The gut microbiome as target for the treatment of cardiovascular disease

[Speaker] Dominik N. Müller:1,2,3
1:Experimental and Clinical Research Ctr & Max-Delbruck Ctr, Germany, 2:Berlin Institute of Health, Germany, 3:DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany

Hypertension promotes the progressive damage to the kidney, heart and the vasculature. An inflammatory response involving T cells and macrophages plays a pivotal role in the pathogenesis of hypertensive organ damage, although mechanisms leading to such immune cell activation are insufficiently understood. The gut microbiota is a complex bacterial community with importance for host health. Importantly, the microbiota takes a bidirectional role in immune system development and maintenance meaning that shifts in microbiome composition and function may alter the function of certain immune cells and vice versa. The presentation will focus on the role of high salt on the microbiome and salt-sensitive hypertension. Further, it will focus on short-chain fatty acids (SCFA), which can be produced by gut bacteria from dietary fiber and their role host immune homeostasis and cardiovascular disease.

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