Program

PO2-12-40

Effect of Rujiexiao Granule on mammary hyperplasia rats with syndrome of stagnation of liver Qi

[Speaker] Chenren Lin:1
[Co-author] Junmei Li:1, Min Wang:1, Honghai Li:1, Bin Yang:1, Xiaoxia Dong:1, Jianxun Liu:1
1:Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences, China

Background: To observe the effect of Rujiexiao Granule on mammary hyperplasia rats with syndrome of stagnation of liver Qi.
Method: The animal model was constructed by chronic unpredictable stimulation and injection of estrogen in the subaxillary region. After the establishment of the animal model, rats were divided in 7 groups including normal group, model group, Rujiexiao of high, medium and low dose groups (12, 6, 3g crude drug/kg), Rujiling granule group (8g/kg), tamoxifen group (3.6mg/kg). Then each group was given the corresponding drug once daily for 30 days.
Results: Rujiexiao granules significantly reduced the nipple diameter, breast volume and weight, number of mammary lobules and acinus of rat model. It also could decrease the level of E2, PRL,MDA , lower the expression of ER, PR, KI67 and increase SOD activity in serum. In addition, Rujiexiao could obviously improve the performance of appearance, behavior and emotion of the model rats.The above effects were significant in high and middle doses of Rujiexiao groups (p<0.05~0.01).
Conclusion: Rujiexiao granules showed an obvious effect on mammary hyperplasia rat model with liver Qi stagnation syndrome.
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