Methylphenidate enhances memory consolidation and amplifies long-term potentiation: differential involvement of the prefrontal dopamine receptor and norepinephrine receptor

[Speaker] Xue-Han Zhang:1
[Co-author] Shu-Su Liu:1, Feng Yi:1, Hou-Cheng Zhou:1
1:Institutes of Brain Science, Fudan University, China

Methylphenidate (MPH; Ritalin) is the most commonly prescribed treatment for attention-deficit hyperactive disorder (ADHD). MPH causes behavioral and academic performance improvements in children with ADHD, as well as in healthy subjects. MPH has become one of the most widely abused drugs on college campuses. Previously, improvements were considered to be associated with the increased attention. In this study, we examined the effects of MPH on memory storage through administrating MPH after behavioral training, which eliminating the effect of increased attention on memory acquisition, and indicated a direct role of MPH on memory storage. Additionally, this MPH enhancement arose from action via norepinephrine beta-1receptor, but not dopamine D1/D5 receptor. Electrophysiological recordings in vitro showed that MPH enhanced synaptic plasticity by amplifying the magnitude of long-term potentiation (LTP), and this MPH enhancement involved action via both beta-1receptor and D1/D5 receptor. While there was differential role between dopamine and norepinephrine receptor, D1/D5 receptor was more response for the induction of LTP through suppressing GABAergic input.
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