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NOVEL OXAZOLO-OXAZOLE DERIVATIVES OF FINGOLIMOD INDUCE LYMPHOPENIA AND REDUCE SYMPTOMS OF EAE IN MICE

[Speaker] Andrea Huwiler:1
[Co-author] Faik Imeri:1, Bisera Stepanovska:1, Aleksandra Zivkovic:2, Josef Pfeilschifter:3, Britta Engelhardt:4, Holger Stark:2
1:Institute of Pharmacology, University of Bern, Switzerland, 2:Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany, 3:Pharmazentrum Frankfurt, University Hospital, Goethe University Frankfurt am Main, Germany, 4:Theodor-Kocher Institute, University of Bern, Switzerland

Contribution of activated glial cells in epileptogenesis after status epilepticus

[Speaker] Fumikazu Sano:1,2
[Co-author] Eiji Shigetomi:1, Schuichi Koizumi:1, Hideaki Kanemura:2, Katsuhiko Mikoshiba:3, Masao Aihara:2
1:Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Japan, 2:Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Japan, 3:Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Japan

Metabotropic glutamate receptor 5 (mGluR5) blockade ameliorates Huntington's disease pathology via activating convergent mechanisms of autophagy

[Speaker] Khaled S Abd-Elrahman:1,2
[Co-author] Alison Hamilton:1, Shaunessy Hutchinson:1, Stephen S. G. Ferguson:1
1:Cellular and Molecular Medicine, University of Ottawa Brain and Mind Institute, Canada, 2:Pharmacology and Toxicology, Faculty of Pharmacy, University of Alexandria, Egypt

Non-invasive and allele-specific gene silencing therapy for Machado-Joseph disease

[Speaker] Luis Pereira de Almeida:1,2,7
[Co-author] Rui Jorge Nobre:1,2,3, Joana Saraiva:1, Clelia Fusco:1, Susana Paixao:1, Magda Santana:1, Joao Castelhano:4, Jose Sereno:5, Miguel Castelo-Branco:4,5, Miguel Sena-Esteves:6
1:CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, 2:ViraVector - Viral Vectors for Gene Transfer Core facility, University of Coimbra, Portugal, 3:Institute for Inter-disciplinary Research, University of Coimbra, Portugal, 4:ICNAS - Institute of Nuclear Sciences Applied to Health, Coimbra, Portugal, 5:IBILI - Institute for Biomedical Imaging and Life Sciences, University of Coimbra, Portugal, 6:Neurology Department, Gene Therapy Center, University of Massachusetts Medical School, MA, USA, 7:Faculty of Pharmacy, University of Coimbra, Portugal

Prenatal neurogenesis induction therapy normalizes brain structure and functions in Down syndrome mice

[Speaker] Akiko Kobayashi:1
[Co-author] Tomonari Awaya:1, Isao Kii:1, Yuto Sumida:2, Yukiko Okuno:3, Keiko Wanezaki:1, Suguru Yoshida:2, Haruhisa Inoue:4, Takamitsu Hosoya:2, Masatoshi Hagiwara:1
1:Kyoto University, Japan, 2:Tokyo Medical and Dental University, Japan, 3:Medical Research Support Center, Kyoto University, Japan, 4:Center for iPS Cell Research and Application, Kyoto University, Japan

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