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PO1-1-52

20C, a novel bibenzyl compound, protected mice from MPTP/p injuries by regulating a-synuclein related inflammatory responds

[Speaker] Yu-he Yuan:1
[Co-author] Nai-Hong Chen:1
1:Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, China

The novel bibenzyl compound 20C from Gastrodia elata plays a neuroprotective role in vitro, but its effects in vivo is unknown. In this study, we studied the effects of 20C and its associated-mechanisms on these effects on 1-methyl-4phenyl-1, 2, 3, 6-tetrahydropyridine/probenecide (MPTP/p) mouse model. Experiment results showed that the neuroprotective effects of 20C were as follows: improving behavioral deficit; attenuating DA depletion; reducing dopaminergic neuron loss; protecting BBB structure; ameliorating a-synuclein dysfunction, suppressing glial activation and regulating both the NF-kB signaling and the NLRP3 inflammasome pathways. All these results suggested that 20C might prevent the neurodegeneration of chronic MPTP/p treated mouse through regulating the a-synuclein related inflammatory responds, including BBB damages, glial activation, NF-kB signaling and NLRP3 inflammasome pathway.
*Correspondence to:
Yu-He Yuan, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, Tel: +86 10 63165182, Fax: +86 10 63165177, E-mail: yuanyuhe@imm.ac.cn
Nai-Hong Chen, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, Tel: +86 10 63165177, Fax: +86 10 63165177, E-mail: chennh@imm.ac.cn

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