Sessions

Anticancer effect of fluoxetine on stress-induced depression mice bearing Lewis lung cancer

[Speaker] Feng Xu:1
[Co-author] Yu Ren:1, Ting Zhou:1
1:Fengxian Hospital, Southern Medical University, China

Increased expression levels of cysteinyl leukotriene type 1 receptors, runt-related transcription factor 1 and matrix metalloproteinase-1 in meningiomas

[Speaker] Ruenruthai Kaeopu:1
[Co-author] Laphatrada Yurasakpong:2, Kulathida Chaithirayanon:2, Wuttipong Tirakotai:3, Prasert Iampreechakul:3, Nathawut Sibmooh:1, Pornpun Vivithanaporn:1
1:Department of Pharmacology, Faculty of Science, Mahidol university, Bangkok, Thailand, 2:Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand, 3:Prasat Neurological Institute, Bangkok, Thailand

Suberoylanilide Hydroxamic Acid-Mediated Repression of Temozolomide Resistant Cells in Glioblastoma Multiforme

[Speaker] Chiung-Yuan Ko:1
[Co-author] Yu-Ting Tsai:2, Jian-Ying Chuang:1, Wen-Chang Chang:2
1:The PH. D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, 11031, Taiwan, 2:Graduate Institute of Medical Sciences, Taipei Medical University Taipei, 11031, Taiwan

Dehydroepiandrosterone induces Temozolomide Resistance through Attenuating DNA Damage under the Control of Sp1 Phosphorylation and Deacetylation in Glioblastoma

[Speaker] Tsung-I Hsu:1
[Co-author] Jian-Ying Chuang:1, Wen-Chang Chang:1
1:Center for Neurotrauma and Regeneration, Taipei Medical University, Taiwan

Montelukast Induces Apoptosis and Inhibits Proliferation of Human Glioblastoma Cells by Decreasing B-cell Lymphoma 2 Expression

[Speaker] Pornpun Vivithanaporn:1
[Co-author] Pannaree Piromkraipak:1, Tipparat Parakaw:2, Suttinee Phaugkhaopong:1
1:Department of Pharmacology, Faculty of Science, Mahidol University, Thailand, 2:Department of Pharmacology, Faculty of Dentistry, Mahidol University, Thailand

IGF-1-enhanced miR-513a-5p signaling modulates glioma cell sensitivity to temozolomide by targeting NEDD4L-inhibited Wnt/β-Catenin pathway

[Speaker] Kuo-Hao Ho:1,2
[Co-author] Peng-Hsu Chen:1,2, Chwen-Ming Shih:1,2, Ku-Chung Chen:1,2
1:Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taiwan, 2:Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taiwan

Inhibition of the HDAC6/Sp1 pathway by azaindolylsulfonamide reduces cancer stemness and restores treatment susceptibility in glioblastoma

[Speaker] Jian-Ying Chuang:1
[Co-author] Che-Chia Hsu:2, Kwang-Yu Chang:3, Wen-Chang Chang:2
1:The Ph. D. Program for Neural Regenerative Medicine, Taipei Medical University, Taiwan, 2:Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan, 3:National Institute of Cancer Research, National Health Research Institutes, Taiwan

TLR-4/Wnt modulation as new therapeutic strategy in the treatment of glioblastomas

[Speaker] Emanuela Esposito:1
[Co-author] Giovanna Casili:1, Maria Caffo:2, Michela Campolo:1, Marika Lanza:1, Alessia Filippone:1, Alfredo Conti:2, Germanò Antonino:2, Salvatore Cuzzocrea:1
1:Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy, 2:Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Unit of Neurosurgery, University of Messina, Messina, Italy

Dynamic structure and localization of G protein-coupled receptor (GPCR) complexes determines unique signalling outcomes

[Speaker] Srgjan Chivchiristov:1
[Co-author] Arisbel Batista Gondin:1, Ghizal Siddiqui:2, Oded Kleifeld:3,4, Darren J Creek:2, Meritxell Canals:1, Michelle L Halls:1
1:Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Australia, 2:Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Australia, 3:Department of Biochemistry and Molecular Biology, Monash University, Australia, 4:Faculty of Biology, Technion-Israel Institute of Technology, Technion City, Haifa, Israel

Quantifying VEGF binding at VEGFR2 and Neuropilin-1 using NanoBRET

[Speaker] Chloe Peach:1
[Co-author] Laura Kilpatrick:1, Rachel Friedman-Ohana:2, Matt Robers:2, Jeanette Woolard:1, Steve Hill:1
1:Cell Signalling Research Group, University of Nottingham, UK, 2:Promega Corporation, Madison, USA

Angiotensin II increase the pulmonary metastasis through the vascular endothelial cell adherent pathway in hematogenous metastasis of melanoma cells

[Speaker] Shin Ishikane:1,2
[Co-author] Hiroshi Hosoda:3, Takashi Nojiri:2, Takeshi Tokudome:2, Tetsuya Mizutani:4, Yumiko Toyohira:1, Mikiya Miyazato:2, Kaoru Miyamoto:4, Kenji Kangawa:5, Fumi Takahashi-Yanaga:1
1:Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan, 2:Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Japan, 3:Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, Japan, 4:Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Japan, 5:National Cerebral and Cardiovascular Center Research Institute, Japan

Anti-apoptotic effects of dexamethasone and phosphoinositide 3-kinase inhibitors on PUMA-mediated apoptosis of lovastatin-treated cells

[Speaker] Jae Won Choi:1
[Co-author] Jichang Seong:1, Junghan Yoon:2, Hyoshik Shin:1
1:Department of Pharmacology, Yonsei University Wonju College of Medicine, Korea, 2:Department of Internal Medicine, Yonsei University Wonju College of Medicine, Korea

Using bioluminescence resonance energy transfer (BRET) and super-resolution microscopy to investigate complex formation between VEGFR2, its co-receptor Neuropilin-1 and G protein coupled receptors

[Speaker] Laura Kilpatrick:1
[Co-author] Diana C Alcobia:1, Jackie R Glenn:1, Kris Zimmerman:2, Rachel Friedman Ohana:2, Matthew B Robers:2, Keith V Wood:2, Jeanette Woolard:1, Stephen J Hill:1
1:Centre of Membrane Proteins and Receptors (COMPARE), University of Nottingham, UK, 2:Promega Corporation, Madison, Wisconsin, USA

The discovery of novel CK1 delta inhibitors for bladder cancer therapy

[Speaker] Chun-Han Chen:1
1:Department of Pharmacology, Taipei Medical University, Taiwan

Effects of culturing prostate cancer cells in acidic conditions upon the endocannabinoid signalling system

[Speaker] Christopher J Fowler:1
[Co-author] Linda Stafberg:1, Jessica Karlsson:1
1:Pharmacology and Clinical Neuroscience, Umea University, Sweden

Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells

[Speaker] Masayuki Shiota:1
[Co-author] Kazuaki Kita:2, Masako Tanaka:3, Hiroshi Iwao:4, Katsuyuki Miura:5, Tatsuya Nakatani:2, Shuhei Tomita:6
1:Res. Sprt. Platf., Osaka City Univ. Grad. Sch. Med., Japan, 2:Dept. Urol., Osaka City Univ. Grad. Sch. Med., Japan, 3:Dept. Life Sci. Med. BioSci., Sch. Sci. Eng., Waseda Univ., Japan, 4:Dept. Edu, Shitennoji Univ., Japan, 5:Dept. Appl. Pharmacol. Ther., Osaka City Univ. Grad. Sch. Med., Japan, 6:Dept. Pharmacol., Osaka City Univ. Grad. Sch. Med., Japan

Ca2+-activated K+ channel KCa2.2 as a possible therapeutic target for androgen-sensitive prostate cancer

[Speaker] Satomi Niwa:1
[Co-author] Yuki Kobayashi:1, Anowara Khatun:1, Taku Naiki:2,3, Takahiro Yasui:2, Satoru Takahashi:3, Masanori Fujii:1, Susumu Ohya:1,4
1:Department of Pharmacology, Kyoto Pharmaceutical University, Japan, 2:Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Japan, 3:Department of Experimental Pathology & Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, Japan, 4:Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Japan

PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors

[Speaker] Hiromichi Fujino:1
[Co-author] Yumi Araki:1,2, Akiko Suganami:3, Suzu Endo:1, Harumi Takano:1, Yuta Masuda:1, Keijo Fukushima:1, John W Regan:4, Toshihiko Murayama:2, Yutaka Tamura:3
1:Department of Molecular Pharmacology, Tokushima University, Graduate School of Pharmaceutical Sciences, Japan, 2:Laboratory of Chemical Pharmacology, Chiba University, Graduate School of Pharmaceutical Sciences, Japan, 3:Department of Bioinformatics, Chiba University, Graduate School of Medicine, Japan, 4:Department of Pharmacology & Toxicology, The University of Arizona, College of Pharmacy, USA

The synergistic antitumor effect of combined Trastuzumab and gamma interferon therapy to drug resistant Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer cells

[Speaker] Toshihiko Gocho:1
[Co-author] Hiromichi Tsuchiya:1, Shotaro Kamijyo:1, Yoshitaka Yamazaki:2, Yui Akita:3, Yoko Ao:1, Akiko Sasaki:1, Yuji Kiuchi:1
1:Medical pharmacology, Showa University, Japan, 2:Department of Hospital Pharmaceutics, Showa University, Japan, 3:School of Pharmacy, Showa University, Japan

In Vivo anti-tumor effect of Eckol, a phlorotannin component isolated from brown algae, associated with regulating dendritic cells in sarcoma 180 (S180) xenografts-bearing mice

[Speaker] Jun Wang:1
[Co-author] Mengya Zhang:1, Shuqi Zhao:1, Juan Liu:1, Xianmin Hu:1
1:Department of Pharmacology, Medical College, Wuhan University of Science and Technology, China

Identification of Structural-Activity Features of Long Chain Polyunsaturated Fatty Acid Epoxides in Angiogenesis

[Speaker] Rebekah Betts:1
[Co-author] Kin Sing Lee:1, Maris Cinelli:1, Joe Luca:1, Nick Confer:1
1:Pharmacology and Toxicology, Michigan State University, USA

Highly Selective HDAC6 inhibitor targets glioblastoma promoting HDAC6 degradation via autophagy inhibition and immune modulation

[Speaker] Jia-Rong Liu:1
[Co-author] Chao-Wu Yu:1, Ji-Wang Chern:1
1:School of Pharmacy, National Taiwan University, Taiwan

Antioxidant, anti-inflammatory, and Hep G2 cell growth-inhibitory effects of extracts from Sargassum crassifolium

[Speaker] Chun-Yung Huang:1
1:Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung, Taiwan

The role of NLRP3 inflammasome in regulating the progression of prostate cancer

[Speaker] Hsin-En Wu:1
[Co-author] Chia-Yang Li:1
1:Graduate Institute of Medicine, College of Medicine, Chia-Yang Li Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

Losses of cytokines and chemokines are common genetic features of human cancers: the somatic copy number alterations are correlated with patient prognoses and therapeutic resistance

[Speaker] Henry Sung Ching Wong:1
[Co-author] Wei-Chiao Chang:1
1:Department of Pharmacy, Taipei Medical University, Taiwan

PID1 promotes hepatocarcinogenesis by interacting with ARG1 and EGFR

[Speaker] Ming Xiang:1
[Co-author] Qianqian Xu:1, Senlin Li:1
1:Huazhong University of Science and Technology, China

Syk modulates EGFR signaling and functions in keratinocyte differentiation and squamous cell carcinoma progression

[Speaker] Yen-Yu Chang:1
[Co-author] Duen-Yi Huang:1, Wan-Wan Lin:1, Wei-Yu Chen:2, Chi-Long Chen:2
1:Department of Pharmacology, National Taiwan University, Taipei, Taiwan, 2:Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

Evaluation of tumor infiltrating lymphocyte (TIL) using CT26WT-bearing mice model

[Speaker] Shinichiro Tsunesumi:1
[Co-author] Shigenori Enoki:1, Seiichi Katayama:1, Naoyuki Hironaka:1, Katsuhide Nishi:1
1:Pharmacology Department, Kumamoto Laboratory, LSI Medience Corporation, Japan

Exploiting the Cross-talk between Glioblastoma Cells and Tumor-associated Macrophages with a Nano-drug for regulating Tumor Immune Microenvironment

[Speaker] Tong-Fei Li:1
[Co-author] Xiao Chen:1
1:Department of Pharmacology, School of Basic Medicine, Wuhan University, China

Benefits of metronomic therapy targeting muscarinic receptors in breast cancer as a sensitizer of cells to classic chemotherapy with paclitaxel

[Speaker] Maria Elena E. Sales:1,2
[Co-author] Agustina R. Salem:1,2, Yamila Sanchez:1,2, Paola Martinez Pulido:1,2, Francisco Sanchez:1,2, Español Alejandro J.:1,2
1:CEFYBO-CONICET, Argentina, 2:Facultad de Medicina-UBA, Argentina

Histone inhibitor (IOX-1) inhibits osteosarcoma cell stemness and inhibits osteosarcoma cell migration

[Speaker] Tsung-Ming Chang:1
[Co-author] Pei-Wen Peng:2, Wei-Fang Lee:2, Ju-Fang Liu:1
1:Central Laboratory, Shin-Kong Wu Ho-Su Memorial Hospital, Taiwan, 2:School of Dental Technology, Taipei Medical University, Taiwan

Establishment of a prostate cancer organoid using the dog urine stem cells

[Speaker] Tatsuya Usui:1
[Co-author] Kazuaki Sasaki:1
1:Laboratory of Veterinary Pharmacology, Tokyo University of Agriculture and Technology, Japan

Cancer stem-like cells induce cisplatin resistance and miR-17 and miR-93 regulate p21 expression in triple-negative breast cancer

[Speaker] Akiko Sasaki:1
[Co-author] Yuko Tsunoda:2, Kanji Furuya:1, Hideto Oyamada:1, Mayumi Tsuji:1, Yuko Udaka:1, Yuji Kiuchi:1
1:Department of Pharmacology School of Medicine, Showa University, Japan, 2:Kameda Medical Center, Breast Center, Japan

Oleic acid-induced ANGPTL4 facilitates metastasis via up-regulation of NOX4 in human colorectal cancer

[Speaker] Chih-Jie Shen:1,2,3
[Co-author] Wen-Chang Chang:2, Ben-Kuen Chen:1,2,3
1:Pharmacology, National Cheng Kung University, Taiwan, 2:Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan, 3:Institute for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

Novel strategy for treatment of cancer cachexia based on metabolic alteration in central nervous system in a mouse model

[Speaker] Miaki Uzu:1
[Co-author] Miki Nonaka:1, Kanako Miyano:1, Hiromi Sato:2, Nagomi Kurebayashi:3, Takashi Murayama:3, Takashi Sakurai:3, Akihiro Hisaka:2, Yasuhito Uezono:1,4
1:Division of Cancer Pathophysiology, National Cancer Center Research Institute, Japan, 2:Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan, 3:Department of Pharmacology, Juntendo University School of Medicine, Japan, 4:Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Research Institute, Japan

Induction of anti-apoptotic signaling via ATF4 confers resistance to the inhibition of essential amino acid transporter LAT1

[Speaker] Takashi Yamaga:1
[Co-author] Junichi Suehiro:1, Hiroyuki Sakurai:1
1:Department of Pharmacology, Kyorin University School of Medicine, Japan

Elevated O-GlcNAcylation in the tumor microenvironment promotes B16 melanoma cell progression through the suppression of p38 MAPK

[Speaker] Kazumasa Moriwaki:1
[Co-author] Michio Asahi:1
1:Pharmacology, Faculty of Medicine, Osaka Medical Collage, Japan

A new strategy to prevent prostate cancer stem cells

[Speaker] Saki Kaneko:1
[Co-author] Tomohiro Yano:1
1:Graduate School of Food and Nutritional Science, Toyo University, Japan

Structure activity relations of aromatic amino acid derivatives to interact with organic anion transporter OAT1 reveal critical moieties for renal accumulation of tumor imaging probes

[Speaker] Chunhuan Jin:1
[Co-author] Ryuichi Ohgaki:1, Hideyuki Tominaga:2, Suguru Okuda:1, Shushi Nagamori:1,3, Yoshikatsu Kanai:1
1:Graduate School of Medicine, Osaka University, Bio-system Pharmacology, Japan, 2:Advanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan, 3:Laboratory of Biomolecular Dynamics, Department of Collaborative Research, Nara Medical University, Nara, Japan

Search for drugs that attenuate the antitumor effect of bevacizumab using adverse event database

[Speaker] Yoshito Zamami:1,2
[Co-author] Yuki Izawa-Ishizawa:3, Kenshi Takechi:4, Masaki Imanishi:2, Keijo Fukushima:5, Yuya Horinouchi:3, Yasumasa Ikeda:3, Hiromichi Fujino:5, Toshiaki Tamaki:3, Keisuke Ishizawa:1,2
1:Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 2:Department of Pharmacy, Tokushima University Hospital, Japan, 3:Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan, 4:Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Japan, 5:Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences & Institute of Biomedical Sciences, Graduate School, Tokushima University, Japan

PHARMACOMETRIC APPROACH TO SUPPORT DOSING STRATEGY OF NIMOTUZUMAB IN PATIENTS WITH BREAST CANCER

[Speaker] Leyanis Rodriguez Vera:1
[Co-author] Mayra Ramoz Suzarte:2, Eduardo Fernandez Sanchez:1, Jorge Luis Soriano:3, Gilberto Castaneda:4, Niurys De Castro Suarez:1, Helena Colom Codina:5
1:Department of Pharmacy, Institute of Pharmacy and Foods, University of Havana, Cuba, 2:Center of Molecular Immunology, Havana, Cuba, 3:Hermanos Ameijeiras Hospital, Havana, Cuba, 4:CINVESTAV- IPN, Mexico, 5:University of Barcelona, Spain

Establishment and Characterization of Novel Leukemic Cell Lines Resistant to New-Generation Dihydrofolate Reductase Inhibitor, Pralatrexate

[Speaker] Kana Oiwa:1
[Co-author] Naoko Hosono:1, Rie Nishi:1, Takanori Ueda:1, Takahiro Yamauchi:1
1:Department of Hematology and Oncology, University of Fukui, Japan

SNP as a nitric oxide donor induces apoptosis of HepG2 cells by targeting the MAPK-mediated mitochondrial pathway

[Speaker] Zi-le Huang:1
[Co-author] Jian-Gang Wang:1, San-Qing Li:1, Ling Liu:1
1:Henan University of Science and Technology, Luoyang, China

The role of NSAIDs in the prevention of colorectal cancer

[Speaker] Mehdi Bouhlel:1
[Co-author] Mehdi Dridi:1
1:Department of Pharmacology, College of Pharmacy, University of Monastir, Tunisia

The role of nutraceuticals in the chemoprevention of the colorectal neoplasm

[Speaker] Mehdi Bouhlel:1
[Co-author] Mehdi Dridi:1, Abderrahman Bouraoui:1
1:Department of Pharmacology, College of Pharmacy, University of Monastir TUNISIA, Tunisia

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