, produces cytotoxicity in neuronal/glial cultures

[Speaker] May-Jywan Tsai:1
[Co-author] Huai-Sheng Kuo:1, Dann-Ying Liou:1, Ming-Chao Huang:1, Wen-Cheng Huang:1, Henrich Cheng:1,2
1:Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taiwan, 2:Department of Pharmacology, National Yang-Ming University, Taipei, Taiwan

Benzophenone-3 and its proapoptotic activity in the rat brain

[Speaker] Bartosz Pomierny:1
[Co-author] Weronika Krzyzanowska:1, Beata Strach:1, Beata Starek-Swiechowicz:1, Zaneta Broniowska:1, Boguslawa Budziszewska:1
1:Department of Biochemical Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, Poland

The effect of benzophenone-3 on the steroid receptors expression in the brain

[Speaker] Beata Starek-Swiechowicz:1
[Co-author] Zaneta Broniowska:1, Bartosz Pomierny:1, Weronika Krzyzanowska:1, Beata Strach:1, Agnieszka Basta-Kaim:2, Boguslawa Budziszewska:1
1:Department of Biochemical Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, Poland, 2:Department of Experimental Endocrinology, Institute of Pharmacology, Polish Academy of Science, Poland

Effect of nitric oxide synthase inhibitor on methamphetamine-induced dopaminergic neurotoxicity in rats

[Speaker] Kazue Kikuchi-Utsumi:1
[Co-author] Masahiko Watabe:1, Nobuko Matsumura:1, Toshio Nakaki:1
1:Department of Pharmacology, Teikyo University, School of Medicine, Japan

The effect of physiological stress as a risk factor of neurolathyrism

[Speaker] Kimino Minagawa:1
[Co-author] Toshio Kumai:1, Shinichi Yamada:2, Ayano Suzuki:2, Kuniko Kusama-Eguchi:2
1:St. Marianna University, Japan, 2:Nihon University, School of Pharmacy, Japan

A plausible involvement of plasmalemmal voltage-dependent anion channel in the neurotoxicity of 15-deoxy-Δ12, 14-prostaglandin J2

[Speaker] Yasuhiro Yamamoto:1
[Co-author] Hiromi Koma:1, Tatsurou Yagami:1
1:Pharmaceutical Sciences, Himeji Dokkyo University, Japan

Hemoglobin-related molecules injure blood-brain barrier via iron accumulation

[Speaker] Takahiko Imai:1
[Co-author] Sena Iwata:1, Tasuku Hirayama:2, Hideko Nagasawa:2, Shinsuke Nakamura:1, Masamitsu Shimazawa:1, Hideaki Hara:1
1:Molecular Pharmacology, Gifu Pharmaceutical University, Japan, 2:Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Japan

Mechanism underlying anti-depressive action of novel Alzheimer's disease therapeutic candidate, SAK3

[Speaker] Kohji Fukunaga:1
[Co-author] Jing Xu:1, Mengze Yu:1, Yasushi Yabuki:1
1:Pharmacology, Tohoku University Graduate School of Pharmaceutical Sciences, Japan

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