The role of fibroblast growth factor 21 on atherosclerosis via amelioration of Fas-mediated apoptosis in apoE (-/-) mice

[Speaker] Xinxin Yan:1
[Co-author] Zhongshan Gou:1, Qian Zhang:1
1:Affiliated Suzhou Hospital of Nanjing Medical University, China

Background: Fibroblast growth factor 21 (FGF21) is a very important endogenous regulator to energy homeostasis and systemic glucose and lipid metabolism. Despite intensive study on metabolic functions of FGF21, its important role in cardiovascular system is needing further explored. The apoptosis of vascular endothelial cell induced by ox-LDL is an important step during the development of atherosclerosis.
Methods: The apoptosis of HUVECs treated with or without FGF21 induced by ox-LDL were analyzed. The role of FGF21 in atherosclerosis was investigated by evaluating the effect of FGF21 in adiponectin E(-/-) mice.
Results: We found that the apoptosis of HUVECs was alleviated with FGF21 treatment. The effect of FGF21 was ERK1/2 pathway independent and was mediated through inhibiting the Fas signaling pathway. FGF21 suppressed the development of atherosclerosis and the administration of FGF21 amelioraed Fas-mediated apoptosis in apoE(-/-) mice.
Conclusion: FGF21 protects against apoptosis of HUVECs through suppressing the expression of Fas and alleviated atherosclerosis via amelioration of Fas-mediated apoptosis in apoE(-/-) mice.

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