Resveratrol Decrease of Reactive Oxygen Species-Derived Cognitive Impairment in Angiotensin II Induced Rat Model of Early Alzheimer's disease

[Speaker] Peiwen Cheng:1
[Co-author] Gwo-Ching Sun:2, Yi-Chung Wu:3, Ching-Jiunn Tseng:1
1:Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Taiwan, 2:Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, 3:Section of Neurology, Zouying Branch of Kaohsiung Armed Forces General Hospital Kaohsiung, Taiwan

Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide. Interesting findings of clinical study showed that several antihypertensive or type 2 DM can prevent the disease. Oxidative stress is an important pathogenic factor in the development of hypertension. Nevertheless, the relation between AD and hypertension and the related modulation of oxidative stress in the central nervous system have yet to be established. The aim of this study is to examine whether resveratrol decrease ROS generation, thereby improving cognitive impairment in rats with AngII induced early AD. ROS levels in the NTS was higher, by contrast, the BDNF level in the hippocampus was significantly decreased in AngII groups, while treatment with a resveratrol (10mg/kg/day) for 2 week decreased the BP and ROS production in the NTS and the BDNF level in the hippocampus was significantly increased of AngII groups.

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