Design and synthesis of fullerene/Polyvinylpyrrolidone/ Leontopodic acid nanoparticles: protection of skin from particulate matter-induced aging, inflammation and stratum corneum damage

[Speaker] Chiang-Wen Lee:1
1:Chang Gung University of Science and Technology, Taiwan

Numerous epidemiological and public health studies have shown that exposure to particular air pollutants is closely associated with the development of many serious diseases.However,
few studies have investigated the effects of particulate air pollutants on the skin, which acts as the interface between internal organs and the external environment. Besides its protective barrier function, the skin also plays a role in water retention, temperature regulation, and protection from invasive microbial pathogens. Our recent studies have shown that particulate matter can induce skin inflammation and oxidative stress, and decrease the expression of skin barrier proteins, leading to reduced skin barrier function and ageing. In addition, the mitochondria may be a major source of reactive oxygen species following exposure to particulate matter. Mitochondrial damage has been shown to be a major cause of ageing. Damage to the mitochondria can result in a series of cellular changes, including increased oxidative stress, abnormalities in cellular energy metabolism, mutations in mitochondrial DNA and genome damage, eventually leading to cellular ageing. However, the involvement of particulate matter in mitochondrial damage and keratinocyte ageing is not well defined. Furthermore, increased activity and expression of collagenase may be associated with skin ageing. Various compounds derived from natural plant sources (for example Leontopodic acid) can inhibit collagenase activity and are often included in skin cosmeceutical products. Our investigations showed that although many plant products or pharmaceutical steroids may greatly suppress particulate matter-induced skin inflammation and oxidative stress, they do not have significant reparative effects on skin barrier proteins.
Fullerene (C60) is a super free radical scavenger, and has been widely used in skin protective care products, including skin whitening, moisture retention, antimicrobial and wrinkle reduction. Fullerene has high biosafety profile, and is commonly used in novel nanoparticle formulations. The potential protective effects of fullerene on particulate matter-induced skin ageing, inflammation, oxidative stress, and skin barrier proteins have not been previously investigated. Therefore, this study will aim to synthesize Fullerene/Leontopodic acid nanoparticle formulations, and investigate their protective effects on particulate matter-induced skin ageing, inflammation and loss of barrier function in keratinocytes and mice skin.
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