Function-related Dynamics of Membrane Proteins

[Speaker] Ichio Shimada:1
1:The University of Tokyo, Graduate School of Pharmaceutical Sciences, Japan

Membrane proteins play fundamental roles in many physiological processes and also are target proteins for drug development. For better understanding of the functions of the membrane proteins, precise static three-dimensional structures, for example, derived from X-ray crystallography, are very useful without a doubt. We should also note that dynamics of the membrane proteins is important for some functions of the membrane proteins. NMR (nuclear magnetic resonance spectroscopy) basically provide the dynamic of the membrane proteins. However, it is frequently difficult to obtain structural information about the membrane protein dynamics related to the functions, by NMR. This is mainly due to the difficulties in sample preparation: expression and purification of the membrane proteins with the biological activities, and lack of appropriate NMR strategy. In this paper, we will show our recent results of dynamical aspects of G-protein coupled receptors (GPCR) and ion channels, which are responsible for the biological functions.
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