Program

PO1-2-20

Use of carvedilol is associated with hearing loss

[Speaker] Dileep K Rohra:1
[Co-author] Bandar Alghamdi:2, Gheid Abuharb:2, Hala Alkofide:2, Nadiah Alruwaili:2, Mohamed Shoukri:2, Peter Cahusac:1
1:Pharmacology, Alfaisal University, Saudi Arabia, 2:Heart Centre, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

Objective: This study was conducted to investigate the hypothesis that patients using beta-blockers will develop hearing loss. Design: A cross-sectional study. Study sample: A total of 125 patients completed the study. Sixty three patients were on beta-blockers and 62 were not on beta-blockers. Results: Carvedilol was significantly associated with hearing loss. Other beta-blockers including metroprolol and atenolol showed no association with hearing loss. Linear multiple regression analysis was run including variables of gender, age, ischemic heart disease, cardiac failure / dilated cardiomyopathy, frusemide and carvedilol use as predictors for total hearing loss severity at all frequencies. Age and gender, as well as carvedilol, were found to be the only statistically significant predictors for hearing loss severity. Conclusion: Chronic use of carvedilol was associated with significant hearing loss. This may need to be taken into account when prescribing the drug. Further randomized controlled studies with baseline audiometric hearing tests before starting treatment, and periodic follow up tests, would provide a better assessment of the effect of carvedilol on hearing.
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