Sessions

Dopamine-induced phosphorylation of NPAS4 through MAPK regulates reward-related learning and memory

[Speaker] Yasuhiro Funahashi:1
[Co-author] Anthoy Ariza:1, Shan Wei:2, Sachi Kozawa:1, Ryosuke Emi:1, Ko Suzuki:1, Keiichiro Okuda:1, Keisuke Kuroda:1, Taku Nagai:2, Kozo Kaibuchi:1
1:Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Japan, 2:Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan

Resveratrol regulates the alternative splicing of tau exon 10 to improve learning and memory in hTau mice

[Speaker] Wei Qian:1
[Co-author] Shuo Qian:1, Jianlan Gu:1, Qin Huang:1
1:Department of Biochemistry, Medical School, Nantong University, China

Effect of environmental enrichment components on memory impairment and addictive behavior induced by toluene

[Speaker] Nayeli Paez-Martinez:1,2
[Co-author] Ricardo Mosco-Aquino:2,3, Roberto E Mercadillo:3,4
1:Seccion de Posgrado e Investigacion, School of Medicine. Instituto Politecnico Nacional, Mexico, 2:Laboratorio Integrativo para el Estudio de Sustancias Inhalables Adictivas. Instituto Nacional de Psiquiatria. Ciudad de Mexico., Mexico, 3:Area de Neurociencias, Departamento de Biologia de la Reproduccion. Universidad Autonoma Metropolitana-Iztapalapa. Ciudad de Mexico., Mexico, 4:Consejo Nacional de Ciencia y Tecnologia. Ciudad de Mexico, Mexico

Spatial representation of hippocampal cells in response to aversive stimulus in a T-maze task

[Speaker] Sakura Okada:1
[Co-author] Hideyoshi Igata:1, Takuya Sasaki:1,2, Yuji Ikegaya:1
1:Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, Tokyo, Japan, 2:Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Japan

Transcranial direct current stimulation enhances hippocampal CA1 long-term potentiation via BDNF secretion and TrkB activation

[Speaker] Ting-Hsuan Yu:1
[Co-author] Yi-Jen Wu:2, Kuei-Sen Hsu:1,3
1:Institute of Basic Medical Sciences, Natioanal Cheng Kung University, Taiwan, 2:Department of Neurology, Natioanal Cheng Kung University, Taiwan, 3:Department of Pharmacology, College of Medicine, Natioanal Cheng Kung University, Taiwan

Involvement of ROS/8-nitro-cGMP signals in cerebellar synaptic plasticity in mice

[Speaker] Sho Kakizawa:1
[Co-author] Shogo Endo:2
1:Department of Biological Chemistry, Kyoto University, Graduate School of Pharmaceutical Sciences, Japan, 2:Memory Neuroscience Section, Aging Neuroscience Research Team, Tokyo Metropolitan Institute of Gerontology, Japan

Sleep Consolidates Motor Learning of Complex Movement Sequences in Mice

[Speaker] Hirotaka Nagai:1,2
[Co-author] Luisa De Vivo:2, Michele Bellesi:2, Maria F Ghilardi:3, Giulio Tononi:2, Chiara Cirelli:2
1:Pharmacology, Kobe University, Japan, 2:Psychiatry, University of Wisconsin-Madison, USA, 3:Physiology and Pharmacology, City University of New York Medical School, USA

Adolescent mouse hippocampal function was impaired by prenatal nicotine exposure

[Speaker] Takayoshi Mamiya:1,2
[Co-author] Shota Tanase:1, Maki Hada:1, Shunsuke Kato:1, Shino Takeuchi:1, Daisuke Ibi:1, Toshitaka Nabeshima:1,2,3, Masayuki Hiramatsu:1,2
1:Faculty of Pharmacy, Meijo University, Japan, 2:NPO Japanese Drug Organization of Appropriate Use and Research, Japan, 3:Graduate School of Health Sciences, Fujita Health University, Japan

Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome

[Speaker] Norifumi Shioda:1
[Co-author] Hiroshi Sugiyama:2, Takahito Wada:3, Kohji Fukunaga:4
1:Department of Biofunctional Analysis Laboratory of Molecular Biology, Gifu Pharmaceutical University, Japan, 2:Department of Chemistry, Graduate School of Science, Kyoto University, Japan, 3:Department of Medical Ethics and Medical Genetics, Graduate School of Medicine, Kyoto University, Japan, 4:Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan

Developmental immaturity of the maintenance mechanisms for long-term potentiation is functionally linked to infantile amnesia

[Speaker] Tsung-Chih Tsai:1
[Co-author] Chiung-Chun Huang:1, Kuei-Sen Hsu:1,2
1:The Institute of Basic Medical Sciences, National Cheng Kung University, Taiwan, 2:Department of Pharmacology, College of Medicine, National Cheng Kung University, Taiwan

Brain histamine boosts reactivation of weak memory engrams and restores forgotten long-term memories in mice and humans

[Speaker] Hiroshi Nomura:1,2
[Co-author] Hiroto Mizuta:3, Hiroaki Norimoto:2, Fumitaka Masuda:2, Yuki Miura:2, Ayame Kubo:1, Ryoki Saito:1, Masabumi Minami:1, Hidehiko Takahashi:3, Yuji Ikegaya:2,4
1:Hokkaido University, Japan, 2:The University of Tokyo, Japan, 3:Kyoto University Graduate School of Medicine, Japan, 4:Center for Information and Neural Networks, Japan

M1 muscarinic receptor facilitates cognitive function by interplay with AMPA receptor GluA1 subunit

[Speaker] Yu Qiu:1
[Co-author] Lan-Xue Zhao:1, Yan-Hui Ge:1, Cai-Hong Xiong:1, Hong-Zhuan Chen:1
1:Shanghai Jiao Tong University School of Medicine, China

Methylphenidate enhances memory consolidation and amplifies long-term potentiation: differential involvement of the prefrontal dopamine receptor and norepinephrine receptor

[Speaker] Xue-Han Zhang:1
[Co-author] Shu-Su Liu:1, Feng Yi:1, Hou-Cheng Zhou:1
1:Institutes of Brain Science, Fudan University, China

Cognitive dysfunction induced by the deletion of NAA synthase Shati/Nat8l in mice

[Speaker] Kyosuke Uno:1
[Co-author] Kousuke Endo:1, Kazuyuki Sumi:1, Haddar Meriem:1, Yoshiaki Miyamoto:1, Shin-Ichi Muramatsu:2,3, Atsumi Nitta:1
1:Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan, 2:Division of Neurology, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan, 3:Center for Gene & Cell Therapy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Microinjection of Reelin into the medial prefrontal cortex improves MK801-induced memory impairment

[Speaker] Masahito Sawahata:1
[Co-author] Kanako Kitagawa:1, Yumi Tsuneura:1, Taku Nagai:1, Takao Kohno:2, Toshitaka Nabeshima:3,4, Mitsuharu Hattori:2, Kiyofumi Yamada:1
1:Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan, 2:Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan, 3:Advanced Diagnostic System Research Laboratory Fujita Health University, Graduate School of Health Sciences, Japan, 4:Aino University, Japan

Effects of Euterpe oleracea on learning and memory in adult male rats

[Speaker] Cafer Yildirim:1
[Co-author] Sule Aydin:1, Basak Donertas:1, Setenay Oner:2, Fatma Sultan Kilic:1
1:Department of Pharmacology, Eskisehir Osmangazi University, School of Medicine, Turkey, 2:Department of Biostatistic, Eskisehir Osmangazi University, School of Medicine, Turkey

Removal of perineuronal nets in the deep cerebellar nuclei enhances GABAergic transmission and improves delay eyeblink conditioning

[Speaker] Moritoshi Hirono:1,2
[Co-author] Satoshi Watanabe:3, Shigenori Kawahara:4, Soichi Nagao:2,5, Yuchio Yanagawa:6, Hiroaki Misonou:1
1:Graduate School of Brain Science, Doshisha University, Japan, 2:Laboratory for Motor Learning Control, RIKEN BSI, Japan, 3:National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan, 4:Graduate School of Science and Engineering, University of Toyama, Japan, 5:Laboratory for Integrative Brain Functions, Nozomi Hospital, Japan, 6:Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Japan

Hippocampal neuron firing is variable across laps in a linear track task

[Speaker] Saichiro Yagi:1
[Co-author] Hideyoshi Igata:1, Yu Shikano:1, Yuki Aoki:1, Takuya Sasaki:1,2, Yuji Ikegaya:1
1:Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan, 2:Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Japan

The opposite role of D-serine in immediate and retrieval extinction of contextual fear memory

[Speaker] Hisashi Mori:1
[Co-author] Gourango Talukdar:1, Ran Inoue:1
1:Department of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan

δ-opioid receptor inverse agonist SYK-623 improved stress-induced learning dysfunction in mice

[Speaker] Takashi Iwai:1,3
[Co-author] Toya Okonogi:1,3, Rei Mishima:1,3, Kayoko Yoshida:1,3, Misa Oyama:1,3, Shun Watanabe:1,3, Shigeto Hirayama:2,3, Hideaki Fujii:2,3, Mitsuo Tanabe:1,3
1:Lab. Pharmacol., Sch. Pharm., Kitasato University, Japan, 2:Lab. Med. Chem., Sch. Pharm., Kitasato University, Japan, 3:Med. Res. Lab., Sch. Pharm., Kitasato University, Japan

Contribution of intracellular acetylcholine receptor to hippocampal long-term potentiation

[Speaker] Takayoshi Masuoka:1
[Co-author] Makiko Kudo:1, Matomo Nishio:1, Ikunobu Muramatsu:1, Takaharu Ishibashi:1
1:Department of Pharmacology, School of Medicine, Kanazawa Medical University, Japan

Correlation between rat personality and learning ability, and possible involvement of NR1 subunit

[Speaker] Hirotaka Oikawa:1
[Co-author] Shouhei Miyazaki:2, Rina Kato:1, Masato Ogata:3, Takahiko Fujikawa:1,2,3
1:Faculty of Pharmaceutical Science, Suzuka University of Medical Science, Japan, 2:Division of Clinical Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Suzuka University of Medical Science, Japan, 3:Graduate School of Medicine, Mie University, Japan

Effects of intracerebroventricular administration of CGRP on fear memory in mice

[Speaker] Shuta Mishima:1
[Co-author] Ami Otsuka:1, Naoya Hashikawa:1, Narumi Hashikawa-Hobara:1
1:Okayama University of Science, Japan

α-lipoic acid attenuates apoptosis and accompany with autophagy in chronic hypoperfusion animal models

[Speaker] Ji-Hye Park:1,3
[Co-author] Yong Cheon Na:2, Chang Yeob Han:3, Seong Bin Park:4, Mi Jeong Han:3, Seoul Lee:1,3
1:Wonkwang Brain Reserch Institute, Korea, 2:Wonkwang Medical Institue, Korea, 3:Department of Pharmacology, Wonkwang University School of Medicine, Korea, 4:Korea Human Resource Development Institute For Health & Welfare, Korea

Exploring the therapeutic potential of vitamin D supplementation for Alzheimer's disease

[Speaker] Fang-Yu Lin:1
[Co-author] Hsiao-Wei Jao:2, Ya-Hsin Hsiao:1
1:Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan, 2:School of Pharmacy, College of Medicine, National Cheng-Kung University, Tainan, Taiwan

Characterization of ferulic acid and its derivatives on the aggregation of α-synuclein

[Speaker] Mengge Chen:1
[Co-author] Ryuichi Harada:1,2, Takeo Yoshikawa:1, Yukitsuka Kudo:2, Nobuyuki Okamura:3, Kazuhiko Yanai:1
1:Department of Pharmacology, Tohoku University School of Medicine, Japan, 2:Institute of Development, Aging and Cancer, Tohoku University, Japan, 3:Division of Pharmacology, Tohoku Medical and Pharmaceutical University, Japan

In response to monomeric α-synuclein, brain pericytes release inflammatory cytokines to impair brain endothelial barrier

[Speaker] Shinya Dohgu:1
[Co-author] Fuyuko Takata:1, Junichi Matsumoto:1, Ikuya Kimura:1, Atsushi Yamauchi:1, Yasufumi Kataoka:1
1:Department of Pharmaceutical Care and Health Sciences, Fukuoka University, Japan

Tetrahydroxystilbene glucoside regulates amyloid precursor protein expression via activation of AKT-GSK3β pathway in cells and in APP/PS1 transgenic mice

[Speaker] Xiaomin Yin:1,2
[Co-author] Chen Chen:1, Ting Xu:2, Lin Li:1
1:Department of Pharmacology, Xuanwu Hospital of Capital Medical University, China, 2:Department of Biochemistry, Medical College, Nantong University, China

Based on Nrf2/Keap1 signaling pathways of ginseng CK targeted regulating A beta molecular mechanism research to protect the damaged neurons

[Speaker] Na Li:1
[Co-author] Qing Yang:1, Xin Sui:1, Zheng Xiao Shi:1, Hua Xiao Li:1, Dong Han:1, Bo Xiao Qu:1, Jun Dian Sui:1
1:Changchun University of Chinese Medicine, China

Cu (II) compromises lysosome function and reduces autophagy-mediated amyloid beta1-42 clearance in microglia

[Speaker] Juan Li:1
[Co-author] Xiaofang Tan:1, Yongyao Cui:1, Hongzhuan Chen:1
1:Department of Pharmacology, Shanghai Jiao Tong University School of Medicine, China

EPIGALLOGATECHIN-3-GALLATE IMPROVES COGNITIVE DECLINE AND METABOLIC ALTERATIONS IN APP/PS1 FAMILIAL MODEL OF ALZHEIMER'S DISEASE FED WITH HIGH FAT DIET

[Speaker] Miren Ettcheto:1,2,3,4
[Co-author] Amanda Cano:5,6, Oriol Busquets:1,2,3,4, Saghar Rabiei-Poor:1, Carme Auladell:2,3,7, Jaume Folch:2,4, Antoni Camins:1,2,3
1:Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Spain, 2:Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Madrid., Spain, 3:Institute of Neuroscience, University of Barcelona, Spain, 4:Department of Biochemistry, Faculty of Medicine and Life Science, University of Rovira i Virgili, Reus., Spain, 5:Unit of Pharmacy, Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Spain, 6:Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Spain, 7:Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Spain

Withdrawn

Alpha-synuclein aggregations are promoted by fatty acid-binding protein 3 and arachidonic acid

[Speaker] Yasuharu Shinoda:1
[Co-author] An Cheng:1, Shuto Hachinohe:1, Kohji Fukunaga:1
1:Department of Pharmacology, Tohoku University Graduate School of Pharmaceutical Sciences, Japan

Enhancement of the autophagy-lysosomal pathway modulates the process of amyloid β-protein generation

[Speaker] Wataru Araki:1
[Co-author] Fumiko Yamamoto:1,2, Kaori Taniguchi:1, Naomi Mamada:2, Akira Tamaoka:2, Fuyuki Kametani:3, Madepalli K Lakshmana:4
1:Dept of Demyelinating Dis & Aging, National Inst of Neurosci, NCNP, Japan, 2:Dept of Neurology, Faculty of Medicine, Univ of Tsukuba, Japan, 3:Dept of Dementia and Higher Brain Function, Tokyo Metropolitan Inst of Medical Science, Japan, 4:Torrey Pines Inst for Molecular Studies, USA

Diosgenin-induced reduction of HSC70 results in axonal regeneration and improvement of memory function in a mouse model of Alzheimer's disease

[Speaker] Ximeng Yang:1
[Co-author] Chihiro Tohda:1
1:Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Japan

Systemic insulin resistance induces cognitive and psychiatric symptoms in Alzheimer's disease model mice

[Speaker] Naotaka Izuo:1
[Co-author] Nobuhiro Watanabe:2, Yoshihiro Noda:3, Takashi Saito:4, Takaomi Saido:4, Harumi Hotta:2, Takahiko Shimizu:1
1:Department of Advanced Aging Medicine, Graduate School of Medicine, Chiba University, Japan, 2:Department of Autonomic Neuroscience, Tokyo Metropolitan Institute of Gerontology, Japan, 3:Animal Facility, Tokyo Metropolitan Institute of Gerontology, Japan, 4:Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Japan

Calmodulin-like skin protein is downregulated in human cerebrospinal fluids of Alzheimer's disease patients with apolipoprotein E4; a pilot study using postmortem samples

[Speaker] Yuichi Hashimoto:1
[Co-author] Takahiko Umahara:2, Haruo Hanyu:2, Toshihiko Iwamoto:3, Masaaki Matsuoka:1,4
1:Department of Pharmacology, Tokyo Medical University, Japan, 2:Department of Geriatric Medicine, Tokyo Medical University, Japan, 3:Department of Geriatric Medicine, International University of Health and Welfare, Japan, 4:Department of Dermatological Neuroscience, Tokyo Medical University, Japan

KATP channel is novel targets for Alzheimer's disease therapeutics

[Speaker] Shigeki Moriguchi:1
[Co-author] Kohji Fukunaga:1
1:Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan

Malfunction of calcineurin-NFAT signaling pathway is associated to the development of Alzheimer's disease in adults with Down syndrome

[Speaker] Masashi Asai:1,2
[Co-author] Aimi Kinjo:2, Shoko Kimura:2, Ryotaro Mori:1, Takashi Kawakubo:1, Sosuke Yagishita:3, Kei Maruyama:3, Nobuhisa Iwata:1,2
1:Department of Genome-based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, Japan, 2:Department of Genome-based Drug Discovery, School of Pharmaceutical Sciences, Nagasaki University, Japan, 3:Department of Pharmacology, Faculty of Medicine, Saitama Medical University, Japan

Nanoformulated alpha-mangostin ameliorates Alzheimer's disease neuropathology by elevating LDLR expression and accelerating amyloid-beta clearance

[Speaker] Xiaoling Gao:1
[Co-author] Lei Yao:1, Meng Hu:1, Xiao Gu:1
1:Shanghai Jiao Tong University School of Medicine, China

Epigenetic mechanisms in Alzheimer's Disease: Therapeutic potential of Class specific HDAC inhibitors in insulin resistance induced cognitive impairments

[Speaker] Rajeev Taliyan:1
[Co-author] Sorabh Sharma:1
1:Pharmacy, Birla Institute of Technology and Science, Pilani, India

Anti-High Mobility Group Box-1 Antibody Therapy Might Prevent Cognitive Dysfunction After Traumatic Brain Injury

[Speaker] Yu Okuma:1
[Co-author] Keyue Liu:2, Hidenori Wake:2, Kiyoshi Teshigawara:2, Shuji Mori:3, Hideo K Takahashi:4, Nobuyuki Hirotsune:1, Shigeki Nishino:1, Masahiro Nishibori:2
1:Department of Neurological Surgery, Hiroshima City Hiroshima Citizens Hospital, Japan, 2:Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences., Japan, 3:Department of Pharmacology, School of Pharmacy, Shujitsu University, Japan, 4:Department of Pharmacology, Kinki University School of Medicine, Japan

Role of Dolichol Kinase and GPT cascade in amyloid induced dementia of Alzheimer type

[Speaker] Priyanka:1
[Co-author] Anil Kumar:1, Rohit Goyal:1
1:School of Pharmaceutical sciences, Shoolini University Solan H. P. India, India

Polygalae Radix extract prevents axonal degeneration and memory deficits in a transgenic mouse model of Alzheimer's disease

[Speaker] Tomoharu Kuboyama:1
[Co-author] Chihiro Tohda:1
1:Div of Neuromedical Sci, Instit of Natural Med, Univ of Toyama, Japan

Chronic intermittent hypoxia aggravates neurocognitive decline in an animal model of Alzheimer's disease

[Speaker] Lida Du:1,2
[Co-author] Chun Kwan O:1,2, Linting Geng:1,2, Linhao Xu:3, Ya Ke:1,2, Wing Ho Yung:1,2
1:School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, 2:Gerald Choa Neuroscience Centre, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, 3:Department of Anatomy, Hangzhou Medical College, China

Neuroinflammation and acetylcholinesterase overexpression as the main targets for low doses of GABA-A receptor agonists in Alzheimer's disease rat model

[Speaker] Baiba Jansone:1
[Co-author] Vladimirs Pilipenko:1, Karina Narbute:1, Juris Rumaks:1, Jolanta Pupure:1, Zane Dzirkale:1, Vija Klusa:1
1:Department of Pharmacology, University of Latvia, Faculty of Medicine, Latvia

Therapeutic galactose effect on metabolic dysfunction and cognition in sporadic rat model of Alzheimer's disease

[Speaker] Ana Knezovic:1
[Co-author] Jelena Osmanovic Barilar:1, Ana Babic:1, Robert Bagaric:2, Vladimir Farkas:2, Peter Riederer:3,4, Melita Salkovic-Petrisic:1
1:Pharmacology, School of Medicine, University of Zagreb, Croatia, 2:Department of Experimental Physics, Rudjer Boskovic Institute, Zagreb, Croatia, 3:Center of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Würzburg, Germany, 4:Department and Research Unit of Psychiatry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

Conditional deletion of CC2D1A reduces hippocampal synaptic plasticity and impairs cognitive function

[Speaker] Cheng-Yi Yang:1
[Co-author] Pin Ling:1,2, Kuei-Sen Hsu:1,3
1:Institute of Basic Medical Sciences, Natioanal Cheng Kung University, Taiwan, 2:Department of Microbiology & Immunology, Taiwan, 3:Department of Pharmacology, College of Medicine, Taiwan

DJ-1-binding compound ameliorates spatial learning and memory impairment in a mouse model of Alzheimer's disease

[Speaker] Yoshihisa Kitamura:1
[Co-author] Masanori Hijioka:1
1:College of Pharmaceutical Sciences, Ritsumeikan University, Japan

20C, a novel bibenzyl compound, protected mice from MPTP/p injuries by regulating a-synuclein related inflammatory responds

[Speaker] Yu-he Yuan:1
[Co-author] Nai-Hong Chen:1
1:Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, China

Iso-α-acids, bitter components in beer, suppress inflammation and neural activation in the hippocampus of Alzheimer's model mice, resulting in cognitive improvement

[Speaker] Yasuhisa Ano:1
[Co-author] Yuka Yoshino:2, Misato Yoshikawa:3, Kazuyuki Uchida:2, Hiroyuki Nakayama:2, Akihiko Takashima:3
1:Research Laboratories for Health Science & Food Technologies, Kirin Company, Limited, Japan, 2:Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan, 3:Faculty of Science, Gakushuin University, Japan

Exploration of effect of metformin in Amyloid beta (1-42) and streptozotocin induced rodent models of Alzheimer's disease

[Speaker] Harish Kumar:1
[Co-author] Bikash Medhi:1, Amitava Chakrabarti:1, Bd Radotra:2, Manish Modi:3, Dibyajyoti Banerjee:4
1:Pharmacology, PGIMER, Chandigarh, India, 2:Department of Histopathology, PGIMER, India, 3:Department of Neurology, PGIMER, India, 4:Department of Experimental medicine and biotechnology, PGIMER, India

Transglutaminases derived from astrocytes might accelerate amyloid-beta aggregation

[Speaker] Katsura Takano:1
[Co-author] Kenji Kawabe:2, Mitsuaki Moriyama:1, Yoichi Nakamura:1
1:Laboratory of Integrative Physiology in Veterinary Sciences, Osaka Prefecture University, Japan, 2:Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan

Changes in PGC-1a and Mfn1/Drp1 levels are indicative of amyloid b-induced mitocondrial dysfunction induced by P2X2-mediated Ca2+ overload in a cellular model of Alzheimer's disease

[Speaker] Jorge Fuentealba:1
[Co-author] Jessica D Panes:1, Tiare Silva-Grecchi:1, Javiera Gavian:1, Daniela Mennickent:1, Pamela A Godoy:1, Gustavo Moraga-Cid:1, Gonzalo E Yevenes:1, Leonrardo Guzman:1, Patricio A Castro:1
1:Physiology, University of Concepcion, Chile

Selective potentiation of muscarinic acetylcholine receptor subtype 1 demonstrates efficacy and safety in preclinical models of Alzheimer's disease and schizophrenia

[Speaker] Jerri M Rook:1
[Co-author] Jonathan W Dickerson:1,2, Ryan M Hanson:1,2, Craig W Lindsley:1,2,3, P Jeffrey Conn:1,2
1:Pharmacology, Vanderbilt University, USA, 2:Vanderbilt Center for Neuroscience Drug Discovery, USA, 3:Chemistry, Vanderbilt University, USA

Natural Acetylcholinesterase Inhibitors Used in Alzheimer's Disease Treatment

[Speaker] Ozan Demirkilic:1
[Co-author] Feyza Alyu:2, Hulya Tuba Kiyan:2
1:Department of Medical Pharmacology, Eskisehir Osmangazi University, Turkey, 2:Department of Pharmacology, Anadolu University, Turkey

Pharmacological characterization of the amyloid beta peptide Abeta42 for its modulation of the chemerin receptor CMKLR1

[Speaker] Richard D Ye:1
[Co-author] Shuo Zhang:2, Dan Liao:2, Hao Gong:2
1:University of Macau, Macao, 2:Shanghai Jiao Tong University, China

Abeta-induced cerebral endothelial cell death via LKB1-AMPK-p38MAPK cascade

[Speaker] Yu-Fan Chuang:1
[Co-author] Ming-Jen Hsu:1
1:Taipei Medical University, Taiwan

T-type calcium channel enhancer SAK3 improves cognition and inhibits amyloid beta accumulation in AppNL-F knock-in mice

[Speaker] Hisanao Izumi:1
[Co-author] Yasuharu Shinoda:1, Takashi Saito:2, Takaomi Saido:2, Yusaku Nakabeppu:3, Kohji Fukunaga:1
1:Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan, 2:Laboratory for Proteolytic Neuroscience, Brain Science Institute, RIKEN, Japan, 3:Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Japan

Activation of glucagon-like peptide-1 receptors might be a mechanism of the beneficial effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer's disease

[Speaker] Jelena Osmanovic Barilar:1
[Co-author] Ana Knezovic:1, Ana Babic:1, Peter Riederer:2,3, Melita Salkovic-Petrisic:1
1:Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia, 2:Center of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, Wuerzburg, Germany, 3:Department and Research Unit of Psychiatry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

Cornel iridoid glycoside protected synaptic function by inhibiting tau hyperphosphorylation

[Speaker] Lan Zhang:1
1:Xuanwu Hospital of Capital Medical University, China

Deficiency of FPR2 improves learning and attenuates tau hyperphosphorylation in ICV-STZ Alzheimer's disease mouse model

[Speaker] Yang Yu:1
[Co-author] Ding Wang:1, Haibo Zhang:1
1:School of Pharmacy, Shanghai Jiao Tong University, China

Astrocyte-neuron interplay in Alzheimer's disease: evidence from an innovative and promising pharmacological manipulation in a triple transgenic model of the disease

[Speaker] Maria Rosanna Bronzuoli:1
[Co-author] Roberta Facchinetti:1, Tommaso Cassano:2, Luca Steardo:1, Caterina Scuderi:1
1:Department of Physiology and Pharmacology, Sapienza University of Rome, Italy, 2:Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy

The analysis of the differentially expressed Genes in entorhinal cortex and hippocampus for Alzheimer's disease

[Speaker] Ailin Liu:1
[Co-author] Xiaocong Pang:1, Ying Zhao:1, Lvjie Xu:1, Guanhua Du:1
1:Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, China

Memantine treatment improves hyperactivity induced by Na+, K+-ATPase dysfunction in mice

[Speaker] Taishi Yamada:1
[Co-author] Yuki Kurauchi:1, Akinori Hisatsune:2,3, Takahiro Seki:1, Hiroshi Katsuki:1
1:Chemico-Pharmacological Sciences, Kumamoto University, Japan, 2:Priority Organization for Innovation and Excellence, Kumamoto University, Japan, 3:Program for Leading Grad. Sch. HIGO Program, Kumamoto University, Japan

Differentiation of microglia-like cells from mice hematopoietic stem cells in peripheral blood for therapeutic strategy against Alzheimer's disease

[Speaker] Eriko Kuroda:1
[Co-author] Kazuyuki Takata:1, Syohei Kawanishi:1, Yuki Toda:1, Eishi Ashihara:1
1:Clinical and Translational Physiology, Kyoto Pharmaceutical University, Japan

The novel, pseudo-irreversible mu opioid receptor antagonist SH-1 attenuates the reinforcing and respiratory-depressant effects of heroin in rhesus monkeys

[Speaker] David R Maguire:1
[Co-author] Lisa R Gerak:1, James H Woods:1, Stephen M Husbands:2, Alex Disney:2, Charles P France:1
1:Pharmacology, University of Texas Health Science Center at San Antonio, USA, 2:Pharmacy and Pharmacology, University of Bath, UK

Involvement of Gq/11 in methamphetamine-induced behavioral sensitization in mice

[Speaker] Kyungin Kim:1
[Co-author] Young-Jung Kim:1, Jee-Yeon Seo:1, Yong-Hyun Ko:1, Choon-Gon Jang:1
1:Pharmacy, Sungkyunkwan University, Korea

Expression of microRNAs in methamphetamine-induced rewarding effect

[Speaker] Keisuke Mizuo:1
[Co-author] Satoshi Watanabe:1
1:Department of Legal Medicine, Sapporo Medical University School of Medicine, Japan

Effect of caffeine on acquisition, expression and re-instatement of alcohol induced condition place preference in albino mice

[Speaker] Agbonlahor Okhuarobo:1
[Co-author] Ighodaro Igbe:1
1:Department of Pharmacology and Toxicology, University of Benin, Nigeria

The rewarding effects of 2C-C and 2C-P, the new designer drugs of the 2C family, in rodents

[Speaker] Young-Jung Kim:1
[Co-author] Shi-Xun Ma:1, Kwang-Hyun Hur:1, Seok-Yong Lee:1, Choon-Gon Jang:1
1:Sungkyunkwan University, Korea

MDPV induces a rapid up-regulation of striatal dopamine transporter function. A comparative study with cocaine

[Speaker] Raul Lopez-Arnau:1
[Co-author] Vanessa Mosquera:1, Elena Escubedo:1, Camarasa Jordi:1, Pubill David:1
1:Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Spain

Abuse-related effects of MDPV, α-PVP, and related synthetic cathinones: structural determinants of reinforcing potency and effectiveness

[Speaker] Gregory T Collins:1,2
[Co-author] Brenda M Gannon:1, Michael H Baumann:3, Agnieszka Sulima:4, Kenner C Rice:4
1:Pharmacology, University of Texas Health Science Center at San Antonio, USA, 2:South Texas Veterans Health Care System, USA, 3:Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, USA, 4:Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, USA

Evaluation of efavirenz alone or in combination with tetrahydrocannabinol (THC) on addictive-like bio-behavioral alterations in rats

[Speaker] Marisa Moller:1
[Co-author] Jaco Fourie:1, Brian H Harvey:2
1:Pharmacology, Nort-West University, Potchefstroom, South Africa, 2:Center of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa

Involvement of cannabinoid CB1 receptors on impairment of prepulse inhibition during withdrawal state after the repeated administration of methamphetamine in mice

[Speaker] Ryo Fukumori:1
[Co-author] Taku Yamaguchi:1, Tsuneyuki Yamamoto:1
1:Pharmacology, Nagasaki International University, Japan

Cocaine Regulates Endocannabinoids-Containing Extracellular Vesicles Release in Ventral Tegmental Area via Sigma-1 Receptor and ADP-Ribosylation Factor 6 Pathway

[Speaker] Yoki Nakamura:1,2
[Co-author] Dilyan I Dryanovski:3, Shelley N Jackson:4, Shang-Yi A Tsai:2, Amina S Woods:4, Carl R Lupica:3, Tsung-Ping Su:2
1:Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan, 2:Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA, 3:Electrophysiology Research Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA, 4:Structural Biology Unit, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA

Neonatal programming with estradiol valerate increases behavioral and neurochemical effects of morphine in the adulthood

[Speaker] Ramon Sotomayor Zarate:1
[Co-author] Victoria B Velasquez:1, Gabriel Zamorano:1, Christian Bonansco:1
1:Institute of Physiology, Faculty of Sciences, Universidad de Valparaiso, Chile

Inflammatory pain suppresses the development of tolerance to and dependence on nicotine mediated by endogenous opioid system in mice

[Speaker] Shiroh Kishioka:1
[Co-author] Daichi Kobayashi:1, Fumihiro Saika:1, Norikazu Kiguchi:1, Shinsuke Matsuzaki:1
1:Pharmacology, Wakayama Medical University, Japan

Repeated restraint stress reduces the acquisition and relapse of methamphetamine-conditioned place preference but not behavioral sensitization

[Speaker] Jee-Yeon Seo:1
[Co-author] Yong-Hyun Ko:1, Shi-Xun Ma:1, Bo-Ram Lee:1, Seok-Yong Lee:1, Choon-Gon Jang:1
1:Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Korea

A transgenic mouse disrupted a circadian clock-related gene showed increased locomotor sensitization and conditioned place preference toward methamphetamine

[Speaker] Hee Jin Kim:1
[Co-author] Mikyung Kim:1, Joo Ha Lee:1, Min Young Park:1, Jae Hoon Cheong:1
1:Uimyung Research Institute for Neuroscience, Sahmyook University, Korea

Inhibitory effects of accumbal transmembrane protein 168 (TMEM168) on methamphetamine-induced place

[Speaker] Atsumi Nitta:1
[Co-author] Kequan Fu:1, Kazuya Otake:1, Kazuyuki Sumi:1, Eriko Saika:1, Naoki Sato:1, Yuka Ueno:1, Kyosuke Uno:1, Shin-Ichi Muramatsu:2,3, Yoshiaki Miyamoto:1
1:University of Toyama, Toyama, Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, Japan, 2:Division of Neurology, Department of Medicine, Jichi Medical University, Japan, 3:Center for Gene and Cell Therapy, Institute of Medical Science, The University of Tokyo, Japan

Ethanol enhances the psychostimulant effect and the monoamine release induced by mephedrone in rats

[Speaker] Jordi Camarasa:1
[Co-author] Raul Lopez-Arnau:1, Mario Buenrostro-Jauregui:2, Elena Escubedo:1, David Pubill:1
1:Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Spain, 2:Neuroscience Laboratory, Department of Psychology, Universidad Iberoamericana, Ciudad de Mexico, Mexico

Xylopic acid prevents the development of tolerance and physical dependence to morphine in rats

[Speaker] Priscilla K Mante:1
[Co-author] Adoley A Mingle:1, Mustapha S Kpienaan:1, Kweku Abakah-Ewusi:1, Samuel Offei-Twum:1
1:Department of Pharmacology, Kwame Nkrumah University of Science and Technology, Ghana

Thalidomide attenuates development of morphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways

[Speaker] Muhammad Imran Khan:1
[Co-author] Vahid Nikoui:2, Jamal Ahmad:3, Bashir Ahmad:3, Mughal Qayum:1, Ahmad-Reza Dehpour:4,5
1:Department of Pharmacy, Kohat University of Science and Technology, 26000 Kohat, KPK, Pakistan, 2:Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran, 3:Khyber Medical University, 28100, KPK, Pakistan, 4:Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran, 5:Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Involvement of AMPA receptor-mTOR activation in the reinforcing effect of ketamine

[Speaker] Mei-Yi Lee:1
[Co-author] Yu-Ching Hsiao:2, Hwei-Hsien Chen:2
1:Master Program/PhD Program in Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan, 2:Center for Neuropsychiatric Research, National Health Research Institutes Zhunan, Taiwan

Nicotine has an opposite effect on neurite outgrowth of rat cervical ganglia cells and PC12 cells

[Speaker] Shingo Takatori:1
[Co-author] Yuna Kondo:1, Hayato Hino:2,3, Hidenori Sagara:1, Fusako Takayama:2, Yoshihisa Kitamura:3, Toshiaki Sendou:3, Hiromu Kawasaki:1
1:Matsuyama University, Japan, 2:Okayama University, Japan, 3:Okayama University Hospital, Japan

Thalidomide attenuates the development and expression of antinociceptive tolerance to mu-opioid agonist morphine through L-arginine-iNOS and nitric oxide pathway

[Speaker] Muhammad Imran Khan:1
[Co-author] Vahid Nikoui:2, Jamal Ahmad:3, Bashir Ahmad:3, Amir Rashidian:4, Ahmad-Reza Dehpour:4,5
1:Department of Pharmacy, Kohat University of Science and Technology, 26000 Kohat, KPK, Pakistan, 2:Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran, 3:Khyber Medical University, 28100, KPK, Pakistan, 4:Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 5:Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

The nociceptin/orphan FQ system plays a role in the locus coeruleus of buprenorphine-induced withdrawal

[Speaker] Yao-Chang Chiang:1,2
[Co-author] Junyi Wu:1,3, Dong Chuang Wu:3
1:Center for Drug Abuse and Addiction, China Medical University Hospital, China Medical University, Taiwan, 2:Department of Nursing, Division of Basic Medical Sciences, Chang Gung Institute of Technology, Taiwan, 3:Graduate Institute of Biomedical Sciences, China Medical University, Taiwan

Lamotrigine reduces motivation and relapse for ketamine self-administration in rats

[Speaker] Yu-Ching Hsiao:1
[Co-author] Hwei-Hsien Chen:1,2, Mei-Yi Lee:1,2
1:R1-5121, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, 2:Department of Pharmacology and Toxicology Tzu Chi University, Hualien, Taiwan

The BDNF-TrkB signaling pathway is involved differently in the development of locomotor sensitization and place conditioning by MDPV and cocaine

[Speaker] Elena Escubedo:1
[Co-author] Leticia Duart-Castells:1, Raul Lopez-Arnau:1, David Pubill:1, Jorge Camarasa:1
1:Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Spain

Inhibitory effects of Shati/Nat8l overexpression in the medial prefrontal cortex on the methamphetamine induced-CPP in mice

[Speaker] Meriem Haddar:1
[Co-author] Kyosuke Uno:1, Shin-Ichi Muramatsu:2,3, Atsumi Nitta:1
1:Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Graduate School of Medecine and Pharmaceutical Sciences for Education, University of Toyama, Toyama, Japan, 2:Division of Neurology, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan, 3:Center for Gene & Cell Therapy, Institute of Medical Science, The University of Tokyo, Japan

Inhibitory effect of knockdown Piccolo on methamphetamine-induced behavioral changes via dopamine/GABA release in the nucleus accumbens of mice

[Speaker] Yuka Kusui:1
[Co-author] Kyosuke Uno:1, Bin Ge:1, Seiya Morishita:1, Yoshiaki Miyamoto:1, Shin-Ichi Muramatsu:2,3, Atsumi Nitta:1
1:Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan, 2:Division of Neurology, Department of Medicine, Jichi Medical University, Japan, 3:Center for Gene and Cell Therapy, Institute of Medical Science, The University of Tokyo, Japan

Modulatory effects of caffeine on behavioral and neural visual contrast sensitivity of rats

[Speaker] Keisuke Tsunoda:1
[Co-author] Akinori Sato:1, Ryo Mizuyama:1, Satoshi Shimegi:1,2
1:Graduate school of Frontier Biosciences, Osaka University, Japan, 2:Graduate school of Medicine, Osaka University, Japan

Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in medium spiny neurons

[Speaker] Xinjian Zhang:1
[Co-author] Taku Nagai:2, Rijwan Uddin Ahammad:1, Keisuke Kuroda:1, Shinichi Nakamuta:1, Takashi Nakano:3, Mutsuki Amano:1, Junichiro Yoshimoto:3,4, Kiyofumi Yamada:2, Kozo Kaibuchi:1
1:Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Japan, 2:Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan, 3:Graduate School of Information Science, Nara Institute of Science and Technology, Japan, 4:Neural Computation Unit, Okinawa Institute of Science and Technology Graduate University, Japan

Mechanisms underlying down-regulation of mGluR5 in astrocytes with ages

[Speaker] Masayoshi Tanaka:1
[Co-author] Eiji Shigetomi:1, Bijay Parajuli:1, Youichi Shinozaki:1, Yuri Hirayama:1, Kozo Saito:2, Junichi Nabekura:3,4, Schuichi Koizumi:1
1:Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Japan, 2:Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, 3:Division of Homeostatic Development, National Institute for Physiological Sciences, Okazaki, Aichi, Japan, 4:Department of Physiological Sciences, The Graduate School for Advanced Study, Hayama, Kanagawa, Japan

Involvement of IL-4-induced intracellular zinc release in microglial M2 phenotype

[Speaker] Takaaki Aratake:1
[Co-author] Youichirou Higashi:1, Takahiro Shimizu:1, Shogo Shimizu:1, Yusuke Ueba:1, Tomoya Hamada:1, Zou Suo:1, Masaki Yamamoto:1, Yoshiki Nagao:1, Motoaki Saito:1
1:Pharmacology, Kochi Medical School, Kochi University, Japan

Fibroblast growth factor 2 enhances ATP release and extracellular purine metabolism in rat spinal astrocytes

[Speaker] Ryota Eguchi:1
[Co-author] Soichiro Yamaguchi:1, Ken-Ichi Otsuguro:1
1:Graduate School of Veterinary Medicine, Hokkaido University, Japan

The inhibition of Notch signaling ameliorates the motor functional deficits and astrocytic abnormality of in vitro and in vivo spinal muscular atrophy models

[Speaker] Kazuki Ohuchi:1,2
[Co-author] Michinori Funato:2, Shiori Ando:1,2, Satoshi Inagaki:1,2, Chizuru Kawase:2, Junko Seki:2, Shinsuke Nakamura:1, Masamitsu Shimazawa:1, Hideo Kaneko:2, Hideaki Hara:1
1:Molecular Pharmacology, Gifu Pharmaceutical University, Japan, 2:Department of Clinical Research, National Hospital Organization, Nagara Medical Center, Japan

Ginkgo biloba extract promoted the astrocyte-mediated clearance of intercellular alpha-Syn via autophagy and proteasome pathway

[Speaker] Yi Fan:1
[Co-author] Jun Hua:1, Nuo Yin:1, Gang Hu:1
1:Department of Pharmacology, Nanjing Medical University, China

Inhibition of Kir4.1 channel elevates BDNF expression in primary cultures of astrocytes

[Speaker] Yukihiro Ohno:1
[Co-author] Masato Kinboshi:1,2,3, Saki Shimizu:1, Takahiro Mukai:1, Yuki Nagao:1, Hidefumi Ito:3, Akio Ikeda:2
1:Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan, 2:Department of Epilepsy, Movement Disorders and Physiology, Graduate School of Medicine, Kyoto University, Japan, 3:Department of Neurology, Wakayama Medical University, Japan

Dual color Ca2+ imaging of neuron-astrocyte interaction

[Speaker] Eiji Shigetomi:1
[Co-author] Yukiho J Hirayama:1, Kazuhiro Ikenaka:2, Kenji F Tanaka:3, Haruhiko Bito:4, Schuichi Koizumi:1
1:Department of Neuropharmacology, University of Yamanashi, Japan, 2:Division of Neurobiology and Bioinfomatics, NIPS, Japan, 3:Department of Neuropsychiatry, Keio University School of Medicine, Japan, 4:Department of Neurochemistry, Graduate School of Medicine, University of Tokyo, Japan

Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model

[Speaker] Kozo Saito:1,2
[Co-author] Eiji Shigetomi:2, Rei Yasuda:1, Ryuichi Sato:3, Kenji F Tanaka:4,5, Katsuhiko Mikoshiba:6, Ikuko Mizuta:1, Tomokatsu Yoshida:1, Toshiki Mizuno:1, Schuichi Koizumi:2
1:Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan, 2:Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Japan, 3:Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Japan, 4:Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Japan, 5:Department of Neuropsychiatry, Keio University School of Medicine, Japan, 6:Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Japan

TRPV4 is functionally expressed in oligodendrocyte precursor cells and enhances their proliferation

[Speaker] Kana Ohashi:1
[Co-author] Ayane Deyashiki:1, Takahito Miyake:1, Kazuki Nagayasu:1, Koji Shibasaki:2, Hisashi Shirakawa:1, Shuji Kaneko:1
1:Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2:Department of Molecular and Cellular Neurology, Graduate School of Medicine, Gunma University, Japan

Visualization of Ca2+ dynamics within the endoplasmic reticulum for the study of astrocytic functions

[Speaker] Yohei Okubo:1
[Co-author] Kazunori Kanemaru:1, Masamitsu Iino:2
1:Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Japan, 2:Department of Cellular and Molecular Pharmacology, Nihon University School of Medicine, Japan

Effect of brefelamide on growth factor-induced cell proliferation in 1321N1 human astrocytoma cells

[Speaker] Shigeyoshi Honma:1
[Co-author] Takahiro Shibuya:1, Takahiro Ishikawa:1, Sachina Takasaka:1, Keita Kouno:1, Makoto Yoshida:1
1:Faculty of Pharmacy, Takasaki University of Health and Welfare, Japan

Inhibitory effect of the gut microbial linoleic acid metabolites on BV-2 microglial cell activation

[Speaker] Shiori Ikeguchi:1
[Co-author] Yasuhiko Izumi:1,2, Shigenobu Kishino:3, Jun Ogawa:3, Akinori Akaike:1, Toshiaki Kume:1,4
1:Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2:Department of Pharmacology, Kobe Pharmaceutical University, Japan, 3:Department of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan, 4:Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan

Imipramine enhances the expression of astrocytic interleukin-10 under inflammatory state

[Speaker] Yosuke Yamawaki:1
[Co-author] Satomi Shirawachi:1, Munechika Takaishi:1, Shigeto Yamawaki:2, Takashi Kanematsu:1
1:Department of Cellular and Molecular Pharmacology Institute of Biomedical and Health Sciences, Hiroshima University, Japan, 2:Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, Japan

The activation of Nrf2 contributes to the inhibitory effect of salvianolic acid A on NF-kappaB signaling in BV2 microglia cells

[Speaker] Junke Song:1,2
[Co-author] Wen Zhang:1,2, Guanhua Du:1,2
1:Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, China, 2:Beijing Key Laboratory of Drug Target Identification and Drug Screening, China

Remodeling the brain after stroke by astrocytic phagocytosis

[Speaker] Yosuke Morizawa:1
[Co-author] Schuichi Koizumi:2
1:Super-network Brain Physiology, Tohoku University, Japan, 2:Dept. Neuropharmacology, Univ. Yamanashi, Japan

Live imaging of synapse engulfment by microglia in vitro

[Speaker] Megumi Andoh:1
[Co-author] Ryuta Koyama:1, Yuji Ikegaya:1
1:Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan

Purinergic P2Y2 receptor is involved in dying cell phagocytosis and mediator production in Toll-like receptor 4-activated microglia

[Speaker] Izumi Hide:1
[Co-author] Hiroko Shiraki:1, Yuhki Yanase:2, Toshihiko Shirafuji:1, Shigeru Tanaka:1, Michihiro Hide:2, Norio Sakai:1
1:Department of Molecular and Pharmacological Neuroscience, Hiroshima University, Japan, 2:Department of Dermatology, Hiroshima University, Japan

Elucidation of the how mechanism glial cells are actirated by the neural model cells of spinocerebellar ataxia type 21 in a cell death-independent manner

[Speaker] Tomoko Ohta:1
[Co-author] Takahiro Seki:1, Yuki Kurauchi:1, Akinori Hisatsune:2,3, Hiroshi Katsuki:1
1:Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 2:Priority Organization for lnnovation and Excellence, Kumamoto University, Japan, 3:Program for Leading Graduation School HIGO Program, Kumamoto University, Japan

Coincident activation of adenosine A1 receptors and metabotropic glutamate receptor 5 differentially influences signalling in primary brain cell cultures

[Speaker] Karen J Gregory:1
[Co-author] Shane D Hellyer:1, Sabine Albold:1, Phuc T Nguyen:1, Katie Leach:1, Lauren T May:1
1:Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Australia

Kinetic investigations into G protein activation and biased agonism at the dopamine D2 receptor

[Speaker] Alastair C Keen:1,2
[Co-author] David A Sykes:2, Steven J Charlton:2, J Robert Lane:1
1:Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Australia, 2:School of Life Sciences, Queen's Medical Centre, University of Nottingham, UK

Identification of residues in the fifth transmembrane-spanning domain of the D2-like dopamine receptors that engender signaling bias

[Speaker] Marta Sanchez-Soto:1
[Co-author] Blair K A Willette:1, Elizabeth C Gonye:1, Annah M Moore:1, Lani S Chun:1, Amy E Moritz:1, Hideaki Yano:2, Lei Shi:2, R Benjamin Free:1, David R Sibley:1
1:Molecular Neuropharmacology Section, NINDS, NIH, USA, 2:Computational Chemistry and Molecular Biophysics Unit, NIDA, NIH, USA

Both 5-HT1A and 5-HT1B receptor-mediated inhibition of glutamatergic transmission onto cholinergic neurons in basal forebrain

[Speaker] Takuma Nishijo:1
[Co-author] Toshihiko Momiyama:1
1:Department of Pharmacology, Jikei University School of Medicine, Japan

Biased agonism for dopamine at alpha1A-adrenoceptors towards receptor internalization

[Speaker] Andre S. Pupo:1
[Co-author] Rodrigo R. Wandekin:1, Vanessa Lima:1
1:Pharmacology, Instituto de Biociiencias, UNESP, Botucatu, SP, Brazil

Na+, K+-ATPase dysfunction induces hyperactivity and impulsivity via dopamine D2 receptor activation in mice

[Speaker] Yuki Kurauchi:1
[Co-author] Yuko Yoshimaru:1, Taishi Yamada:1, Akinori Hisatsune:2, Takahiro Seki:1, Hiroshi Katsuki:1
1:Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan, 2:Priority Organization for Innovation and Excellence, Kumamoto University, Japan

Nanoscale organization of synaptic proteins in response to glutamate stimulation

[Speaker] Noriko Koganezawa:1
[Co-author] Tomoaki Shirao:1
1:Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Japan

TRPA1 channel mediates organophosphate-induced delayed neuropathy

[Speaker] Zhaobing Gao:1
[Co-author] Qiang Ding:1, Xin Xie:1, Bernard Attali:2, Jian Li:3
1:Shanghai Institute of Materia Medica, China, 2:Sackler Faculty of Medicine, Tel Aviv University, Israel, 3:School of Pharmacy, East China University of Science and Technology, China

The Effects of HIV-1 GP120 on the Puncta Count and Expression of α5-Containing GABAA Receptors in Cultured Rat Hippocampal Neurons

[Speaker] Adrienne Y Jo:1
[Co-author] Matthew Green:2, Stanley A Thayer:2
1:Claremont McKenna College, USA, 2:University of Minnesota, USA

M2 muscarinic receptor mediates arginine-vasopressin synthesis possibly through decreasing presynaptic GABA release in the supraoptic nuclei

[Speaker] Hiroshi Nagano:1
[Co-author] Jeffrey G Tasker:2, Hayato Matsuyama:3, Yuki Sobue:3, Shoichiro Saito:4, Hiroki Sakai:5,6, Toshiaki Ishii:7, Yasuyuki Tanahashi:8, Toshihiro Unno:3
1:Department of Pathogenetic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, Japan, 2:Department of Cell and Molecular Biology, Tulane University, USA, 3:Laboratory of Veterinary Pharmacology, Faculty of Applied Biological Science, Gifu University, Japan, 4:Laboratory of Veterinary Anatomy, Faculty of Applied Biological Science, Gifu University, Japan, 5:Laboratory of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, Japan, 6:Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University, Japan, 7:Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Japan, 8:Department of Animal Medical Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Japan

SKF-10047, a prototype Sigma-1 receptor agonist, accelerated the membrane trafficking and uptake activity of serotonin transporter and its mutant via the mechanism independent of Sigma-1receptor

[Speaker] Norio Sakai:1
[Co-author] Masaya Asano:1, Chika Yokota:1, Naoto Usuki:1, Hikaru Yamamoto:1, Isumi Hide:1, Shigeru Tanaka:1
1:Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan

Presynaptic modulation of GABAergic transmission onto striatal cholinergic interneuron by M1 acetylcholine receptor activation

[Speaker] Etsuko Suzuki:1
[Co-author] Toshihiko Momiyama:1
1:Department of Pharmacology, Jikei University School of Medicine, Japan

Analysis of the roles of μ receptor subtypes in the regulation of acetylcholine and dopamine efflux in the nucleus accumbens of freely moving rats

[Speaker] Yuri Aono:1
[Co-author] Yuriko Watanabe:2, Tadashi Saigusa:1
1:Department of Pharmacology, Nihon University School of Dentistry at Matsudo, Japan, 2:Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Japan

Metabotropic glutamate receptor 1 (mGluR1) forms hetero-oligomer with other G-protein coupled receptors and they regulate their signal transduction each other at neurons

[Speaker] Hakushun Sakairi:1
[Co-author] Yuji Kamikubo:2, Masayoshi Abe:3, Kenta Matsuoka:3, Toshihide Tabata:3, Takashi Sakurai:1,2
1:Department of Pharmacology, Juntendo University Graduate School of Medicine, Japan, 2:Department of Pharmacology, Juntendo University School of Medicine, Japan, 3:Laboratory for Neural Information, Graduate School of Science and Engineering, University of Toyama, Japan

Understanding the physiological role of endogenous allosteric modulators at the muscarinic acetylcholine receptors

[Speaker] Ee Von Moo:1
[Co-author] Patrick M Sexton:1, Arthur Christopoulos:1, Celine Valant:1
1:Monash Institute of Pharmaceutical Sciences, Australia

Histamine H3 receptor-mediated G-protein activation in postmortem human prefrontal cortical membranes

[Speaker] Yuji Odagaki:1
[Co-author] Masakazu Kinoshita:1, Toshio Ota:1, J. Javier Meana:2, Luis F. Callado:2, Jesus A. Garcia-Sevilla:3
1:Department of Pharmacology, Saitama Medical University, Faculty of Medicine, Japan, 2:Department of Pharmacology, University of the Basque Country, Spain, 3:Laboratory of Neuropharmacology, University of the Balearic Islands, Spain

D1 receptor subtype mediates acute stress-induced dendritic growth of excitatory neurons and gene expression changes associated with stress resilience in the medial prefrontal cortex

[Speaker] Masayuki Taniguchi:1
[Co-author] Ryota Shinohara:1, Aliza T Ehrlich:2, Kentarou Yokogawa:2, Yuichi Deguchi:2, Atsubumi Ogawa:2, Shiho Kitaoka:1, Akira Sawa:3, Shuh Narumiya:2, Tomoyuki Furuyashiki:1
1:Division of Pharmacology, Kobe University Graduate School of Medicine, Japan, 2:Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan, 3:Department of Psychiatry, Johns Hopkins University School of Medicine, USA

Inhibition of butyrylcholinesterase improves prepulse inhibition deficits and enhances M1 muscarinic acetylcholine receptor-mediated responses via ghrelin signaling in mice

[Speaker] Shinji Tsukada:1
[Co-author] Kosuke Higashino:1, Sumiko Kunimoto:1, Nigel H. Greig:2, Toshio Matsuda:1, Hitoshi Hashimoto:1,3,4, Yukio Ago:1
1:Graduate School of Pharmaceutical Sciences, Osaka University, Japan, 2:Translational Gerontology Branch, National Institute on Aging, NIH, USA, 3:United Graduate School of Child Development, Osaka University, Japan, 4:Institute for Datability Science, Osaka University, Japan

Signalling and agonist-selective antagonism at corticotropin-releasing factor receptors

[Speaker] Christopher S Walker:1
[Co-author] Zoe Tasma:1, Debbie L Hay:1
1:School of Biological Sciences, University of Auckland, New Zealand

A Novel Target for Migraine Therapy: the α6 Subunit-Containing GABAA Receptor

[Speaker] Lih-Chu Chiou:1,2,5,9
[Co-author] Pi-Chuan Fan:3,4,5, Po-Kai Huang:6, Werner Sieghart:7, Ming-Tatt Lee:1,2, Margot Ernst:7, Daniel E Knutson:8, James Cook:8
1:Department of Pharmacology, College of Medicine, National Taiwan University, Taiwan, 2:Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan, 3:Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan, 4:Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, 5:Clinical Center for Neuroscience and Behavioral, National Taiwan University Hospital, Taipei, Taiwan, 6:Department of Pediatrics, E-da Dachang Hospital, Kaohsiung, Taiwan, 7:Center for Brain Research, Department of Molecular Neurosciences, Medical University Vienna, Vienna, Austria, 8:Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, WI, USA, 9:Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung, Taiwan

Potassium channels mediate the antidepressant-like effect of nitrazepam in forced swimming test and tail suspension test in mice

[Speaker] Vahid Nikoui:1
[Co-author] Muhammad Imran Khan:2, Azam Bakhtiarian:3,4, Mohammad Yahya Karimi:1, Pardis Azhand:5, Saeed Mehrzadi:1, Mehrdad Foroohandeh:6, Ahmad-Reza Dehpour:3,4, Mohamad-Reza Aghanoori:7,8
1:Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran, 2:Department of Pharmacy, Kohat University of Science and Technology, 26000 Kohat, KPK, Pakistan, 3:Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 4:Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran, 5:School of Pharmacy, International Campus of Tehran University of Medical Sciences, Tehran, Iran, 6:Department of Oral Pathology, Dental School, Isfahan University of Medical Science, Isfahan, Iran, 7:Division of Neurodegenerative Disorders, St Boniface Hospital Research Centre, Winnipeg, MB, Canada, 8:Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada

Do the interactions between buprenorphine and benzodiazepines promote prolonged opioid dependence?

[Speaker] Antoine P. Coquerel:1,2,3,4
[Co-author] Ozlem Yildirim:1,2, Sonia Haddad:1,2, Lin Lin Ma:1,2, Remy Morello:5
1:Medical Pharmacology, University of Caen - Normandie. 14032 Caen, France, 2:UMR INSERM u1075 - Universite de Caen - Normandie, 14032 Caen, France, 3:Centre Regional de Pharmacovigilance, Av. Cote de Nacre. 14033 Caen, France, 4:Departement d ePharmacologie. CHU de Caen. 14033 Caen cedex 9, France, 5:Unite de biostatistiques. Depertement de recherche clinqiue. 14033. Caen, France

Corticosterone level and central dopaminergic activity involved in agile and exploratory behaviours in male Formosan wood mice

[Speaker] Kun-Ruey Shieh:1
[Co-author] Shu-Chuan Yang:2, Hsien-Yong Lai:3
1:Department of Physiology, Tzu Chi University, Taiwan, 2:Holistic Education Center, Tzu Chi University of Science and Technology, Taiwan, 3:Division of Anesthesiology, Mennonite Christian Hospital, Taiwan

Emotional and exploratory responses in male Formosan wood mice

[Speaker] Shu-Chuan Yang:1
[Co-author] Hsien-Yong Lai:2, Kun-Ruey Shieh:3
1:Holistic Education Center, Tzu Chi University of Science and Technology, Taiwan, 2:Division of Anesthesiology, Mennonite Christian Hospital, Taiwan, 3:Department of Physiology, Tzu Chi University, Taiwan

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