演題

PJ057-7

Gender Differences in Clinical Factors Associated with Age-related Left Ventricular Diastolic Dysfunction in the General Population

[演者] 澤田 直子:1
[共同演者] 大門 雅夫:2, 川田 貴之:1, 木村 公一:1, 中尾 倫子:2, 廣川 愛美:1, 石渡 惇平:1, 徐 博卿:2, 上妻 佳代子:3, 渡辺 昌文:1, 小室 一成:1
1:東京大学 循環器内科, 2:東京大学 検査部, 3:東京大学 健康科学・看護学専攻 生物統計学分野

Background: The prevalence of left ventricular (LV) diastolic dysfunction increases with age, particularly in elderly women, and may contribute to the high prevalence of diastolic heart failure in elderly women. We hypothesized that there are gender differences in clinical factors associated with age-related LV diastolic dysfunction in the general population over 60 years old.Methods and Results: We performed echocardiography in 513 (243 women) over 60 years old without overt heart disease. Then, we examined association between LV diastolic parameters and clinical factors as explanatory variables using multivariable regression analysis and examined their interactions with gender. Age was similar between men and women. Diabetes had a positive association with E/e´ in men but negative in women (p=0.023). On the other hand, positive associations between HDL-cholesterol and E/A, and hypertension and LA volume were observed in women, while they were negative in men (p=0.001 and 0.017, respectively). Furthermore, low hemoglobin and high triglyceride were more strongly associated with increased LV mass in women (p=0.021 and 0.026, respectively).Conclusions: There may be gender differences in clinical factors associated with LV diastolic dysfunction in the general population over 60 years.

[Keywords] echocardiography / diastole
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