演題

PJ069-4

Clinical Factors Associated with Left Ventricular Reverse Remodeling in Non-ischemic Dilated Cardiomyopathy

[演者] 石渡 惇平:1
[共同演者] 川田 貴之:1, 大門 雅夫:2, 木村 公一:1, 中尾 倫子:2, 廣川 愛美:1, 澤田 直子:1, 徐 博卿:2, 桐山 皓行:1, Purevsuren Munkhtuul:3, 網谷 英介:1, 波多野 将:3, 加藤 倫子:4, 渡辺 昌文:1, 小室 一成:1
1:東京大学 循環器内科, 2:東京大学 検査部, 3:東京大学 重症心不全治療開発講座, 4:東京都健康長寿医療センター 心臓外科

Aim: We aimed to explore clinical factors associated with left ventricular (LV) reverse remodeling (LVRR) by beta-blocker therapy in non-ischemic dilated cardiomyopathy (DCM) using transthoracic echocardiography. Methods: We retrospectively analyzed 64 non-ischemic DCM patients who underwent transthoracic echocardiography and optimal medical treatment. Primary outcomes were defined as cardiac resynchronization therapy device or LV assist device implantation or cardiac death within 12 months. LVRR was defined as an increase in LV ejection fraction (LVEF) and/or a decrease in LV end-diastolic diameter within 12 months after the beta-blocker therapy. We divided patients into 2 groups according to LVRR: (1)patients with LVRR; (2)patients without LVRR or those who had an outcome. We compared general characteristics, laboratory and echocardiographic data at baseline between 2 groups. Results: LVRR was found in 11 patients (17.2 %). Compared with the group without LVRR, the group with LVRR had thicker relative wall thickness (0.25±0.08 vs. 0.20±0.03, p<0.01), higher right ventricular (RV) fractional area change (37.2±12.4 vs. 26.3±11.4 %, p<0.01), smaller inferior vena cava diameter (13.6±4.8 vs. 18.6±5.3 mm, p<0.01), and smaller left atrium volume index (43.1±19.0 vs. 62.5±27.6 ml/m2, p<0.05). The group with LVRR also had higher blood pressure, lower brain natriuretic peptide, lower total bilirubin, and higher albumin. Conclusion: Preserved LV relative wall thickness, RV function, and less congestion may be associated with LVRR in DCM.

[Keywords] cardiomyopathy / echocardiography
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