Sessions

Effects of vitamins A and E supplementation on the pharmacokinetics and toxicity profile of aspirin in rats

[Speaker] Mohammed A. Mahdi:1
[Co-author] Abdulrahman U. Zezi:1, Ibrahim A. Aguye:1, Janet I. Ejiofor:1, Musa A. Usman:2
1:Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria, 2:Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria

Pharmacokinetics of ritodrine in pregnant women and their neonates

[Speaker] Mayuko Soma:1
[Co-author] Ainari Konda:2, Yoichi Sasaki:1, Takashi Mishima:3, Mitsuaki Keira:3, Hiroshi Yoshida:3, Yuji Mukai:2, Takaki Toda:2, Nobuo Inotsume:2
1:Department of Pharmacy, Tenshi Hospital, Japan, 2:Hokkaido Pharmaceutical University School of Pharmacy, Sapporo, Japan, 3:Department of Obstetrics and Gynecology, Tenshi Hospital, Sapporo, Japan

The application of pharmacokinetics for Busulfan dose adjustment in hematopoietic stem cell transplantation (HSTC) in Thai children

[Speaker] Nuttawut Jenjirattithigarn:1
[Co-author] Santirat Prommas:1, Sassawat Lertrit-Anan:2, Chonlaphat Sukasem:1
1:Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 2:Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Safety, Pharmacodynamics and Pharmacokinetics of the Oral Selective Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor Molidustat in Japanese Healthy Subjects

[Speaker] Kenichi Yoshikawa:1
[Co-author] Miho Uemura:1, Kumi Matsuno:1, Shunji Matsuki:2, Koki Furusho:2, Mariko Kajikawa:1, Silvia Lentini:3
1:Bayer Yakuhin, Ltd., Japan, 2:SOUSEIKAI Fukuoka Mirai Hospital, Japan, 3:Bayer AG, Germany

Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats

[Speaker] Beikang Ge:1
[Co-author] Te Qi:1, Liang Zhao:1, Ming Xue:1
1:Capital Medical University, China

Glucuronidation is the dominating in-vivo metabolism pathway of herbacetin: Elucidation of herbacetin pharmacokinetics after intravenous and oral administration in rats

[Speaker] Te Qi:1
[Co-author] Bei-Kang Ge:1, Liang Zhao:1, Ming Xue:1
1:Pharmacology, Capital Medical University, China

Pharmacokinetics and Safety of the Oral Prostaglandin F2alpha Receptor Antagonist OBE022: A First-In-Human Study in Healthy Post-Menopausal Women

[Speaker] Ulrike Lorch:1
[Co-author] Oliver Pohl:2, Line Marchand:2, Jean-Pierre Gotteland:2
1:Richmond Pharmacology, UK, 2:ObsEva SA, 1228 Plan-les-Ouates, Geneva, Switzerland

PHARMACOKINETICS EVALUATION OF NIMOTUZUMAB IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

[Speaker] Leyanis Rodriguez Vera:1
[Co-author] Niurys De Castro-Suarez:1, Carlos Villegas:2, Jose M. Davalos:3, Raymed Bacallao:3, Patricia Luaces:4, Mayra Ramos Suzarte:4
1:Pharmacy Department, Institute of Food and Pharmacy, University of Havana, Cuba, 2:National Institute of Radiobiology and Oncology (INOR), Havana, Cuba, 3:National Institute of Nephrology, Havana, Cuba, 4:Center of Molecular Immunology (CIM), Havana, Cuba

Preclinical and Clinical Pharmacokinetics of a Novel Dipeptide Anxiolytic GB-115

[Speaker] Pavel O Bochkov:1
[Co-author] Larisa G Kolik:1, Vladimir P Zherdev:1, Gennadiy B Kolyvanov:1, Alexander A Litvin:1, Sergei Yu Raskin:1, Roman V Shevchenko:1, Oxana G Grybakina:1, Tatiana A Gudasheva:1, Sergei B Seredenin:1
1:FSBI, Russia

Bioavailability and disposition kinetic of Cucurbitacin B in rats

[Speaker] Natthaphon Hunsakunachai:1
[Co-author] Weena Jiratchariyakul:2, Tanawan Kummalue:3, Phisit Khemawoot:1
1:Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand, 2:Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Thailand, 3:Department of Clinical Pathology, Faculty of Medicine, Siriraj Hospital, Thailand

A Multicentre Open-Label Pharmacokinetic-Pharmacodynamic Study of Febuxostat in Patients with Chronic Gout

[Speaker] Richard Day:1,2,3
[Co-author] Bishoy Kamel:1,2, Garry G Graham:1,2, Kenneth M Williams:1,2, Sophie L Stocker:1,3, Jane E Carland:1,3, Kevin D Pile:4, Louis E Mcguigan:5, Ian J Portek:6, Neil W Mcgill:7
1:Department of Clinical Pharmacology & Toxicology, St Vincent's Hospital, Sydney, Australia, 2:School of Medical Sciences, University of New South Wales, Sydney, Australia, 3:St Vincent's Clinical School, University of New South Wales, Sydney, Australia, 4:Department of Medicine, Western Sydney University, Sydney, Australia, 5:Department of Rheumatology, Narrabri Hospital, Australia, 6:Department of Rheumatology, St George Hospital, Sydney, Australia, 7:Department of Medicine, University of Sydney, Sydney, Australia

Safety, pharmacokinetics, and pharmacodynamics in first-in-human study of a novel compound E6742, a Toll-like receptor 7 and 8 antagonist

[Speaker] Kenya Nakai:1
[Co-author] Sanae Yasuda:1, Min-Kun Chang:2, Mark Matijevic:2, Shannon Mcgrath:2, Hua Yang:2, Nancy Hall:2, Jagadeesh Aluri:2, Robert Lai:3, Sally Ishizaka:2
1:Eisai Co., Ltd., Japan, 2:Eisai Inc., USA, 3:Eisai Ltd., UK

Pharmacokinetics and Food Effect of Enalapril Maleate/Folic Acid Tablets in Healthy Chinese Volunteers: A Phase I, Randomized, Open-label, Single- and Multiple-dose Study

[Speaker] Hengyan Qu:1
[Co-author] Yuanyuan Zhang:1, Zeyuan Liu:1
1:307 Hospital, China

Gender differences in pharmacokinetics, mass balance and phototoxicity of single-dose intravenous hemoporfin in healthy volunteers

[Speaker] Junyu Xu:1
[Co-author] Xia Zhao:1, Yan Wu:2, Ping Tu:2, Peihong Sun:1, Ying Zhou:1, Xiaoyan Chen:3, Yifan Zhang:3, Jining Tao:4, Yimin Cui:1
1:Department of Pharmacy, Peking University First Hospital, China, 2:Department of Dermatology and Venereology, Peking University First Hospital, China, 3:Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China, 4:Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co, Ltd, China

Pharmacokinetic parameters of nicotine and its metabolites in Thai smokers with different CYP2A6 enzyme activity

[Speaker] Pajaree Chariyavilaskul:1
[Co-author] Khwanreun Petchnoi:1, Napakawat Buathong:2, Rasmon Kalayasiri:2, Nantaporn Prompila:3, Supeecha Wittayalertpanya:1
1:Clinical Pharmacokinetics and Pharmacogenomics Research Unit, Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Thailand, 2:Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Thailand, 3:Pharmacokinetic Research Unit, Research Affairs, Faculty of Medicine, Chulalongkorn University, Thailand

Safety, tolerability and pharmacokinetics of a novel oral hepatitis C virus NS5A inhibitor DAG181PA Capsules in Chinese healthy volunteers

[Speaker] Ran Xie:1
[Co-author] Xia Zhao:1, Nan Zhao:1, Lin Luo:2, Zhangma Huang:2, Hongming Xie:2, Yingjun Zhang:2, Junyu Xu:1, Yimin Cui:1
1:Department of Pharmacy, Peking University First Hospital, China, 2:Sunshine Lake Pharma Co. Ltd, China

Novel high-sensitive drug detecting, PID method reveals intra-tumor pharmacokinetics of trastuzumab and factors affect to its remarkable heterogeneity

[Speaker] Ryosuke Matsukane:1,3
[Co-author] Mitsuhiro Hayashi:1, Masaru Takahashi:2, Mayu Ouchi:1, Hiroaki Aikawa:1, Hisatake Okada:2, Satohiro Masuda:3, Akinobu Hamada:1
1:Division of Molecular Pharmacology, National Cancer Center Research Institute, Tokyo, Japan, 2:Product Development Division, Bio-Healthcare Business Unit, Healthcare Business Headquarters, Konica Minolta, Inc., Tokyo, Japan, 3:Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

Pharmacokinetic Evaluation of a Novel Synthesis Anti-malarial Compound

[Speaker] Pravin Kendrekar:1
[Co-author] Samson Mashele:1, Deepak Salunke:2
1:Central University of Technology, South Africa, 2:Department of Chemistry & Centre for Advanced Studies in Chemistry, Punjab University, Chandigarh, India

Pharmacokinetic and pharmacodynamic comparison of 3 formulations of epoetin alfa in healthy volunteers

[Speaker] Roberto A Diez:1
[Co-author] Guillermo Di Girolamo:1, Fornari María C:1, Guillermo A Keller:1, Eliseo Gonzalez:2, Carolina Costas:3, Rosana Di Vita:3, Lola Musfeldt:3
1:Pharmacology, School of Medicine, UBA, Argentina, 2:CDM, Buenos Aires, Argentina, 3:Biosidus SA, Buenos Aires, Argentina

Population pharmacokinetics and pharmacodynamics of apixaban in Japanese patients with atrial fibrillation

[Speaker] Satoshi Ueshima:1
[Co-author] Daiki Hira:2, Chiho Tomitsuka:1, Miki Nomura:1, Yuuma Kimura:1, Takuya Yamane:1, Yohei Tabuchi:2, Tomoya Ozawa:3, Hideki Itoh:3, Seiko Ohno:3, Minoru Horie:3, Tomohiro Terada:2, Toshiya Katsura:1
1:Laboratory of Clinical Pharmaceutics and Therapeutics, College of Pharmaceutical Sciences, Ritsumeikan University, Japan, 2:Department of Pharmacy, Shiga University of Medical Science Hospital, Japan, 3:Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan

Pharmacokinetics and Safety of CK-30 in Comparison with Red Ginseng Extracts in Healthy Subjects

[Speaker] Eunwoo Kim:1
[Co-author] Yun Kim:1, Hong-Keun Chung:2, Sang Chun Ji:2, Byung-Ryul Han:2, Sunyong Lee:2, Seunghee Ham:2, Kyung-Sang Yu:1, In-Jin Jang:1, Seunghwan Lee:1
1:Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea, 2:MGINBIO., Korea

A survey of hepatic impairment pharmacokinetic studies for new drug approvals and proposal for the setting of the criteria for hepatic impairment

[Speaker] Sumire Shimada:1
[Co-author] Megumi Inoue:2, Kimio Terao:1
1:Clinical Pharmacology, Chugai Pharmaceutical Co., Ltd., Japan, 2:PS CLINIC, Medical Co. LTA, Japan

Ethnic Differences in Pharmacokinetics and Dermatopharmacokinetics

[Speaker] Eunhee Chung:1
[Co-author] Hiroko Kumashiro:2, Izumi Noritomo:2, Kaori Inoue:2, Hinako Uchimaru:2, Kayo Tahira:2, Masanari Shiramoto:2, Shin Irie:3
1:SOUSEIKAI Global Clinical Research Center, Japan, 2:SOUSEIKAI Hakata Clinic, Japan, 3:SOUSEIKAI, Japan

Development of Physiologically Based Pharmacokinetic Model of Ethionamide in Pediatric Population by Application of Flavin-containing Monooxygenase 3 Maturation

[Speaker] Phuong T. T Nguyen:1,2
[Co-author] Parvez Md Masud:1,3, Min Jung Kim:1, Jung Ho Lee:1, Jong Lyul Ghim:1,4, Jae Gook Shin:1,4
1:Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Korea, 2:Faculty of Pharmacy, Hai Phong University of Medicine and Pharmacy, Viet Nam, 3:Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada, 4:Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Korea

The effect of sex on the pharmacokinetics/pharmacodynamics: A systematic review

[Speaker] Seonghae Yoon:1
1:Seoul National University Bundang Hospital, Korea

The Pharmacokinetic Profile of Ursodeoxycholic Acid And Its Metabolites In Healthy Elderly Subjects

[Speaker] Seonghae Yoon:1
[Co-author] Soyoung Lee:2, Jae-Yong Chung:1
1:Seoul National University Bundang Hospital, Korea, 2:Seoul National University College of Medicine and Hospital, Korea

Pharmacokinetic characteristics of first-line anti-tuberculous drugs in gastrectomized patients

[Speaker] Jaeseong Oh:1
[Co-author] Jin Young Oh:2, In-Jin Jang:1, Hee Seok Lee:3
1:Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Korea, 2:Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang-si Gyeonggi-do, Korea, 3:Respiratory Clinic and Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, National Cancer Center, Goyang-si Gyeonggi-do, Korea

Pharmacokinetic comparison of JLP-1401 and co-administration of telmisartan/amlodipine and rosuvastatin in healthy adult volunteers

[Speaker] Sun-Young Kim:1
[Co-author] Ji-Young Jeon:1, Seol Ju Moon:1, Yong Woo Lee:2, Eun Young Son:2, Jun Hong Park:2, Kyungho Jang:1, Min-Gul Kim:1,3
1:Biomedical Research Institute, Chonbuk National University Hospital, Center for Clinical Pharmacology, Korea, 2:Jeil Pharmaceutical Co, Ltd, Korea, 3:Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, Korea

Prediction and optimization of photo-activated curcumin dosage schedule in human, a promising antimicrobial candidate: A physiologically-based pharmacokinetic (PBPK) modeling

[Speaker] Teerachat Saeheng:1,2
[Co-author] Kesara Na-Bangchang:3,4, Rajith K. R. Rajoli:5, Marco Siccardi:5, Andrew Owen:5, Juntra Laothavorn:2
1:Infection Research, Leading Program, Graduate School of Biomedical Sciences, Nagasaki University, Japan, 2:Department of Clinical Product Development, Institute of Tropical Medicine, Nagasaki University, Japan, 3:Chulabhorn International College of Medicine, Thammasat University, PathumThani, Thailand, 4:Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, PathumThani, Thailand, 5:Department of Molecular and Clinical Pharmacology, University of Liverpool, UK

Pharmacokinetic comparison of HCP1102 and co-administration of montelukast and levocetirizine in healthy male volunteers

[Speaker] So Jin Lee:1
[Co-author] Ji-Young Jeon:1, Seol Ju Moon:1, Min-Gul Kim:1,2, Kyungho Jang:1
1:Biomedical Research Institute, Chonbuk National University Hospital, Center for Clinical Pharmacology, Korea, 2:Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, Korea

Physiologically-based pharmacokinetic modeling and simulation of drug-drug interactions between azole antifungals, macrolide antibiotics or proton pump inhibitors and tacrolimus for provision of quantitative information to clinical practice

[Speaker] Yukio Otsuka:1
[Co-author] Akira Koibuchi:1, Atsunori Kaibara:1, Yukako Tsukamoto:2, Kumi Koide:2, Kazuya Iwamoto:2, Masato Yamazaki:2, Manabu Murakami:1, Naoko Sato:2
1:Clinical Pharmacology, Development, Astellas Pharma Inc., Japan, 2:Medical Communications, Medical Affairs, Astellas Pharma Inc., Japan

Particle size modification of curcumin in relation to its pharmacokinetics and tissue distribution profile

[Speaker] Wenny T Ramadanty:1
[Co-author] Regina Pu Satyana:2, Gaviota Hartono:2, Serlie Fatrin:2, I Instiaty:3, N Nafrialdi:3, Ari Estuningtyas:3, Wawaimuli Arozal:3, Melva Louisa:3
1:Master Student in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Indonesia, 2:Medical Student, Faculty of Medicine, Universitas Indonesia, Indonesia, 3:Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Indonesia

A simplified LC-MS/MS method for determination of isoniazid and pyrazinamide in human plasma using protein precipitation technique and its application to a pharmacokinetic study

[Speaker] Phongpan Mokmued:1
[Co-author] Archawin Rojanawiwat:1, Surakameth Mahasirimongkol:1, Ingorn Prasanchaimontri:2, Katsushi Tokunaka:3, Taisei Mushiroda:4
1:Department of Medical Sciences, Medical Life Science Institute, Thailand, 2:Department of Medical Sciences, Bureau of Drug and Narcotic, Thailand, 3:Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Japan, 4:Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

Validated LC-MS/MS method for the determination of cycloserine in human plasma: Application to pharmacokinetic studies

[Speaker] Phongpan Mokmued:1
[Co-author] Triporn Wattananat:2, Surakameth Mahasirimongkol:1, Katsushi Tokunaka:3
1:Department of Medical Sciences, Medical Genetic Center, Medical Life Science Institute, Thailand, 2:Department of Medical Sciences, Bureau of Drug and Narcotic, Thailand, 3:Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Japan

Effect of Green Tea Extract on the Pharmacokinetics of Digoxin in Healthy Volunteers

[Speaker] Tae-Eun Kiim:1
[Co-author] Kwang-Hee Shin:2, Jeong-Eun Park:2, Jongmin Lee:3
1:Department of Clinical Pharmacology, Konkuk University Medical Center, Korea, 2:College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Korea, 3:Department of Rehabilitation Medicine, Konkuk University School of Medicine, Korea

Evidence of interethnic differences in the pharmacokinetics of a marker of cyp1a2 activity

[Speaker] Miriam C. Carrasco-Portugal:1
[Co-author] Francisco J. Flores-Murrieta:1,2
1:Unidad de Investigacion en Farmacologia, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico, 2:Escuela Superior de Medicina del Instituto Politecnico Nacional, Mexico

Pharmacokinetic evaluation of Xiaoxuming decoction for anti-cerebral ischemic stroke and its protection mechanism in blood-brain barrier

[Speaker] Zhihong Yang:1
[Co-author] Yuyang You:2
1:Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, China, 2:Beijing Institute of Technology, China

Clinical pharmacologist in the field of population pharmacokinetics

[Speaker] Aurelija Radzeviciene:1
[Co-author] Silvijus Abramavicius:2, Edgaras Stankevicius:2, Franck Saint-Marcoux:3, Edmundas Kadusevicius:2
1:Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Lithuania, 2:Institute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, Lithuania, 3:INSERM UMR 850, Limoges, Department of Pharmacology and Toxicology, CHU Limoges, Limoges Cedex, University of Limoges, Limoges, France

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