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PO1-8-24

Antioxidant, anti-inflammatory, and Hep G2 cell growth-inhibitory effects of extracts from Sargassum crassifolium

[Speaker] Chun-Yung Huang:1
1:Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung, Taiwan

There is growing interest in the bioactive components of marine algae due to their biomedical importance. In this study, a novel puffing process was adopted to pretreat algal samples of Sargassum crassifolium (SC), and the bioactive components of non-puffed and puffed SCs were extracted using aqueous-ethanol solution. Two extracts, namely, NPSC (non-puffed) and PSC (puffed) were obtained and their biological functions including antioxidant activity, anti-inflammatory activity, and inhibition of liver cancer cell growth were assessed. The results showed that extracts of both NPSC and PSC exhibited antioxidant activity, but only NPSC extract showed anti-inflammatory activity. Liver cancer cell growth inhibition experiments showed that PSC extract had a more cytotoxic effect in Hep G2 hepatoma cells and induced more DNA fragmentation of Hep G2 hepatoma cells compared with the effects exerted by NPSC extract. In conclusion, both NPSC and PSC extracts exhibited antioxidant activity. NPSC extract had higher anti-inflammatory activity and can be used as a natural and safe agent in the protection of human health by modulating the immune system. PSC extract had higher inhibitory activity in liver cancer cell growth and may have potential as an effective agent for the prevention or adjuvant treatment of hepatocellular carcinoma.
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