25-hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese

[Speaker] Raymond Yh Leung:1,2
[Co-author] Bernard My Cheung:1, Kathryn Cb Tan:1, Annie Wc Kung:1, Ching-Lung Cheung:2
1:Medicine, The University of Hong Kong, Hong Kong, 2:Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong

Introduction: Vitamin D is a steroid hormone which is essential for skeletal and non-skeletal health. Studies have shown that the low level of 25-hydroxyvitamin D [25(OH)D] is associated with increased risk of cardiometabolic disorders including diabetes [1,2]. Nevertheless, the findings were inconsistent among observational studies and meta-analyses.
We previously showed significant association between serum calcium and incident diabetes in Hong Kong Chinese [3]; however the role of vitamin D in the association remains unclear. In this study, we aimed to evaluate the relationship between serum 25(OH)D and risk of incident diabetes in Hong Kong Chinese.

Method: We conducted a retrospective cohort study. 4,342 participants aged 20 or above (1,395 men, 2,947 women; mean age ±SD: 54.3 ±16.5 years) from the Hong Kong Osteoporosis Study were included, who were free of diabetes at baseline [4]. Incident diabetes was ascertained using electronic medical records. Serum 25(OH)D was measured at baseline, and its association with incident diabetes was evaluated using multivariable Cox-proportional hazard regression.

Results: During 43,238.3 person-years of follow-up (a median of 10.3), 443 participants developed diabetes. The mean levels ±SD of 25(OH)D was 54.3nmol/L ±16.5. Age, sex and BMI-adjusted Cox-proportional hazard regression has showed no significant difference between the lowest quintile and the highest quintiles of 25(OH)D. In the analysis of the interaction effect between 25(OH)D and serum calcium, the interaction term did not affect the risk of incident diabetes significantly (p=0.700).

Conclusion: Serum vitamin D level was not associated with the risk of incident diabetes in Hong Kong Chinese and this relationship was not modified by the serum level of calcium.

1. Holick, M.F., Vitamin D deficiency. New England Journal of Medicine, 2007. 357(3): p. 266-281.
2. Mitri, J., Muraru, and A.Pittas, Vitamin D and type 2 diabetes: a systematic review. Eur. J. Clin. Nutr. 65(2011) 1005-1015.
3. Sing, C., et al., Serum calcium and incident diabetes: an observational study and meta-analysis. Osteoporosis International, 2016. 27(5): p. 1747-1754.
4. Cheung CL, et al., Low handgrip strength is a predictor of osteoporotic fractures: cross-sectional and prospective evidence from the Hong Kong Osteoporosis Study. Age (Dordr) 34(5):1239-1248.

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