In vitro biotransformation and enzyme kinetic characterization of R- and S-praziquantel metabolism: predicting and rationalizing in vivo drug clearance and drug-drug interactions

[Speaker] Roslyn S. Thelingwani:1
[Co-author] Xueqing Li:2, Nada Abla:3, Ralf Schmidt:4, Wilma Bagchus:4, Dolgos Hughues:5, Jutta Reinhard-Rupp:6
1:DMPK & BAC, African Institute of Biomedical Science and Technology, Zimbabwe, 2:CVMD iMed DMPK, AstraZeneca, Sweden, 3:Medicines for Malaria Venture, Switzerland, 4:EMD Serono, Switzerland, 5:Merk KGaA, Germany, 6:Merck Serono, Switzerland

Child-Pugh versus NCI-ODWG categorization for hepatic impairment studies - observations from a renal and hepatic impairment study with darolutamide, a novel investigational androgen receptor antagonist

[Speaker] Christian Zurth:1
[Co-author] Gary Wilkinson:1, Katrin Kettelhake:2, Kristina Graudenz:3, Atef Halabi:4
1:Bayer AG, Germany, 2:Research and Clinical Sciences Statistics, Bayer AG, Wuppertal, Germany, 3:Clinical Pharmacology Oncology, Bayer AG, Berlin, Germany, 4:CRS Clinical Research Services Kiel GmbH, Kiel, Germany

Characterizing important determinants of Tacrolimus pharmacokinetic variability in renal transplant patients: PBPK modeling approach using genotyped patients information

[Speaker] Chie Emoto:1,2
[Co-author] David Hahn:1, Uwe Christians:3, Rita R. Alloway:4, Alexander A. Vinks:1,2, Tsuyoshi Fukuda:1,2
1:Division of Clinical Pharmacology, Cincinnati Childrens Hospital Medical Center, USA, 2:Department of Pediatrics, College of Medicine, University of Cincinnati, USA, 3:iC42 Clinical Research and Development, University of Colorado, USA, 4:Division of Nephrology and Hypertension, Department of Internal Medicine, College of Medicine, University of Cincinnati, USA

The pharmacokinetic interaction of the selective PGF2α receptor antagonist OBE022 on co-administration with MgSO4, atosiban, nifedipine or betamethasone

[Speaker] Ulrike Lorch:1
[Co-author] Jorg Taubel:1,2, Oliver Pohl:3, Line Marchand:3, Jean-Pierre Gotteland:3
1:Richmond Pharmacology, St. George's University, UK, 2:St. George's University London, UK, 3:ObsEva SA, 1228 Plan-les-Ouates, Switzerland

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