Targeting astrocytic MAO-B of the putrescine degradation pathway to treat Alzheimer's disease

[Speaker] C Justin Lee:1
1:Center for Glia-Neuron Interaction, Korea Institute of Science and Technology (KIST), Korea

Brain is composed of not only neurons but also glia. It has been recently established that in addition to neurons, glial cells including astrocytes can release various transmitters (termed gliotransmitters), such as GABA, glutamate, and d-serine. The functional significance of these gliotransmitters is beginning to unravel as the detailed mechanisms of biosynthesis and release have become available. We have recently demonstrated the role of GABA, synthesized via MAO-B and released through GABA-permeable Best1 channel from reactive astrocytes, in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. During the course of these studies, we have developed various molecular and pharmacological tools and novel animal models to address the etiology of Alzheimer's disease. These newly developed targets and tools have proven to be useful in developing novel therapeutics for Alzheimer's disease that currently has no cure.
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